Glycemic control, inflammation, and cognitive function in older patients with type 2 diabetes

International Journal of Geriatric Psychiatry

Volumn 30, Issue 10, 2015, Pages 1093-1100

  Akrivos, Jimmy ^a,b   Ravona Springer, Ramit ^c   Schmeidler, James ^a   Leroith, Derek ^a,d   Heymann, Anthony ^e   Preiss, Rachel ^e   Hoffman, Hadas ^e   Koifman, Keren ^c   Silverman, Jeremy M ^a,b   Schnaider Beeri, Michal ^a,c,f  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c SHEBA MEDICAL CENTER   (Israel)

^d RAMBAM MEDICAL CENTER   (Israel)

^e MACCABI HEALTHCARE SERVICES   (Israel)

^f INTERDISCIPLINARY CENTER   (Israel)

Author keywords

C reactive protein; cognitive function; HbA1c; older people; type 2 diabetes

Indexed keywords

C REACTIVE PROTEIN; GLUCOSE; HEMOGLOBIN A1C; BIOLOGICAL MARKER; GLUCOSE BLOOD LEVEL; GLYCOSYLATED HEMOGLOBIN;

AGED; ARTICLE; ATTENTION; CLINICAL ASSESSMENT; COGNITIVE DEFECT; COHORT ANALYSIS; COMMUNITY SAMPLE; DISEASE ASSOCIATION; DISEASE EXACERBATION; EXECUTIVE FUNCTION; FEMALE; GLUCOSE BLOOD LEVEL; GLYCEMIC CONTROL; HUMAN; INFLAMMATION; ISRAEL; MAJOR CLINICAL STUDY; MALE; MEMORY; MENTAL PERFORMANCE; NON INSULIN DEPENDENT DIABETES MELLITUS; RETROSPECTIVE STUDY; SEMANTICS; ADULT; BLOOD; COGNITION; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY; REGRESSION ANALYSIS;

ADULT; AGED; ATTENTION; BIOMARKERS; BLOOD GLUCOSE; C-REACTIVE PROTEIN; COGNITION; DIABETES MELLITUS, TYPE 2; EXECUTIVE FUNCTION; FEMALE; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INFLAMMATION; ISRAEL; MALE; MEMORY; MIDDLE AGED; REGRESSION ANALYSIS; RETROSPECTIVE STUDIES;

EID: 84941807568     PISSN: 08856230     EISSN: 10991166     Source Type: Journal    
DOI: 10.1002/gps.4267     Document Type: Article

References (30)

1. Abbatecola AM, Rizzo MR, Barbieri M, et al., 2006. Postprandial plasma glucose excursions and cognitive functioning in aged type 2 diabetics. Neurology 67: 235-40.
2. Akiyama H, Barger S, Barnum S, et al., 2000. Inflammation and Alzheimer's disease. Neurobiol Aging 21: 383-421.
3. Beeri MS, Schmeidler J, Silverman JM, et al., 2008. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology 71: 750-7.
4. Beeri MS, Ravona-Springer R, Silverman JM, Haroutunian V,. 2009. The effects of cardiovascular risk factors on cognitive compromise. Dialogues Clin Neurosci 11: 201-12.
5. Ceriello A, Esposito K, Piconi L, et al., 2008. Oscillating glucose is more deleterious to endothelial function and oxidative stress than mean glucose in normal and type 2 diabetic patients. Diabetes 57: 1349-54.
6. Derr R, Garrett E, Stacy GA, Saudek CD,. 2003. Is HbA(1c) affected by glycemic instability? Diabetes Care 26: 2728-33.
7. Dik MG, Jonker C, Comijs HC, et al., 2007. Contribution of metabolic syndrome components to cognition in older individuals. Diabetes Care 30: 2655-60.
8. Engelhart MJ, Geerlings MI, Meijer J, et al., 2004. Inflammatory proteins in plasma and the risk of dementia: the Rotterdam study. Arch Neurol 61: 668-72.
9. Festa A, D'Agostino R, Jr., Howard G, Mykkanen L, Tracy RP, Haffner SM,. 2000. Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS). Circulation 102: 42-7.
10. Guerrero-Berroa E, Ravona-Springer R, Schmeidler J, et al., 2014. Age, gender, and education are associated with cognitive performance in an older Israeli sample with type 2 diabetes. Int J Geriatr Psychiatry 29: 299-309.
11. Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA,. 2008. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med 359: 1577-89.
12. Imtiaz B, Tolppanen AM, Kivipelto M, Soininen H,. 2014. Future directions in Alzheimer's disease from risk factors to prevention. Biochem Pharmacol 88: 661-70.
13. de Jager J, Dekker JM, Kooy A, et al., 2006. Endothelial dysfunction and low-grade inflammation explain much of the excess cardiovascular mortality in individuals with type 2 diabetes: the Hoorn study. Arterioscler Thromb Vasc Biol 26: 1086-93.
14. Jefferson AL, Massaro JM, Beiser AS, et al., 2011. Inflammatory markers and neuropsychological functioning: the Framingham Heart Study. Neuroepidemiology 37: 21-30.
15. Jenny NS, French B, Arnold AM, et al., 2012. Long-term assessment of inflammation and healthy aging in late life: the cardiovascular health study all stars. J Gerontol A Biol Sci Med Sci 67: 970-6.
16. Luchsinger JA, Palmas W, Teresi JA, et al., 2011. Improved diabetes control in the elderly delays global cognitive decline. J Nutr Health Aging 15: 445-9.
17. Monnier L, Colette C,. 2008. Glycemic variability: should we and can we prevent it? Diabetes Care 31 (Suppl. 2): S150-4.
18. Monnier L, Mas E, Ginet C, et al., 2006. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA 295: 1681-1687.
19. Mooijaart SP, Sattar N, Trompet S, et al., 2011. C-reactive protein and genetic variants and cognitive decline in old age: the PROSPER study. PLoS One 6: e23890.
20. Nissen SE, Tuzcu EM, Schoenhagen P, et al., 2005. Statin therapy, LDL cholesterol, C-reactive protein, and coronary artery disease. N Engl J Med 352: 29-38.
21. Noble JM, Manly JJ, Schupf N, Tang MX, Mayeux R, Luchsinger JA,. 2010. Association of C-reactive protein with cognitive impairment. Arch Neurol 67: 87-92.
22. Ravona-Springer R, Heymann A, Schmeidler J, et al., 2013. Haptoglobin 1-1 genotype is associated with poorer cognitive functioning in the elderly with type 2 diabetes. Diabetes Care 36: 3139-45.
23. Ridker PM, Buring JE, Cook NR, Rifai N,. 2003. C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation 107: 391-7.
24. Rizzo MR, Marfella R, Barbieri M, et al., 2010. Relationships between daily acute glucose fluctuations and cognitive performance among aged type 2 diabetic patients. Diabetes Care 33: 2169-74.
25. Schmidt R, Schmidt H, Curb JD, Masaki K, White LR, Launer LJ,. 2002. Early inflammation and dementia: a 25-year follow-up of the Honolulu-Asia aging study. Ann Neurol 52: 168-74.
26. Singh-Manoux A, Dugravot A, Brunner E, et al., 2014. Interleukin-6 and C-reactive protein as predictors of cognitive decline in late midlife. Neurology 83: 486-93.
27. West RK, Ravona-Springer R, Schmeidler J, et al., 2014. The association of duration of type 2 diabetes with cognitive performance is modulated by long-term glycemic control. Am J Geriatr Psychiatry 22: 1055-9.
28. Yaffe K, Kanaya A, Lindquist K, et al., 2004. The metabolic syndrome, inflammation, and risk of cognitive decline. JAMA 292: 2237-2242.
29. Yaffe K, Haan M, Blackwell T, Cherkasova E, Whitmer RA, West N,. 2007. Metabolic syndrome and cognitive decline in elderly Latinos: findings from the Sacramento area Latino study of aging study. J Am Geriatr Soc 55: 758-762.
30. Zhong Y, Zhang XY, Miao Y, et al., 2012. The relationship between glucose excursion and cognitive function in aged type 2 diabetes patients. Biomed Environ Sci 25: 1-7.