Blocking peripheral serotonin synthesis by telotristat etiprate (LX1032/LX1606) reduces severity of both chemical-and infection-induced intestinal inflammation

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 309, Issue 6, 2015, Pages G455-G465

  Kim, Janice J ^a   Wang, Huaqing ^a   Terc, Joshua D ^a   Zambrowicz, Brian ^b   Yang, Qi M ^b   Khan, Waliul I ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b LEXICON PHARMACEUTICALS INC   (United States)

Author keywords

Enterochromaffin cells; Experimental colitis; Inflammatory bowel disease; Tryptophan hydroxylase

Indexed keywords

DEXTRAN SULFATE; INTERLEUKIN 10; SEROTONIN; TELOTRISTAT ETIPRATE; CYTOKINE; PEROXIDASE; PHENYLALANINE; PYRIMIDINE DERIVATIVE; SEROTONIN ANTAGONIST; TELOTRISTAT; TRYPTOPHAN HYDROXYLASE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DISEASE ACTIVITY SCORE; DISEASE SEVERITY; ENTERITIS; GOBLET CELL; HELMINTHIASIS; IMMUNE RESPONSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROPHYLAXIS; TRICHURIS MURIS; WORM EXPULSION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; C57BL MOUSE; CHEMICALLY INDUCED; COLON; COMPLICATION; DRUG EFFECTS; ENTEROCHROMAFFIN CELL; INFLAMMATORY BOWEL DISEASES; METABOLISM; PARASITOLOGY; TRICHURIASIS; TRICHURIS;

ANIMALS; COLON; CYTOKINES; DEXTRAN SULFATE; ENTEROCHROMAFFIN CELLS; INFLAMMATORY BOWEL DISEASES; MICE; MICE, INBRED C57BL; PEROXIDASE; PHENYLALANINE; PYRIMIDINES; SEROTONIN; SEROTONIN ANTAGONISTS; TRICHURIASIS; TRICHURIS; TRYPTOPHAN HYDROXYLASE;

EID: 84941655831     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00299.2014     Document Type: Article

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