The immunology and inflammatory responses of human melanocytes in infectious diseases

Journal of Infection

Volumn 71, Issue 4, 2015, Pages 413-421

  Gasque, Philippe ^a   Jaffar Bandjee, Marie Christine ^a,b  

^a UNIVERSITÉ DE LA RÉUNION   (France)

^b Service d'ORL et de chirurgie cervico faciale   (Reunion)

Author keywords

Autoimmunity; Infection; Inflammation; Innate immunity; Melanocyte

Indexed keywords

ALPHA INTERMEDIN DERIVATIVE; CD40 ANTIGEN; CXCL2 CHEMOKINE; DOPACHROME TAUTOMERASE; GAMMA INTERFERON; HIGH MOBILITY GROUP B1 PROTEIN; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 26; INTERLEUKIN 8; MELANIN; MELANOCORTIN 1 RECEPTOR; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MONOPHENOL MONOOXYGENASE; NITRIC OXIDE; PATTERN RECOGNITION RECEPTOR; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TRANSFORMING GROWTH FACTOR BETA; TYROSINASE RELATED PROTEIN 1; UNINDEXED DRUG; VASCULAR CELL ADHESION MOLECULE 1; CYTOKINE; TUMOR NECROSIS FACTOR ALPHA;

APOPTOSIS; AUTOIMMUNITY; B LYMPHOCYTE; CELL DEATH; CELL FUNCTION; CYTOKINE PRODUCTION; DEPIGMENTATION; HUMAN; IMMUNOCOMPETENT CELL; INFLAMMATION; INNATE IMMUNITY; KERATINOCYTE; LANGERHANS CELL; LYMPHOCYTIC INFILTRATION; MELANOCYTE; MELANOGENESIS; NONHUMAN; PIGMENTATION; PROTEIN FUNCTION; PROTEIN INTERACTION; REVIEW; SKIN INFECTION; T LYMPHOCYTE; UNFOLDED PROTEIN RESPONSE; VITILIGO; BACTERIAL INFECTIONS; BIOSYNTHESIS; DENGUE; IMMUNOLOGY; METABOLISM; MICROBIOLOGY; SKIN; ULTRASTRUCTURE; VIROLOGY;

BACTERIAL INFECTIONS; CYTOKINES; DENGUE; HUMANS; IMMUNITY, INNATE; INFLAMMATION; MELANOCYTES; SKIN; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84941738580     PISSN: 01634453     EISSN: 15322742     Source Type: Journal    
DOI: 10.1016/j.jinf.2015.06.006     Document Type: Review

References (66)

1. Tolleson W.H. Human melanocyte biology, toxicology, and pathology. J Environ Sci Health Part C Environ Carcinog Ecotoxicol Rev 2005, 23(2):105-161. PubMed PMID: 16291526. Epub 2005/11/18. eng.
2. Lin J.Y., Fisher D.E. Melanocyte biology and skin pigmentation. Nature 2007 Feb 22, 445(7130):843-850. PubMed PMID: 17314970. Epub 2007/02/23. eng.
3. Costin G.E., Hearing V.J. Human skin pigmentation: melanocytes modulate skin color in response to stress. FASEB J 2007 Apr, 21(4):976-994. PubMed PMID: 17242160. Epub 2007/01/24. eng.
4. Yamaguchi Y., Takahashi K., Zmudzka B.Z., Kornhauser A., Miller S.A., Tadokoro T., et al. Human skin responses to UV radiation: pigment in the upper epidermis protects against DNA damage in the lower epidermis and facilitates apoptosis. FASEB J Off Publ Fed Am Soc Exp Biol 2006 Jul, 20(9):1486-1488. PubMed PMID: 16793869. Epub 2006/06/24. eng.
5. Raposo G., Marks M.S. Melanosomes-dark organelles enlighten endosomal membrane transport. Nat Rev Mol Cell Biol 2007 Oct, 8(10):786-797. PubMed PMID: 17878918. Pubmed Central PMCID: 2786984. Epub 2007/09/20. eng.
6. Swope V.B., Jameson J.A., McFarland K.L., Supp D.M., Miller W.E., McGraw D.W., et al. Defining MC1R regulation in human melanocytes by its agonist alpha-melanocortin and antagonists agouti signaling protein and beta-defensin 3. J Invest Dermatol 2012 Sep, 132(9):2255-2262. PubMed PMID: 22572817. Pubmed Central PMCID: 3627493. Epub 2012/05/11. eng.
7. Richmond J.M., Frisoli M.L., Harris J.E. Innate immune mechanisms in vitiligo: danger from within. Curr Opin Immunol 2013 Dec, 25(6):676-682. PubMed PMID: 24238922. Pubmed Central PMCID: 3935321. Epub 2013/11/19. eng.
8. Das P.K., van den Wijngaard R.M., Wankowicz-Kalinska A., Le Poole I.C. A symbiotic concept of autoimmunity and tumour immunity: lessons from vitiligo. Trends Immunol 2001 Mar, 22(3):130-136. PubMed PMID: 11286727. Epub 2001/04/05. eng.
9. Iverson M.V. Hypothesis: vitiligo virus. Pigment Cell Res/Spons Eur Soc Pigment Cell Res Int Pigment Cell Soc 2000 Aug, 13(4):281-282. PubMed PMID: 10952397. Epub 2000/08/22. eng.
10. Erf G.F., Bersi T.K., Wang X., Sreekumar G.P., Smyth J.R. Herpesvirus connection in the expression of autoimmune vitiligo in Smyth line chickens. Pigment cell Res/Spons Eur Soc Pigment Cell Res Int Pigment Cell Soc 2001 Feb, 14(1):40-46. PubMed PMID: 11277493. Epub 2001/03/30. eng.
11. Wang S., Liu D., Ning W., Xu A. Cytosolic dsDNA triggers apoptosis and pro-inflammatory cytokine production in normal human melanocytes. Exp Dermatol 2015 Apr, 24(4):298-300. 10.1111/exd.12621.
12. Munz C., Lunemann J.D., Getts M.T., Miller S.D. Antiviral immune responses: triggers of or triggered by autoimmunity?. Nat Rev Immunol 2009 Apr, 9(4):246-258. PubMed PMID: 19319143. Pubmed Central PMCID: 2854652. Epub 2009/03/26. eng.
13. Alikhan A., Felsten L.M., Daly M., Petronic-Rosic V. Vitiligo: a comprehensive overview Part I. Introduction, epidemiology, quality of life, diagnosis, differential diagnosis, associations, histopathology, etiology, and work-up. J Am Acad Dermatol 2011 Sep, 65(3):473-491. PubMed PMID: 21839315. Epub 2011/08/16. eng.
14. Harson R., Grose C. Egress of varicella-zoster virus from the melanoma cell: a tropism for the melanocyte. J Virol 1995 Aug, 69(8):4994-5010. PubMed PMID: 7609070. Pubmed Central PMCID: 189316. Epub 1995/08/01. eng.
15. Paglino J.C., Andres W., van den Pol A.N. Autonomous parvoviruses neither stimulate nor are inhibited by the type I interferon response in human normal or cancer cells. J Virol 2014 May, 88(9):4932-4942. PubMed PMID: 24554651. Pubmed Central PMCID: 3993814.
16. Robin S., Ramful D., Zettor J., Benhamou L., Jaffar-Bandjee M.C., Riviere J.P., et al. Severe bullous skin lesions associated with Chikungunya virus infection in small infants. Eur J Pediatr 2010 Jan, 169(1):67-72. PubMed PMID: 19401826. Epub 2009/04/30. eng.
17. Suhrbier A., Jaffar-Bandjee M.C., Gasque P. Arthritogenic alphaviruses-an overview. Nat Rev Rheumatol 2012 Jul, 8(7):420-429. PubMed PMID: 22565316. Epub 2012/05/09. eng.
18. Willems M., Munte K., Vrolijk J.M., Den Hollander J.C., Bohm M., Kemmeren M.H., et al. Hyperpigmentation during interferon-alpha therapy for chronic hepatitis C virus infection. Br J Dermatol 2003 Aug, 149(2):390-394. PubMed PMID: 12932249. Epub 2003/08/23. eng.
19. Natarajan V.T., Ganju P., Ramkumar A., Grover R., Gokhale R.S. Multifaceted pathways protect human skin from UV radiation. Nat Chem Biol 2014 Jul, 10(7):542-551. PubMed PMID: 24937072. Epub 2014/06/18. eng.
20. Sternberg E.M. Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens. Nat Rev Immunol 2006 Apr, 6(4):318-328. PubMed PMID: 16557263. Pubmed Central PMCID: 1783839. Epub 2006/03/25. eng.
21. Wikberg J.E., Muceniece R., Mandrika I., Prusis P., Lindblom J., Post C., et al. New aspects on the melanocortins and their receptors. Pharmacol Res 2000 Nov, 42(5):393-420. PubMed PMID: 11023702. Epub 2000/10/12. eng.
22. Mackintosh J.A. The antimicrobial properties of melanocytes, melanosomes and melanin and the evolution of black skin. J Theor Biol 2001 Jul 21, 211(2):101-113. PubMed PMID: 11419954. Epub 2001/06/23. eng.
23. Le Poole I.C., Mutis T., van den Wijngaard R.M., Westerhof W., Ottenhoff T., de Vries R.R., et al. A novel, antigen-presenting function of melanocytes and its possible relationship to hypopigmentary disorders. J Immunol 1993 Dec 15, 151(12):7284-7292. PubMed PMID: 8258725. Epub 1993/12/15. eng.
24. Hari A., Flach T.L., Shi Y., Mydlarski P.R. Toll-like receptors: role in dermatological disease. Mediat Inflamm 2010, 2010:437246. PubMed PMID: 20847936. Pubmed Central PMCID: 2933899. Epub 2010/09/18. eng.
25. Le Poole I.C., van den Wijngaard R.M., Westerhof W., Verkruisen R.P., Dutrieux R.P., Dingemans K.P., et al. Phagocytosis by normal human melanocytes in vitro. Exp Cell Res 1993 Apr, 205(2):388-395. PubMed PMID: 8482344. Epub 1993/04/01. eng.
26. Martinez-Lorenzo M.J., Meresse S., de Chastellier C., Gorvel J.P. Unusual intracellular trafficking of Salmonella typhimurium in human melanoma cells. Cell Microbiol 2001 Jun, 3(6):407-416. PubMed PMID: 11422083. Epub 2001/06/26. eng.
27. Kupper T.S., Fuhlbrigge R.C. Immune surveillance in the skin: mechanisms and clinical consequences. Nat Rev Immunol 2004 Mar, 4(3):211-222. PubMed PMID: 15039758. Epub 2004/03/25. eng.
28. al Badri A.M., Foulis A.K., Todd P.M., Gariouch J.J., Gudgeon J.E., Stewart D.G., et al. Abnormal expression of MHC class II and ICAM-1 by melanocytes in vitiligo. J Pathol 1993 Feb, 169(2):203-206. PubMed PMID: 8095298. Epub 1993/02/01. eng.
29. Lu Y., Zhu W.Y., Tan C., Yu G.H., Gu J.X. Melanocytes are potential immunocompetent cells: evidence from recognition of immunological characteristics of cultured human melanocytes. Pigment Cell Res/Spons Eur Soc Pigment Cell Res Int Pigment Cell Soc 2002 Dec, 15(6):454-460. PubMed PMID: 12453188. Epub 2002/11/28. eng.
30. Yohn J.J., Critelli M., Lyons M.B., Norris D.A. Modulation of melanocyte intercellular adhesion molecule-1 by immune cytokines. J Invest Dermatol 1990 Aug, 95(2):233-237. PubMed PMID: 1974278. Epub 1990/08/01. eng.
31. Zou Z., Shin S.W., Alvarez K.S., Kokoza V., Raikhel A.S. Distinct melanization pathways in the mosquito Aedes aegypti. Immunity 2010 Jan 29, 32(1):41-53. PubMed PMID: 20152169. Epub 2010/02/16. eng.
32. Christensen B.M., Li J., Chen C.C., Nappi A.J. Melanization immune responses in mosquito vectors. Trends Parasitol 2005 Apr, 21(4):192-199. PubMed PMID: 15780842. Epub 2005/03/23. eng.
33. Janeway C.A. The immune system evolved to discriminate infectious nonself from noninfectious self. Immunol Today 1992 Jan, 13(1):11-16. PubMed PMID: 1739426. Epub 1992/01/11. eng.
34. Briant L., Despres P., Choumet V., Misse D. Role of skin immune cells on the host susceptibility to mosquito-borne viruses. Virology 2014 Sep, 464-465:26-32. PubMed PMID: 25043586. Epub 2014/07/22. eng.
35. Kawai T., Akira S. Pathogen recognition with toll-like receptors. Curr Opin Immunol 2005 Aug, 17(4):338-344. PubMed PMID: 15950447. Epub 2005/06/14. eng.
36. Kawai T., Akira S. Toll-like receptor and RIG-I-like receptor signaling. Ann NY Acad Sci 2008 Nov, 1143:1-20. PubMed PMID: 19076341. Epub 2008/12/17. eng.
37. Franchi L., Munoz-Planillo R., Nunez G. Sensing and reacting to microbes through the inflammasomes. Nat Immunol 2012 Apr, 13(4):325-332. PubMed PMID: 22430785. Pubmed Central PMCID: 3449002. Epub 2012/03/21. eng.
38. Rathinam V.A., Jiang Z., Waggoner S.N., Sharma S., Cole L.E., Waggoner L., et al. The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses. Nat Immunol 2010 May, 11(5):395-402. PubMed PMID: 20351692. Pubmed Central PMCID: 2887480. Epub 2010/03/31. eng.
39. Beutler B., Eidenschenk C., Crozat K., Imler J.L., Takeuchi O., Hoffmann J.A., et al. Genetic analysis of resistance to viral infection. Nat Rev Immunol 2007 Oct, 7(10):753-766. PubMed PMID: 17893693. Epub 2007/09/26. eng.
40. Bald T., Quast T., Landsberg J., Rogava M., Glodde N., Lopez-Ramos D., et al. Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma. Nature 2014 Mar 6, 507(7490):109-113. PubMed PMID: 24572365. Epub 2014/02/28. eng.
41. Yu N., Zhang S., Zuo F., Kang K., Guan M., Xiang L. Cultured human melanocytes express functional toll-like receptors 2-4, 7 and 9. J Dermatol Sci 2009 Nov, 56(2):113-120. PubMed PMID: 19740627. Epub 2009/09/11. eng.
42. Besch R., Poeck H., Hohenauer T., Senft D., Hacker G., Berking C., et al. Proapoptotic signaling induced by RIG-I and MDA-5 results in type I interferon-independent apoptosis in human melanoma cells. J Clin Investigation 2009 Aug, 119(8):2399-2411. PubMed PMID: 19620789. Pubmed Central PMCID: 2719920. Epub 2009/07/22. eng.
43. Samuel C.E. Antiviral actions of interferons. Clin Microbiol Rev 2001 Oct, 14(4):778-809. PubMed PMID: 11585785. Pubmed Central PMCID: 89003. Epub 2001/10/05. eng.
44. Levy D.E., Garcia-Sastre A. The virus battles: IFN induction of the antiviral state and mechanisms of viral evasion. Cytokine Growth Factor Rev 2001 Jun-Sep, 12(2-3):143-156. PubMed PMID: 11325598. Epub 2001/04/28. eng.
45. Randall R.E., Goodbourn S. Interferons and viruses: an interplay between induction, signalling, antiviral responses and virus countermeasures. J Gen Virol 2008, 89(Pt 1):1-47. PubMed PMID: 18089727. Epub 2007/12/20. eng.
46. Iwasaki A., Medzhitov R. Toll-like receptor control of the adaptive immune responses. Nat Immunol 2004, 5(10):987-995. PubMed PMID: 15454922. Epub 2004/09/30. eng.
47. Kato H., Sato S., Yoneyama M., Yamamoto M., Uematsu S., Matsui K., et al. Cell type-specific involvement of RIG-I in antiviral response. Immunity 2005, 23(1):19-28. PubMed PMID: 16039576. Epub 2005/07/26. eng.
48. Kawai T., Takahashi K., Sato S., Coban C., Kumar H., Kato H., et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol 2005, 6(10):981-988. PubMed PMID: 16127453. Epub 2005/08/30. eng.
49. Malmgaard L. Induction and regulation of IFNs during viral infections. J Interferon Cytokine Res 2004, 24(8):439-454. PubMed PMID: 15320958. Epub 2004/08/24. eng.
50. Taniguchi T., Takaoka A. The interferon-alpha/beta system in antiviral responses: a multimodal machinery of gene regulation by the IRF family of transcription factors. Curr Opin Immunol 2002, 14(1):111-116. PubMed PMID: 11790540. Epub 2002/01/16. eng.
51. Clemens M.J. PKR-a protein kinase regulated by double-stranded RNA. Int J Biochem Cell Biol 1997, 29(7):945-949. PubMed PMID: 9375375. Epub 1997/07/01. eng.
52. Samuel C.E. Antiviral actions of interferon. Interferon-regulated cellular proteins and their surprisingly selective antiviral activities. Virology 1991, 183(1):1-11. PubMed PMID: 1711253. Epub 1991/07/01. eng.
53. Hall J.C., Rosen A. Type I interferons: crucial participants in disease amplification in autoimmunity. Nat Rev Rheumatol 2010, 6(1):40-49. PubMed PMID: 20046205. Pubmed Central PMCID: 3622245. Epub 2010/01/05. eng.
54. MacMicking J.D. Interferon-inducible effector mechanisms in cell-autonomous immunity. Nat Rev Immunol 2012, 12(5):367-382. PubMed PMID: 22531325. Pubmed Central PMCID: 4150610. Epub 2012/04/26. eng.
55. Satomi H., Wang B., Fujisawa H., Otsuka F. Interferon-beta from melanoma cells suppresses the proliferations of melanoma cells in an autocrine manner. Cytokine 2002, 18(2):108-115. PubMed PMID: 12096926.
56. Ralph S.J., Wines B.D., Payne M.J., Grubb D., Hatzinisiriou I., Linnane A.W., et al. Resistance of melanoma cell lines to interferons correlates with reduction of IFN-induced tyrosine phosphorylation. Induction of the anti-viral state by IFN is prevented by tyrosine kinase inhibitors. J Immunol 1995, 154(5):2248-2256. PubMed PMID: 7532663. Epub 1995/03/01. eng.
57. Garbe C., Krasagakis K., Zouboulis C.C., Schroder K., Kruger S., Stadler R., et al. Antitumor activities of interferon alpha, beta, and gamma and their combinations on human melanoma cells in vitro: changes of proliferation, melanin synthesis, and immunophenotype. J Invest Dermatol 1990, 95(6 Suppl):231S-237S. PubMed PMID: 2124247. Epub 1990/12/01. eng.
58. Witte K., Gruetz G., Volk H.D., Looman A.C., Asadullah K., Sterry W., et al. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun 2009, 10(8):702-714. PubMed PMID: 19798076. Epub 2009/10/03. eng.
59. Mason M.J., Van Epps D. Modulation of IL-1, tumor necrosis factor, and C5a-mediated murine neutrophil migration by alpha-melanocyte-stimulating hormone. J Immunol 1989, 142(5):1646-1651. PubMed PMID: 2537358.
60. Swope V.B., Sauder D.N., McKenzie R.C., Sramkoski R.M., Krug K.A., Babcock G.F., et al. Synthesis of interleukin-1 alpha and beta by normal human melanocytes. J Invest Dermatol 1994, 102(5):749-753. PubMed PMID: 8176258. Epub 1994/05/01. eng.
61. Mattei S., Colombo M.P., Melani C., Silvani A., Parmiani G., Herlyn M. Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes. Int J Cancer 1994, 56(6):853-857. PubMed PMID: 7509778.
62. Krasagakis K., Garbe C., Eberle J., Orfanos C.E. Tumour necrosis factors and several interleukins inhibit the growth and modulate the antigen expression of normal human melanocytes in vitro. Arch Dermatol Res 1995, 287(3-4):259-265. PubMed PMID: 7598530.
63. Funasaka Y., Chakraborty A.K., Hayashi Y., Komoto M., Ohashi A., Nagahama M., et al. Modulation of melanocyte-stimulating hormone receptor expression on normal human melanocytes: evidence for a regulatory role of ultraviolet B, interleukin-1alpha, interleukin-1beta, endothelin-1 and tumour necrosis factor-alpha. Br J Dermatol 1998, 139(2):216-224. PubMed PMID: 9767234.
64. Natarajan V.T., Ganju P., Singh A., Vijayan V., Kirty K., Yadav S., et al. IFN-gamma signaling maintains skin pigmentation homeostasis through regulation of melanosome maturation. Proc Natl Acad Sci USA 2014, 111(6):2301-2306. PubMed PMID: 24474804. Pubmed Central PMCID: 3926048. Epub 2014/01/30. eng.
65. Wang S., Zhou M., Lin F., Liu D., Hong W., Lu L., et al. Interferon-gamma induces senescence in normal human melanocytes. PLoS One 2014, 9(3):e93232. PubMed PMID: 24681574. Pubmed Central PMCID: 3969336. Epub 2014/04/01. eng.
66. Marchini G., Hultenby K., Nelson A., Yektaei-Karin E., Stabi B., Lonne-Rahm S., et al. Increased expression of HMGB-1 in the skin lesions of erythema toxicum. Pediatr Dermatol 2007, 24(5):474-482. PubMed PMID: 17958791. Epub 2007/10/26. eng.