Plasma biomarkers of brain injury as diagnostic tools and outcome predictors after extracorporeal membrane oxygenation

Critical Care Medicine

Volumn 43, Issue 10, 2015, Pages 2202-2211

  Bembea, Melania M ^a   Rizkalla, Nicole ^a   Freedy, James ^b   Barasch, Noah ^c   Vaidya, Dhananjay ^a   Pronovost, Peter J ^a,c   Everett, Allen D ^a   Mueller, Gregory ^b  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Biomarker; Brain; Child; Extracorporeal life support; Extracorporeal membrane oxygenation; Outcome assessment (healthcare)

Indexed keywords

BIOLOGICAL MARKER; BRAIN DERIVED NEUROTROPHIC FACTOR; CELL ADHESION MOLECULE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERCELLULAR ADHESION MOLECULE 5; MONOCYTE CHEMOTACTIC PROTEIN 1; NEURON SPECIFIC ENOLASE; PROTEIN S100B; UNCLASSIFIED DRUG;

ADOLESCENT; ARTICLE; BLOOD SAMPLING; BRAIN INJURY; CHILD; CHILDHOOD DISEASE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DISEASE ASSOCIATION; EXTRACORPOREAL MEMBRANE OXYGENATION DEVICE; EXTRACORPOREAL OXYGENATION; FEMALE; HEART FAILURE; HOSPITAL DISCHARGE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; MEMBRANE OXYGENATOR; NEUROIMAGING; NEUROMONITORING; NEWBORN; NUCLEAR MAGNETIC RESONANCE IMAGING; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; OXYGENATOR; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; RESERVOIR; RESPIRATORY FAILURE; ROLLER PUMP; SEPSIS; TERTIARY HEALTH CARE; ADVERSE EFFECTS; BLOOD; BRAIN INJURIES; PREDICTIVE VALUE; PRESCHOOL CHILD; PROGNOSIS;

ADOLESCENT; BIOMARKERS; BRAIN INJURIES; CHILD; CHILD, PRESCHOOL; EXTRACORPOREAL MEMBRANE OXYGENATION; FEMALE; HUMANS; INFANT; MALE; PREDICTIVE VALUE OF TESTS; PROGNOSIS; PROSPECTIVE STUDIES;

EID: 84941896712     PISSN: 00903493     EISSN: 15300293     Source Type: Journal    
DOI: 10.1097/CCM.0000000000001145     Document Type: Article

References (66)

1. Zabrocki LA, Brogan TV, Statler KD, et al: Extracorporeal membrane oxygenation for pediatric respiratory failure: Survival and predictors of mortality. Crit Care Med 2011;39:364-370
2. Raymond TT, Cunnyngham CB, Thompson MT, et al; American Heart Association National Registry of CPR Investigators: Outcomes among neonates, infants, and children after extracorporeal cardiopulmonary resuscitation for refractory inhospital pediatric cardiac arrest: A report from the National Registry of Cardiopulmonary Resuscitation. Pediatr Crit Care Med 2010;11:362-371
3. Peek GJ, Mugford M, Tiruvoipati R, et al; CESAR trial collaboration: Efficacy and economic assessment of conventional ventilatory support versus extracorporeal membrane oxygenation for severe adult respiratory failure (CESAR): A multicentre randomised controlled trial. Lancet 2009;374:1351-1363
4. Mugford M, Elbourne D, Field D: Extracorporeal membrane oxygenation for severe respiratory failure in newborn infants. Cochrane Database Syst Rev 2008;3:CD001340
5. MacLaren G, Combes A, Bartlett RH: Contemporary extracorporeal membrane oxygenation for adult respiratory failure: Life support in the new era. Intensive Care Med 2012;38:210-220
6. Rehder KJ, Turner DA, Cheifetz IM: Extracorporeal membrane oxygenation for neonatal and pediatric respiratory failure: An evidence-based review of the past decade (2002-2012). Pediatr Crit Care Med 2013;14:851-861
7. Cengiz P, Seidel K, Rycus PT, et al: Central nervous system complications during pediatric extracorporeal life support: Incidence and risk factors. Crit Care Med 2005;33:2817-2824
8. Paden ML, Conrad SA, Rycus PT, et al; ELSO Registry: Extracorporeal Life Support Organization Registry Report 2012. ASAIO J 2013;59:202-210
9. Lidegran MK, Mosskin M, Ringertz HG, et al: Cranial CT for diagnosis of intracranial complications in adult and pediatric patients dur ing ECMO: Clinical benefits in diagnosis and treatment. Acad Radiol 2007;14:62-71
10. Raets MM, Dudink J, Ijsselstijn H, et al: Brain injury associated with neonatal extracorporeal membrane oxygenation in the Netherlands: A nationwide evaluation spanning two decades. Pediatr Crit Care Med 2013;14:884-892
11. Rollins MD, Yoder BA, Moore KR, et al: Utility of neuroradiographic imaging in predicting outcomes after neonatal extracorporeal membrane oxygenation. J Pediatr Surg 2012;47:76-80
12. Hanekamp MN, Mazer P, Van Der Cammen-Van Zijp MH, et al: Followup of newborns treated with extracorporeal membrane oxygenation: A nationwide evaluation at 5 years of age. Crit Care 2006;10:R127
13. Khambekar K, Nichani S, Luyt DK, et al: Developmental outcome in newborn infants treated for acute respiratory failure with extracorporeal membrane oxygenation: Present experience. Arch Dis Child Fetal Neonatal Ed 2006;91:F21-F25
14. Nijhuis-Van Der Sanden MW, Van Der Cammen-Van Zijp MH, Janssen AJ, et al: Motor performance in five-year-old extracorporeal membrane oxygenation survivors: A population-based study. Crit Care 2009;13:R47
15. Short BL, Walker LK, Traystman RJ: Impaired cerebral autoregulation in the newborn lamb during recovery from severe, prolonged hypoxia, combined with carotid artery and jugular vein ligation. Crit Care Med 1994;22:1262-1268
16. Short BL: The effect of extracorporeal life support on the brain: A focus on ECMO. Semin Perinatol 2005;29:45-50
17. O'Brien NF, Hall MW: Extracorporeal membrane oxygenation and cerebral blood flow velocity in children. Pediatr Crit Care Med 2013;14:e126-e134
18. Liem KD, Hopman JC, Kollée LA, et al: Assessment of cerebral oxygenation and hemodynamics by near infrared spectrophotometry during induction of ECMO: Preliminary results. The ECMO Research Group. Adv Exp Med Biol 1992;317:841-846
19. Lidegran M, Palmér K, Jorulf H, et al: CT in the evaluation of patients on ECMO due to acute respiratory failure. Pediatr Radiol 2002;32:567-574
20. Gannon CM, Kornhauser MS, Gross GW, et al: When combined, early bedside head ultrasound and electroencephalography predict abnormal computerized tomography or magnetic resonance brain images obtained after extracorporeal membrane oxygenation treatment. J Perinatol 2001;21:451-455
21. Bulas D, Glass P: Neonatal ECMO: Neuroimaging and neurodevelopmental outcome. Semin Perinatol 2005;29:58-65
22. Niebrój-Dobosz I, Rafałowska J, Lukasiuk M, et al: Immunochemical analysis of some proteins in cerebrospinal fluid and serum of patients with ischemic strokes. Folia Neuropathol 1994;32:129-137
23. Herrmann M, Vos P, Wunderlich MT, et al: Release of glial tissuespecific proteins after acute stroke: A comparative analysis of serum concentrations of protein S-100B and glial fibrillary acidic protein. Stroke 2000;31:2670-2677
24. Dvorak F, Haberer I, Sitzer M, et al: Characterisation of the diagnostic window of serum glial fibrillary acidic protein for the differentiation of intracerebral haemorrhage and ischaemic stroke. Cerebrovasc Dis 2009;27:37-41
25. Jauch EC, Lindsell C, Broderick J, et al; NINDS rt-PA Stroke Study Group: Association of serial biochemical markers with acute ischemic stroke: The National Institute of Neurological Disorders and Stroke recombinant tissue plasminogen activator Stroke Study. Stroke 2006;37:2508-2513
26. Foerch C, Wunderlich MT, Dvorak F, et al: Elevated serum S100B levels indicate a higher risk of hemorrhagic transformation after thrombolytic therapy in acute stroke. Stroke 2007;38:2491-2495
27. Wunderlich MT, Lins H, Skalej M, et al: Neuron-specific enolase and tau protein as neurobiochemical markers of neuronal damage are related to early clinical course and long-term outcome in acute ischemic stroke. Clin Neurol Neurosurg 2006;108:558-563
28. Selakovic V, Raicevic R, Radenovic L: The increase of neuron-specific enolase in cerebrospinal fluid and plasma as a marker of neuronal damage in patients with acute brain infarction. J Clin Neurosci 2005;12:542-547
29. Oertel M, Schumacher U, McArthur DL, et al: S-100B and NSE: Markers of initial impact of subarachnoid haemorrhage and their relation to vasospasm and outcome. J Clin Neurosci 2006;13:834-840
30. Kaneko T, Kasaoka S, Miyauchi T, et al: Serum glial fibrillary acidic protein as a predictive biomarker of neurological outcome after cardiac arrest. Resuscitation 2009;80:790-794
31. Piazza O, Cotena S, Esposito G, et al: S100B is a sensitive but not specific prognostic index in comatose patients after cardiac arrest. Minerva Chir 2005;60:477-480
32. Hayashida H, Kaneko T, Kasaoka S, et al: Comparison of the predictability of neurological outcome by serum procalcitonin and glial fibrillary acidic protein in postcardiac-arrest patients. Neurocrit Care 2010;12:252-257
33. Grubb NR, Simpson C, Sherwood RA, et al: Prediction of cognitive dysfunction after resuscitation from out-of-hospital cardiac arrest using serum neuron-specific enolase and protein S-100. Heart 2007;93:1268-1273
34. Wiesmann M, Steinmeier E, Magerkurth O, et al: Outcome prediction in traumatic brain injury: Comparison of neurological status, CT findings, and blood levels of S100B and GFAP. Acta Neurol Scand 2010;121:178-185
35. Pelinka LE, Kroepfl A, Leixnering M, et al: GFAP versus S100B in serum after traumatic brain injury: Relationship to brain damage and outcome. J Neurotrauma 2004;21:1553-1561
36. Pelinka LE, Kroepfl A, Schmidhammer R, et al: Glial fibrillary acidic protein in serum after traumatic brain injury and multiple trauma. J Trauma 2004;57:1006-1012
37. Nylén K, Ost M, Csajbok LZ, et al: Increased serum-GFAP in patients with severe traumatic brain injury is related to outcome. J Neurol Sci 2006;240:85-91
38. Fraser DD, Close TE, Rose KL, et al; Canadian Critical Care Translational Biology Group: Severe traumatic brain injury in children elevates glial fibrillary acidic protein in cerebrospinal fluid and serum. Pediatr Crit Care Med 2011;12:319-324
39. Berger RP, Adelson PD, Pierce MC, et al: Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children. J Neurosurg 2005;103:61-68
40. Savage WJ, Barron-Casella E, Fu Z, et al: Plasma glial fibrillary acidic protein levels in children with sickle cell disease. Am J Hematol 2011;86:427-429
41. Ennen CS, Huisman TA, Savage WJ, et al: Glial fibrillary acidic protein as a biomarker for neonatal hypoxic-ischemic encephalopathy treated with whole-body cooling. Am J Obstet Gynecol 2011;205:251.e1-251.e7
42. Conductier G, Blondeau N, Guyon A, et al: The role of monocyte chemoattractant protein MCP1/CCL2 in neuroinflammatory diseases. J Neuroimmunol 2010;224:93-100
43. Gazzolo D, Masetti P, Meli M, et al: Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation. Acta Paediatr 2002;91:218-221
44. Bembea MM, Savage W, Strouse JJ, et al: Glial fibrillary acidic protein as a brain injury biomarker in children undergoing extracorporeal membrane oxygenation. Pediatr Crit Care Med 2011;12:572-579
45. Floerchinger B, Philipp A, Foltan M, et al: Neuron-specific enolase serum levels predict severe neuronal injury after extracorporeal life support in resuscitation. Eur J Cardiothorac Surg 2014;45:496-501
46. Nguyen DN, Huyghens L, Wellens F, et al: Serum S100B protein could help to detect cerebral complications associated with extracorporeal membrane oxygenation (ECMO). Neurocrit Care 2014;20:367-374
47. Fiser DH: Assessing the outcome of pediatric intensive care. J Pediatr 1992;121:68-74
48. Fiser DH, Long N, Roberson PK, et al: Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med 2000;28:2616-2620
49. Fortenberry JD, Bhardwaj V, Niemer P, et al: Neutrophil and cytokine activation with neonatal extracorporeal membrane oxygenation. J Pediatr 1996;128:670-678
50. Fink EL, Berger RP, Clark RS, et al: Serum biomarkers of brain injury to classify outcome after pediatric cardiac arrest. Crit Care Med 2014;42:664-674
51. Hirsch JC, Jacobs ML, Andropoulos D, et al: Protecting the infant brain during cardiac surgery: A systematic review. Ann Thorac Surg 2012;94:1365-1373
52. Foerch C, Curdt I, Yan B, et al: Serum glial fibrillary acidic protein as a biomarker for intracerebral haemorrhage in patients with acute stroke. J Neurol Neurosurg Psychiatry 2006;77:181-184
53. Gazzolo D, Masetti P, Meli M, et al: Elevated S100B protein as an early indicator of intracranial haemorrhage in infants subjected to extracorporeal membrane oxygenation. Acta Paediatr 2002;91:218-221
54. Bembea MM, Schwartz JM, Shah N, et al: Anticoagulation monitoring during pediatric extracorporeal membrane oxygenation. ASAIO J 2013;59:63-68
55. Yoshida T, Ishikawa M, Niitsu T, et al: Decreased serum levels of mature brain-derived neurotrophic factor (BDNF), but not its precursor proBDNF, in patients with major depressive disorder. PLoS One 2012;7:e42676
56. Södersten K, Pålsson E, Ishima T, et al: Abnormality in serum levels of mature brain-derived neurotrophic factor (BDNF) and its precursor proBDNF in mood-stabilized patients with bipolar disorder: A study of two independent cohorts. J Affect Disord 2014;160:1-9
57. McCrory MC, Gower EW, Simpson SL, et al: Off-hours admission to pediatric intensive care and mortality. Pediatrics 2014;134:e1345-e1353
58. Martínez Hardigree JF, Katz HE: Through thick and thin: Tuning the threshold voltage in organic field-effect transistors. Acc Chem Res 2014;47:1369-1377
59. Hahn JS, Vaucher Y, Bejar R, et al: Electroencephalographic and neuroimaging findings in neonates undergoing extracorporeal membrane oxygenation. Neuropediatrics 1993;24:19-24
60. Graziani LJ, Streletz LJ, Kornhauser MS, et al: Electroencephalographic and cranial ultrasound studies in neonates treated with extracorporeal membrane oxygenation. Pediatr Rev Commun 1989;4:71-75
61. Liem KD, Hopman JC, Oeseburg B, et al: Cerebral oxygenation and hemodynamics during induction of extracorporeal membrane oxygenation as investigated by near infrared spectrophotometry. Pediatrics 1995;95:555-561
62. Fenik JC, Rais-Bahrami K: Neonatal cerebral oximetry monitoring during ECMO cannulation. J Perinatol 2009;29:376-381
63. Wong JK, Smith TN, Pitcher HT, et al: Cerebral and lower limb nearinfrared spectroscopy in adults on extracorporeal membrane oxygenation. Artif Organs 2012;36:659-667
64. Rollins MD, Hubbard A, Zabrocki L, et al: Extracorporeal membrane oxygenation cannulation trends for pediatric respiratory failure and central nervous system injury. J Pediatr Surg 2012;47:68-75
65. Polito A, Barrett CS, Wypij D, et al: Neurologic complications in neonates supported with extracorporeal membrane oxygenation. An analysis of ELSO registry data. Intensive Care Med 2013;39:1594-1601
66. De Veber GA, MacGregor D, Curtis R, et al: Neurologic outcome in survivors of childhood arterial ischemic stroke and sinovenous thrombosis. J Child Neurol 2000;15:316-324