DICER/AGO-dependent epigenetic silencing of D4Z4 repeats enhanced by exogenous siRNA suggests mechanisms and therapies for FSHD

Human Molecular Genetics

Volumn 24, Issue 17, 2015, Pages 4817-4828

  Lim, Jong Won ^a   Snider, Lauren ^a   Yao, Zizhen ^b   Tawil, Rabi ^c   Van Der Maarel, Silvère M ^d   Rigo, Frank ^e   Bennett, C Frank ^e   Filippova, Galina N ^a   Tapscott, Stephen J ^a  

^a USA   (United States)

^b ALLEN INSTITUTE FOR BRAIN SCIENCE   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e ISIS PHARMACEUTICALS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2' O METHOXYETHYL ANTISENSE OLIGONUCLEOTIDE; ANTISENSE OLIGONUCLEOTIDE; ARGONAUTE PROTEIN; DICER; HISTONE H3; MESSENGER RNA; MICROSATELLITE DNA; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; CHROMATIN; DUX4 PROTEIN, HUMAN; HISTONE; HOMEODOMAIN PROTEIN; RIBONUCLEASE III;

ARTICLE; CONTROLLED STUDY; D4Z4 GENE; DRUG EFFECT; DUX4 GENE; EPIGENETIC REPRESSION; FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; GENE; GENE EXPRESSION; GENE SILENCING; HISTONE METHYLATION; HUMAN; HUMAN CELL; MOLECULAR BIOLOGY; MUSCLE CELL; MYOBLAST; PRIORITY JOURNAL; RNA INTERFERENCE; TRANSCRIPTION INITIATION SITE; CELL LINE; CHROMATIN; GENE EXPRESSION REGULATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; MUSCULAR DYSTROPHY, FACIOSCAPULOHUMERAL;

ARGONAUTE PROTEINS; CELL LINE; CHROMATIN; EPIGENESIS, GENETIC; GENE EXPRESSION REGULATION; GENE SILENCING; HISTONES; HOMEODOMAIN PROTEINS; HUMANS; MICROSATELLITE REPEATS; MUSCULAR DYSTROPHY, FACIOSCAPULOHUMERAL; RIBONUCLEASE III; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION INITIATION SITE;

EID: 84941914076     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddv206     Document Type: Article

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