The natural compound codonolactone impairs tumor induced angiogenesis by downregulating BMP signaling in endothelial cells

Phytomedicine

Volumn 22, Issue 11, 2015, Pages 1017-1026

  Wang, Shan ^a   Cai, Rui ^a   Ma, Junchao ^a   Liu, Ting ^a   Ke, Xiaoqin ^a   Lu, Hong ^a   Fu, Jianjiang ^a  

^a JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Angiogenesis; BMP signaling pathway; Breast cancer; Codonolactone; Matrix metalloproteinases; VEGF

Indexed keywords

ANGIOGENESIS INHIBITOR; BATIMASTAT; BONE MORPHOGENETIC PROTEIN; CODONOLACTONE; GELATIN; PLANT EXTRACT; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ATRACTYLENOLIDE III; LACTONE; MATRIX METALLOPROTEINASE; RUNX2 PROTEIN, HUMAN; SESQUITERPENE; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2, HUMAN; VASCULOTROPIN A; VEGFA PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ARTICLE; ATRACTYLODES LANCEA; BREAST CANCER; CANCER INHIBITION; CELL INVASION; CELL MIGRATION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENDOTHELIUM CELL; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WESTERN BLOTTING; ZYMOGRAPHY; ANIMAL; AORTA; ATRACTYLODES; CELL MOTION; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; MALE; METABOLISM; NEOVASCULARIZATION (PATHOLOGY); SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGIOGENESIS INHIBITORS; ANIMALS; AORTA; ATRACTYLODES; BONE MORPHOGENETIC PROTEINS; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IN VITRO TECHNIQUES; LACTONES; MALE; MATRIX METALLOPROTEINASES; NEOVASCULARIZATION, PATHOLOGIC; RATS, SPRAGUE-DAWLEY; SESQUITERPENES; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84941554974     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2015.07.009     Document Type: Article

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