Increased epithelial sodium channel activity contributes to hypertension caused by Na+-HCO3- cotransporter electrogenic 2 deficiency

Hypertension

Volumn 66, Issue 1, 2015, Pages 68-74

  Wen, Donghai ^a   Yuan, Yang ^a   Warner, Paige C ^a   Wang, Bangchen ^a   Cornelius, Ryan J ^a   Wang France, Jun ^a   Li, Huaqing ^a   Boettger, Thomas ^b   Sansom, Steven C ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b MAX PLANCK INSTITUTE FOR HEART AND LUNG RESEARCH   (Germany)

Author keywords

epithelial Na+ channel blockers; hypertension; NBCe2 protein; punctures

Indexed keywords

AMILORIDE; BICARBONATE SODIUM COTRANSPORTER; EPITHELIAL SODIUM CHANNEL; HYDROCHLOROTHIAZIDE; ANTIHYPERTENSIVE AGENT; DIURETIC AGENT; POTASSIUM; SLC4A5 PROTEIN, MOUSE; SODIUM; SODIUM CHANNEL BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTROGENIC 2 DEFICIENCY; HEMATOCRIT; HYPERTENSION; KIDNEY DISTAL TUBULE; MEAN ARTERIAL PRESSURE; MICROELECTRODE; MOUSE; NONHUMAN; POTASSIUM EXCRETION; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PUNCH BIOPSY; SODIUM ABSORPTION; SODIUM BLOOD LEVEL; SODIUM EXCRETION; SODIUM RETENTION; UPREGULATION; URINARY EXCRETION; WESTERN BLOTTING; WILD TYPE; ANIMAL; C57BL MOUSE; CONGENIC STRAIN; DEFICIENCY; DISEASE MODEL; DRUG EFFECTS; GENETICS; HYPERTENSION, RENAL; HYPOKALEMIA; KNOCKOUT MOUSE; MEMBRANE POTENTIAL; METABOLISM; NATRIURESIS; PH; PHYSIOLOGY; SINGLE NUCLEOTIDE POLYMORPHISM;

AMILORIDE; ANIMALS; ANTIHYPERTENSIVE AGENTS; DISEASE MODELS, ANIMAL; DIURETICS; EPITHELIAL SODIUM CHANNELS; HEMATOCRIT; HYDROCHLOROTHIAZIDE; HYDROGEN-ION CONCENTRATION; HYPERTENSION, RENAL; HYPOKALEMIA; KIDNEY TUBULES, DISTAL; MEMBRANE POTENTIALS; MICE; MICE, CONGENIC; MICE, INBRED C57BL; MICE, KNOCKOUT; NATRIURESIS; POLYMORPHISM, SINGLE NUCLEOTIDE; POTASSIUM; SODIUM; SODIUM CHANNEL BLOCKERS; SODIUM-BICARBONATE SYMPORTERS;

EID: 84941659683     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05394     Document Type: Article

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