Injectable Progestin-Only Contraception is Associated With Increased Levels of Pro-Inflammatory Cytokines in the Female Genital Tract

American Journal of Reproductive Immunology

Volumn 74, Issue 4, 2015, Pages 357-367

  Deese, Jennifer ^a,b   Masson, Lindi ^c,d   Miller, William ^e   Cohen, Myron ^e   Morrison, Charles ^a   Wang, Meng ^f   Ahmed, Khatija ^g   Agot, Kawango ^h   Crucitti, Tania ⁱ   Abdellati, Saïd ⁱ   Van Damme, Lut ^j  

^a FAMILY HEALTH INTERNATIONAL   (United States)

^b University of North Carolina at Chapel Hill   (United States)

^c UNIVERSITY OF CAPE TOWN   (South Africa)

^d UNIVERSITY OF KWAZULU NATAL   (South Africa)

^e UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^f CROS NT LLC   (United States)

^g Setshaba Research Centre   (South Africa)

^h IMPACT RESEARCH AND DEVELOPMENT ORGANIZATION   (Kenya)

ⁱ INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^j BILL AND MELINDA GATES FOUNDATION   (United States)

more..

Author keywords

Cytokines; Depot medroxyprogesterone acetate; Mucosal; Secretory leukocyte peptidase inhibitor; Sexually transmitted infections

Indexed keywords

CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; GESTAGEN; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MEDROXYPROGESTERONE ACETATE; NORETHISTERONE ENANTATE; RANTES; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; CONTRACEPTIVE AGENT; NORETHISTERONE;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; CONDOM USE; CONTRACEPTION; CONTRACEPTIVE BEHAVIOR; FEMALE; FEMALE GENITAL SYSTEM; HERPES SIMPLEX VIRUS 2; HORMONAL CONTRACEPTION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; INFLAMMATION; LIMIT OF DETECTION; OPTICAL DENSITY; PHASE 3 CLINICAL TRIAL (TOPIC); PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SELF REPORT; SEXUAL INTERCOURSE; TARGET CELL; VAGINA FLORA; ADOLESCENT; ANALOGS AND DERIVATIVES; CHEMICALLY INDUCED; CROSS-SECTIONAL STUDY; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; KENYA; METABOLISM; MICROBIOLOGY; PATHOLOGY; PREGNANCY; PROCEDURES; SEXUALLY TRANSMITTED DISEASE; SOUTH AFRICA; VAGINITIS; VIROLOGY; YOUNG ADULT;

ADOLESCENT; ADULT; CONTRACEPTION; CONTRACEPTIVE AGENTS, FEMALE; CROSS-SECTIONAL STUDIES; CYTOKINES; FEMALE; GENITALIA, FEMALE; HIV INFECTIONS; HUMANS; INFLAMMATION; KENYA; MEDROXYPROGESTERONE ACETATE; NORETHINDRONE; PREGNANCY; PROGESTINS; SEXUALLY TRANSMITTED DISEASES, BACTERIAL; SOUTH AFRICA; VAGINOSIS, BACTERIAL; YOUNG ADULT;

EID: 84941746778     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12415     Document Type: Article

References (36)

1. Haase AT: Targeting early infection to prevent HIV-1 mucosal transmission. Nature 2010; 464:217-223.
2. Galvin SR, Cohen MS: The role of sexually transmitted diseases in HIV transmission. Nat Rev Microbiol 2004; 2:33-42.
3. Morrison CS, Chen PL, Kwok C, Baeten J, Brown J, Crook A, Van Damme L, Delany-Moretlwe S, Francis S, Friedland B, Hayes R, Heffron R, Kapiga S, Karim QA, Karpoff S, Rupert K, McClelland RS, McCormack S, McGrath N, Myer L, Rees H, der van Straten A, Watson-Jones D, de van Wijgert J, Stalter R, Low N: Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis. PLoS Med 2015; 12:e1001778.
4. Ralph LJ, McCoy SI, Shiu K, Padian NS: Hormonal contraceptive use and women's risk of HIV acquisition: a meta-analysis of observational studies. Lancet Infect Dis, 2015; 15:181-189.
5. Passmore JA: Genital inflammation and HIV risk in prevention research. Presented at the R4P 2014 conference, Cape Town, South Africa.
6. Morrison C, Fichorova RN, Mauck C, Chen PL, Kwok C, Chipato T, Salata R, Doncel GF: Cervical inflammation and immunity associated with hormonal contraception, pregnancy, and HIV-1 seroconversion. J Acquir Immune Defic Syndr 2014; 66:109-117.
7. Ikram N, Hassam K, Tufail S: Review article: cytokines. Int J Pathol 2004; 2:47-58.
8. Osborn L, Kunkel S, Nabel GJ: Tumor necrosis factor alpha and interleukin 1 stimulate the human immunodeficiency virus enhancer by activation of the nuclear factor kappa B. Proc Natl Acad Sci USA 1989; 86:2336-2340.
9. Ghanem KG, Shah N, Klein RS, Mayer KH, Sobel JD, Warren DL, Jamieson DJ, Duerr AC, Rompalo AM: Influence of sex hormones, HIV status, and concomitant sexually transmitted infection on cervicovaginal inflammation. J Infect Dis 2005; 191:358-366.
10. Cohen CR, Moscicki AB, Scott ME, Ma Y, Shiboski S, Bukusi E, Daud I, Rebbapragada A, Brown J, Kaul R: Increased levels of immune activation in the genital tract of healthy young women from sub-Saharan Africa. AIDS 2010; 24:2069-2074.
11. Kyongo JK, Jespers V, Goovaerts O, Michiels J, Menten J, Fichorova RN, Crucitti T, Vanham G, Arien KK: Searching for lower female genital tract soluble and cellular biomarkers: defining levels and predictors in a cohort of healthy caucasian women. PLoS ONE 2012; 7:e43951.
12. Masson L, Mlisana K, Little F, Werner L, Mkhize NN, Ronacher K, Gamieldien H, Williamson C, McKinnon LR, Walzl G, Abdool Karim Q, Abdool Karim S, Passmore JA: Defining genital tract cytokine signatures of sexually transmitted infections and bacterial vaginosis in women at high risk of HIV infection: a cross-sectional study. Sex Transm Infect 2014; 90:580-587.
13. Van Damme L, Corneli A, Ahmed K, Agot K, Lombaard J, Kapiga S, Malahleha M, Owino F, Manongi R, Onyango J, Temu L, Monedi MC, Mak'Oketch P, Makanda M, Reblin I, Makatu SE, Saylor L, Kiernan H, Kirkendale S, Wong C, Grant R, Kashuba A, Nanda K, Mandala J, Fransen K, Deese J, Crucitti T, Mastro TD, Taylor D: Preexposure prophylaxis for HIV infection among African women. N Engl J Med 2012; 367:411-422.
14. Agnew KJ, Aura J, Nunez N, Lee Z, Lawler R, Richardson CE, Culhane J, Hitti J: Effect of semen on vaginal fluid cytokines and secretory leukocyte protease inhibitor. Infect Dis Obstet Gynecol, 2008; 2008:820845. doi: 10.1155/2008/820845.
15. SAS® v9.3: 2012; Cary, NC, SAS Institute Inc.
16. Macaluso M, Lawson L, Akers R, Valappil T, Hammond K, Blackwell R, Hortin G: Prostate-specific antigen in vaginal fluid as a biologic marker of condom failure. Contraception 1999; 59:195-201.
17. Kamenev L, Leclercq M, Francois-Gerard C: An enzyme immunoassay for prostate-specific p30 antigen detection in the postcoital vaginal tract. J Forensic Sci Soc 1989; 29:233-241.
18. Wall K, Kilembe W, Naw HK, Brill I, Vwalika B, Chomba E, Johnson B, Haddad L, Tichacek A, Allen S.:Weighing 17 years of evidence: does hormonal contraception increase HIV acquisition risk among Zambian women in discordant couples? Presented at the AIDS 2014 conference, Melbourne, Australia.
19. Kapiga SH, Lyamuya EF, Lwihula GK, Hunter DJ: The incidence of HIV infection among women using family planning methods in Dar es Salaam, Tanzania. AIDS 1998; 12:75-84.
20. Myer L, Denny L, Wright TC, Kuhn L: Prospective study of hormonal contraception and women's risk of HIV infection in South Africa. Int J Epidemiol 2007; 36:166-174.
21. Kleinschmidt I, Rees H, Delany S, Smith D, Dinat N, Nkala B, McIntyre JA: Injectable progestin contraceptive use and risk of HIV infection in a South African family planning cohort. Contraception 2007; 75:461-467.
22. McCoy SI, Zheng W, Montgomery ET, Blanchard K, der van Straten A, de Bruyn G, Padian NS: Oral and injectable contraception use and risk of HIV acquisition among women in sub-Saharan Africa. AIDS 2013; 27:1001-1009.
23. Wand H, Ramjee G: The effects of injectable hormonal contraceptives on HIV seroconversion and on sexually transmitted infections. AIDS 2012; 26:375-380.
24. Morrison CS, Skoler-Karpoff S, Kwok C, Chen PL, de van Wijgert J, Gehret-Plagianos M, Patel S, Ahmed A, Ramjee G, Friedland B, Lahteenmaki P: Hormonal contraception and the risk of HIV acquisition among women in South Africa. AIDS 2012; 26:497-504.
25. Huijbregts RP, Helton ES, Michel KG, Sabbaj S, Richter HE, Goepfert PA, Hel Z: Hormonal contraception and HIV-1 infection: medroxyprogesterone acetate suppresses innate and adaptive immune mechanisms. Endocrinology 2013; 154:1282-1295.
26. Gillgrass AE, Ashkar AA, Rosenthal KL, Kaushic C: Prolonged exposure to progesterone prevents induction of protective mucosal responses following intravaginal immunization with attenuated herpes simplex virus type 2. J Virol 2003; 77:9845-9851.
27. Abel K, Rourke T, Lu D, Bost K, McChesney MB, Miller CJ: Abrogation of attenuated lentivirus-induced protection in rhesus macaques by administration of depo-provera before intravaginal challenge with simian immunodeficiency virus mac239. J Infect Dis 2004; 190:1697-1705.
28. Koubovec D, Vanden Berghe W, Vermeulen L, Haegeman G, Hapgood JP: Medroxyprogesterone acetate downregulates cytokine gene expression in mouse fibroblast cells. Mol Cell Endocrinol 2004; 221:75-85.
29. Trunova N, Tsai L, Tung S, Schneider E, Harouse J, Gettie A, Simon V, Blanchard J, Cheng-Mayer C: Progestin-based contraceptive suppresses cellular immune responses in SHIV-infected rhesus macaques. Virology 2006; 352:169-177.
30. Genesca M, Li J, Fritts L, Chohan P, Bost K, Rourke T, Blozis SA, McChesney MB, Miller CJ: Depo-Provera abrogates attenuated lentivirus-induced protection in male rhesus macaques challenged intravenously with pathogenic SIVmac239. J Med Primatol 2007; 36:266-275.
31. Hughes GC, Thomas S, Li C, Kaja MK, Clark EA: Cutting edge: progesterone regulates IFN-alpha production by plasmacytoid dendritic cells. J Immunol 2008; 180:2029-2033.
32. Roberts L, Passmore J, Mlisana K, Williamson C, Little F, Bebell LM, Walzl G, Abrahams MR, Woodman Z, Abdool Karim Q, Abdool Karim S: Genital tract inflammation during early HIV-1 infection predicts rapid disease progression in women. JID 2012; 205:194-203.
33. Thurman AR: Effect of BV on Markers of Genital Tract Inflammation and Mucosal Immunity: Mechanisms for Susceptibility to HIV Infection. Presented at the R4P 2014 conference, Cape Town, South Africa.
34. Stanford MM, Issekutz TB: The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. J Leukoc Biol 2003; 74:791-799.
35. Narimatsu R, Wolday D, Patterson BK: IL-8 increases transmission of HIV type 1 in cervical explant tissue. AIDS Res Hum Retroviruses 2005; 21:228-233.
36. AVAC, Px Wire: Launch of the ECHO Trial, M. Warren, Editor 2015.