MiR-122 induces radiosensitization in non-small cell lung cancer cell line

International Journal of Molecular Sciences

Volumn 16, Issue 9, 2015, Pages 22137-22150

  Ma, Debin ^a   Jia, Hui ^a   Qin, Mengmeng ^a   Dai, Wenjie ^b   Wang, Tao ^c   Liang, Erguang ^c   Dong, Guofu ^d   Wang, Zuojun ^a   Zhang, Zhiyuan ^a   Feng, Fan ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b BEIJING CHUIYANGLIU HOSPITAL   (China)

^c BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^d BEIJING INSTITUTE OF RADIATION MEDICINE   (China)

Author keywords

Adenoviral vector; Ionizing radiation; Microrna122; Non small cell lung cancer; Radiosensitization

Indexed keywords

MICRORNA 122; MICRORNA; MIRN122 MICRORNA, HUMAN;

APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL VIABILITY; COLONY FORMATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; NON SMALL CELL LUNG CANCER; RADIOSENSITIZATION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; TRANSCRIPTION REGULATION; TUMOR INVASION; WESTERN BLOTTING; CELL MOTION; GENETICS; IONIZING RADIATION; METABOLISM; RADIATION RESPONSE; RADIATION TOLERANCE; TUMOR CELL LINE;

CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HUMANS; MICRORNAS; RADIATION TOLERANCE; RADIATION, IONIZING;

EID: 84941686928     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160922137     Document Type: Article

References (30)

1. Bussink, J.; van der Kogel, A.J.; Kaanders, J.H. Activation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer. Lancet Oncol. 2008, 9, 288–296.
2. Niu, C.; Liang, C.; Guo, J.; Cheng, L.; Zhang, H.; Qin, X.; Zhang, Q.; Ding, L.; Yuan, B.; Xu, X.; et al. Downregulation and growth inhibitory role of FHL1 in lung cancer. Int. J. Cancer 2012, 130, 2549–2956.
3. Herbst, R.S.; Heymach, J.V.; Lippman, S.M. Lung cancer. N. Engl. J. Med. 2008, 359, 1367–1380.
4. Webb, J.D.; Simon, M.C. Novel insights into the molecular origins and treatment of lung cancer. Cell Cycle 2010, 9, 4098–4105.
5. Eliasz, S.; Liang, S.; Chen, Y.; de Marco, M.A.; Machek, O; Skucha, S.; Miele, L.; Bocchetta, M. Notch-1 stimulates survival of lung adenocarcinoma cells during hypoxia by activating the IGF-1R pathway. Oncogene 2010, 29, 2488–2498.
6. Kang, J.; Kim, E.; Kim, W.; Seong, K.M.; Youn, H.; Kim, J.W.; Kim, J.; Youn, B. Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines. J. Biol. Chem. 2013, 288, 27343–27357.
7. Cullen, B.R. Viral and cellular messenger RNA targets of viral microRNAs. Nature 2009, 457, 421–425.
8. Qian, B.; Nag, S.A.; Su, Y.; Voruganti, S.; Qin, J.J.; Zhang, R.; Cho, W.C. miRNAs in cancer prevention and treatment and as molecular targets for natural product anticancer agents. Curr. Cancer Drug Targets 2013, 13, 519–541.
9. Takamizawa, J.; Konishi, H.; Yanagisawa, K.; Tomida, S.; Osada, H.; Endoh, H.; Harano, T.; Yatabe, Y.; Nagino, M.; Nimura, Y.; et al. Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival. Cancer Res. 2004, 64, 3753–3756.
10. Jopling, C. Liver-specific microRNA-122: Biogenesis and function. RNA Biol. 2012, 9, 137–142.
11. Ma, L.; Liu, J.; Shen, J.; Liu, L.; Wu, J.; Li, W.; Luo, J.; Chen, Q.; Qian, C. Expression of miR-122 mediated by adenoviral vector induces apoptosis and cell cycle arrest of cancer cells. Cancer Biol. Ther. 2010, 9, 554–561.
12. Ma, D.B.; Feng, F.; Zhang, F.; Yang, J.L.; Shi, G.B.; Han, Y.L.; Zhang, Z.Y. MicroRNA122 enhances the cytotoxic activity of Gemcitabine on A549 cells. Acad. J. Chin. PLA Med. Sch. 2014, 35, 1160–1164.
13. Kutay, H.; Bai, S.; Datta, J.; Motiwala, T.; Pogribny, I.; Frankel, W.; Jacob, S.T.; Ghoshal, K. Downregulation of miR-122 in the rodent and human hepatocellular carcinomas. J. Cell. Biochem. 2006, 99, 671–678.
14. Lynch, T.J.; Bell, D.W.; Sordella, R.; Gurubhagavatula, S.; Okimoto, R.A.; Brannigan, B.W.; Harris, P.L.; Haserlat, S.M.; Supko, J.G.; Haluska, F.G.; et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N. Engl. J. Med. 2004, 350, 2129–2139.
15. Bai, S.; Nasser, M.W.; Wang, B.; Hsu, S.H.; Datta, J.; Kutay, H.; Yadav, A.; Nuovo, G.; Kumar, P.; Ghoshal, K. MicroRNA-122 inhibits tumorigenic properties of hepatocellular carcinoma cells and sensitizes these cells to sorafenib. J. Biol. Chem. 2009, 284, 32015–32027.
16. Fornari, F.; Gramantieri, L.; Giovannini, C.; Veronese, A.; Ferracin, M.; Sabbioni, S.; Calin, G.A.; Grazi, G.L.; Croce, C.M.; Tavolari, S.; et al. miR-122/cyclin G1 interaction modulates p53 activity and affects doxorubicin sensitivity of human hepatocarcinoma cells. Cancer Res. 2009, 69, 5761–5767.
17. Cory, S.; Adams, J.M. The Bcl2 family: Regulators of the cellular life-or-death switch. Nat. Rev. Cancer 2002, 2, 647–656.
18. Zhang, F.; Sun, S.H.; Yang, J.L. Research of specific of properties of Survivin and anti-tumor drugs. J. Chin. PLA Postgrad. Med. Sch. 2009, 30, 755–757.
19. Chen, Y.; Feng, F.; Gao, X.; Wang, C.; Sun, H.; Zhang, C.; Zeng, Z.; Lu, Y.; An, L.; Qu, J.; et al. MiRNA153 reduces effects of chemotherapeutic agents or small molecular kinase inhibitor in HCC cells. Curr. Cancer Drug Targets 2015, 15, 176–187.
20. Gao, X.; Liu, Y.; Deeb, D.; Arbab, A.S.; Gautam, S.C. Anticancer activity of pristimerin in ovarian carcinoma cells is mediated through the inhibition of prosurvival Akt/NF-κB/mTOR signaling. J. Exp. Ther. Oncol. 2014, 10, 275–283.
21. Feng, Y.; Xu, X.; Zhang, Y.; Ding, J.; Wang, Y.; Zhang, X.; Wu, Z.; Kang, L.; Liang, Y.; Zhou, L.; et al. HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion. Sci. Rep. 2015, 5, 9429.
22. Yang, Y.P.; Qu, J.H.; Chang, X.J.; Lu, Y.Y.; Bai, W.L.; Dong, Z.; Wang, H.; An, L.J.; Xu, Z.X.; Wang, C.P.; et al. High intratumoral metastasis-associated in colon cancer-1 expression predicts poor outcomes of cryoablation therapy for advanced hepatocellular carcinoma. J. Transl. Med. 2013, 11, 41.
23. Tsai, P.C.; Bake, S.; Balaraman, S.; Rawlings, J.; Holgate, R.R.; Dubois, D.; Miranda, R.C. MiR-153 targets the nuclear factor-1 family and protects against teratogenic effects of ethanol exposure in fetal neural stem cells. Biol. Open 2014, 3, 741–758.
24. Kim, W.; Youn, H.; Kwon, T.; Kang, J.; Kim, E.; Son, B.; Yang, H.J.; Jung, Y.; Youn, B. PIM1 kinase inhibitors induce radiosensitization in non-small cell lung cancer cells. Pharmacol. Res. 2013, 70, 90–101.
25. Cui, L.; Li, M.; Feng, F.; Yang, Y.; Hang, X.; Cui, J.; Gao, J. MEIS1 functions as a potential AR negative regulator. Exp. Cell Res. 2014, 328, 58–68.
26. Zhang, P.; Ma, X.; Song, E.; Chen, W.; Pang, H.; Ni, D.; Gao, Y.; Fan, Y.; Ding, Q.; Zhang, Y.; et al. Tubulin cofactor A functions as a novel positive regulator of ccRCC progression, invasion and metastasis. Int. J. Cancer 2013, 133, 2801–2811.
27. Lu, Y.; Feng, F.; Yang, Y.; Gao, X.; Cui, J.; Zhang, C.; Zhang, F.; Xu, Z.; Qv, J.; Wang, C.; et al. LINE-1 ORF-1p functions as a novel androgen receptor co-activator and promotes the growth of human prostatic carcinoma cells. Cell Signal. 2013, 25, 479–489.
28. Zhu, M.; Li, M.; Zhang, F.; Feng, F.; Chen, W.; Yang, Y.; Cui, J.; Zhang, D.; Linghu, E. FBI-1 enhances ETS-1 signaling activity and promotes proliferation of human colorectal carcinoma cells. PLoS ONE 2014, 9, e98041.
29. Egloff, A.M.; Rothstein, M.E.; Seethala, R.; Siegfried, J.M.; Grandis, J.R.; Stabile, L.P. Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma. Clin. Cancer Res. 2009, 15, 6529–6540.
30. Yang, Q.; Feng, F.; Zhang, F.; Wang, C.; Lu, Y.; Gao, X.; Zhu, Y.; Yang, Y. LINE-1 ORF-1p functions as a novel HGF/ETS-1 signaling pathway co-activator and promotes the growth of MDA-MB-231 cell. Cell Signal. 2013, 25, 2652–2660.