Effects of treatment modalities for Graves' hyperthyroidism on Graves' orbitopathy: A 2015 Italian Society of Endocrinology Consensus Statement

Journal of Endocrinological Investigation

Volumn 38, Issue 4, 2015, Pages 481-487

  Bartalena, L ^a   Macchia, P E ^b   Marcocci, C ^c   Salvi, M ^d   Vermiglio, F ^e  

^a UNIVERSITY OF INSUBRIA   (Italy)

^b UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^c UNIVERSITY OF PISA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e UNIVERSITY OF MESSINA   (Italy)

Author keywords

Antithyroid drugs; Glucocorticoids; Graves' disease; Graves' orbitopathy; Radioiodine; Thionamides; Thyroidectomy

Indexed keywords

ANTITHYROID AGENT; RADIOACTIVE IODINE;

ABLATION THERAPY; DISEASE SEVERITY; ENDOCRINE OPHTHALMOPATHY; GRAVES DISEASE; HUMAN; REVIEW; THYROIDECTOMY; TOTAL THYROID ABLATION; TREATMENT OUTCOME; CONSENSUS; GRAVES OPHTHALMOPATHY; ITALY; MEDICAL SOCIETY; PRACTICE GUIDELINE; STANDARDS;

CONSENSUS; GRAVES DISEASE; GRAVES OPHTHALMOPATHY; HUMANS; ITALY; PRACTICE GUIDELINES AS TOPIC; SOCIETIES, MEDICAL;

EID: 84941785709     PISSN: 03914097     EISSN: 17208386     Source Type: Journal    
DOI: 10.1007/s40618-015-0257-z     Document Type: Review

References (59)

1. Bartalena L (2013) Diagnosis and management of Graves disease: a global overview. Nature Rev Endocrinol 9:724-734
2. Bartalena L, Fatourechi V (2014) Extrathyroidal manifestations of Graves' disease: a 2014 update. J Endocrinol Invest 37:691-700
3. Tanda ML, Piantanida E, Liparulo L, Veronesi G, Lai A, Sassi L, Pariani N, Gallo D, Azzolini C, Ferrario M, Bartalena L (2013) Prevalence and natural history of Graves' orbitopathy in a large series of patients with newly diagnosed Graves' hyperthyroidism seen at a single center. J Clin Endocrinol Metab 98:1443-1449
4. Piantanida E, Tanda ML, Lai A, Sassi L, Bartalena L (2013) Prevalence and natural history of Graves' orbitopathy in the XXI century. J Endocrinol Invest 36:444-449
5. Prummel MF, Wiersinga WM, Mourits MP, Koornneef L, Berghout A, van der Gaag R (1989) Amelioration of eye changes of Graves' ophthalmopathy by achieving euthyroidism. Acta Endocrinol (Copenh) 121(Suppl 2):185-189
6. Karlsson FA, Dahlberg PA, Jansson R, Westermark K, Enoksson P (1989) Importance of TSH receptor activation in the development of severe endocrine ophthalmopathy. Acta Endocrinol (Copenh) 121(suppl 2):132-141
7. Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, Mourits M, Perros P, Boboridis K, Boschi A, Currò N, Daumerie C, Kahaly GJ, Krassas GE, Lane CM, Lazarus JH, Marinò M, Nardi M, Neoh C, Orgiazzi J, Pearce S, Pinchera A, Pitz S, Salvi M, Sivelli P, Stahl M, von Arx G, Wiersinga WM (2008) Consensus statement of the European Group on Graves' Orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol 158:273-285
8. Bartalena L (2011) The dilemma of how to manage Graves' hyperthyroidism in patients with associated orbitopathy. J Clin Endocrinol Metab 96:592-599
9. Swiglo BA, Murad MH, Schunemann HJ, Kunz R, Vigersky RA, Guyatt GH, Montori VM (2008) A case for clarity, consistency, and helpfulness: state-of-the-art clinical practice guidelines in endocrinology using the grading of recommendations, assessment, development, and evaluation system. J Clin Endocrinol Metab 93:666-673
10. Bartalena L, Burch HB, Burman KD, Kahaly GJ (2014) A 2013 European survey of clinical practice patterns in the management of Graves' disease. Clin Endocrinol (Oxf). doi: 10.1111/cen.12688 (epub ahead of print)
11. Burch HB, Burman KD, Cooper DS (2012) A survey of clinical practice patterns in the management of Graves' disease. J Clin Endocrinol Metab 97:4549-4558
12. Emiliano AB, Governale L, Parks M, Cooper DS (2010) Shifts in propylthiouracil and methimazole prescribing practices: antithyroid drug use in the United States from 1991 to 2008. J Clin Endocrinol Metab 95:2227-2233
13. Abraham P, Avenell A, Park CM, Watson WA, Bevan JS (2005) A systematic review of drug therapy for Graves' hyperthyroidism. Eur J Endocrinol 153:489-498
14. Hegedus L (2009) Treatment of Graves' hyperthyroidism: evidence-based and emerging modalities. Endocrinol Metab Clin N Am 38:355-371
15. Marinò M, Latrofa F, Menconi F, Chiovato L, Vitti P (2014) An update on the medical treatment of Graves hyperthyroidism. J Endocrinol Invest 37:1041-1048
16. Bartalena L, Marcocci C, Bogazzi F, Manetti L, Tanda ML, Dell'Unto E, Bruno-Bossio G, Nardi M, Bartolomei MP, Lepri A, Rossi G, Martino E, Pinchera A (1998) Relation between therapy for hyperthyroidism and the course of Graves' ophthalmopathy. N Engl J Med 338:73-78
17. Laurberg P, Wallin G, Tallstedt L, Abraham-Nordling M, Lundell G, Torring O (2008) TSH-receptor autoimmunity in Graves' disease after therapy with anti-thyroid drugs, surgery, or radioiodine: a 5-year prospective randomized study. Eur J Endocrinol 158:69-75
18. Bogazzi F, Giovannetti C, Fessehatsion R, Tanda ML, Campomori A, Compri E, Rossi G, Ceccarelli C, Vitti P, Pinchera A, Bartalena L, Martino E (2010) Impact of lithium on efficacy of radioactive iodine therapy for Graves' disease: a cohort study on cure rate, time to cure, and frequency of increase in serum thyroxine after antithyroid drug withdrawal. J Clin Endocrinol Metab 95:201-208
19. Tanda ML, Lai A, Bartalena L (2008) Relation between Graves' orbitopathy and radioiodine therapy for hyperthyroidism: facts and unsolved questions. Clin Endocrinol (Oxf) 69:845-847
20. Bartalena L, Marcocci C, Bogazzi F, Panicucci M, Lepri A, Pinchera A (1989) Use of corticosteroids to prevent progression of Graves' ophthalmopathy after radioiodine therapy for hyperthyroidism. N Engl J Med 321:1349-1352
21. Tallstedt L, Lundell G, Torring O, Wallin G, Ljunggren JG, Blomgren H, Taube A, The Thyroid Study Group (1992) Occurrence of ophthalmopathy after treatment for Graves' hyperthyroidism. N Engl J Med 326:1733-1738
22. Traisk F, Tallstedt L, Abraham-Nordling M, Andersson T, Berg G, Calissendorff J, Hallengren B, Hedner P, Lantz M, Nystrom E, Ponjavic V, Taube A, Torring O, Wallin G, Asman P, Lundell G, The Thyroid Study Group of TT96 (2009) Thyroid-associated ophthalmopathy after treatment for Graves' hyperthyroidism with antithyroid drugs or iodine-131. J Clin Endocrinol Metab 94:3700-3707
23. Tallstedt L, Lundell G, Blomgren H, Bring J (1994) Does early administration of thyroxine reduce the development of Graves' ophthalmopathy after radioiodine treatment? Eur J Endocrinol 130:494-497
24. Perros P, Kendall-Taylor P, Neoh C, Frewin S, Dickinson J (2005) A prospective study of the effects of radioiodine therapy for hyperthyroidism in patients with minimally active Graves' ophthalmopathy. J Clin Endocrinol Metab 90:5321-5323
25. Eckstein AK, Plicht M, Lax H, Neuhauser M, Mann K, Lederbegen S, Heckmann C, Esser J, Morgenthaler NG (2006) Thyrotropin receptor autoantibodies are independent risk factors for Graves' ophthalmopathy and help to predict severity and outcome of the disease. J Clin Endocrinol Metab 91:3464-3470
26. Kung AWC, Yau CC, Cheng A (1994) The incidence of ophthalmopathy after radioiodine therapy: prognostic factors and the role of methimazole. J Clin Endocrinol Metab 79:542-546
27. Vannucchi G, Campi I, Covelli D, Dazzi D, Currò N, Simonetta S, Ratiglia R, Beck-Peccoz P, Salvi M (2009) Graves' orbitopathy activation after radioactive iodine therapy with and without steroid prophylaxis. J Clin Endocrinol Metab 94:3381-3386
28. Bartalena L, Tanda ML (2009) Clinical practice - Graves' ophthalmopathy. N Engl J Med 360:994-1001
29. Acharya SH, Avenell A, Philip S, Burr J, Bevan JS, Abraham P (2008) Radioiodine therapy (RAI) for Graves' disease (GD) and the effect on ophthalmopathy: a systematic review. Clin Endocrinol (Oxf) 69:943-950
30. Shiber S, Stiebel-Kalish H, Shimon I, Grossman A, Robensthok E (2014) Glucocorticoids regimens for prevention of Graves' ophthalmopathy progression following radioiodine treatment - systematic review and meta-analysis. Thyroid 24:1515-1523
31. Lai A, Sassi L, Compri E, Marino F, Sivelli P, Piantanida E, Tanda ML, Bartalena L (2010) Lower dose prednisone prevents radioiodine-associated exacerbation of initially mild or absent Graves' orbitopathy: a retrospective cohort study. J Clin Endocrinol Metab 95:1333-1337
32. Bartalena L (2014) Steroid prophylaxis after radioiodine treatment for Graves' hyperthyroidism: selective or universal? Thyroid 24:1441-1442
33. Palit TK, Miller CC III, Miltenburg DM (2000) The efficacy of thyroidectomy for Graves' disease: a meta-analysis. J Surg Res 90:161-165
34. Feroci F, Rettori M, Borrelli A, Coppola A, Castagnoli A, Perigli G, Cianchi F, Scatizzi M (2014) A systematic review and meta-analysis of total thyroidectomy versus bilateral subtotal thyroidectomy for Graves' disease. Surgery 155:529-540
35. Guo Z, Yu P, Liu Z, Si Y, Jin M (2013) Total thyroidectomy vs bilateral subtotal thyroidectomy in patients with Graves' disease: a meta-analysis of randomized clinical trials. Clin Endocrinol (Oxf) 79:739-746
36. Genovese BM, Noureldine SI, Gleeson EM, Tufano RP, Kandil E (2013) What is the best definitive treatment for Graves' disease? A systematic review of the existing literature. Ann Surg Oncol 20:660-667
37. Marcocci C, Bruno-Bossio G, Manetti L, Tanda ML, Miccoli P, Iacconi P, Bartolomei MP, Nardi M, Pinchera A, Bartalena L (1999) The course of Graves' ophthalmopathy is not influenced by near total thyroidectomy: a case-control study. Clin Endocrinol (Oxf) 51:503-508
38. Weber KJ, Solorzano CC, Lee JK, Gaffud MJ, Prinza RA (2006) Thyroidectomy remains an effective treatment option for Graves' disease. Am J Surg 191:400-405
39. Bartalena L, Pinchera A, Marcocci C (2000) Management of Graves' ophthalmopathy: reality and perspectives. Endocr Rev 21:168-199
40. Menconi F, Marinò M, Pinchera A, Rocchi R, Mazzi B, Nardi M, Bartalena L, Marcocci C (2007) Effects of total thyroid ablation versus near-total thyroidectomy alone on mild to moderate Graves' orbitopathy treated with intravenous glucocorticoids. J Clin Endocrinol Metab 92:1653-1658
41. Leo M, Marcocci C, Pinchera A, Nardi M, Megna L, Rocchi R, Latrofa F, Altea MA, Mazzi B, Sisti E, Profilo MA, Marinò M (2012) Outcome of Graves' orbitopathy after total thyroid ablation and glucocorticoid treatment: follow-up of a randomized clinical trial. J Clin Endocrinol Metab 97:E44-E48
42. Moleti M, Violi MA, Montanini D, Trombetta C, Di Bella B, Sturniolo G, Presti S, Alibrandi A, Campenni A, Baldari S, Trimarchi F, Vermiglio F (2014) Radioiodine ablation of postsurgical thyroid remnants with recombinant huma TSH (rhTSH) in patients with moderate-to-severe Graves' orbitopathy (GO): a prospective, randomized, single-blind clinical trial. J Clin Endocrinol Metab 99:1783-1789
43. Moleti M, Mattina F, Salamone I, Violi MA, Nucera C, Baldari S, Lo Schiavo MG, Regalbuto C, Trimarchi F, Vermiglio F (2003) Effects of thyroidectomy alone or followed by radioiodine ablation of thyroid remnants on the outcome of Graves' ophthalmopathy. Thyroid 13:653-658
44. De Bellis A, Conzo G, Cennamo G, Pane E, Bellastella G, Colella C, Iacovo AD, Paglionico VA, Sinisi AA, Wall JR, Bizzarro A, Bellastella A (2012) Time course of Graves' ophthalmopathy after total thyroidectomy alone or followed by radioiodine therapy: a 2-year longitudinal study. Endocrine 41:320-326
45. Gerding MN, Terwee CB, Dekker FW, Koornneef L, Prummel MF, Wiersinga WM (1997) Quality of life in patients with Graves' ophthalmopathy is markedly decreased: measurements by the Medical Outcomes Study Instrument. Thyroid 7:885-889
46. Kahaly GJ, Petrak T, Hardt J, Pitz S, Egle UT (2005) Psychosocial morbidity of Graves' orbitopathy. Clin Endocrinol (Oxf) 63:395-402
47. Marcocci C, Kahaly GJ, Krassas GE, Bartalena L, Prummel M, Stahl M, Altea MA, Nardi M, Pitz S, Boboridis K, Sivelli P, von Arx G, Mourits MP, Baldeschi L, Bencivelli W, Wiersinga W, The European Group on Graves' Orbitopathy (2011) Selenium and the course of mild Graves' orbitopathy. N Engl J Med 364:1920-1931
48. Dharmasena A (2014) Selenium supplementation in thyroid-associated ophthalmopathy: an update. Int J Ophthalmol 18:365-375
49. Zang S, Ponto KA, Kahaly GJ (2011) Intravenous glucocorticoids for Graves' orbitopathy: efficacy and morbidity. J Clin Endocrinol Metab 96:320-332
50. Bartalena L, Krassas GE, Wiersinga W, Marcocci C, Salvi M, Daumerie C, Bournaud C, Stahl M, Sassi L, Veronesi C, Azzolini C, Boborisis KG, Mourits MP, Soeters MR, Baldeschi L, Nardi M, Currò N, Boschi A, Bernard M, von Arx G, European Group on Graves' Orbitopathy (2012) Efficacy and safety of three different cumulative doses of intravenous methylprednisolone for moderate to severe and active Graves' orbitopathy. J Clin Endocrinol Metab 97:4454-4463
51. Macchia PE, Bagattini M, Lupoli G, Vitale M, Vitale G, Fenzi G (2001) High-dose intravenous corticosteroid therapy for Graves' ophthalmopathy. J Endocrinol Invest 24:152-158
52. Tanda ML, Bartalena L (2012) Efficacy and safety of orbital radiotherapy for Graves' orbitopathy. J Clin Endocrinol Metab 97:3857-3865
53. Salvi M, Vannucchi G, Beck-Peccoz P (2013) Potential utility of rituximab for Graves' orbitopathy. J Clin Endocrinol Metab 98:4291-4299
54. Stan MN, Garrity JA, Carranza Leon BG, Prabin T, Bradley EA, Bahn RS (2014) Randomized controlled trial of rituximab in patients with Graves' orbitopathy. J Clin Endocrinol Metab: jc201442572 (epub ahead of print)
55. Salvi M, Vannucchi G, Currò N, Campi I, Covelli D, Dazzi D, Simonetta S, Guastella C, Pignataro L, Avignone S, Beck-Peccoz P (2014) Efficacy of B-cell targeted therapy with rituximab in patients with active moderate-severe Graves' orbitopathy: a randomized controller study. J Clin Endocrinol Metab: jc201443014 (epub ahead of print)
56. Elbers L, Mourits M, Wiersinga W (2011) Outcome of very long-term treatment with antithyroid drugs in Graves' hyperthyroidism associated with Graves' orbitopathy. Thyroid 21:279-283
57. Laurberg P, Berman DC, Andersen S, Bulow Pedersen I (2011) Sustained control of Graves' hyperthyroidism during long-term low-dose antithyroid drug therapy of patients with severe Graves' orbitopathy. Thyroid 21:951-956
58. Wakelkamp IMMJ, Baldeschi L, Saeed P, Mourits MP, Prummel MF, Wiersinga WM (2005) Surgical or medical decompression as a first-line treatment of optic neuropathy in Graves' ophthalmopathy? A randomized controlled trial. Clin Endocrinol (Oxf) 63:323-328
59. Currò N, Covelli D, Vannucchi G, Campi I, Pirola G, Simonetta S, Dazzi D, Guastella C, Pignataro L, Beck-Peccoz P, Ratiglia R, Salvi M (2014) Therapeutic outcomes of high-dose intravenous steroids in the treatment of dysthyroid optic neuropathy. Thyroid 24:897-905