Randomized trial of allergen-induced asthmatic response in smokers and non-smokers: Effects of inhaled corticosteroids

Clinical and Experimental Allergy

Volumn 45, Issue 10, 2015, Pages 1531-1541

  Cahn, A ^a   Boyce, M ^b   Mistry, S ^a   Musani, N ^a   Rambaran, C ^a   Storey, J ^a   Ventresca, P ^a   Michel, O ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Hammersmith Medicines Research Limited and Trio Medicines Limited   (United Kingdom)

^c UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

Allergen challenge; Asthma; Atopic; Cigarette smoking; Inhaled corticosteroids; Late asthmatic response

Indexed keywords

ALLERGEN; FLUTICASONE PROPIONATE; METHACHOLINE; NITRIC OXIDE; PLACEBO; CORTICOSTEROID; FLUTICASONE;

ADULT; ALLERGIC ASTHMA; ARTICLE; BRONCHOCONSTRICTION; BRONCHUS HYPERREACTIVITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORTICOSTEROID THERAPY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; EOSINOPHIL; EVENING DOSAGE; FEMALE; FORCED EXPIRATORY VOLUME; HEADACHE; HUMAN; INFLAMMATORY CELL; MALE; MORNING DOSAGE; MULTICENTER STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING; SPUTUM ANALYSIS; TREATMENT RESPONSE; ADOLESCENT; ASTHMA; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; MIDDLE AGED;

ADMINISTRATION, INHALATION; ADOLESCENT; ADRENAL CORTEX HORMONES; ADULT; ALLERGENS; ASTHMA; CROSS-OVER STUDIES; DOUBLE-BLIND METHOD; FEMALE; FLUTICASONE; HUMANS; MALE; MIDDLE AGED; SMOKING;

EID: 84941633778     PISSN: 09547894     EISSN: 13652222     Source Type: Journal    
DOI: 10.1111/cea.12610     Document Type: Article

References (36)

1. Thomson NC, Chaudhuri R, Livingston E. Asthma and cigarette smoking. Eur Respir J 2004; 24:822-33.
2. Althuis M, Sexton M, Prybylski D. Cigarette smoking and asthma symptom severity among adult asthmatics. J Asthma 1999; 36:257-64.
3. Siroux V, Pin I, Oryszcyn MP, Le Moual N, Kauffmann F. Relationships of active smoking to asthma and asthma severity in the EGEA study. Eur Respir J 2000; 15:470-7.
4. Gallefoss F, Bakke P. Does smoking affect the outcome of patient education and self management in asthmatics? Patient Educ Couns 2003; 49:91-7.
5. Sippel JM, Pedula KL, Vollmer WM, Buist AS, Osborne ML. Associations of smoking with hospital-based care and quality of life in patients with obstructive airway disease. Chest 1999; 115:691-6.
6. Apostol G, Jacobs D, Tsai A et al. Early life factors contribute to the decrease in lung function between ages 18 and 40. Am J Respir Crit Care Med 2002; 166:166-72.
7. Lange P, Parner J, Vestbo J, Schnohr P, Jensen G. A 15 year follow-up study of ventilatory function in adults with asthma. N Engl J Med 1998; 339:1194-200.
8. Marquette C, Saulnier F, Leroy O et al. Long-term prognosis of near-fatal asthma. Am Rev Respir Dis 1992; 146:76-81.
9. Chaudhuri R, Livingston E, McMahon AD, Thomson L, Borland W, Thomson NC. Cigarette smoking impairs the therapeutic response to oral corticosteroids in chronic asthma. Am J Respir Crit Care Med 2003; 168:1308-11.
10. Chalmers GW, Macleod KJ, Little SA, Thomson LJ, McSharry CP, Thomson NC. Influence of cigarette smoking on inhaled corticosteroid treatment in mild asthma. Thorax 2002; 57:226-30.
11. Pedersen SE, Bateman ED, Bousquet J, Busse WW, Yoxall S, Clark TJ, Gaining Optimal Asthma controL Steering CommitteeInvestigators. Determinants of response to fluticasone propionate and salmeterol/fluticasone propionate combination in the Gaining Optimal Asthma controL study. J Allergy Clin Immunol 2007; 120:1036-42.
12. Tomlinson JEM, McMahon AD, Chaudhuri R, Thompson JM, Wood SF, Thomson NC. Efficacy of low and high dose inhaled corticosteroid in smokers versus non-smokers with mild asthma. Thorax 2005; 60:282-7.
13. Clearie KL, McKinlay L, Williamson PA, Lipworth BJ. Fluticasone/salmeterol combination confers benefits in people with asthma who smoke. Chest 2012; 141:330-8.
14. Chalmers G, MacLeod K, Thomson L, Little S, McSharry C, Thomson N. Smoking and airway inflammation in patients with mild asthma. Chest 2001; 120:1917-22.
15. Rouhos A, Ekroos H, Karjalainen J, Sarna S, Haahtela T, Sovijärvi ARA. Smoking attenuates increase in exhaled nitric oxide in atopic but not in nonatopic young adults with asthma. Int Arch Allergy Immunol 2010; 152:226-32.
16. Verleden GM, Dupont LJ, Verpeut AC, Demedts MG. The effect of cigarette smoking on exhaled nitric oxide in mild steroid-naive asthmatics. Chest 1999; 116:59-64.
17. Thomson NC, Chaudhuri R, Heaney LG et al. Clinical outcomes and inflammatory biomarkers in current smokers and exsmokers with severe asthma. J Allergy Clin Immunol 2013; 131:1008-16.
18. Meghji Z, Dua B, Watson RM, Gauvreau GM, O'Byrne PM. Allergen inhalation challenge in smoking compared with non-smoking asthmatic subjects. Clin Exp Allergy 2011; 41:1084-90.
19. Joos GF, O'Connor B, Anderson SD et al. Indirect airway challenges. Eur Respir J 2003; 21:1050-68.
20. Pavord ID, Pizzichini MM, Pizzichini E, Hargreave FE. The use of induced sputum to investigate airway inflammation. Thorax 1997; 52:498-501.
21. Diamant Z, Gauvreau GM, Cockcroft DW et al. Inhaled allergen bronchoprovocation tests. J Allergy Clin Immunol 2013; 132:1045-55.
22. Melgert BN, Postma DS, Geerlings M et al. Short-term smoke exposure attenuates ovalbumin-induced airway inflammation in allergic mice. Am J Respir Cell Mol Biol 2004; 30:880-5.
23. Robbins CS, Pouladi MA, Fattouh R et al. Mainstream cigarette smoke exposure attenuates airway immune inflammatory responses to surrogate and common environmental allergens in mice, despite evidence of increased systemic sensitization. J Immunol 2005; 175:2834-42.
24. Thatcher TH, Benson RP, Phipps RP, Sime PJ. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol 2008; 295:L412-21.
25. Polosa R, Thomson NC. Smoking and asthma: dangerous liaisons. Eur Respir J 2013; 41:716-26.
26. Borgerding M, Klus H. Analysis of complex mixtures - Cigarette smoke. Exp Pathol 2005; 7:43-73.
27. Witschi H, Joad JP, Pinkerton KE. The toxicology of environmental tobacco smoke. Annu Rev Pharmacol Toxicol 1997; 37:29-52.
28. Mishra NC, Rir-sima-ah J, Langley RJ et al. Nicotine primarily suppresses lung Th2 but not goblet cell and muscle cell responses to allergens. J Immunol 2008; 180:7655-63.
29. Bencherif M, Lippiello PM, Lucas R, Marrero MB. Alpha7 nicotinic receptors as novel therapeutic targets for inflammation-based diseases. Cell Mol Life Sci 2011; 68:931-49.
30. McSharry C, Spears M, Chaudhuri R, Cameron EJ, Husi H, Thomson NC. Increased sputum endotoxin levels are associated with an impaired lung function response to oral steroids in asthmatic patients. J Allergy Clin Immunol 2014; 134:1068-75.
31. Eisenbarth S, Piggott D, Huleatt J, Visintin I, Herrick C, Bottomly K. Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen. J Exp Med 2002; 196:1645-51.
32. Kim Y, Oh S, Jeon S et al. Airway exposure levels of lipopolysaccharide determine type 1 versus type 2 experimental asthma. J Immunol 2007; 178:5375-82.
33. de Boer JD, Roelofs JJTH, de Vos AF et al. Lipopolysaccharide inhibits Th2 lung inflammation induced by house dust mite allergens in mice. Am J Respir Cell Mol Biol 2013; 48:382-9.
34. Hasday JD, Bascom R, Costa JJ, Fitzgerald T, Dubin W. Bacterial endotoxin is an active component of cigarette smoke. Chest 1999; 115:829-35.
35. Hunt LW, Gleich GJ, Ohnishi T et al. Endotoxin contamination causes neutrophilia following pulmonary allergen challenge. Am J Respir Crit Care 1994; 149:1471-5.
36. Global surveillance, prevention and control of chronic respiratory diseases: a comprehensive approach. World Health Organisation publication: http://apps.who.int/iris/handle/10665/43776. Last accessed 21 May 2014.