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Volumn 122, Issue 2, 2008, Pages 265-270

S35225 is a direct inhibitor of Plasminogen Activator Inhibitor type-1 activity in the blood

Author keywords

Antithrombotics; Fibrinolysis; inhibitor; PAI 1; Thrombolysis

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; PLASMINOGEN ACTIVATOR INHIBITOR; S 35225; TIPLAXTININ; WAY 140312;

EID: 44549084070     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2007.11.006     Document Type: Article
Times cited : (24)

References (28)
  • 1
    • 0036117399 scopus 로고    scopus 로고
    • Impaired fibrinolytic compensation for hypercoagulability in obese patients with type 2 diabetes: association with increased plasminogen activator inhibitor-1
    • Aso Y., Matsumoto S., Fujiwara Y., Tayama K., Inukai T., and Takemura Y. Impaired fibrinolytic compensation for hypercoagulability in obese patients with type 2 diabetes: association with increased plasminogen activator inhibitor-1. Metabolism 51 (2002) 471-476
    • (2002) Metabolism , vol.51 , pp. 471-476
    • Aso, Y.1    Matsumoto, S.2    Fujiwara, Y.3    Tayama, K.4    Inukai, T.5    Takemura, Y.6
  • 2
    • 0034711728 scopus 로고    scopus 로고
    • Association of blood pressure with fibrinolytic potential in the Framingham offspring population
    • Poli K.A., Tofler G.H., Larson M.G., Evans J.C., Sutherland P.A., Lipinska I., et al. Association of blood pressure with fibrinolytic potential in the Framingham offspring population. Circulation 101 (2000) 264-269
    • (2000) Circulation , vol.101 , pp. 264-269
    • Poli, K.A.1    Tofler, G.H.2    Larson, M.G.3    Evans, J.C.4    Sutherland, P.A.5    Lipinska, I.6
  • 3
    • 0027350625 scopus 로고
    • Impaired fibrinolysis in hypertension and obesity due to high plasminogen activator inhibitor-1 level in plasma
    • Urano T., Kojima Y., Takahashi M., Serizawa K., Sakakibara K., Takada Y., et al. Impaired fibrinolysis in hypertension and obesity due to high plasminogen activator inhibitor-1 level in plasma. Jpn J Physiol 43 (1993) 221-228
    • (1993) Jpn J Physiol , vol.43 , pp. 221-228
    • Urano, T.1    Kojima, Y.2    Takahashi, M.3    Serizawa, K.4    Sakakibara, K.5    Takada, Y.6
  • 4
    • 0023185776 scopus 로고
    • Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction
    • Hamsten A., de Faire U., Walldius G., Dahlen G., Szamosi A., Landou C., et al. Plasminogen activator inhibitor in plasma: risk factor for recurrent myocardial infarction. Lancet 2 (1987) 3-9
    • (1987) Lancet , vol.2 , pp. 3-9
    • Hamsten, A.1    de Faire, U.2    Walldius, G.3    Dahlen, G.4    Szamosi, A.5    Landou, C.6
  • 5
    • 0032564442 scopus 로고    scopus 로고
    • High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor
    • Thogersen A.M., Jansson J.H., Boman K., Nilsson T.K., Weinehall L., Huhtasaari F., et al. High plasminogen activator inhibitor and tissue plasminogen activator levels in plasma precede a first acute myocardial infarction in both men and women: evidence for the fibrinolytic system as an independent primary risk factor. Circulation 98 (1998) 2241-2247
    • (1998) Circulation , vol.98 , pp. 2241-2247
    • Thogersen, A.M.1    Jansson, J.H.2    Boman, K.3    Nilsson, T.K.4    Weinehall, L.5    Huhtasaari, F.6
  • 6
    • 0033871468 scopus 로고    scopus 로고
    • Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study
    • Wiman B., Andersson T., Hallqvist J., Reuterwall C., Ahlbom A., and deFaire U. Plasma levels of tissue plasminogen activator/plasminogen activator inhibitor-1 complex and von Willebrand factor are significant risk markers for recurrent myocardial infarction in the Stockholm Heart Epidemiology Program (SHEEP) study. Arterioscler Thromb Vasc Biol 20 (2000) 2019-2023
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 2019-2023
    • Wiman, B.1    Andersson, T.2    Hallqvist, J.3    Reuterwall, C.4    Ahlbom, A.5    deFaire, U.6
  • 7
    • 33644525975 scopus 로고    scopus 로고
    • PAI-1 and homocysteine, but not lipoprotein (a) nor thrombophilic polymorphism, are associated with the occurrence of major adverse cardiac events after successful coronary stenting
    • Marcucci R., Brogi D., Sofi F., Giglioli C., Valente S., Alessandrello L.A., et al. PAI-1 and homocysteine, but not lipoprotein (a) nor thrombophilic polymorphism, are associated with the occurrence of major adverse cardiac events after successful coronary stenting. Heart 92 (2006) 377-381
    • (2006) Heart , vol.92 , pp. 377-381
    • Marcucci, R.1    Brogi, D.2    Sofi, F.3    Giglioli, C.4    Valente, S.5    Alessandrello, L.A.6
  • 8
    • 0037162388 scopus 로고    scopus 로고
    • Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1
    • Eren M., Painter C.A., Atkinson J.B., Declerck P.J., and Vaughan D.E. Age-dependent spontaneous coronary arterial thrombosis in transgenic mice that express a stable form of human plasminogen activator inhibitor-1. Circulation 106 (2002) 491-496
    • (2002) Circulation , vol.106 , pp. 491-496
    • Eren, M.1    Painter, C.A.2    Atkinson, J.B.3    Declerck, P.J.4    Vaughan, D.E.5
  • 9
    • 0025371467 scopus 로고
    • Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene
    • Erickson L.A., Fn ici G.J., Lund J.E., Boyle T.P., Polites H.G., and Marotti K.R. Development of venous occlusions in mice transgenic for the plasminogen activator inhibitor-1 gene. Nature 346 (1990) 74-76
    • (1990) Nature , vol.346 , pp. 74-76
    • Erickson, L.A.1    Fn ici, G.J.2    Lund, J.E.3    Boyle, T.P.4    Polites, H.G.5    Marotti, K.R.6
  • 10
    • 0027135792 scopus 로고
    • Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis
    • Carmeliet P., Stassen J.M., Schoonjans L., Ream B., van den Oord J.J., De Mol M., et al. Plasminogen activator inhibitor-1 gene-deficient mice. II. Effects on hemostasis, thrombosis, and thrombolysis. J Clin Invest 92 (1993) 2756-2760
    • (1993) J Clin Invest , vol.92 , pp. 2756-2760
    • Carmeliet, P.1    Stassen, J.M.2    Schoonjans, L.3    Ream, B.4    van den Oord, J.J.5    De Mol, M.6
  • 11
    • 0034650976 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice
    • Eitzman D.T., Westrick R.J., Nabel E.G., and Ginsburg D. Plasminogen activator inhibitor-1 and vitronectin promote vascular thrombosis in mice. Blood 95 (2000) 577-580
    • (2000) Blood , vol.95 , pp. 577-580
    • Eitzman, D.T.1    Westrick, R.J.2    Nabel, E.G.3    Ginsburg, D.4
  • 12
    • 0034235468 scopus 로고    scopus 로고
    • Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice
    • Kawasaki T., Dewerchin M., Lijnen H.R., Vermylen J., and Hoylaerts M.F. Vascular release of plasminogen activator inhibitor-1 impairs fibrinolysis during acute arterial thrombosis in mice. Blood 96 (2000) 153-160
    • (2000) Blood , vol.96 , pp. 153-160
    • Kawasaki, T.1    Dewerchin, M.2    Lijnen, H.R.3    Vermylen, J.4    Hoylaerts, M.F.5
  • 13
    • 0034672348 scopus 로고    scopus 로고
    • Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery
    • Eitzman D.T., Westrick R.J., Xu Z., Tyson J., and Ginsburg D. Plasminogen activator inhibitor-1 deficiency protects against atherosclerosis progression in the mouse carotid artery. Blood 96 (2000) 4212-4215
    • (2000) Blood , vol.96 , pp. 4212-4215
    • Eitzman, D.T.1    Westrick, R.J.2    Xu, Z.3    Tyson, J.4    Ginsburg, D.5
  • 14
    • 0029894647 scopus 로고    scopus 로고
    • Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity
    • Charlton P.A., Faint R.W., Bent F., Bryans J., Chicarelli-Robinson I., Mackie I., et al. Evaluation of a low molecular weight modulator of human plasminogen activator inhibitor-1 activity. Thromb Haemost 75 (1996) 808-815
    • (1996) Thromb Haemost , vol.75 , pp. 808-815
    • Charlton, P.A.1    Faint, R.W.2    Bent, F.3    Bryans, J.4    Chicarelli-Robinson, I.5    Mackie, I.6
  • 16
    • 12544250776 scopus 로고    scopus 로고
    • Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy
    • Crandall D.L., Elokdah H., Di L., Hennan J.K., Gorlatova N.V., and Lawrence D.A. Characterization and comparative evaluation of a structurally unique PAI-1 inhibitor exhibiting oral in-vivo efficacy. J Thromb Haemost 2 (2004) 1422-1428
    • (2004) J Thromb Haemost , vol.2 , pp. 1422-1428
    • Crandall, D.L.1    Elokdah, H.2    Di, L.3    Hennan, J.K.4    Gorlatova, N.V.5    Lawrence, D.A.6
  • 17
    • 3042687515 scopus 로고    scopus 로고
    • Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization
    • Elokdah H., Abou-Gharbia M., Hennan J.K., McFarlane G., Mugford C.P., Krishnamurthy G., et al. Tiplaxtinin, a novel, orally efficacious inhibitor of plasminogen activator inhibitor-1: design, synthesis, and preclinical characterization. J Med Chem 47 (2004) 3491-3494
    • (2004) J Med Chem , vol.47 , pp. 3491-3494
    • Elokdah, H.1    Abou-Gharbia, M.2    Hennan, J.K.3    McFarlane, G.4    Mugford, C.P.5    Krishnamurthy, G.6
  • 18
    • 0030857519 scopus 로고    scopus 로고
    • Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits
    • Friederich P.W., Levi M., Biemond B.J., Charlton P., Templeton D., van Zonneveld A.J., et al. Novel low-molecular-weight inhibitor of PAI-1 (XR5118) promotes endogenous fibrinolysis and reduces postthrombolysis thrombus growth in rabbits. Circulation 96 (1997) 916-921
    • (1997) Circulation , vol.96 , pp. 916-921
    • Friederich, P.W.1    Levi, M.2    Biemond, B.J.3    Charlton, P.4    Templeton, D.5    van Zonneveld, A.J.6
  • 19
    • 0036301837 scopus 로고    scopus 로고
    • Characterization and comparative evaluation of a novel PAI-1 inhibitor
    • Gils A., Stassen J.M., Nar H., Kley J.T., Wienen W., Ries U.J., et al. Characterization and comparative evaluation of a novel PAI-1 inhibitor. Thromb Haemost 88 (2002) 137-143
    • (2002) Thromb Haemost , vol.88 , pp. 137-143
    • Gils, A.1    Stassen, J.M.2    Nar, H.3    Kley, J.T.4    Wienen, W.5    Ries, U.J.6
  • 20
    • 19944434102 scopus 로고    scopus 로고
    • Characterization of a small molecule PAI-1 inhibitor, ZK4044
    • Liang A., Wu F., Tran K., Jones S.W., Deng G., Ye B., et al. Characterization of a small molecule PAI-1 inhibitor, ZK4044. Thromb Res 115 (2005) 341-350
    • (2005) Thromb Res , vol.115 , pp. 341-350
    • Liang, A.1    Wu, F.2    Tran, K.3    Jones, S.W.4    Deng, G.5    Ye, B.6
  • 21
    • 0037687834 scopus 로고    scopus 로고
    • New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation
    • De Nanteuil G., Lila-Ambroise C., Rupin A., Vallez M.O., and Verbeuren T.J. New fibrinolytic agents: benzothiophene derivatives as inhibitors of the t-PA-PAI-1 complex formation. Bioorg Med Chem Lett 13 (2003) 1705-1708
    • (2003) Bioorg Med Chem Lett , vol.13 , pp. 1705-1708
    • De Nanteuil, G.1    Lila-Ambroise, C.2    Rupin, A.3    Vallez, M.O.4    Verbeuren, T.J.5
  • 22
    • 0020472522 scopus 로고
    • Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin
    • Hoylaerts M., Rijken D.C., Lijnen H.R., and Collen D. Kinetics of the activation of plasminogen by human tissue plasminogen activator. Role of fibrin. J Biol Chem 257 (1982) 2912-2919
    • (1982) J Biol Chem , vol.257 , pp. 2912-2919
    • Hoylaerts, M.1    Rijken, D.C.2    Lijnen, H.R.3    Collen, D.4
  • 23
    • 0028999048 scopus 로고
    • The significance of fibrin binding by plasminogen activator inhibitor 1 for the mechanism of tissue-type plasminogen activator-mediated fibrinolysis
    • Stringer H.A., and Pannekoek H. The significance of fibrin binding by plasminogen activator inhibitor 1 for the mechanism of tissue-type plasminogen activator-mediated fibrinolysis. J Biol Chem 270 (1995) 11205-11208
    • (1995) J Biol Chem , vol.270 , pp. 11205-11208
    • Stringer, H.A.1    Pannekoek, H.2
  • 24
    • 21744450401 scopus 로고    scopus 로고
    • Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1
    • Hu B., Jetter J.W., Wrobel J.E., Antrilli T.M., Bauer J.S., Di L., et al. Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1. Bioorg Med Chem Lett 15 (2005) 3514-3518
    • (2005) Bioorg Med Chem Lett , vol.15 , pp. 3514-3518
    • Hu, B.1    Jetter, J.W.2    Wrobel, J.E.3    Antrilli, T.M.4    Bauer, J.S.5    Di, L.6
  • 25
    • 34247871548 scopus 로고    scopus 로고
    • Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor
    • Gorlatova N.V., Cale J.M., Elokdah H., Li D., Fan K Warnock M., Crandall D.L., et al. Mechanism of inactivation of plasminogen activator inhibitor-1 by a small molecule inhibitor. J Biol Chem 282 (2007) 9288-9296
    • (2007) J Biol Chem , vol.282 , pp. 9288-9296
    • Gorlatova, N.V.1    Cale, J.M.2    Elokdah, H.3    Li, D.4    Fan K Warnock, M.5    Crandall, D.L.6
  • 26
    • 22944431859 scopus 로고    scopus 로고
    • Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1, in a canine model of coronary artery thrombosis
    • Hennan J.K., Elokdah H., Leal M., Ji A., Friedrichs G.S., Morgan G.A., et al. Evaluation of PAI-039 [{1-benzyl-5-[4-(trifluoromethoxy)phenyl]-1H-indol-3-yl}(oxo)acetic acid], a novel plasminogen activator inhibitor-1, in a canine model of coronary artery thrombosis. J Pharmacol Exp Ther 314 (2005) 710-716
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 710-716
    • Hennan, J.K.1    Elokdah, H.2    Leal, M.3    Ji, A.4    Friedrichs, G.S.5    Morgan, G.A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.