Mitochondria and DNA Targeting of 5,10,15,20-Tetrakis(7-sulfonatobenzo[b]thiophene) Porphyrin-Induced Photodynamic Therapy via Intrinsic and Extrinsic Apoptotic Cell Death

Journal of Medicinal Chemistry

Volumn 58, Issue 17, 2015, Pages 6864-6874

  Rangasamy, Sabarinathan ^a   Ju, Hee ^a   Um, Soohyun ^a   Oh, Dong Chan ^a   Song, Joon Myong ^a  

^a Seoul National University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

5,10,15,20 TETRAKIS(7 SULFONATOBENZO[B]THIOPHENE) PORPHYRIN; CALCIUM ION; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; PHOTOSENSITIZING AGENT; PORPHYRIN DERIVATIVE; UNCLASSIFIED DRUG; 5,10,15,20-TETRAKIS(7-SULFONATOBENZO(B)THIOPHENE)PORPHYRIN; ARYLSULFONIC ACID DERIVATIVE; CALCIUM; DNA; PORPHYRIN; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; DRUG DISTRIBUTION; ENZYME ACTIVATION; FLUORESCENCE ACTIVATED CELL SORTING; GENE TARGETING; HUMAN; HUMAN CELL; IC50; IN VITRO STUDY; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MCF 7 CELL LINE; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION; MTT ASSAY; PHOTOCYTOTOXICITY; PHOTODYNAMIC THERAPY; PROTON NUCLEAR MAGNETIC RESONANCE; QUANTUM YIELD; TARGET CELL; CHEMISTRY; CYTOSOL; DRUG EFFECTS; METABOLISM; PHOTOCHEMOTHERAPY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

APOPTOSIS; ARYLSULFONATES; CALCIUM; CASPASE 3; CYTOSOL; DNA; DNA FRAGMENTATION; ENZYME ACTIVATION; HUMANS; MCF-7 CELLS; MITOCHONDRIA; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; PORPHYRINS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84941564501     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b01095     Document Type: Article

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