Photo-activatable Cre recombinase regulates gene expression in vivo

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Schindler, Suzanne E ^a   McCall, Jordan G ^a,b   Yan, Ping ^a   Hyrc, Krzystof L ^a   Li, Mingjie ^a   Tucker, Chandra L ^c   Lee, Jin Moo ^a   Bruchas, Michael R ^a,b   Diamond, Marc I ^d  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Department of Anesthesiology Washington University Pain Center ^*  (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; INTEGRASE;

ANIMAL; BRAIN; CELL CULTURE; FIBER OPTICS; FLUORESCENCE MICROSCOPY; GENE EXPRESSION REGULATION; GENE ORDER; GENETICS; HIPPOCAMPUS; LIGHT; METABOLISM; MOUSE; NERVE CELL; PHOTON; RADIATION RESPONSE;

ANIMALS; BRAIN; CELLS, CULTURED; FIBER OPTIC TECHNOLOGY; GENE EXPRESSION REGULATION; GENE ORDER; HIPPOCAMPUS; INTEGRASES; LIGHT; MICE; MICROSCOPY, FLUORESCENCE; NEURONS; PHOTONS;

EID: 84941585556     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep13627     Document Type: Article

References (22)

1. Oh, S. W., et al. A mesoscale connectome of the mouse brain. Nature 508, 207-214, doi: 10.1038/nature13186 (2014
2. Ng, L., et al. An anatomic gene expression atlas of the adult mouse brain. Nature neuroscience 12, 356-362, doi: 10.1038/nn.2281 (2009
3. Lewandoski, M. Conditional control of gene expression in the mouse. Nature reviews. Genetics 2, 743-755, doi: 10.1038/35093537 (2001
4. Ornitz, D. M., Moreadith, R. W. & Leder, P. Binary system for regulating transgene expression in mice: targeting int-2 gene expression with yeast GAL4/UAS control elements. Proceedings of the National Academy of Sciences of the United States of America 88, 698-702 (1991
5. Gossen, M. & Bujard, H. Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proceedings of the National Academy of Sciences of the United States of America 89, 5547-5551 (1992
6. Feil, R., et al. Ligand-Activated site-specific recombination in mice. Proceedings of the National Academy of Sciences of the United States of America 93, 10887-10890 (1996
7. Kellendonk, C., et al. Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic acids research 24, 1404-1411 (1996
8. Gunschmann, C., et al. Transgenic mouse technology in skin biology: inducible gene knockout in mice. The Journal of investigative dermatology 134, e22, doi: 10.1038/jid.2014.213 (2014
9. Soden, M. E., Gore, B. B. & Zweifel, L. S. Defining functional gene-circuit interfaces in the mouse nervous system. Genes, brain, and behavior 13, 2-12, doi: 10.1111/gbb.12082 (2014
10. Brooks, A. I., Cory-Slechta, D. A. & Federoff, H. J. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proceedings of the National Academy of Sciences of the United States of America 97, 13378-13383, doi: 10.1073/pnas.230169397 (2000
11. Fenno, L., Yizhar, O. & Deisseroth, K. The development and application of optogenetics. Annual review of neuroscience 34, 389-412, doi: 10.1146/annurev-neuro-061010-113817 (2011
12. Liu, H., et al. Photoexcited CRY2 interacts with CIB1 to regulate transcription and floral initiation in Arabidopsis. Science 322, 1535-1539, doi: 10.1126/science.1163927 (2008
13. Kennedy, M. J., et al. Rapid blue-light-mediated induction of protein interactions in living cells. Nature methods 7, 973-975, doi: 10.1038/nmeth.1524 (2010
14. Konermann, S., et al. Optical control of mammalian endogenous transcription and epigenetic states. Nature 500, 472-476, doi: 10.1038/nature12466 (2013
15. Boulina, M., Samarajeewa, H., Baker, J. D., Kim, M. D. & Chiba, A. Live imaging of multicolor-labeled cells in Drosophila. Development 140, 1605-1613, doi: 10.1242/dev.088930 (2013
16. Edwards, W. F., Young, D. D. & Deiters, A. Light-Activated Cre recombinase as a tool for the spatial and temporal control of gene function in mammalian cells. ACS chemical biology 4, 441-445, doi: 10.1021/cb900041s (2009
17. Madisen, L., et al. A robust and high-Throughput Cre reporting and characterization system for the whole mouse brain. Nature neuroscience 13, 133-140, doi: 10.1038/nn.2467 (2010
18. Lo, W. D., et al. Adeno-Associated virus-mediated gene transfer to the brain: duration and modulation of expression. Human gene therapy 10, 201-213, doi: 10.1089/10430349950018995 (1999
19. Leone, D. P., et al. Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Molecular and cellular neurosciences 22, 430-440 (2003
20. Aschauer, D. F., Kreuz, S. & Rumpel, S. Analysis of transduction efficiency, tropism and axonal transport of AAV serotypes 1, 2, 5, 6, 8 and 9 in the mouse brain. PloS one 8, e76310, doi: 10.1371/journal.pone.0076310 (2013
21. Denk, W., Strickler, J. H. & Webb, W. W. Two-photon laser scanning fluorescence microscopy. Science 248, 73-76 (1990
22. Yan, P., et al. Characterizing the appearance and growth of amyloid plaques in APP/PS1 mice. The Journal of neuroscience: the official journal of the Society for Neuroscience 29, 10706-10714, doi: 10.1523/JNEUROSCI.2637-09.2009 (2009