-
2
-
-
0036661077
-
Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin (vn): Mapping the binding sites on PAI-1 and Vn
-
Schroeck F, Arroyo de Prada N, Sperl S, Schmitt M, Viktor M. Interaction of plasminogen activator inhibitor type-1 (PAI-1) with vitronectin (Vn): mapping the binding sites on PAI-1 and Vn. Biol Chem 2002;383: 1143-9.
-
(2002)
Biol Chem
, vol.383
, pp. 1143-1149
-
-
Schroeck, F.1
Arroyo De Prada, N.2
Sperl, S.3
Schmitt, M.4
Viktor, M.5
-
3
-
-
84878308272
-
The apparent uPA/PAI-1 paradox in cancer: More than meets the eye
-
Kwaan HC, Mazar AP, McMahon BJ. The apparent uPA/PAI-1 paradox in cancer: more than meets the eye. Semin Thromb Hemost 2013;39: 382-91.
-
(2013)
Semin Thromb Hemost
, vol.39
, pp. 382-391
-
-
Kwaan, H.C.1
Mazar, A.P.2
McMahon, B.J.3
-
4
-
-
0036005954
-
The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: Roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment
-
Wind T, Hansen M, Jensen JK, Andreasen PA. The molecular basis for anti-proteolytic and non-proteolytic functions of plasminogen activator inhibitor type-1: roles of the reactive centre loop, the shutter region, the flexible joint region and the small serpin fragment. Biol Chem 2002; 383:21-36.
-
(2002)
Biol Chem
, vol.383
, pp. 21-36
-
-
Wind, T.1
Hansen, M.2
Jensen, J.K.3
Andreasen, P.A.4
-
5
-
-
0033968403
-
The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients
-
Foekens JA, Peters HA, Look MP, Portengen H, Schmitt M, Kramer MD, et al. The urokinase system of plasminogen activation and prognosis in 2780 breast cancer patients. Cancer Res 2000;60:636-43.
-
(2000)
Cancer Res
, vol.60
, pp. 636-643
-
-
Foekens, J.A.1
Peters, H.A.2
Look, M.P.3
Portengen, H.4
Schmitt, M.5
Kramer, M.D.6
-
6
-
-
0032101178
-
Direct binding of smad3 and smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 1998;17:3091-100.
-
(1998)
EMBO J
, vol.17
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Ten Dijke, P.4
Huet, S.5
Gauthier, J.M.6
-
7
-
-
77957797829
-
Therapeutic potential of plasminogen activator inhibitor-1 inhibitors
-
Brown NJ. Therapeutic potential of plasminogen activator inhibitor-1 inhibitors. Ther Adv Cardiovasc Dis 2010;4:315-24.
-
(2010)
Ther Adv Cardiovasc Dis
, vol.4
, pp. 315-324
-
-
Brown, N.J.1
-
8
-
-
0035911151
-
The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for anti-angiogenic strategies
-
Bajou K, Masson V, Gerard RD, Schmitt PM, Albert V, Praus M, et al. The plasminogen activator inhibitor PAI-1 controls in vivo tumor vascularization by interaction with proteases, not vitronectin. Implications for anti-angiogenic strategies. J Cell Biol 2001;152:777-84.
-
(2001)
J Cell Biol
, vol.152
, pp. 777-784
-
-
Bajou, K.1
Masson, V.2
Gerard, R.D.3
Schmitt, P.M.4
Albert, V.5
Praus, M.6
-
9
-
-
0035878864
-
Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin
-
Isogai C, Laug WE, Shimada H, Declerck PJ, Stins MF, Durden DL, et al. Plasminogen activator inhibitor-1 promotes angiogenesis by stimulating endothelial cell migration toward fibronectin. Cancer Res 2001;61: 5587-94.
-
(2001)
Cancer Res
, vol.61
, pp. 5587-5594
-
-
Isogai, C.1
Laug, W.E.2
Shimada, H.3
Declerck, P.J.4
Stins, M.F.5
Durden, D.L.6
-
10
-
-
4644247804
-
Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth
-
Bajou K, Maillard C, Jost M, Lijnen RH, Gils A, Declerck P, et al. Host-derived plasminogen activator inhibitor-1 (PAI-1) concentration is critical for in vivo tumoral angiogenesis and growth. Oncogene 2004;23:6986-90.
-
(2004)
Oncogene
, vol.23
, pp. 6986-6990
-
-
Bajou, K.1
Maillard, C.2
Jost, M.3
Lijnen, R.H.4
Gils, A.5
Declerck, P.6
-
11
-
-
53149129492
-
Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis
-
Bajou K, Peng H, Laug WE, Maillard C, Noel A, Foidart JM, et al. Plasminogen activator inhibitor-1 protects endothelial cells from FasL-mediated apoptosis. Cancer cell 2008;14:324-34.
-
(2008)
Cancer Cell
, vol.14
, pp. 324-334
-
-
Bajou, K.1
Peng, H.2
Laug, W.E.3
Maillard, C.4
Noel, A.5
Foidart, J.M.6
-
12
-
-
84867293505
-
Protumorigenic activity of plasminogen activator inhibitor-1 through anantiapoptotic function
-
Fang H, Placencio VR, DeClerck YA. Protumorigenic activity of plasminogen activator inhibitor-1 through anantiapoptotic function. J Natl Cancer Inst 2012;104:1470-84.
-
(2012)
J Natl Cancer Inst
, vol.104
, pp. 1470-1484
-
-
Fang, H.1
Placencio, V.R.2
DeClerck, Y.A.3
-
13
-
-
84896690172
-
Serpins promote cancer cell survival and vascular co-option in brain metastasis
-
Valiente M, Obenauf AC, Jin X, Chen Q, Zhang XH, Lee DJ, et al. Serpins promote cancer cell survival and vascular co-option in brain metastasis. Cell 2014;156:1002-16.
-
(2014)
Cell
, vol.156
, pp. 1002-1016
-
-
Valiente, M.1
Obenauf, A.C.2
Jin, X.3
Chen, Q.4
Zhang, X.H.5
Lee, D.J.6
-
14
-
-
33747347557
-
A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells
-
Balsara RD, Castellino FJ, Ploplis VA. A novel function of plasminogen activator inhibitor-1 in modulation of the AKT pathway in wild-type and plasminogen activator inhibitor-1-deficient endothelial cells. J Biol Chem 2006;281:22527-36.
-
(2006)
J Biol Chem
, vol.281
, pp. 22527-22536
-
-
Balsara, R.D.1
Castellino, F.J.2
Ploplis, V.A.3
-
15
-
-
57349155553
-
The effect of plasminogen activator inhibitor type 1 on apoptosis
-
Schneider DJ, Chen Y, Sobel BE. The effect of plasminogen activator inhibitor type 1 on apoptosis. Thromb Haemost 2008;100:1037-40.
-
(2008)
Thromb Haemost
, vol.100
, pp. 1037-1040
-
-
Schneider, D.J.1
Chen, Y.2
Sobel, B.E.3
-
16
-
-
0034667385
-
Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1
-
Gutierrez LS, Schulman A, Brito-Robinson T, Noria F, Ploplis VA, Castellino FJ. Tumor development is retarded in mice lacking the gene for urokinase-type plasminogen activator or its inhibitor, plasminogen activator inhibitor-1. Cancer Res 2000;60:5839-47.
-
(2000)
Cancer Res
, vol.60
, pp. 5839-5847
-
-
Gutierrez, L.S.1
Schulman, A.2
Brito-Robinson, T.3
Noria, F.4
Ploplis, V.A.5
Castellino, F.J.6
-
17
-
-
0031902286
-
Absence of host plasminogen activator inhibitor1prevents cancer invasion and vascularization
-
Bajou K, Noel A, Gerard RD, Masson V, Brunner N, Holst-Hansen C, et al. Absence of host plasminogen activator inhibitor1prevents cancer invasion and vascularization. Nat Med 1998;4:923-8.
-
(1998)
Nat Med
, vol.4
, pp. 923-928
-
-
Bajou, K.1
Noel, A.2
Gerard, R.D.3
Masson, V.4
Brunner, N.5
Holst-Hansen, C.6
-
18
-
-
18044377584
-
Malignant transformation of wild-type but not plasminogen activator inhibitor-1 gene-deficient fibroblasts decreases cellular sensitivity to chemotherapy-mediated apoptosis
-
Lademann U, Romer MU, Jensen PB, Hofland KF, Larsen L, Christensen IJ, et al. Malignant transformation of wild-type but not plasminogen activator inhibitor-1 gene-deficient fibroblasts decreases cellular sensitivity to chemotherapy-mediated apoptosis. Eur J Cancer 2005;41: 1095-100.
-
(2005)
Eur J Cancer
, vol.41
, pp. 1095-1100
-
-
Lademann, U.1
Romer, M.U.2
Jensen, P.B.3
Hofland, K.F.4
Larsen, L.5
Christensen, I.J.6
-
19
-
-
27144539218
-
Indication of a role of plasminogen activator inhibitor type I in protecting murine fibrosarcoma cells against apoptosis
-
Romer MU, Kirkebjerg Due A, Knud Larsen J, Hofland KF, Christensen IJ, Buhl-Jensen P, et al. Indication of a role of plasminogen activator inhibitor type I in protecting murine fibrosarcoma cells against apoptosis. Thromb Haemost 2005;94:859-66.
-
(2005)
Thromb Haemost
, vol.94
, pp. 859-866
-
-
Romer, M.U.1
Kirkebjerg Due, A.2
Knud Larsen, J.3
Hofland, K.F.4
Christensen, I.J.5
Buhl-Jensen, P.6
-
20
-
-
54249140457
-
Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway
-
Romer MU, Larsen L, Offenberg H, Brunner N, Lademann UA. Plasminogen activator inhibitor 1 protects fibrosarcoma cells from etoposide-induced apoptosis through activation of the PI3K/Akt cell survival pathway. Neoplasia 2008;10:1083-91.
-
(2008)
Neoplasia
, vol.10
, pp. 1083-1091
-
-
Romer, M.U.1
Larsen, L.2
Offenberg, H.3
Brunner, N.4
Lademann, U.A.5
-
21
-
-
0029956043
-
Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma
-
Eitzman DT, Krauss JC, Shen T, Cui J, Ginsburg. Lack of plasminogen activator inhibitor-1 effect in a transgenic mouse model of metastatic melanoma. Blood 1996;87:4718-22.
-
(1996)
Blood
, vol.87
, pp. 4718-4722
-
-
Eitzman, D.T.1
Krauss, J.C.2
Shen, T.3
Cui, J.4
Ginsburg5
-
22
-
-
0035823504
-
Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis
-
McMahon GA, Petitclerc E, Stefansson S, Smith E, Wong MK, Westrick RJ, et al. Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis. J Biol Chem 2001;276:33964-8.
-
(2001)
J Biol Chem
, vol.276
, pp. 33964-33968
-
-
McMahon, G.A.1
Petitclerc, E.2
Stefansson, S.3
Smith, E.4
Wong, M.K.5
Westrick, R.J.6
-
23
-
-
13444292786
-
Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner
-
Maillard C, Jost M, Romer MU, Brunner N, Houard X, Lejeune A, et al. Host plasminogen activator inhibitor-1 promotes human skin carcinoma progression in a stage-dependent manner. Neoplasia 2005;7:57-66.
-
(2005)
Neoplasia
, vol.7
, pp. 57-66
-
-
Maillard, C.1
Jost, M.2
Romer, M.U.3
Brunner, N.4
Houard, X.5
Lejeune, A.6
-
24
-
-
0042804870
-
Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice
-
Almholt K, Nielsen BS, Frandsen TL, Brunner N, Dano K, Johnsen M. Metastasis of transgenic breast cancer in plasminogen activator inhibitor-1 gene-deficient mice. Oncogene 2003;22:4389-97.
-
(2003)
Oncogene
, vol.22
, pp. 4389-4397
-
-
Almholt, K.1
Nielsen, B.S.2
Frandsen, T.L.3
Brunner, N.4
Dano, K.5
Johnsen, M.6
-
25
-
-
14944384306
-
Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor)
-
Fen Li C, Kandel C, Baliko F, Nadesan P, Brunner N, Alman BA. Plasminogen activator inhibitor-1 (PAI-1) modifies the formation of aggressive fibromatosis (desmoid tumor). Oncogene 2005;24:1615-24.
-
(2005)
Oncogene
, vol.24
, pp. 1615-1624
-
-
Fen Li, C.1
Kandel, C.2
Baliko, F.3
Nadesan, P.4
Brunner, N.5
Alman, B.A.6
-
26
-
-
56049102601
-
Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors
-
Maillard CM, Bouquet C, Petitjean MM, Mestdagt M, Frau E, Jost M, et al. Reduction of brain metastases in plasminogen activator inhibitor-1-deficient mice with transgenic ocular tumors. Carcinogenesis 2008; 29:2236-42.
-
(2008)
Carcinogenesis
, vol.29
, pp. 2236-2242
-
-
Maillard, C.M.1
Bouquet, C.2
Petitjean, M.M.3
Mestdagt, M.4
Frau, E.5
Jost, M.6
-
27
-
-
78649560431
-
Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor
-
Masset A, Maillard C, Sounni NE, Jacobs N, Bruyere F, Delvenne P, et al. Unimpeded skin carcinogenesis in K14-HPV16 transgenic mice deficient for plasminogen activator inhibitor. Int J Cancer 2011;128:283-93.
-
(2011)
Int J Cancer
, vol.128
, pp. 283-293
-
-
Masset, A.1
Maillard, C.2
Sounni, N.E.3
Jacobs, N.4
Bruyere, F.5
Delvenne, P.6
-
28
-
-
0035893565
-
Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin
-
Biliran H Jr, Sheng S. Pleiotrophic inhibition of pericellular urokinase-type plasminogen activator system by endogenous tumor suppressive maspin. Cancer Res 2001;61:8676-82.
-
(2001)
Cancer Res
, vol.61
, pp. 8676-8682
-
-
Biliran, H.1
Sheng, S.2
-
29
-
-
0027762119
-
Evidence for the regulation of urokinase and tissue type plasminogen activators by the serpin, protein C inhibitor, in semen and blood plasma
-
Espana F, Estelles A, Fernandez PJ, Gilabert J, Sanchez-Cuenca J, Griffin JH. Evidence for the regulation of urokinase and tissue type plasminogen activators by the serpin, protein C inhibitor, in semen and blood plasma. Thromb Haemost 1993;70:989-94.
-
(1993)
Thromb Haemost
, vol.70
, pp. 989-994
-
-
Espana, F.1
Estelles, A.2
Fernandez, P.J.3
Gilabert, J.4
Sanchez-Cuenca, J.5
Griffin, J.H.6
-
30
-
-
0032726657
-
Retinoic acid stimulates plasminogen activator inhibitor 2 production by blood mononuclear cells and inhibits urokinase-induced extracellular proteolysis
-
Montemurro P, Barbuti G, Conese M, Gabriele S, Petio M, Colucci M, et al. Retinoic acid stimulates plasminogen activator inhibitor 2 production by blood mononuclear cells and inhibits urokinase-induced extracellular proteolysis. Br J Haematol 1999;107:294-9.
-
(1999)
Br J Haematol
, vol.107
, pp. 294-299
-
-
Montemurro, P.1
Barbuti, G.2
Conese, M.3
Gabriele, S.4
Petio, M.5
Colucci, M.6
-
31
-
-
0022261318
-
Protease nexin. Properties and a modified purification procedure
-
Scott RW, Bergman BL, Bajpai A, Hersh RT, Rodriguez H, Jones BN, et al. Protease nexin. Properties and a modified purification procedure. J Biol Chem 1985;260:7029-34.
-
(1985)
J Biol Chem
, vol.260
, pp. 7029-7034
-
-
Scott, R.W.1
Bergman, B.L.2
Bajpai, A.3
Hersh, R.T.4
Rodriguez, H.5
Jones, B.N.6
-
32
-
-
84879333770
-
Plasminogen activator inhibitor-1 inhibitors: A patent review (2006-present)
-
Fortenberry YM. Plasminogen activator inhibitor-1 inhibitors: a patent review (2006-present). Expert Opin Ther Pat 2013;23:801-15.
-
(2013)
Expert Opin Ther Pat
, vol.23
, pp. 801-815
-
-
Fortenberry, Y.M.1
-
33
-
-
0029894647
-
Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity
-
Charlton PA, Faint RW, Bent F, Bryans J, Chicarelli-Robinson I, Mackie I, et al. Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost 1996;75: 808-15.
-
(1996)
Thromb Haemost
, vol.75
, pp. 808-815
-
-
Charlton, P.A.1
Faint, R.W.2
Bent, F.3
Bryans, J.4
Chicarelli-Robinson, I.5
Mackie, I.6
-
34
-
-
0030857519
-
Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits
-
Friederich PW, Levi M, Biemond BJ, Charlton P, Templeton D, van Zonneveld AJ, et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation 1997;96:916-21.
-
(1997)
Circulation
, vol.96
, pp. 916-921
-
-
Friederich, P.W.1
Levi, M.2
Biemond, B.J.3
Charlton, P.4
Templeton, D.5
Van Zonneveld, A.J.6
-
35
-
-
19944434102
-
Characterization of a small molecule PAI-1 inhibitor, ZK4044
-
Liang A, Wu F, Tran K, Jones SW, Deng G, Ye B, et al. Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res 2005;115:341-50.
-
(2005)
Thromb Res
, vol.115
, pp. 341-350
-
-
Liang, A.1
Wu, F.2
Tran, K.3
Jones, S.W.4
Deng, G.5
Ye, B.6
-
36
-
-
44549084070
-
S35225 is a direct inhibitor of plasminogen activator inhibitor type-1 activity in the blood
-
Rupin A, Gaertner R, Mennecier P, Richard I, Benoist A, De Nanteuil G, et al. S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood. Thromb Res 2008;122:265-70.
-
(2008)
Thromb Res
, vol.122
, pp. 265-270
-
-
Rupin, A.1
Gaertner, R.2
Mennecier, P.3
Richard, I.4
Benoist, A.5
De Nanteuil, G.6
-
37
-
-
56249117664
-
Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production
-
Miyazaki H, Ogiku T, Sai H, Ohmizu H, Murakami J, Ohtani A. Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production. Bioorg Med Chem Lett 2008;18: 6419-22.
-
(2008)
Bioorg Med Chem Lett
, vol.18
, pp. 6419-6422
-
-
Miyazaki, H.1
Ogiku, T.2
Sai, H.3
Ohmizu, H.4
Murakami, J.5
Ohtani, A.6
-
38
-
-
3042687515
-
Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: Design, synthesis, and preclinical characterization
-
Elokdah H, Abou-Gharbia M, Hennan JK, McFarlane G, Mugford CP, Krishnamurthy G, et al. Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem 2004;47:3491-4.
-
(2004)
J Med Chem
, vol.47
, pp. 3491-3494
-
-
Elokdah, H.1
Abou-Gharbia, M.2
Hennan, J.K.3
McFarlane, G.4
Mugford, C.P.5
Krishnamurthy, G.6
-
39
-
-
49849096654
-
Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis
-
Hennan JK, Morgan GA, Swillo RE, Antrilli TM, Mugford C, Vlasuk GP, et al. Effect of tiplaxtinin (PAI-039), an orally bioavailable PAI-1 antagonist, in a rat model of thrombosis. J Thromb Haemost 2008;6:1558-64.
-
(2008)
J Thromb Haemost
, vol.6
, pp. 1558-1564
-
-
Hennan, J.K.1
Morgan, G.A.2
Swillo, R.E.3
Antrilli, T.M.4
Mugford, C.5
Vlasuk, G.P.6
-
40
-
-
77954484040
-
Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis
-
Lucking AJ, Visvanathan A, Philippou H, Fraser S, Grant PJ, Connolly TM, et al. Effect of the small molecule plasminogen activator inhibitor-1 (PAI-1) inhibitor, PAI-749, in clinical models of fibrinolysis. J Thromb Haemost 2010;8:1333-9.
-
(2010)
J Thromb Haemost
, vol.8
, pp. 1333-1339
-
-
Lucking, A.J.1
Visvanathan, A.2
Philippou, H.3
Fraser, S.4
Grant, P.J.5
Connolly, T.M.6
-
41
-
-
47249142795
-
Enhanced clearance of abeta in brain by sustaining the plasmin proteolysis cascade
-
Jacobsen JS, Comery TA, Martone RL, Elokdah H, Crandall DL, Oganesian A, et al. Enhanced clearance of Abeta in brain by sustaining the plasmin proteolysis cascade. Proc Natl Acad Sci U S A 2008;105:8754-9.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 8754-8759
-
-
Jacobsen, J.S.1
Comery, T.A.2
Martone, R.L.3
Elokdah, H.4
Crandall, D.L.5
Oganesian, A.6
-
42
-
-
84863455906
-
Activators and inhibitors of the plasminogen system in Alzheimer's disease
-
Barker R, Kehoe PG, Love S. Activators and inhibitors of the plasminogen system in Alzheimer's disease. J Cell Mol Med 2012;16:865-76.
-
(2012)
J Cell Mol Med
, vol.16
, pp. 865-876
-
-
Barker, R.1
Kehoe, P.G.2
Love, S.3
-
43
-
-
42249111398
-
Inhibition of plasminogen activator inhibitor-1: Its mechanism and effectiveness on coagulation and fibrosis
-
Izuhara Y, Takahashi S, Nangaku M, Takizawa S, Ishida H, Kurokawa K, et al. Inhibition of plasminogen activator inhibitor-1: its mechanism and effectiveness on coagulation and fibrosis. Arterioscler Thromb Vasc Biol 2008;28:672-7.
-
(2008)
Arterioscler Thromb Vasc Biol
, vol.28
, pp. 672-677
-
-
Izuhara, Y.1
Takahashi, S.2
Nangaku, M.3
Takizawa, S.4
Ishida, H.5
Kurokawa, K.6
-
44
-
-
77952011905
-
A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates
-
Izuhara Y, Yamaoka N, Kodama H, Dan T, Takizawa S, Hirayama N, et al. A novel inhibitor of plasminogen activator inhibitor-1 provides antithrombotic benefits devoid of bleeding effect in nonhuman primates. J Cereb Blood Flow Metab 2010;30:904-12.
-
(2010)
J Cereb Blood Flow Metab
, vol.30
, pp. 904-912
-
-
Izuhara, Y.1
Yamaoka, N.2
Kodama, H.3
Dan, T.4
Takizawa, S.5
Hirayama, N.6
-
45
-
-
77951730692
-
Structure-activity relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as plasminogen activator inhibitor-1 inhibitors
-
Yamaoka N, Kawano Y, Izuhara Y, Miyata T, Meguro K. Structure-activity relationships of new 2-acylamino-3-thiophenecarboxylic acid dimers as plasminogen activator inhibitor-1 inhibitors. Chem Pharm Bull 2010; 58:615-9.
-
(2010)
Chem Pharm Bull
, vol.58
, pp. 615-619
-
-
Yamaoka, N.1
Kawano, Y.2
Izuhara, Y.3
Miyata, T.4
Meguro, K.5
-
46
-
-
34247871548
-
Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor
-
Gorlatova NV, Cale JM, Elokdah H, Li D, Fan K, Warnock M, et al. Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. J Biol Chem 2007;282:9288-96.
-
(2007)
J Biol Chem
, vol.282
, pp. 9288-9296
-
-
Gorlatova, N.V.1
Cale, J.M.2
Elokdah, H.3
Li, D.4
Fan, K.5
Warnock, M.6
-
47
-
-
84922309247
-
Small molecules inhibitors of plasminogen activator inhibitor-1 - An overview
-
Rouch A, Vanucci-Bacque C, Bedos-Belval F, Baltas M. Small molecules inhibitors of plasminogen activator inhibitor-1 - An overview. Eur J Med Chem 2015;92:619-36.
-
(2015)
Eur J Med Chem
, vol.92
, pp. 619-636
-
-
Rouch, A.1
Vanucci-Bacque, C.2
Bedos-Belval, F.3
Baltas, M.4
-
48
-
-
77950885069
-
Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1
-
Cale JM, Li SH, Warnock M, Su EJ, North PR, Sanders KL, et al. Characterization of a novel class of polyphenolic inhibitors of plasminogen activator inhibitor-1. J Biol Chem 2010;285:7892-902.
-
(2010)
J Biol Chem
, vol.285
, pp. 7892-7902
-
-
Cale, J.M.1
Li, S.H.2
Warnock, M.3
Su, E.J.4
North, P.R.5
Sanders, K.L.6
-
49
-
-
84890850269
-
Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1
-
Li SH, Reinke AA, Sanders KL, Emal CD, Whisstock JC, Stuckey JA, et al. Mechanistic characterization and crystal structure of a small molecule inactivator bound to plasminogen activator inhibitor-1. Proc Natl Acad Sci U S A 2013;110:E4941-9.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. E4941-E4949
-
-
Li, S.H.1
Reinke, A.A.2
Sanders, K.L.3
Emal, C.D.4
Whisstock, J.C.5
Stuckey, J.A.6
-
50
-
-
41849114540
-
Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in min mice
-
Mutoh M, Niho N, Komiya M, Takahashi M, Ohtsubo R, Nakatogawa K, et al. Plasminogen activator inhibitor-1 (Pai-1) blockers suppress intestinal polyp formation in Min mice. Carcinogenesis 2008;29:824-9.
-
(2008)
Carcinogenesis
, vol.29
, pp. 824-829
-
-
Mutoh, M.1
Niho, N.2
Komiya, M.3
Takahashi, M.4
Ohtsubo, R.5
Nakatogawa, K.6
-
51
-
-
84887488313
-
SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis
-
Masuda T, Hattori N, Senoo T, Akita S, Ishikawa N, Fujitaka K, et al. SK-216, an inhibitor of plasminogen activator inhibitor-1, limits tumor progression and angiogenesis. Mol Cancer Ther 2013;12:2378-88.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2378-2388
-
-
Masuda, T.1
Hattori, N.2
Senoo, T.3
Akita, S.4
Ishikawa, N.5
Fujitaka, K.6
-
52
-
-
84890471598
-
Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model
-
Gomes-Giacoia E, Miyake M, Goodison S, Rosser CJ. Targeting plasminogen activator inhibitor-1 inhibits angiogenesis and tumor growth in a human cancer xenograft model. Mol Cancer Ther 2013;12: 2697-708.
-
(2013)
Mol Cancer Ther
, vol.12
, pp. 2697-2708
-
-
Gomes-Giacoia, E.1
Miyake, M.2
Goodison, S.3
Rosser, C.J.4
-
53
-
-
84924551759
-
Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer
-
Mashiko S, Kitatani K, Toyoshima M, Ichimura A, Dan T, Usui T, et al. Inhibition of plasminogen activator inhibitor-1 is a potential therapeutic strategy in ovarian cancer. Cancer Biol Ther 2015:16:253-60.
-
(2015)
Cancer Biol Ther
, vol.16
, pp. 253-260
-
-
Mashiko, S.1
Kitatani, K.2
Toyoshima, M.3
Ichimura, A.4
Dan, T.5
Usui, T.6
-
54
-
-
84941636578
-
Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity
-
(manuscript submitted)
-
Placencio VR, Ichimura A, Miyata T, DeClerck YA. Small molecule inhibitors of plasminogen activator inhibitor-1 elicit anti-tumorigenic and anti-angiogenic activity. PLoS ONE 2015 (manuscript submitted).
-
(2015)
PLoS ONE
-
-
Placencio, V.R.1
Ichimura, A.2
Miyata, T.3
DeClerck, Y.A.4
-
55
-
-
0023685082
-
Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of s protein (vitronectin)
-
Declerck PJ, De Mol M, Alessi MC, Baudner S, Paques EP, Preissner KT, et al. Purification and characterization of a plasminogen activator inhibitor 1 binding protein from human plasma. Identification as a multimeric form of S protein (vitronectin). J Biol Chem 1988;263: 15454-61.
-
(1988)
J Biol Chem
, vol.263
, pp. 15454-15461
-
-
Declerck, P.J.1
De Mol, M.2
Alessi, M.C.3
Baudner, S.4
Paques, E.P.5
Preissner, K.T.6
-
56
-
-
0030997665
-
Human plasminogen activator inhibitor-1 (PAI-1) deficiency: Characterization of a large kindred with a null mutation in the PAI-1 gene
-
Fay WP, Parker AC, Condrey LR, Shapiro AD. Human plasminogen activator inhibitor-1 (PAI-1) deficiency: characterization of a large kindred with a null mutation in the PAI-1 gene. Blood 1997;90:204-8.
-
(1997)
Blood
, vol.90
, pp. 204-208
-
-
Fay, W.P.1
Parker, A.C.2
Condrey, L.R.3
Shapiro, A.D.4
-
57
-
-
0033081498
-
The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion
-
Sharp AM, Stein PE, Pannu NS, Carrell RW, Berkenpas MB, Ginsburg D, et al. The active conformation of plasminogen activator inhibitor 1, a target for drugs to control fibrinolysis and cell adhesion. Structure 1999;7:111-8.
-
(1999)
Structure
, vol.7
, pp. 111-118
-
-
Sharp, A.M.1
Stein, P.E.2
Pannu, N.S.3
Carrell, R.W.4
Berkenpas, M.B.5
Ginsburg, D.6
-
58
-
-
0034713878
-
Structures of active and latent PAI-1: A possible stabilizing role for chloride ions
-
Stout TJ, Graham H, Buckley DI, Matthews DJ. Structures of active and latent PAI-1: a possible stabilizing role for chloride ions. Biochemistry 2000;39:8460-9.
-
(2000)
Biochemistry
, vol.39
, pp. 8460-8469
-
-
Stout, T.J.1
Graham, H.2
Buckley, D.I.3
Matthews, D.J.4
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