Asymmetric bidirectional transcription from the FSHD-causing D4Z4 array modulates DUx4 production

PLoS ONE

Volumn 7, Issue 4, 2012, Pages

  Block, Gregory J ^a   Petek, Lisa M ^a   Narayanan, Divya ^a   Amell, Amanda M ^a   Moore, James M ^b   Rabaia, Natalia A ^b   Tyler, Ashlee ^b   van der Maarel, Silvere M ^d   Tawil, Rabi ^c   Filippova, Galina N ^b   Miller, Daniel G ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b Fred Hutchinson Cancer Research Center   (United States)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL FACTOR; DNA; DOUBLE HOMEOBOX PROTEIN 4; PROTEIN D4Z4; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; COMPLEMENTARY RNA; DUX4 PROTEIN, HUMAN; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; HOMEODOMAIN PROTEIN; MICROSATELLITE DNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; D4Z4 GENE; DNA FLANKING REGION; DNA MICROARRAY; DNA RESPONSIVE ELEMENT; DUX4 GENE; EMBRYO; FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY; GENE; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; MUSCLE DEVELOPMENT; MYOBLAST; MYOTUBE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS REGULATION; REPORTER GENE; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION REGULATION; ANIMAL; BINDING SITE; BIOSYNTHESIS; CELL CULTURE; CHROMATIN; EMBRYONIC STEM CELL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HAPLOTYPE; METABOLISM; MOLECULAR GENETICS; MULTIGENE FAMILY; SITE DIRECTED MUTAGENESIS; SKELETAL MUSCLE;

ANIMALS; BASE SEQUENCE; BINDING SITES; CELLS, CULTURED; CHROMATIN; EMBRYONIC STEM CELLS; GENE EXPRESSION REGULATION; GENES, REPORTER; GREEN FLUORESCENT PROTEINS; HAPLOTYPES; HOMEODOMAIN PROTEINS; HUMANS; MICE; MICROSATELLITE REPEATS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; MUSCLE FIBERS, SKELETAL; MUSCULAR DYSTROPHY, FACIOSCAPULOHUMERAL; MUTAGENESIS, SITE-DIRECTED; MYOBLASTS, SKELETAL; PROMOTER REGIONS, GENETIC; RNA, ANTISENSE; TRANSCRIPTION INITIATION SITE; TRANSCRIPTION, GENETIC;

EID: 84859991523     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0035532     Document Type: Article

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