Multimerization of a Proline-Rich Antimicrobial Peptide, Chex-Arg20, Alters Its Mechanism of Interaction with the Escherichia coli Membrane

Chemistry and Biology

Volumn 22, Issue 9, 2015, Pages 1250-1258

  Li, Wenyi ^a   O'Brien Simpson, Neil M ^b,c   Tailhades, Julien ^a   Pantarat, Namfon ^b   Dawson, Raymond M ^d   Otvos, Laszlo ^e,f   Reynolds, Eric C ^b,c   Separovic, Frances ^a,c   Hossain, Mohammed Akhter ^a   Wade, John D ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d DEFENCE SCIENCE AND TECHNOLOGY ORGANISATION   (Australia)

^e Temple University   (United States)

^f SEMMELWEIS UNIVERSITY OF MEDICINE   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

DIMER; MONOMER; POLYMER; POLYPEPTIDE ANTIBIOTIC AGENT; PROLINE RICH PROTEIN; TETRAMER; ANTIMICROBIAL CATIONIC PEPTIDE; MEMBRANE PROTEIN; PEPTIDE; PROLINE;

ARTICLE; BACTERIAL MEMBRANE; COLONY FORMING UNIT; DISULFIDE BOND; ESCHERICHIA COLI; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HYPERPOLARIZATION; MEMBRANE POTENTIAL; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MULTIMERIZATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; CHEMISTRY; DIMERIZATION; DRUG EFFECTS; METABOLISM; MICROBIAL SENSITIVITY TEST; PROLINE RICH PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIMICROBIAL CATIONIC PEPTIDES; DIMERIZATION; ESCHERICHIA COLI; FLOW CYTOMETRY; MEMBRANE PROTEINS; MICROBIAL SENSITIVITY TESTS; MICROSCOPY, FLUORESCENCE; PEPTIDES; PROLINE; PROLINE-RICH PROTEIN DOMAINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941898140     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2015.08.011     Document Type: Article

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