Combined usefulness of the platelet-to-lymphocyte ratio and the neutrophil-to-lymphocyte ratio in predicting the long-term adverse events in patients who have undergone percutaneous coronary intervention with a drug-eluting stent

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Cho, Kyoung Im ^a   Ann, Soe Hee ^b   Singh, Gillian Balbir ^b   Her, Ae Young ^c   Shin, Eun Seok ^b  

^a Kosin University   (South Korea)

^b University of Ulsan College of Medicine   (South Korea)

^c Kangwon National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CARDIOVASCULAR RISK; DRUG ELUTING STENT; FEMALE; FOLLOW UP; HEART DEATH; HEART INFARCTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; NEUTROPHIL LYMPHOCYTE RATIO; NON ST SEGMENT ELEVATION MYOCARDIAL INFARCTION; PATIENT CODING; PERCUTANEOUS CORONARY INTERVENTION; PLATELET LYMPHOCYTE RATIO; RECEIVER OPERATING CHARACTERISTIC; STABLE ANGINA PECTORIS; UNSTABLE ANGINA PECTORIS; VERY ELDERLY; ADVERSE EFFECTS; ANGINA, STABLE; ANGINA, UNSTABLE; BLOOD; CELL COUNT; CYTOLOGY; LYMPHOCYTE; MIDDLE AGED; MYOCARDIAL INFARCTION; NEUTROPHIL; PROGNOSIS; RISK FACTOR; THROMBOCYTE;

ADULT; AGED; AGED, 80 AND OVER; ANGINA, STABLE; ANGINA, UNSTABLE; BLOOD PLATELETS; CELL COUNT; DRUG-ELUTING STENTS; FEMALE; HUMANS; LYMPHOCYTES; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; NEUTROPHILS; PERCUTANEOUS CORONARY INTERVENTION; PROGNOSIS; RISK FACTORS;

EID: 84941622450     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0133934     Document Type: Article

References (33)

1. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med. 1999; 340: 115-126. PMID: 9887164
2. Libby P, Ridker PM, Hansson GK. Leducq Transatlantic Network on atherothrombosis. Inflammation in atherosclerosis: from pathophysiology to practice. J Am Coll Cardiol 2009; 54: 2129-2138 doi: 10. 1016/j.jacc.2009.09.009 PMID: 19942084
3. Gurm HS, Bhatt DL, Gupta R, Ellis SG, Topol EJ, Lauer MS. Preprocedural white blood cell count and death after percutaneous coronary intervention. Am Heart J. 2003; 146: 692-698. PMID: 14564325
4. Prasad A, Stone GW, Stuckey TD, Costantini CO, Mehran R, Garcia E, et al. Relation between leucocyte count, myonecrosis, myocardial perfusion, and outcomes following primary angioplasty. Am J Cardiol. 2007;. 99: 1067-1071. PMID: 17437729
5. Fowler AJ, Agha RA. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography-The growing versatility of NLR. Atherosclerosis. 2013; 228: 44-45. doi: 10.1016/j.atherosclerosis.2013.02.008 PMID: 23474126
6. Poludasu S, Cavusoglu E, Khan W, Marmur JD. Neutrophil to lymphocyte ratio as a predictor of longterm mortality in African Americans undergoing percutaneous coronary intervention. Clin Cardiol. 2009; 32: E6-E10.
7. Tamhane UU, Aneja S, Montgomery D, Rogers EK, Eagle KA, Gurm HS. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute coronary syndrome. Am J Cardiol. 2008; 102: 653-657. doi: 10.1016/j.amjcard.2008.05.006 PMID: 18773982
8. Park JJ, Jang HJ, Oh IY, Yoon CH, Suh JW, Cho YS, et al. Prognostic value of neutrophil to lymphocyte ratio in patients presenting with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention. Am J Cardiol. 2013; 111: 636-642. doi: 10.1016/j.amjcard.2012.11.012 PMID: 23273716
9. Han YC, Yang TH, Kim DI, Jin HY, Chung SR, Seo JS, et al. Neutrophil to lymphocyte ratio predicts long-term clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. Korean Circ J. 2013; 43: 93-99. doi: 10.4070/kcj.2013.43.2. 93 PMID: 23508782
10. Tsiara S, Elisaf M, Jagroop IA, Mikhailidis DP. Platelets as predictor of vascular risk: is there a practical index of platelet activity? Clin Appl Thromb Hemost. 2003; 9: 177-190 PMID: 14507105
11. Sunbul M, Gerin F, Durmus E, Kivrak T, Sari I, Tigen K, et al. Neutrophil to lymphocyte and platelet to lymphocyte ratio in patients with dipper versus non-dipper hypertension. Clin Exp Hypertens. 2014; 36: 217-221. doi: 10.3109/10641963.2013.804547 PMID: 23786430
12. Açar G, Kalkan ME, Avci A, Alizade E, Tabakci MM, Toprak C, et al. The relation of platelet-lymphocyte ratio and coronary collateral circulation in patients with stable angina pectoris and chronic total occlusion. Clin Appl Thromb Hemost. 2015; 21: 462-468. doi: 10.1177/1076029613508599 PMID: 24142833
13. Gary T, Pichler M, Belaj K, Hafner F, Gerger A, Froehlich H, et al. Platelet-to-lymphocyte ratio: a novel marker for critical limb ischemia in peripheral arterial occlusive disease patients. PLoS One. 2013; 8: e67688 doi: 10.1371/journal.pone.0067688 PMID: 23844064
14. Azab B, Shah N, Akerman M, McGinn JT Jr. Value of platelet/lymphocyte ratio as a predictor of allcause mortality after non-ST-elevation myocardial infarction. J Thromb Thrombolysis. 2012; 34: 326-334. PMID: 22466812
15. Kurtul A, Yarlioglues M, Murat SN, Ergun G, Duran M, Kasapkara HA, et al. Usefulness of the plateletto lymphocyte ratio in predicting angiographic reflow after primary percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction. Am J Cardiol. 2014; 114: 342-347. doi: 10.1016/j.amjcard.2014.04.045 PMID: 24948493
16. Thygesen K, Alpert JS, White HD. Universal definition of myocardial infarction. Eur Heart J 2007; 28: 2525-2538 PMID: 17951287
17. Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, et al. Clinical end points in coronary stent trials: a case for standardized definitions. Circulation. 2007; 115: 2344-2351. PMID: 17470709
18. Wang X, Zhang G, Jiang X, Zhu H, Lu Z, Xu L. Neutrophil to lymphocyte ratio in relation to risk of allcause mortality and cardiovascular events among patients undergoing angiography or cardiac revascularization: a meta-analysis of observational studies. Atherosclerosis. 2014; 234: 206-213. doi: 10.1016/j.atherosclerosis.2014.03.003 PMID: 24681815
19. Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S, et al. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res. 2008; 102: 209-217. PMID: 17991882
20. Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol. 2008; 8: 802-815. doi: 10.1038/nri2415 PMID: 18825131
21. Azab B, Zaher M, Weiserbs KF, Torbey E, Lacossiere K, Gaddam S, et al. Usefulness of neutrophil to lymphocyte ratio in predicting short-and long-term mortality after non-ST-elevation myocardial infarcton. Am J Cardiol. 2010; 106: 470-476. doi: 10.1016/j.amjcard.2010.03.062 PMID: 20691303
22. Ommen SR, Gibbons RJ, Hodge DO, Thomson SP. Usefulness of the lymphocyte concentration as a prognostic marker in coronary artery disease. Am J Cardiol. 1997; 79: 812-814. PMID: 9070569
23. Arbel Y, Finkelstein A, Halkin A, Birati EY, Revivo M, Zuzut M, et al. Neutrophil/lymphocyte ratio is related to the severity of coronary artery disease and clinical outcome in patients undergoing angiography. Atherosclerosis. 2012; 225: 456-460. doi: 10.1016/j.atherosclerosis.2012.09.009 PMID: 23040448
24. Iijima R, Ndrepepa G, Mehilli J, Bruskina O, Schulz S, Schömig A, et al. Relationship between platelet count and 30-day clinical outcomes after percutaneous coronary interventions. Pooled analysis of four ISAR trials. Thromb Haemost. 2007; 98: 852-857. PMID: 17938811
25. Nikolsky E, Grines CL, Cox DA, Garcia E, Tcheng JE, Sadeghi M, et al. Impact of baseline platelet count in patients undergoing primary percutaneous coronary intervention in acute myocardial infarction (from the CADILLAC trial). Am J Cardiol. 2007; 99: 1055-1061. PMID: 17437727
26. Waehre T, Damås JK, Yndestad A, Taskén K, Pedersen TM, Smith C, et al. Effect of activated platelets on expression of cytokines in peripheral blood mononuclear cells-potential role of prostaglandin E2. Thromb Haemost. 2004; 92: 1358-1367. PMID: 15583745
27. Damås JK, Waehre T, Yndestad A, Otterdal K, Hognestad A, Solum NO, et al. Interleukin-7-mediated inflammation in unstable angina: possible role of chemokines and platelets. Circulation. 2003; 107: 2670-2676. PMID: 12742982
28. Balta S, Demirkol S, Kucuk U. The platelet lymphocyte ratio may be useful inflammatory indicator in clinical practice. Hemodial Int. 2013; 17: 668-669. doi: 10.1111/hdi.12058 PMID: 23763539
29. Al Suwaidi J, Reddan DN, Williams K, Pieper KS, Harrington RA, Califf RM, et al. Prognostic implications of abnormalities in renal function in patients with acute coronary syndromes. Circulationl 2002; 106: 974-980l
30. Luft FC. Renal disease as a risk factor for cardiovascular disease. Basic Res Cardiol 2000; 95(Suppl 1): I72-76. PMID: 11192357
31. Smith C, Damås JK, Otterdal K, Øie E, Sandberg WJ, Yndestad A, et al. Increased levels of neutrophilactivating peptide-2 in acute coronary syndromes: possible role of platelet-mediated vascular inflammation. J Am Coll Cardiol. 2006; 48: 1591-1599. PMID: 17045893
32. Lee JM, Youn TJ, Park JJ, Oh IY, Yoon CH, Suh JW, et al. Comparison of 9-month angiographic outcomes of resolute zotarolimus-eluting and everolimus-eluting stents in a real world setting of coronary intervention in Korea. BMC Cardiovasc Disord. 2013; 13: 65. doi: 10.1186/1471-2261-13-65 PMID: 24011332
33. D'Ascenzo F, Cerrato E, Appleton D, Moretti C, Calcagno A, Abouzaki N, et al.; Percutaneous coronary intervention and surgical revascularization in HIV Database (PHD) Study Investigators. Prognostic indicators for recurrent thrombotic events in HIV-infected patients with acute coronary syndromes: use of registry data from 12 sites in Europe, South Africa and the United States. Thromb Res. 2014; 134: 558-564. doi: 10.1016/j.thromres.2014.05.037 PMID: 25064035