Depletion of NADP(H) due to CD38 activation triggers endothelial dysfunction in the postischemic heart

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11648-11653

  Reyes, Levy A ^a   Boslett, James ^a   Varadharaj, Saradhadevi ^a   Pascali, Francesco De ^a   Hemann, Craig ^a   Druhan, Lawrence J ^a   Ambrosio, Giuseppe ^a,b   El Mahdy, Mohamed ^a   Zweier, Jay L ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b UNIVERSITY OF PERUGIA   (Italy)

Author keywords

Endothelial dysfunction; Endothelial nitric oxide synthase; Ischemia reperfusion injury; Nitric oxide; Tetrahydrobiopterin

Indexed keywords

ADENOSINE DIPHOSPHATE RIBOSE; CD38 ANTIGEN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; SMALL INTERFERING RNA; BIOPTERIN; NITRIC OXIDE; SAPROPTERIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DILATATION; ENDOTHELIAL DYSFUNCTION; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME INHIBITION; HEART FUNCTION; HEART INFARCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; ISOLATED HEART; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; SIGNAL TRANSDUCTION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CHEMISTRY; CORONARY ARTERY DISEASE; ELECTRON SPIN RESONANCE; HEART; HYPOXIA; ISCHEMIA; KNOCKOUT MOUSE; METABOLISM; PATHOLOGY; PHYSIOLOGY; SPRAGUE DAWLEY RAT; VASCULAR ENDOTHELIUM;

ANIMALS; ANTIGENS, CD38; BIOPTERIN; CORONARY ARTERY DISEASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ENDOTHELIUM, VASCULAR; HEART; HYPOXIA; ISCHEMIA; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NADP; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; RNA, SMALL INTERFERING;

EID: 84941671290     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1505556112     Document Type: Article

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