Impact of plasma histones in human sepsis and their contribution to cellular injury and inflammation

Critical Care

Volumn 18, Issue 5, 2014, Pages

  Ekaney, Michael Liembo ^a   Otto, Gordon Philipp ^a   Sossdorf, Maik ^a   Sponholz, Christoph ^a   Boehringer, Michael ^a,b   Loesche, Wolfgang ^a   Rittirsch, Daniel ^c   Wilharm, Arne ^a   Kurzai, Oliver ^a,b   Bauer, Michael ^a   Claus, Ralf Alexander ^a  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b HANS KNÖLL INSTITUTE   (Germany)

^c UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; HISTONE; HISTONE H4; LACTATE DEHYDROGENASE; PROPIDIUM IODIDE; TOLL LIKE RECEPTOR 4; CYTOKINE; PROTEIN C; TLR4 PROTEIN, HUMAN;

AGED; ARTICLE; CELL DAMAGE; CELL STIMULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOTOXICITY; ENDOTHELIUM CELL; FEMALE; HUMAN; IMMUNOBLOTTING; IN VITRO STUDY; INFLAMMATION; INTENSIVE CARE UNIT; MALE; MONOCYTE; MORTALITY; MULTIPLE ORGAN FAILURE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RENAL REPLACEMENT THERAPY; SEPSIS; SIGNAL TRANSDUCTION; THROMBOCYTE COUNT; BLOOD; DISEASE COURSE; IMMUNOLOGY; METABOLISM; MIDDLE AGED; MULTIPLE TRAUMA; PROSPECTIVE STUDY;

AGED; CYTOKINES; DISEASE PROGRESSION; FEMALE; HISTONES; HUMANS; INTENSIVE CARE UNITS; L-LACTATE DEHYDROGENASE; MALE; MIDDLE AGED; MULTIPLE ORGAN FAILURE; MULTIPLE TRAUMA; PROSPECTIVE STUDIES; PROTEIN C; SEPSIS; TOLL-LIKE RECEPTOR 4;

EID: 84964313704     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0543-8     Document Type: Article

References (22)

1. Riedemann NC, Guo RF, Ward PA: Novel strategies for the treatment of sepsis. Nat Med 2003, 9:517-524.
2. de Jong HK, van der Poll T, Wiersinga WJ: The systemic pro-inflammatory response in sepsis. J Innate Immun 2010, 2:422-430.
3. Aird WC: The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 2003, 101:3765-3777.
4. Levi M, van der Poll T: Inflammation and coagulation. Crit Care Med 2010, 38:S26-S34.
5. Vincent JL: Acute kidney injury, acute lung injury and septic shock: how does mortality compare? Contrib Nephrol 2011, 174:71-77.
6. Gustot T: Multiple organ failure in sepsis: prognosis and role of systemic inflammatory response. Curr Opin Crit Care 2011, 17:153-159.
7. Kawai T, Akira S: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 2010, 11:373-384.
8. Chan JK, Roth J, Oppenheim JJ, Tracey KJ, Vogl T, Feldmann M, Horwood N, Nanchahal J: Alarmins: awaiting a clinical response. J Clin Invest 2012, 122:2711-2719.
9. Xu J, Zhang X, Pelayo R, Monestier M, Ammollo CT, Semeraro F, Taylor FB, Esmon NL, Lupu F, Esmon CT: Extracellular histones are major mediators of death in sepsis. Nat Med 2009, 15:1318-1321.
10. Fuchs TA, Bhandari AA, Wagner DD: Histones induce rapid and profound thrombocytopenia in mice. Blood 2011, 118:3708-3714.
11. Xu J, Zhang X, Monestier M, Esmon NL, Esmon CT: Extracellular histones are mediators of death through TLR2 and TLR4 in mouse fatal liver injury. J Immunol 2011, 187:2626-2631.
12. Bosmann M, Grailer JJ, Ruemmler R, Russkamp NF, Zetoune FS, Sarma JV, Standiford TJ, Ward PA: Extracellular histones are essential effectors of C5aR- and C5L2-mediated tissue damage and inflammation in acute lung injury. FASEB J 2013, 27:5010-5021.
13. Abrams ST, Zhang N, Manson J, Liu T, Dart C, Baluwa F, Wang SS, Brohi K, Kipar A, Yu W, Wang G, Toh CH: Circulating histones are mediators of trauma-associated lung injury. Am J Respir Crit Care Med 2013, 187:160-169.
14. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, Schein RM, Sibbald WJ: Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis: the ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest 2009, 136(5 Suppl):e28.
15. Neeli I, Khan SN, Radic M: Histone deimination as a response to inflammatory stimuli in neutrophils. J Immunol 2008, 180:1895-1902.
16. Brill A, Fuchs TA, Savchenko AS, Thomas GM, Martinod K, De Meyer SF, Bhandari AA, Wagner DD: Neutrophil extracellular traps promote deep vein thrombosis in mice. J Thromb Haemost 2012, 10:136-144.
17. Filiponi TC, de Souza Durao M Jr: How to choose the ideal renal replacement therapy in sepsis? Shock 2013, 39:50-53.
18. Vanderschueren S, De Weerdt A, Malbrain M, Vankersschaever D, Frans E, Wilmer A, Bobbaers H: Thrombocytopenia and prognosis in intensive care. Crit Care Med 2000, 28:1871-1876.
19. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ: Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 1995, 23:1638-1652.
20. Allam R, Scherbaum CR, Darisipudi MN, Mulay SR, Hagele H, Lichtnekert J, Hagemann JH, Rupanagudi KV, Ryu M, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Liapis H, Moreth K, Schaefer L, Anders HJ: Histones from dying renal cells aggravate kidney injury via TLR2 and TLR4. J Am Soc Nephrol 2012, 23:1375-1388.
21. Padkin A, Goldfrad C, Brady AR, Young D, Black N, Rowan K: Epidemiology of severe sepsis occurring in the first 24 hrs in intensive care units in England, Wales, and Northern Ireland. Crit Care Med 2003, 31:2332-2338.
22. Wildhagen KC, Garcia de Frutos P, Reutelingsperger CP, Schrijver R, Areste C, Ortega-Gomez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA: Non-anticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis. Blood 2013, 21:21.