Optimization of the Büchi B-90 spray drying process using central composite design for preparation of solid dispersions

International Journal of Pharmaceutics

Volumn 491, Issue 1-2, 2015, Pages 208-217

  Gu, Bing ^a   Linehan, Brian ^b   Tseng, Yin Chao ^b  

^a UNIVERSITY OF CONNECTICUT   (United States)

^b BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

Amorphous solid dispersion; B chi B 90; Design of experiment; Model; Spray drying

Indexed keywords

HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; DRUG VEHICLE; EXCIPIENT; HYDROXYPROPYLMETHYLCELLULOSE; METHYLCELLULOSE; POLYMER; SUSPENSION;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; MICROSCOPY; PARTICLE SIZE; PRIORITY JOURNAL; SOLID; SOLID STATE; SPRAY DRYING; SUSPENSION; X RAY POWDER DIFFRACTION; CHEMISTRY; DESICCATION; DEVICES; MEDICINAL CHEMISTRY; NANOTECHNOLOGY; PROCEDURES; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DESICCATION; EXCIPIENTS; HYPROMELLOSE DERIVATIVES; METHYLCELLULOSE; MICROSCOPY, ELECTRON, SCANNING; NANOTECHNOLOGY; PHARMACEUTICAL VEHICLES; POLYMERS; SOLUBILITY; SUSPENSIONS; X-RAY DIFFRACTION;

EID: 84941906033     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2015.06.006     Document Type: Article

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