-
1
-
-
84858046933
-
Association of MRI metrics and cognitive impairment in radiologically isolated syndromes
-
M.P. Amato, B. Hakiki, B. Goretti, and et al. Association of MRI metrics and cognitive impairment in radiologically isolated syndromes Neurology 78 2012 309 314
-
(2012)
Neurology
, vol.78
, pp. 309-314
-
-
Amato, M.P.1
Hakiki, B.2
Goretti, B.3
-
2
-
-
84939890610
-
Effects of delayed-release dimethyl fumarate on MRI measures in the Phase 3 DEFINE study
-
D.L. Arnold, R. Gold, L. Kappos, and et al. Effects of delayed-release dimethyl fumarate on MRI measures in the Phase 3 DEFINE study J. Neurol. 261 2014 1794 1802
-
(2014)
J. Neurol.
, vol.261
, pp. 1794-1802
-
-
Arnold, D.L.1
Gold, R.2
Kappos, L.3
-
3
-
-
0035668416
-
Clinical outcome measures for research in multiple sclerosis
-
L.J. Balcer Clinical outcome measures for research in multiple sclerosis J. Neuroophthalmol. 21 2001 296 301
-
(2001)
J. Neuroophthalmol.
, vol.21
, pp. 296-301
-
-
Balcer, L.J.1
-
4
-
-
84884339141
-
Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: Subgroup analyses of the DEFINE study
-
A. Bar-Or, R. Gold, L. Kappos, and et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the DEFINE study J. Neurol. 260 2013 2297 2305
-
(2013)
J. Neurol.
, vol.260
, pp. 2297-2305
-
-
Bar-Or, A.1
Gold, R.2
Kappos, L.3
-
5
-
-
84899856893
-
Teriflunomide and its mechanism of action in multiple sclerosis
-
A. Bar-Or, A. Pachner, F. Menguy-Vacheron, and et al. Teriflunomide and its mechanism of action in multiple sclerosis Drugs 74 2014 659 674
-
(2014)
Drugs
, vol.74
, pp. 659-674
-
-
Bar-Or, A.1
Pachner, A.2
Menguy-Vacheron, F.3
-
6
-
-
78751542854
-
Natalizumab induces a rapid improvement of disability status and ambulation after failure of previous therapy in relapsing-remitting multiple sclerosis
-
S. Belachew, R. Phan-Ba, E. Bartholomé, and et al. Natalizumab induces a rapid improvement of disability status and ambulation after failure of previous therapy in relapsing-remitting multiple sclerosis Eur. J. Neurol. 18 2011 240 245
-
(2011)
Eur. J. Neurol.
, vol.18
, pp. 240-245
-
-
Belachew, S.1
Phan-Ba, R.2
Bartholomé, E.3
-
7
-
-
84883284823
-
JC virus antibody status underestimates infection rates
-
J.R. Berger, S.A. Houff, J. Gurwell, and et al. JC virus antibody status underestimates infection rates Ann. Neurol. 74 2013 84 90
-
(2013)
Ann. Neurol.
, vol.74
, pp. 84-90
-
-
Berger, J.R.1
Houff, S.A.2
Gurwell, J.3
-
8
-
-
85043144930
-
Efficacy of fingolimod in pre-treated multiple sclerosis patients with disease activity: Pooled analyses of FREEDOMS and FREEDOMS II
-
N. Bergvall, N. Sfikas, P. Chin, and et al. Efficacy of fingolimod in pre-treated multiple sclerosis patients with disease activity: pooled analyses of FREEDOMS and FREEDOMS II Am. Acad. Neurol. P3 2014 174
-
(2014)
Am. Acad. Neurol.
, vol.P3
, pp. 174
-
-
Bergvall, N.1
Sfikas, N.2
Chin, P.3
-
9
-
-
30844464790
-
The measurement and clinical relevance of brain atrophy in multiple sclerosis
-
R.A. Bermel, and R. Bakshi The measurement and clinical relevance of brain atrophy in multiple sclerosis Lancet Neurol. 5 2006 158 170
-
(2006)
Lancet Neurol.
, vol.5
, pp. 158-170
-
-
Bermel, R.A.1
Bakshi, R.2
-
10
-
-
84873353587
-
Predictors of long-term outcome in multiple sclerosis patients treated with interferon β
-
R.A. Bermel, X. You, P. Foulds, and et al. Predictors of long-term outcome in multiple sclerosis patients treated with interferon β Ann. Neurol. 73 2013 95 103
-
(2013)
Ann. Neurol.
, vol.73
, pp. 95-103
-
-
Bermel, R.A.1
You, X.2
Foulds, P.3
-
11
-
-
84896781696
-
Disease activity free status: A new end point for a new era in multiple sclerosis clinical research?
-
C.J. Bevan, and B.A. Cree Disease activity free status: a new end point for a new era in multiple sclerosis clinical research? J. Am. Med. Assoc. Neurol. 71 2014 269 270
-
(2014)
J. Am. Med. Assoc. Neurol.
, vol.71
, pp. 269-270
-
-
Bevan, C.J.1
Cree, B.A.2
-
12
-
-
84941722948
-
-
Dec. Available at: accessed February 2015
-
Biogen Idec Ltd, Dec 2014. Tecfidera SmPC. Available at: 〈http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/002601/WC500162069.pdf〉 (accessed February 2015).
-
(2014)
Tecfidera SmPC
-
-
Biogen Idec Ltd1
-
13
-
-
84941722949
-
-
Dec. Available at: accessed February 2015
-
Biogen Idec Ltd, Dec 2014. TYSABRI SmPC. Available at: 〈http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/000603/WC500044686.pdf〉 (accessed February 2015).
-
(2014)
TYSABRI SmPC
-
-
Biogen Idec Ltd1
-
14
-
-
84941722950
-
-
February. Personal communication
-
Biogen Idec, February 2015. Personal communication.
-
(2015)
-
-
Biogen Idec1
-
15
-
-
84861022041
-
Risk of natalizumab-associated progressive multifocal leukoencephalopathy
-
G. Bloomgren, S. Richman, C. Hotermans, and et al. Risk of natalizumab-associated progressive multifocal leukoencephalopathy N. Engl. J. Med. 366 2012 1870 1880
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 1870-1880
-
-
Bloomgren, G.1
Richman, S.2
Hotermans, C.3
-
16
-
-
84921047168
-
Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: An overview
-
R. Bomprezzi Dimethyl fumarate in the treatment of relapsing-remitting multiple sclerosis: an overview Ther. Adv. Neurol. Dis. 8 2015 20 30
-
(2015)
Ther. Adv. Neurol. Dis.
, vol.8
, pp. 20-30
-
-
Bomprezzi, R.1
-
17
-
-
27444444869
-
The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage
-
W. Brück The pathology of multiple sclerosis is the result of focal inflammatory demyelination with axonal damage J. Neurol. 252 Suppl. 5 2005 v3 v9
-
(2005)
J. Neurol.
, vol.252
, pp. v3-v9
-
-
Brück, W.1
-
18
-
-
84898831795
-
Dimethyl fumarate: A review of its use in patients with relapsing-remitting multiple sclerosis
-
C.B. Burness, and E.D. Deeks Dimethyl fumarate: a review of its use in patients with relapsing-remitting multiple sclerosis CNS Drugs 28 2014 373 387
-
(2014)
CNS Drugs
, vol.28
, pp. 373-387
-
-
Burness, C.B.1
Deeks, E.D.2
-
19
-
-
84901725946
-
Efficacy and safety of natalizumab in multiple sclerosis: Interim observational programme results
-
H. Butzkueven, L. Kappos, F. Pellegrini, and et al. Efficacy and safety of natalizumab in multiple sclerosis: interim observational programme results J. Neurol. Neurosurg. Psychiatry 85 2014 1190 1197
-
(2014)
J. Neurol. Neurosurg. Psychiatry
, vol.85
, pp. 1190-1197
-
-
Butzkueven, H.1
Kappos, L.2
Pellegrini, F.3
-
20
-
-
84923141433
-
Sorting out the risks in progressive multifocal leukoencephalopathy
-
L.H. Calabrese, E. Molloy, and J. Berger Sorting out the risks in progressive multifocal leukoencephalopathy Nat. Rev. Rheumatol. 11 2015 119 123
-
(2015)
Nat. Rev. Rheumatol.
, vol.11
, pp. 119-123
-
-
Calabrese, L.H.1
Molloy, E.2
Berger, J.3
-
21
-
-
84901197534
-
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): A double-blind, randomised, placebo-controlled, phase 3 trial
-
P.A. Calabresi, E.W. Radue, D. Goodin, and et al. Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial Lancet Neurol. 13 2014 545 556
-
(2014)
Lancet Neurol.
, vol.13
, pp. 545-556
-
-
Calabresi, P.A.1
Radue, E.W.2
Goodin, D.3
-
22
-
-
33744758685
-
Clinical course after change of immunomodulating therapy in relapsing-remitting multiple sclerosis
-
C. Caon, M. Din, W. Ching, and et al. Clinical course after change of immunomodulating therapy in relapsing-remitting multiple sclerosis Eur. J. Neurol. 13 2006 471 474
-
(2006)
Eur. J. Neurol.
, vol.13
, pp. 471-474
-
-
Caon, C.1
Din, M.2
Ching, W.3
-
23
-
-
41049110806
-
Therapeutic outcome 3 years after switching of immunomodulatory therapies in patients with relapsing-remitting multiple sclerosis in Argentina
-
A. Carrá, and P. Onaha Luetic G, et al. Therapeutic outcome 3 years after switching of immunomodulatory therapies in patients with relapsing-remitting multiple sclerosis in Argentina Eur. J. Neurol. 15 2008 386 393
-
(2008)
Eur. J. Neurol.
, vol.15
, pp. 386-393
-
-
Carrá, A.1
Onaha, P.2
Luetic, G.3
-
24
-
-
84925484052
-
An observational comparison of natalizumab vs. fingolimod using JCV serology to determine therapy
-
R.L. Carruthers, D.L. Rotstein, B.C. Healy, and et al. An observational comparison of natalizumab vs. fingolimod using JCV serology to determine therapy Mult. Scler. 20 2014 1381 1390
-
(2014)
Mult. Scler.
, vol.20
, pp. 1381-1390
-
-
Carruthers, R.L.1
Rotstein, D.L.2
Healy, B.C.3
-
25
-
-
79751519271
-
Switching multiple sclerosis patients with breakthrough disease to second-line therapy
-
T. Castillo-Trivino, E.M. Mowry, A. Gajofatto, and et al. Switching multiple sclerosis patients with breakthrough disease to second-line therapy PLoS One 6 2011 e16664
-
(2011)
PLoS One
, vol.6
-
-
Castillo-Trivino, T.1
Mowry, E.M.2
Gajofatto, A.3
-
26
-
-
77951073508
-
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis
-
J. Chun, and H.P. Hartung Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis Clin. Neuropharmacol. 33 2010 91 101
-
(2010)
Clin. Neuropharmacol.
, vol.33
, pp. 91-101
-
-
Chun, J.1
Hartung, H.P.2
-
27
-
-
84941722951
-
Clinical Advances in Relapsing-Remitting MS: The Role of Oral Disease-Modifying Therapies
-
CMEcorner.com. Available at: accessed February 2015
-
CMEcorner.com. Clinical Insights in Neurology: Focus on Multiple Sclerosis - Issue 4. Clinical Advances in Relapsing-Remitting MS: The Role of Oral Disease-Modifying Therapies. Available at: 〈http://www.cmecorner.com/wp/clinical-insights-in-neurology-focus-on-multiple-sclerosis-issue-4〉 (accessed February 2015).
-
Clinical Insights in Neurology: Focus on Multiple Sclerosis
, Issue.4
-
-
-
28
-
-
76149140914
-
Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis
-
J.A. Cohen, F. Barkhof, G. Comi, and et al. Oral fingolimod or intramuscular interferon for relapsing multiple sclerosis N. Engl. J. Med. 362 2010 402 415
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 402-415
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
29
-
-
84869492471
-
Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: A randomised controlled phase 3 trial
-
J.A. Cohen, A.J. Coles, D.L. Arnold, and et al. Alemtuzumab versus interferon beta 1a as first-line treatment for patients with relapsing-remitting multiple sclerosis: a randomised controlled phase 3 trial Lancet 380 2012 1819 1828
-
(2012)
Lancet
, vol.380
, pp. 1819-1828
-
-
Cohen, J.A.1
Coles, A.J.2
Arnold, D.L.3
-
30
-
-
84881550415
-
Fingolimod versus intramuscular interferon in patient subgroups from TRANSFORMS
-
J.A. Cohen, F. Barkhof, G. Comi, and et al. Fingolimod versus intramuscular interferon in patient subgroups from TRANSFORMS J. Neurol. 260 2013 2023 2032
-
(2013)
J. Neurol.
, vol.260
, pp. 2023-2032
-
-
Cohen, J.A.1
Barkhof, F.2
Comi, G.3
-
31
-
-
84941654839
-
Long-term safety of fingolimod: Interim evaluation of data from the LONGTERMS trial
-
J.A. Cohen, P. von Rosenstiel, R. Gottschalk, and et al. Long-term safety of fingolimod: interim evaluation of data from the LONGTERMS trial Am. Acad. Neurol. P2 2014 210
-
(2014)
Am. Acad. Neurol.
, vol.P2
, pp. 210
-
-
Cohen, J.A.1
Von Rosenstiel, P.2
Gottschalk, R.3
-
32
-
-
84878344070
-
Alemtuzumab treatment of multiple sclerosis
-
A.J. Coles Alemtuzumab treatment of multiple sclerosis Semin. Neurol. 33 2013 66 73
-
(2013)
Semin. Neurol.
, vol.33
, pp. 66-73
-
-
Coles, A.J.1
-
33
-
-
84869507357
-
Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: A randomised controlled phase 3 trial
-
A.J. Coles, C.L. Twyman, D.L. Arnold, and et al. Alemtuzumab for patients with relapsing multiple sclerosis after disease-modifying therapy: a randomised controlled phase 3 trial Lancet 380 2012 1829 1839
-
(2012)
Lancet
, vol.380
, pp. 1829-1839
-
-
Coles, A.J.1
Twyman, C.L.2
Arnold, D.L.3
-
34
-
-
84860780657
-
Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial
-
A.J. Coles, E. Fox, A. Vladic, and et al. Alemtuzumab more effective than interferon β-1a at 5-year follow-up of CAMMS223 clinical trial Neurology 78 2012 1069 1078
-
(2012)
Neurology
, vol.78
, pp. 1069-1078
-
-
Coles, A.J.1
Fox, E.2
Vladic, A.3
-
36
-
-
84895501035
-
Position and practical use of fingolimod in Europe
-
G. Comi Position and practical use of fingolimod in Europe Clin. Exp. Neuroimmunol. 5 2014 19 33
-
(2014)
Clin. Exp. Neuroimmunol.
, vol.5
, pp. 19-33
-
-
Comi, G.1
-
37
-
-
0035912520
-
Effect of early interferon treatment on conversion to definite multiple sclerosis: A randomised study
-
G. Comi, M. Filippi, F. Barkhof, and et al. Effect of early interferon treatment on conversion to definite multiple sclerosis: a randomised study Lancet 357 2001 1576 1582
-
(2001)
Lancet
, vol.357
, pp. 1576-1582
-
-
Comi, G.1
Filippi, M.2
Barkhof, F.3
-
38
-
-
70350786389
-
Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): A randomised, double-blind, placebo-controlled trial
-
G. Comi, V. Martinelli, M. Rodegher, and et al. Effect of glatiramer acetate on conversion to clinically definite multiple sclerosis in patients with clinically isolated syndrome (PreCISe study): a randomised, double-blind, placebo-controlled trial Lancet 374 2009 1503 1511
-
(2009)
Lancet
, vol.374
, pp. 1503-1511
-
-
Comi, G.1
Martinelli, V.2
Rodegher, M.3
-
39
-
-
84894271594
-
Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): A randomised, double-blind, placebo-controlled, phase 3 trial
-
C. Confavreux, P. O'Connor, G. Comi, and et al. Oral teriflunomide for patients with relapsing multiple sclerosis (TOWER): a randomised, double-blind, placebo-controlled, phase 3 trial Lancet Neurol. 13 2014 247 256
-
(2014)
Lancet Neurol.
, vol.13
, pp. 247-256
-
-
Confavreux, C.1
O'Connor, P.2
Comi, G.3
-
40
-
-
84898057394
-
Management of relapsing-remitting multiple sclerosis in Latin America: Practical recommendations for treatment optimization
-
J. Correale, P. Abad, R. Alvarenga, and et al. Management of relapsing-remitting multiple sclerosis in Latin America: practical recommendations for treatment optimization J. Neurol. Sci. 339 2014 196 206
-
(2014)
J. Neurol. Sci.
, vol.339
, pp. 196-206
-
-
Correale, J.1
Abad, P.2
Alvarenga, R.3
-
41
-
-
77958123700
-
The role of natalizumab in the treatment of multiple sclerosis
-
P.K. Coyle The role of natalizumab in the treatment of multiple sclerosis Am. J. Manag. Care. 16 Suppl. 6 2010 S164 S170
-
(2010)
Am. J. Manag. Care
, vol.16
, pp. S164-S170
-
-
Coyle, P.K.1
-
42
-
-
84878259532
-
Switching therapies in multiple sclerosis
-
P.K. Coyle Switching therapies in multiple sclerosis CNS Drugs 27 2013 239 247
-
(2013)
CNS Drugs
, vol.27
, pp. 239-247
-
-
Coyle, P.K.1
-
43
-
-
77953335345
-
Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes
-
N. De Stefano, A. Giorgio, M. Battaglini, and et al. Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes Neurology 74 2010 1868 1876
-
(2010)
Neurology
, vol.74
, pp. 1868-1876
-
-
De Stefano, N.1
Giorgio, A.2
Battaglini, M.3
-
45
-
-
84896835232
-
Clinical relevance of brain volume measures in multiple sclerosis
-
N. De Stefano, L. Airas, N. Grigoriadis, and et al. Clinical relevance of brain volume measures in multiple sclerosis CNS Drugs 28 2014 147 156
-
(2014)
CNS Drugs
, vol.28
, pp. 147-156
-
-
De Stefano, N.1
Airas, L.2
Grigoriadis, N.3
-
46
-
-
84941722953
-
Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis
-
Epub ahead of print
-
De Stefano, N., Stromillo, M.L., Giorgio, A., et al., 2015. Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis. J. Neurol. Neurosurg. Psychiatry (Epub ahead of print).
-
(2015)
J. Neurol. Neurosurg. Psychiatry
-
-
De Stefano, N.1
Stromillo, M.L.2
Giorgio, A.3
-
47
-
-
79954549499
-
MRI predictors of cognitive outcome in early multiple sclerosis
-
M.S. Deloire, A. Ruet, D. Hamel, and et al. MRI predictors of cognitive outcome in early multiple sclerosis Neurology 76 2011 1161 1167
-
(2011)
Neurology
, vol.76
, pp. 1161-1167
-
-
Deloire, M.S.1
Ruet, A.2
Hamel, D.3
-
48
-
-
85027946124
-
Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: Subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study
-
V. Devonshire, E. Havrdova, E.W. Radue, and et al. Relapse and disability outcomes in patients with multiple sclerosis treated with fingolimod: subgroup analyses of the double-blind, randomised, placebo-controlled FREEDOMS study Lancet Neurol 11 2012 420 428
-
(2012)
Lancet Neurol
, vol.11
, pp. 420-428
-
-
Devonshire, V.1
Havrdova, E.2
Radue, E.W.3
-
49
-
-
84938838488
-
First-dose effects of fingolimod: Pooled safety data from three phase 3 studies
-
J.P. DiMarco, P. O'Connor, J.A. Cohen, and et al. First-dose effects of fingolimod: Pooled safety data from three phase 3 studies Mult. Scler. Relat. Disord. 3 2014 629 638
-
(2014)
Mult. Scler. Relat. Disord.
, vol.3
, pp. 629-638
-
-
DiMarco, J.P.1
O'Connor, P.2
Cohen, J.A.3
-
50
-
-
84895740228
-
Assessing treatment response to interferon-β: Is there a role for MRI?
-
R. Dobson, R.A. Rudick, B. Turner, and et al. Assessing treatment response to interferon-β: is there a role for MRI? Neurology 82 2014 248 254
-
(2014)
Neurology
, vol.82
, pp. 248-254
-
-
Dobson, R.1
Rudick, R.A.2
Turner, B.3
-
51
-
-
44449105085
-
MRI activity and neutralising antibody as predictors of response to interferon beta treatment in multiple sclerosis
-
L. Durelli, P. Barbero, M. Bergui, and et al. MRI activity and neutralising antibody as predictors of response to interferon beta treatment in multiple sclerosis J. Neurol. Neurosurg. Psychiatry 79 2008 646 651
-
(2008)
J. Neurol. Neurosurg. Psychiatry
, vol.79
, pp. 646-651
-
-
Durelli, L.1
Barbero, P.2
Bergui, M.3
-
52
-
-
78549234073
-
Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis
-
R. Dutta, and B.D. Trapp Mechanisms of neuronal dysfunction and degeneration in multiple sclerosis Prog. Neurobiol. 93 2011 1 12
-
(2011)
Prog. Neurobiol.
, vol.93
, pp. 1-12
-
-
Dutta, R.1
Trapp, B.D.2
-
53
-
-
77955762153
-
Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial
-
G.C. Ebers, A. Traboulsee, D. Li, and et al. Analysis of clinical outcomes according to original treatment groups 16 years after the pivotal IFNB-1b trial J. Neurol. Neurosurg. Psychiatry 81 2010 907 912
-
(2010)
J. Neurol. Neurosurg. Psychiatry
, vol.81
, pp. 907-912
-
-
Ebers, G.C.1
Traboulsee, A.2
Li, D.3
-
54
-
-
84874476843
-
Best practice in the use of natalizumab in multiple sclerosis
-
O. Fernández Best practice in the use of natalizumab in multiple sclerosis Ther. Adv. Neurol. Disord. 6 2013 69 79
-
(2013)
Ther. Adv. Neurol. Disord.
, vol.6
, pp. 69-79
-
-
Fernández, O.1
-
55
-
-
27444448187
-
MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system
-
M. Filippi, and M.A. Rocca MRI evidence for multiple sclerosis as a diffuse disease of the central nervous system J. Neurol. 252 Suppl. 5 2005 S16 S24
-
(2005)
J. Neurol.
, vol.252
, pp. S16-S24
-
-
Filippi, M.1
Rocca, M.A.2
-
56
-
-
84863344656
-
Association between pathological and MRI findings in multiple sclerosis
-
M. Filippi, M.A. Rocca, F. Barkhof, and et al. Association between pathological and MRI findings in multiple sclerosis Lancet Neurol. 11 2012 349 360
-
(2012)
Lancet Neurol.
, vol.11
, pp. 349-360
-
-
Filippi, M.1
Rocca, M.A.2
Barkhof, F.3
-
57
-
-
84888231694
-
Gray matter damage predicts the accumulation of disability 13 years later in MS
-
M. Filippi, P. Preziosa, M. Copetti, and et al. Gray matter damage predicts the accumulation of disability 13 years later in MS Neurology 81 2013 1759 1767
-
(2013)
Neurology
, vol.81
, pp. 1759-1767
-
-
Filippi, M.1
Preziosa, P.2
Copetti, M.3
-
58
-
-
77949885488
-
Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: Results from the 15-year analysis of the US prospective open-label study of glatiramer acetate
-
C. Ford, A.D. Goodman, K. Johnson, and et al. Continuous long-term immunomodulatory therapy in relapsing multiple sclerosis: results from the 15-year analysis of the US prospective open-label study of glatiramer acetate Mult. Scler. 16 2010 342 350
-
(2010)
Mult. Scler.
, vol.16
, pp. 342-350
-
-
Ford, C.1
Goodman, A.D.2
Johnson, K.3
-
59
-
-
84866355653
-
Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
-
R.J. Fox, D.H. Miller, J.T. Phillips, and et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis N. Engl. J. Med. 367 2012 1087 1097
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1087-1097
-
-
Fox, R.J.1
Miller, D.H.2
Phillips, J.T.3
-
60
-
-
84866355653
-
Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis
-
Supplementary Appendix
-
R.J. Fox, D.H. Miller, J.T. Phillips, and et al. Placebo-controlled phase 3 study of oral BG-12 or glatiramer in multiple sclerosis N. Engl. J. Med. 367 2012 1087 1097 (Supplementary Appendix)
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1087-1097
-
-
Fox, R.J.1
Miller, D.H.2
Phillips, J.T.3
-
61
-
-
84870717089
-
Multiple sclerosis therapeutic strategies: Use second-line agents as first-line agents when time is of the essence
-
M.S. Freedman Multiple sclerosis therapeutic strategies: use second-line agents as first-line agents when time is of the essence Neurol. Clin. Pract. 1 2011 66 68
-
(2011)
Neurol. Clin. Pract.
, vol.1
, pp. 66-68
-
-
Freedman, M.S.1
-
62
-
-
84883742251
-
Treatment optimization in MS: Canadian MS Working Group updated recommendations
-
M.S. Freedman, D. Selchen, D.L. Arnold, and et al. Treatment optimization in MS: Canadian MS Working Group updated recommendations Can. J. Neurol. Sci. 40 2013 307 323
-
(2013)
Can. J. Neurol. Sci.
, vol.40
, pp. 307-323
-
-
Freedman, M.S.1
Selchen, D.2
Arnold, D.L.3
-
63
-
-
84896455554
-
Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis
-
M.S. Freedman, J.M. Kaplan, and S. Markovic-Plese Insights into the Mechanisms of the Therapeutic Efficacy of Alemtuzumab in Multiple Sclerosis J. Clin. Cell Immunol. 4 2013 1000152
-
(2013)
J. Clin. Cell Immunol.
, vol.4
-
-
Freedman, M.S.1
Kaplan, J.M.2
Markovic-Plese, S.3
-
64
-
-
58149085571
-
Switching first-line disease-modifying therapy after failure: Impact on the course of relapsing-remitting multiple sclerosis
-
A. Gajofatto, P. Bacchetti, B. Grimes, and et al. Switching first-line disease-modifying therapy after failure: impact on the course of relapsing-remitting multiple sclerosis Mult. Scler. 15 2009 50 58
-
(2009)
Mult. Scler.
, vol.15
, pp. 50-58
-
-
Gajofatto, A.1
Bacchetti, P.2
Grimes, B.3
-
65
-
-
84890238745
-
-
Oct. Available at: accessed February 2015
-
Genzyme Corporation, Oct 2014. AUBAGIO Prescribing Information. Available at: 〈http://www.accessdata.fda.gov/drugsatfda-docs/label/2014/202992s001lbl.pdf〉 (accessed February 2015).
-
(2014)
AUBAGIO Prescribing Information
-
-
Genzyme Corporation1
-
66
-
-
84941722955
-
-
March. Available at: accessed February 2015
-
Genzyme Therapeutics Ltd, March 2014. LEMTRADA SmPC. Available at: 〈http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/003718/WC500150521.pdf〉 (accessed February 2015).
-
(2014)
LEMTRADA SmPC
-
-
Genzyme Therapeutics Ltd1
-
67
-
-
79952735730
-
Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: A post-hoc and subgroup analysis
-
G. Giovannoni, S. Cook, K. Rammohan, and et al. Sustained disease-activity-free status in patients with relapsing-remitting multiple sclerosis treated with cladribine tablets in the CLARITY study: a post-hoc and subgroup analysis Lancet Neurol. 10 2011 329 337
-
(2011)
Lancet Neurol.
, vol.10
, pp. 329-337
-
-
Giovannoni, G.1
Cook, S.2
Rammohan, K.3
-
68
-
-
78649926600
-
Evolving expectations around early management of multiple sclerosis
-
R. Gold, J.S. Wolinsky, M.P. Amato, and et al. Evolving expectations around early management of multiple sclerosis Ther. Adv. Neurol. Disord. 3 2010 351 367
-
(2010)
Ther. Adv. Neurol. Disord.
, vol.3
, pp. 351-367
-
-
Gold, R.1
Wolinsky, J.S.2
Amato, M.P.3
-
69
-
-
84866423965
-
Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis
-
R. Gold, L. Kappos, D.L. Arnold, and et al. Placebo-controlled phase 3 study of oral BG-12 for relapsing multiple sclerosis N. Engl. J. Med. 367 2012 1098 1107
-
(2012)
N. Engl. J. Med.
, vol.367
, pp. 1098-1107
-
-
Gold, R.1
Kappos, L.2
Arnold, D.L.3
-
70
-
-
84922895724
-
Efficacy and safety of delayed-release dimethyl fumarate in patients newly diagnosed with relapsing-remitting multiple sclerosis (RRMS)
-
R. Gold, G. Giovannoni, J.T. Phillips, and et al. Efficacy and safety of delayed-release dimethyl fumarate in patients newly diagnosed with relapsing-remitting multiple sclerosis (RRMS) Mult. Scler. 21 2015 57 66
-
(2015)
Mult. Scler.
, vol.21
, pp. 57-66
-
-
Gold, R.1
Giovannoni, G.2
Phillips, J.T.3
-
71
-
-
77956387401
-
Anti-JC virus antibodies: Implications for PML risk stratification
-
L. Gorelik, M. Lerner, S. Bixler, and et al. Anti-JC virus antibodies: implications for PML risk stratification Ann. Neurol. 68 2010 295 303
-
(2010)
Ann. Neurol.
, vol.68
, pp. 295-303
-
-
Gorelik, L.1
Lerner, M.2
Bixler, S.3
-
74
-
-
60049089535
-
Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: A retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study
-
E. Havrdová, S. Galetta, M. Hutchinson, and et al. Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study Lancet Neurol. 8 2009 254 260
-
(2009)
Lancet Neurol.
, vol.8
, pp. 254-260
-
-
Havrdová, E.1
Galetta, S.2
Hutchinson, M.3
-
75
-
-
84928169402
-
Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis
-
A. He, T. Spelman, V. Jokubaitis, and et al. Comparison of switch to fingolimod or interferon beta/glatiramer acetate in active multiple sclerosis J. Am. Med. Assoc. Neurol. 72 2015 405 413
-
(2015)
J. Am. Med. Assoc. Neurol.
, vol.72
, pp. 405-413
-
-
He, A.1
Spelman, T.2
Jokubaitis, V.3
-
76
-
-
66149111820
-
Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: A 5-year longitudinal study
-
D. Horakova, M.G. Dwyer, E. Havrdova, and et al. Gray matter atrophy and disability progression in patients with early relapsing-remitting multiple sclerosis: a 5-year longitudinal study J. Neurol. Sci. 282 2009 112 119
-
(2009)
J. Neurol. Sci.
, vol.282
, pp. 112-119
-
-
Horakova, D.1
Dwyer, M.G.2
Havrdova, E.3
-
77
-
-
84906312694
-
First-dose effects of fingolimod after switching from injectable therapies in the randomized, open-label, multicenter, Evaluate Patient OutComes (EPOC) study in relapsing multiple sclerosis
-
B. Hughes, M. Cascione, M.S. Freedman, and et al. First-dose effects of fingolimod after switching from injectable therapies in the randomized, open-label, multicenter, Evaluate Patient OutComes (EPOC) study in relapsing multiple sclerosis Mult. Scler. Relat. Disord. 3 2014 620 628
-
(2014)
Mult. Scler. Relat. Disord.
, vol.3
, pp. 620-628
-
-
Hughes, B.1
Cascione, M.2
Freedman, M.S.3
-
78
-
-
84884337463
-
Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: Subgroup analyses of the CONFIRM study
-
M. Hutchinson, R.J. Fox, D.H. Miller, and et al. Clinical efficacy of BG-12 (dimethyl fumarate) in patients with relapsing-remitting multiple sclerosis: subgroup analyses of the CONFIRM study J. Neurol. 260 2013 2286 2296
-
(2013)
J. Neurol.
, vol.260
, pp. 2286-2296
-
-
Hutchinson, M.1
Fox, R.J.2
Miller, D.H.3
-
79
-
-
84941650232
-
Clinical efficacy of BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis according to prior therapy: An integrated analysis of the Phase 3 DEFINE and CONFIRM studies
-
M. Hutchinson, R. Gold, R.J. Fox, and et al. Clinical efficacy of BG-12 (dimethyl fumarate) for relapsing-remitting multiple sclerosis according to prior therapy: an integrated analysis of the Phase 3 DEFINE and CONFIRM studies ECTRIMS 2013 P563
-
(2013)
ECTRIMS
, pp. P563
-
-
Hutchinson, M.1
Gold, R.2
Fox, R.J.3
-
80
-
-
0034727059
-
Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis
-
CHAMPS Study Group
-
L.D. Jacobs, R.W. Beck, J.H. Simon, and et al. Intramuscular interferon beta-1a therapy initiated during a first demyelinating event in multiple sclerosis. CHAMPS Study Group N. Engl. J. Med. 343 2000 898 904
-
(2000)
N. Engl. J. Med.
, vol.343
, pp. 898-904
-
-
Jacobs, L.D.1
Beck, R.W.2
Simon, J.H.3
-
81
-
-
0029082566
-
Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: Results of a phase III multicenter, double-blind placebo-controlled trial
-
The Copolymer 1 Multiple Sclerosis Study Group
-
K.P. Johnson, B.R. Brooks, J.A. Cohen, and et al. Copolymer 1 reduces relapse rate and improves disability in relapsing-remitting multiple sclerosis: results of a phase III multicenter, double-blind placebo-controlled trial. The Copolymer 1 Multiple Sclerosis Study Group Neurology 45 1995 1268 1276
-
(1995)
Neurology
, vol.45
, pp. 1268-1276
-
-
Johnson, K.P.1
Brooks, B.R.2
Cohen, J.A.3
-
82
-
-
84902165030
-
Fingolimod after natalizumab and the risk of short-term relapse
-
V.G. Jokubaitis, V. Li, T. Kalincik, and et al. Fingolimod after natalizumab and the risk of short-term relapse Neurology 82 2014 1204 1211
-
(2014)
Neurology
, vol.82
, pp. 1204-1211
-
-
Jokubaitis, V.G.1
Li, V.2
Kalincik, T.3
-
83
-
-
84923772724
-
Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis
-
T. Kalincik, D. Horakova, T. Spelman, and et al. Switch to natalizumab versus fingolimod in active relapsing-remitting multiple sclerosis Ann. Neurol. 77 2015 425 435
-
(2015)
Ann. Neurol.
, vol.77
, pp. 425-435
-
-
Kalincik, T.1
Horakova, D.2
Spelman, T.3
-
84
-
-
22044450811
-
Neutralizing antibodies and efficacy of interferon beta-1a: A 4-year controlled study
-
L. Kappos, M. Clanet, M. Sandberg-Wollheim, and et al. Neutralizing antibodies and efficacy of interferon beta-1a: a 4-year controlled study Neurology 65 2005 40 47
-
(2005)
Neurology
, vol.65
, pp. 40-47
-
-
Kappos, L.1
Clanet, M.2
Sandberg-Wollheim, M.3
-
85
-
-
33749027200
-
Long-term subcutaneous interferon beta-1a therapy in patients with relapsing-remitting MS
-
L. Kappos, A. Traboulsee, C. Constantinescu, and et al. Long-term subcutaneous interferon beta-1a therapy in patients with relapsing-remitting MS Neurology 67 2006 944 953
-
(2006)
Neurology
, vol.67
, pp. 944-953
-
-
Kappos, L.1
Traboulsee, A.2
Constantinescu, C.3
-
86
-
-
76149093586
-
A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis
-
L. Kappos, E.W. Radue, P. O'Connor, and et al. A placebo-controlled trial of oral fingolimod in relapsing multiple sclerosis N. Engl. J. Med. 362 2010 387 401
-
(2010)
N. Engl. J. Med.
, vol.362
, pp. 387-401
-
-
Kappos, L.1
Radue, E.W.2
O'Connor, P.3
-
87
-
-
84902546920
-
Fingolimod in relapsing multiple sclerosis: An integrated analysis of safety findings
-
L. Kappos, J. Cohen, W. Collins, and et al. Fingolimod in relapsing multiple sclerosis: an integrated analysis of safety findings Mult. Scler. Relat. Disord. 3 2014 494 504
-
(2014)
Mult. Scler. Relat. Disord.
, vol.3
, pp. 494-504
-
-
Kappos, L.1
Cohen, J.2
Collins, W.3
-
88
-
-
75849157991
-
Disease-modifying agents in the treatment of multiple sclerosis: A review of long-term outcomes
-
O. Katrych, T.M. Simone, S. Azad, and et al. Disease-modifying agents in the treatment of multiple sclerosis: a review of long-term outcomes CNS Neurol. Disord. Drug Targets 8 2009 512 519
-
(2009)
CNS Neurol. Disord. Drug Targets
, vol.8
, pp. 512-519
-
-
Katrych, O.1
Simone, T.M.2
Azad, S.3
-
89
-
-
79956024142
-
Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: A randomised extension of the TRANSFORMS study
-
B. Khatri, F. Barkhof, G. Comi, and et al. Comparison of fingolimod with interferon beta-1a in relapsing-remitting multiple sclerosis: a randomised extension of the TRANSFORMS study Lancet Neurol. 10 2011 520 529
-
(2011)
Lancet Neurol.
, vol.10
, pp. 520-529
-
-
Khatri, B.1
Barkhof, F.2
Comi, G.3
-
90
-
-
84896547988
-
Effect of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod vs. interferon β-1a intramuscular: Subgroup analyses of the Trial Assessing Injectable Interferon vs. Fingolimod Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS)
-
B.O. Khatri, J. Pelletier, L. Kappos, and et al. Effect of prior treatment status and reasons for discontinuation on the efficacy and safety of fingolimod vs. interferon β-1a intramuscular: Subgroup analyses of the Trial Assessing Injectable Interferon vs. Fingolimod Oral in Relapsing-Remitting Multiple Sclerosis (TRANSFORMS) Mult. Scler. Relat. Disord. 3 2014 355 363
-
(2014)
Mult. Scler. Relat. Disord.
, vol.3
, pp. 355-363
-
-
Khatri, B.O.1
Pelletier, J.2
Kappos, L.3
-
91
-
-
79953803423
-
Determinants of interferon β efficacy in patients with multiple sclerosis
-
J. Killestein, and C.H. Polman Determinants of interferon β efficacy in patients with multiple sclerosis Nat. Rev. Neurol. 7 2011 221 228
-
(2011)
Nat. Rev. Neurol.
, vol.7
, pp. 221-228
-
-
Killestein, J.1
Polman, C.H.2
-
92
-
-
34248597542
-
The safety and efficacy of IFN-beta products for the treatment of multiple sclerosis
-
M. Kremenchutzky, S. Morrow, and C. Rush The safety and efficacy of IFN-beta products for the treatment of multiple sclerosis Expert Opin. Drug Saf. 6 2007 279 288
-
(2007)
Expert Opin. Drug Saf.
, vol.6
, pp. 279-288
-
-
Kremenchutzky, M.1
Morrow, S.2
Rush, C.3
-
93
-
-
84893460044
-
Pathology of multiple sclerosis and related inflammatory demyelinating diseases
-
A. Kutzelnigg, and H. Lassmann Pathology of multiple sclerosis and related inflammatory demyelinating diseases Handb. Clin. Neurol. 122 2014 15 58
-
(2014)
Handb. Clin. Neurol.
, vol.122
, pp. 15-58
-
-
Kutzelnigg, A.1
Lassmann, H.2
-
94
-
-
27644552194
-
Cortical demyelination and diffuse white matter injury in multiple sclerosis
-
A. Kutzelnigg, C.F. Lucchinetti, C. Stadelmann, and et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis Brain 128 2005 2705 2712
-
(2005)
Brain
, vol.128
, pp. 2705-2712
-
-
Kutzelnigg, A.1
Lucchinetti, C.F.2
Stadelmann, C.3
-
95
-
-
81555223903
-
The molecular basis of neurodegeneration in multiple sclerosis
-
H. Lassmann, and J. van Horssen The molecular basis of neurodegeneration in multiple sclerosis FEBS Lett. 585 2011 3715 3723
-
(2011)
FEBS Lett.
, vol.585
, pp. 3715-3723
-
-
Lassmann, H.1
Van Horssen, J.2
-
96
-
-
84941717580
-
Outcome measures in relapsing-remitting multiple sclerosis: Capturing disability and disease progression in clinical trials
-
2014
-
A.M. Lavery, L.H. Verhey, and A.T. Waldman Outcome measures in relapsing-remitting multiple sclerosis: capturing disability and disease progression in clinical trials Mult. Scler. Int. 2014 262350 2014
-
(2014)
Mult. Scler. Int.
-
-
Lavery, A.M.1
Verhey, L.H.2
Waldman, A.T.3
-
97
-
-
84941625114
-
Pooled safety data from four placebo-controlled teriflunomide studies
-
T.P. Leist, M.S. Freedman, M. Benamor, and et al. Pooled safety data from four placebo-controlled teriflunomide studies Am. Acad. Neurol. P2 2014 203
-
(2014)
Am. Acad. Neurol.
, vol.P2
, pp. 203
-
-
Leist, T.P.1
Freedman, M.S.2
Benamor, M.3
-
99
-
-
77954382272
-
Evidence for a two-stage disability progression in multiple sclerosis
-
E. Leray, J. Yaouanq, E. Le Page, and et al. Evidence for a two-stage disability progression in multiple sclerosis Brain 133 2010 1900 1913
-
(2010)
Brain
, vol.133
, pp. 1900-1913
-
-
Leray, E.1
Yaouanq, J.2
Le Page, E.3
-
100
-
-
84905819646
-
Defining the clinical course of multiple sclerosis: The 2013 revisions
-
F.D. Lublin, S.C. Reingold, J.A. Cohen, and et al. Defining the clinical course of multiple sclerosis: the 2013 revisions Neurology 83 2014 278 286
-
(2014)
Neurology
, vol.83
, pp. 278-286
-
-
Lublin, F.D.1
Reingold, S.C.2
Cohen, J.A.3
-
101
-
-
83155173565
-
Inflammatory cortical demyelination in early multiple sclerosis
-
C.F. Lucchinetti, B.F. Popescu, R.F. Bunyan, and et al. Inflammatory cortical demyelination in early multiple sclerosis N. Engl. J. Med. 365 2011 2188 2197
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 2188-2197
-
-
Lucchinetti, C.F.1
Popescu, B.F.2
Bunyan, R.F.3
-
103
-
-
84896842777
-
-
ENS
-
D. Miller, R.J. Fox, J.T. Phillips, and et al. Effects of BG-12 on magnetic resonance imaging outcomes in CONFIRM (Comparator and an Oral Fumarate in Relapsing-Remitting Multiple Sclerosis), a randomized, placebo-controlled, phase 3 study ENS 2012 O259
-
(2012)
Effects of BG-12 on Magnetic Resonance Imaging Outcomes in CONFIRM (Comparator and An Oral Fumarate in Relapsing-Remitting Multiple Sclerosis), a Randomized, Placebo-controlled, Phase 3 Study
, pp. O259
-
-
Miller, D.1
Fox, R.J.2
Phillips, J.T.3
-
104
-
-
0031973909
-
The role of magnetic resonance techniques in understanding and managing multiple sclerosis
-
D.H. Miller, R.I. Grossman, S.C. Reingold, and et al. The role of magnetic resonance techniques in understanding and managing multiple sclerosis Brain 121 Pt 1 1998 3 24
-
(1998)
Brain
, vol.121
, pp. 3-24
-
-
Miller, D.H.1
Grossman, R.I.2
Reingold, S.C.3
-
105
-
-
34247513840
-
MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS
-
D.H. Miller, D. Soon, K.T. Fernando, and et al. MRI outcomes in a placebo-controlled trial of natalizumab in relapsing MS Neurology 68 2007 1390 1401
-
(2007)
Neurology
, vol.68
, pp. 1390-1401
-
-
Miller, D.H.1
Soon, D.2
Fernando, K.T.3
-
107
-
-
48249149487
-
Predicting short-term disability progression in early multiple sclerosis: Added value of MRI parameters
-
A. Minneboo, B. Jasperse, F. Barkhof, and et al. Predicting short-term disability progression in early multiple sclerosis: added value of MRI parameters J. Neurol. Neurosurg. Psychiatry 79 2008 917 923
-
(2008)
J. Neurol. Neurosurg. Psychiatry
, vol.79
, pp. 917-923
-
-
Minneboo, A.1
Jasperse, B.2
Barkhof, F.3
-
109
-
-
84941722958
-
Case of PML confirmed in someone taking Tecfidera
-
Oct. Available at: accessed February 2015
-
Multiple Sclerosis Society News, Oct 2014. Case of PML confirmed in someone taking Tecfidera. Available at: 〈http://www.mssociety.org.uk/ms-news/2014/10/case-pml-confirmed-someone-taking-tecfidera〉 (accessed February 2015).
-
(2014)
Multiple Sclerosis Society News
-
-
-
110
-
-
84941722959
-
-
19 February. Available at: accessed February 2015
-
Multiple Sclerosis Society of Canada, 19 February 2015. Case of PML reported in patient treated with Gilenya®. Available at: 〈https://beta.mssociety.ca/research-news/article/case-of-pml-reported-in-patient-treated-with-gilenya〉 (accessed February 2015).
-
(2015)
Case of PML Reported in Patient Treated with Gilenya®
-
-
-
111
-
-
56349150992
-
Basic and escalating immunomodulatory treatments in multiple sclerosis: Current therapeutic recommendations
-
Multiple Sclerosis Therapy Consensus Group (MSTCG), H. Wiendl, K.V. Toyka, and et al. Basic and escalating immunomodulatory treatments in multiple sclerosis: current therapeutic recommendations J. Neurol. 255 2008 1449 1463
-
(2008)
J. Neurol.
, vol.255
, pp. 1449-1463
-
-
Wiendl, H.1
Toyka, K.V.2
-
112
-
-
84898911579
-
First-line natalizumab in multiple sclerosis: Rationale, patient selection, benefits and risks
-
J.A. Nicholas, M.K. Racke, J. Imitola, and et al. First-line natalizumab in multiple sclerosis: rationale, patient selection, benefits and risks Ther. Adv. Chronic Dis. 5 2014 62 68
-
(2014)
Ther. Adv. Chronic Dis.
, vol.5
, pp. 62-68
-
-
Nicholas, J.A.1
Racke, M.K.2
Imitola, J.3
-
113
-
-
84927144781
-
PML in a patient without severe lymphocytopenia receiving dimethyl fumarate
-
D.J. Nieuwkamp, J.L. Murk, B.W. van Oosten, and et al. PML in a patient without severe lymphocytopenia receiving dimethyl fumarate N. Engl. J. Med. 372 2015 1474 1476
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1474-1476
-
-
Nieuwkamp, D.J.1
Murk, J.L.2
Van Oosten, B.W.3
-
114
-
-
84941722960
-
-
Available at: accessed February 2015
-
Novartis International AG. Novartis Q4 and FY 2014 condensed financial report - data. Available at: 〈http://www.novartis.com/downloads/investors/financial-results/quarterly-results/2015-01-interim-financial-report.pdf〉 (accessed February 2015).
-
Novartis Q4 and FY 2014 Condensed Financial Report - Data
-
-
-
115
-
-
84941722961
-
-
Sep. Available at: accessed February 2015
-
Novartis Pharma GmbH, Sep 2014. GILENYA SmPC. Available at: 〈http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/002202/WC500104528.pdf〉 (accessed February 2015).
-
(2014)
GILENYA SmPC
-
-
Novartis Pharma GmbH1
-
116
-
-
80053533877
-
Randomized trial of oral teriflunomide for relapsing multiple sclerosis
-
P. O'Connor, J.S. Wolinsky, C. Confavreux, and et al. Randomized trial of oral teriflunomide for relapsing multiple sclerosis N. Engl. J. Med. 365 2011 1293 1303
-
(2011)
N. Engl. J. Med.
, vol.365
, pp. 1293-1303
-
-
O'Connor, P.1
Wolinsky, J.S.2
Confavreux, C.3
-
117
-
-
84903964778
-
Long-term safety and effectiveness of natalizumab redosing and treatment in the STRATA MS Study
-
P. O'Connor, A. Goodman, L. Kappos, and et al. Long-term safety and effectiveness of natalizumab redosing and treatment in the STRATA MS Study Neurology 83 2014 78 86
-
(2014)
Neurology
, vol.83
, pp. 78-86
-
-
O'Connor, P.1
Goodman, A.2
Kappos, L.3
-
118
-
-
84941635011
-
Patients free of clinical MS activity in TEMSO and TOWER: Pooled analyses of two Phase 3 placebo-controlled trials
-
T.P. Olsson, G. Comi, M.S. Freedman, and et al. Patients free of clinical MS activity in TEMSO and TOWER: pooled analyses of two Phase 3 placebo-controlled trials Am. Acad. Neurol. P3 2014 164
-
(2014)
Am. Acad. Neurol.
, vol.P3
, pp. 164
-
-
Olsson, T.P.1
Comi, G.2
Freedman, M.S.3
-
119
-
-
84902184354
-
JC-virus seroconversion in multiple sclerosis patients receiving natalizumab
-
Epub ahead of print
-
Outteryck, O., Zephir, H., Salleron, J., et al., 2013. JC-virus seroconversion in multiple sclerosis patients receiving natalizumab. Mult Scler (Epub ahead of print).
-
(2013)
Mult Scler
-
-
Outteryck, O.1
Zephir, H.2
Salleron, J.3
-
120
-
-
84867879942
-
Clinical response to interferon beta and glatiramer acetate in multiple sclerosis patients: A Brazilian cohort
-
V.C. Pereira, F.R. Malfetano, I.D. Meira, and et al. Clinical response to interferon beta and glatiramer acetate in multiple sclerosis patients: a Brazilian cohort Arq. Neuropsiquiatr. 70 2012 774 779
-
(2012)
Arq. Neuropsiquiatr.
, vol.70
, pp. 774-779
-
-
Pereira, V.C.1
Malfetano, F.R.2
Meira, I.D.3
-
121
-
-
84922728949
-
Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: Impact on quality of life
-
R. Planas, R. Martin, and M. Sospedra Long-term safety and efficacy of natalizumab in relapsing-remitting multiple sclerosis: impact on quality of life Patient Relat. Outcome Meas. 5 2014 25 33
-
(2014)
Patient Relat. Outcome Meas.
, vol.5
, pp. 25-33
-
-
Planas, R.1
Martin, R.2
Sospedra, M.3
-
122
-
-
33644584352
-
A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis
-
C.H. Polman, P.W. O'Connor, E. Havrdova, and et al. A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis N. Engl. J. Med. 354 2006 899 910
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 899-910
-
-
Polman, C.H.1
O'Connor, P.W.2
Havrdova, E.3
-
123
-
-
84884582403
-
Brain atrophy and lesion load predict long term disability in multiple sclerosis
-
V. Popescu, F. Agosta, H.E. Hulst, and et al. Brain atrophy and lesion load predict long term disability in multiple sclerosis J. Neurol. Neurosurg. Psychiatry 84 2013 1082 1091
-
(2013)
J. Neurol. Neurosurg. Psychiatry
, vol.84
, pp. 1082-1091
-
-
Popescu, V.1
Agosta, F.2
Hulst, H.E.3
-
124
-
-
84941722962
-
Chapter 2: MRI and New Imaging Technologies in Multiple Sclerosis
-
Cohen, B.A., Pelletier, D., (Eds.). Available at: accessed February 2015
-
Projects in Knowledge, 2013. Chapter 2: MRI and New Imaging Technologies in Multiple Sclerosis. In: Cohen, B.A., Pelletier, D., (Eds.). Living Medical eTextbook. Neurology: Multiple Sclerosis Edition. Available at: 〈http://lmt.projectsinknowledge.com/Activity/index.cfm?showfile=b&i=8&jn=2023&sj=2023.02〉 (accessed February 2015).
-
(2013)
Living Medical ETextbook. Neurology: Multiple Sclerosis Edition
-
-
-
125
-
-
70350135509
-
One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis
-
L. Prosperini, V. Gallo, N. Petsas, and et al. One-year MRI scan predicts clinical response to interferon beta in multiple sclerosis Eur. J. Neurol. 16 2009 1202 1209
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 1202-1209
-
-
Prosperini, L.1
Gallo, V.2
Petsas, N.3
-
126
-
-
79951945249
-
Management of breakthrough disease in patients with multiple sclerosis: When an increasing of Interferon beta dose should be effective?
-
L. Prosperini, G. Borriello, L. De Giglio, and et al. Management of breakthrough disease in patients with multiple sclerosis: when an increasing of Interferon beta dose should be effective? BMC Neurol. 11 2011 26
-
(2011)
BMC Neurol.
, vol.11
, pp. 26
-
-
Prosperini, L.1
Borriello, G.2
De Giglio, L.3
-
127
-
-
84855925874
-
Escalation to natalizumab or switching among immunomodulators in relapsing multiple sclerosis
-
L. Prosperini, C. Gianni, L. Leonardi, and et al. Escalation to natalizumab or switching among immunomodulators in relapsing multiple sclerosis Mult Scler 18 2012 64 71
-
(2012)
Mult Scler
, vol.18
, pp. 64-71
-
-
Prosperini, L.1
Gianni, C.2
Leonardi, L.3
-
128
-
-
84919334429
-
Identifying responders and nonresponders to interferon therapy in multiple sclerosis
-
L. Prosperini, M. Capobianco, and C. Giannì Identifying responders and nonresponders to interferon therapy in multiple sclerosis Degener. Neurol. Neuromuscul. Dis. 4 2014 75 84
-
(2014)
Degener. Neurol. Neuromuscul. Dis.
, vol.4
, pp. 75-84
-
-
Prosperini, L.1
Capobianco, M.2
Giannì, C.3
-
129
-
-
60049090180
-
Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis
-
N. Putzki, K. Kollia, S. Woods, and et al. Natalizumab is effective as second line therapy in the treatment of relapsing remitting multiple sclerosis Eur. J. Neurol. 16 2009 424 426
-
(2009)
Eur. J. Neurol.
, vol.16
, pp. 424-426
-
-
Putzki, N.1
Kollia, K.2
Woods, S.3
-
130
-
-
74249110981
-
Natalizumab reduces clinical and MRI activity in multiple sclerosis patients with high disease activity: Results from a multicenter study in Switzerland
-
N. Putzki, O. Yaldizli, R. Bühler, and et al. Natalizumab reduces clinical and MRI activity in multiple sclerosis patients with high disease activity: results from a multicenter study in Switzerland Eur. Neurol 63 2010 101 106
-
(2010)
Eur. Neurol
, vol.63
, pp. 101-106
-
-
Putzki, N.1
Yaldizli, O.2
Bühler, R.3
-
131
-
-
73449107729
-
Efficacy of natalizumab in second line therapy of relapsing-remitting multiple sclerosis: Results from a multi-center study in German speaking countries
-
N. Putzki, O. Yaldizli, M. Mäurer, and et al. Efficacy of natalizumab in second line therapy of relapsing-remitting multiple sclerosis: results from a multi-center study in German speaking countries Eur. J. Neurol. 17 2010 31 37
-
(2010)
Eur. J. Neurol.
, vol.17
, pp. 31-37
-
-
Putzki, N.1
Yaldizli, O.2
Mäurer, M.3
-
132
-
-
0036789860
-
Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with interferon beta: Implications for clinical trials
-
J. Río, C. Nos, M. Tintoré, and et al. Assessment of different treatment failure criteria in a cohort of relapsing-remitting multiple sclerosis patients treated with interferon beta: implications for clinical trials Ann. Neurol. 52 2002 400 406
-
(2002)
Ann. Neurol.
, vol.52
, pp. 400-406
-
-
Río, J.1
Nos, C.2
Tintoré, M.3
-
133
-
-
67649354558
-
Measures in the first year of therapy predict the response to interferon beta in MS
-
J. Río, J. Castilló, A. Rovira, and et al. Measures in the first year of therapy predict the response to interferon beta in MS Mult. Scler. 15 2009 848 853
-
(2009)
Mult. Scler.
, vol.15
, pp. 848-853
-
-
Río, J.1
Castilló, J.2
Rovira, A.3
-
134
-
-
70349745515
-
Predicting responders to therapies for multiple sclerosis
-
J. Río, M. Comabella, and X. Montalban Predicting responders to therapies for multiple sclerosis Nat. Rev. Neurol. 5 2009 553 560
-
(2009)
Nat. Rev. Neurol.
, vol.5
, pp. 553-560
-
-
Río, J.1
Comabella, M.2
Montalban, X.3
-
136
-
-
84860920485
-
Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response
-
J. Río, M. Tintoré, J. Sastre-Garriga, and et al. Change in the clinical activity of multiple sclerosis after treatment switch for suboptimal response Eur. J. Neurol. 19 2012 899 904
-
(2012)
Eur. J. Neurol.
, vol.19
, pp. 899-904
-
-
Río, J.1
Tintoré, M.2
Sastre-Garriga, J.3
-
137
-
-
77953353229
-
Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS
-
A.T. Reder, G.C. Ebers, A. Traboulsee, and et al. Cross-sectional study assessing long-term safety of interferon-beta-1b for relapsing-remitting MS Neurology 74 2010 1877 1885
-
(2010)
Neurology
, vol.74
, pp. 1877-1885
-
-
Reder, A.T.1
Ebers, G.C.2
Traboulsee, A.3
-
138
-
-
84927155177
-
PML in a patient with lymphocytopenia treated with dimethyl fumarate
-
T. Rosenkranz, M. Novas, and C. Terborg PML in a patient with lymphocytopenia treated with dimethyl fumarate N. Engl. J. Med. 372 2015 1476 1478
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1476-1478
-
-
Rosenkranz, T.1
Novas, M.2
Terborg, C.3
-
140
-
-
33644608613
-
Natalizumab plus interferon beta-1a for relapsing multiple sclerosis
-
R.A. Rudick, W.H. Stuart, P.A. Calabresi, and et al. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis N. Engl. J. Med. 354 2006 911 923
-
(2006)
N. Engl. J. Med.
, vol.354
, pp. 911-923
-
-
Rudick, R.A.1
Stuart, W.H.2
Calabresi, P.A.3
-
141
-
-
20444385866
-
The relationship between whole brain volume and disability in multiple sclerosis: A comparison of normalized gray vs. white matter with misclassification correction
-
M.P. Sanfilipo, R.H. Benedict, J. Sharma, and et al. The relationship between whole brain volume and disability in multiple sclerosis: a comparison of normalized gray vs. white matter with misclassification correction Neuroimage 26 2005 1068 1077
-
(2005)
Neuroimage
, vol.26
, pp. 1068-1077
-
-
Sanfilipo, M.P.1
Benedict, R.H.2
Sharma, J.3
-
142
-
-
85027945635
-
Fingolimod: A review of its use in relapsing-remitting multiple sclerosis
-
M. Sanford Fingolimod: a review of its use in relapsing-remitting multiple sclerosis Drugs 74 2014 1411 1433
-
(2014)
Drugs
, vol.74
, pp. 1411-1433
-
-
Sanford, M.1
-
143
-
-
84941722964
-
-
Nov Available at: accessed February 2015
-
Sanofi-Aventis Groupe, Nov 2014. AUBAGIO SmPC. Available at: 〈http://www.ema.europa.eu/docs/en-GB/document-library/EPAR---Product-Information/human/002514/WC500148682.pdf〉 (accessed February 2015).
-
(2014)
AUBAGIO SmPC
-
-
Sanofi-Aventis Groupe1
-
145
-
-
84863895902
-
Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis
-
A. Shirani, Y. Zhao, M.E. Karim, and et al. Association between use of interferon beta and progression of disability in patients with relapsing-remitting multiple sclerosis J. Am. Med. Assoc. 308 2012 247 256
-
(2012)
J. Am. Med. Assoc.
, vol.308
, pp. 247-256
-
-
Shirani, A.1
Zhao, Y.2
Karim, M.E.3
-
146
-
-
84877726848
-
Interferon beta and long-term disability in multiple sclerosis
-
A. Shirani, Y. Zhao, M.E. Karim, and et al. Interferon beta and long-term disability in multiple sclerosis J. Am. Med. Assoc. Neurol. 70 2013 651 652
-
(2013)
J. Am. Med. Assoc. Neurol.
, vol.70
, pp. 651-652
-
-
Shirani, A.1
Zhao, Y.2
Karim, M.E.3
-
147
-
-
84879105572
-
Fingolimod for the treatment of relapsing multiple sclerosis
-
B.A. Singer Fingolimod for the treatment of relapsing multiple sclerosis Expert Rev. Neurother. 13 2013 589 602
-
(2013)
Expert Rev. Neurother.
, vol.13
, pp. 589-602
-
-
Singer, B.A.1
-
148
-
-
34247191347
-
Patterns of contrast enhancement in the brain and meninges
-
J.G. Smirniotopoulos, F.M. Murphy, E.J. Rushing, and et al. Patterns of contrast enhancement in the brain and meninges Radiographics 27 2007 525 551
-
(2007)
Radiographics
, vol.27
, pp. 525-551
-
-
Smirniotopoulos, J.G.1
Murphy, F.M.2
Rushing, E.J.3
-
149
-
-
10744225329
-
Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis
-
P.S. Sorensen, C. Ross, K.M. Clemmesen, and et al. Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis Lancet 362 2003 1184 1191
-
(2003)
Lancet
, vol.362
, pp. 1184-1191
-
-
Sorensen, P.S.1
Ross, C.2
Clemmesen, K.M.3
-
150
-
-
84881065172
-
Refining response to treatment as defined by the Modified Rio Score
-
M. Sormani A. Signori, and M. Stromillo Refining response to treatment as defined by the Modified Rio Score Mult. Scler. 19 2013 1246 1247
-
(2013)
Mult. Scler.
, vol.19
, pp. 1246-1247
-
-
Sormani, M.1
Signori, A.2
Stromillo, M.3
-
151
-
-
84876546564
-
Scoring treatment response in patients with relapsing multiple sclerosis
-
M. Sormani, J. Rio, M. Tintore, and et al. Scoring treatment response in patients with relapsing multiple sclerosis Mult. Scler. 5 2013 605 612
-
(2013)
Mult. Scler.
, vol.5
, pp. 605-612
-
-
Sormani, M.1
Rio, J.2
Tintore, M.3
-
152
-
-
84879017576
-
MRI lesions as a surrogate for relapses in multiple sclerosis: A meta-analysis of randomised trials
-
M.P. Sormani, and P. Bruzzi MRI lesions as a surrogate for relapses in multiple sclerosis: a meta-analysis of randomised trials Lancet Neurol. 12 2013 669 676
-
(2013)
Lancet Neurol.
, vol.12
, pp. 669-676
-
-
Sormani, M.P.1
Bruzzi, P.2
-
153
-
-
84883739704
-
Defining and scoring response to IFN-β in multiple sclerosis
-
M.P. Sormani, and N. De Stefano Defining and scoring response to IFN-β in multiple sclerosis Nat. Rev. Neurol. 9 2013 504 512
-
(2013)
Nat. Rev. Neurol.
, vol.9
, pp. 504-512
-
-
Sormani, M.P.1
De Stefano, N.2
-
154
-
-
65249154822
-
Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: A meta-analytic approach
-
M.P. Sormani, L. Bonzano, L. Roccatagliata, and et al. Magnetic resonance imaging as a potential surrogate for relapses in multiple sclerosis: a meta-analytic approach Ann. Neurol. 65 2009 268 275
-
(2009)
Ann. Neurol.
, vol.65
, pp. 268-275
-
-
Sormani, M.P.1
Bonzano, L.2
Roccatagliata, L.3
-
155
-
-
82955243995
-
Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis
-
M.P. Sormani, D.K. Li, P. Bruzzi, and et al. Combined MRI lesions and relapses as a surrogate for disability in multiple sclerosis Neurology 77 2011 1684 1690
-
(2011)
Neurology
, vol.77
, pp. 1684-1690
-
-
Sormani, M.P.1
Li, D.K.2
Bruzzi, P.3
-
156
-
-
84894038191
-
Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis
-
M.P. Sormani, D.L. Arnold, and N. De Stefano Treatment effect on brain atrophy correlates with treatment effect on disability in multiple sclerosis Ann. Neurol. 75 2014 43 49
-
(2014)
Ann. Neurol.
, vol.75
, pp. 43-49
-
-
Sormani, M.P.1
Arnold, D.L.2
De Stefano, N.3
-
157
-
-
77949297173
-
Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: Clinical features and pathogenesis
-
C.S. Tan, and I.J. Koralnik Progressive multifocal leukoencephalopathy and other disorders caused by JC virus: clinical features and pathogenesis Lancet Neurol. 9 2010 425 437
-
(2010)
Lancet Neurol.
, vol.9
, pp. 425-437
-
-
Tan, C.S.1
Koralnik, I.J.2
-
158
-
-
33644964929
-
Predictors of long-term clinical response to interferon beta therapy in relapsing multiple sclerosis
-
V. Tomassini, A. Paolillo, P. Russo, and et al. Predictors of long-term clinical response to interferon beta therapy in relapsing multiple sclerosis J. Neurol. 253 2006 287 293
-
(2006)
J. Neurol.
, vol.253
, pp. 287-293
-
-
Tomassini, V.1
Paolillo, A.2
Russo, P.3
-
159
-
-
84941722965
-
-
25 August Available at: accessed February 2015
-
U.S. Food and Drug Administration (FDA), 25 August 2012. Medical Review: Aubagio (teriflunomide). Available at: 〈www.accessdata.fda.gov/drugsatfda-docs/nda/2012/202992Orig1s000MedR.pdf〉 (accessed February 2015).
-
(2012)
Medical Review: Aubagio (Teriflunomide)
-
-
-
161
-
-
84897022266
-
Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: A randomised, controlled phase 3 trial
-
P. Vermersch, A. Czlonkowska, L.M. Grimaldi, and et al. Teriflunomide versus subcutaneous interferon beta-1a in patients with relapsing multiple sclerosis: a randomised, controlled phase 3 trial Mult. Scler. 20 2014 705 716
-
(2014)
Mult. Scler.
, vol.20
, pp. 705-716
-
-
Vermersch, P.1
Czlonkowska, A.2
Grimaldi, L.M.3
-
162
-
-
84883410242
-
Magnetic resonance imaging outcomes from a phase III trial of teriflunomide
-
J.S. Wolinsky, P.A. Narayana, F. Nelson, and et al. Magnetic resonance imaging outcomes from a phase III trial of teriflunomide Mult. Scler. 19 2013 1310 1319
-
(2013)
Mult. Scler.
, vol.19
, pp. 1310-1319
-
-
Wolinsky, J.S.1
Narayana, P.A.2
Nelson, F.3
-
163
-
-
85043019128
-
24-Month interim results of PANGAEA: A 5 year registry study evaluating long-term safety, efficacy and pharmaco-economic data of German multiple sclerosis patients on fingolimod therapy
-
T. Ziemssen, M. Diaz-Lorente, A. Fuchs, and et al. 24-month interim results of PANGAEA: A 5 year registry study evaluating long-term safety, efficacy and pharmaco-economic data of German multiple sclerosis patients on fingolimod therapy Am. Acad. Neurol. P3 2014 152
-
(2014)
Am. Acad. Neurol.
, vol.P3
, pp. 152
-
-
Ziemssen, T.1
Diaz-Lorente, M.2
Fuchs, A.3
-
164
-
-
84883183367
-
Thalamic atrophy is associated with development of clinically definite multiple sclerosis
-
R. Zivadinov, E. Havrdová, N. Bergsland, and et al. Thalamic atrophy is associated with development of clinically definite multiple sclerosis Radiology 268 2013 831 841
-
(2013)
Radiology
, vol.268
, pp. 831-841
-
-
Zivadinov, R.1
Havrdová, E.2
Bergsland, N.3
|