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Volumn 16, Issue 14, 2015, Pages 2017-2022

Capturing the Direct Binding of CFTR Correctors to CFTR by Using Click Chemistry

(13) Sinha, Chandrima a,b Zhang, Weiqiang b Moon, Chang Suk a Actis, Marcelo c Yarlagadda, Sunitha a Arora, Kavisha a Woodroofe, Koryse a Clancy, John P a Lin, Songbai a Ziady, Assem G a Frizzell, Raymond d Fujii, Naoaki c Naren, Anjaparavanda P a,b

a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER (United States)

b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER (United States)

c ST JUDE CHILDREN S RESEARCH HOSPITAL (United States)

d UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE (United States)

Author keywords

CFTR correctors; click chemistry; cystic fibrosis; protein expression; VX 809

Indexed keywords

ALK 809; ALKYNE DERIVATIVE; COPPER; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; LUMACAFTOR; SUL 809; UNCLASSIFIED DRUG; 1,3 BENZODIOXOLE DERIVATIVE; AMINOPYRIDINE DERIVATIVE; PROTEIN BINDING;

ARTICLE; CATALYSIS; CLICK CHEMISTRY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYCLOADDITION; DRUG MECHANISM; DRUG PROTEIN BINDING; HEK293 CELL LINE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; SHORT CIRCUIT CURRENT; CHEMISTRY; CYSTIC FIBROSIS; DRUG DEVELOPMENT; GENETICS; METABOLISM; MUTATION; SYNTHESIS;

AMINOPYRIDINES; BENZODIOXOLES; CLICK CHEMISTRY; CYSTIC FIBROSIS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; DRUG DISCOVERY; HEK293 CELLS; HUMANS; MUTATION; PROTEIN BINDING;

EID: 84941749089 PISSN: 14394227 EISSN: 14397633 Source Type: Journal
DOI: 10.1002/cbic.201500123 Document Type: Article

Times cited : (22)

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