Codonolactone, a sesquiterpene lactone isolated from Chloranthus henryi Hemsl, inhibits breast cancer cell invasion, migration and metastasis by downregulating the transcriptional activity of Runx2

International Journal of Oncology

Volumn 45, Issue 5, 2014, Pages 1891-1900

  Wang, Wei ^a   Chen, Bin ^a   Zou, Ruolan ^b   Tu, Xiuying ^a   Tan, Songlin ^a   Lu, Hong ^a   Liu, Zhaojie ^a   Fu, Jianjiang ^a  

^a JIANGXI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b NANCHANG UNIVERSITY   (China)

Author keywords

Breast cancer; Codonolactone; Invasion; Metastasis; Migration; Runx2

Indexed keywords

ANTINEOPLASTIC AGENT; CODONOLACTONE; COLLAGENASE 3; GELATINASE B; HERBACEOUS AGENT; SESQUITERPENE LACTONE DERIVATIVE; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG; VASCULOTROPIN; LACTONE; PLANT EXTRACT; RUNX2 PROTEIN, HUMAN; SESQUITERPENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BREAST CANCER; BREAST CANCER CELL LINE; CANCER INHIBITION; CANCER SIZE; CANCER SURVIVAL; CELL ADHESION; CELL GROWTH; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CHLORANTHUS HENRYI HEMSL; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DOWN REGULATION; DRUG ISOLATION; DRUG SCREENING; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG METASTASIS; MEDICINAL PLANT; METASTASIS; MOUSE; NONHUMAN; OVERALL SURVIVAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; WESTERN BLOTTING; BIOSYNTHESIS; BREAST NEOPLASMS; CHEMISTRY; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; PATHOLOGY; TRANSCRIPTION INITIATION; TUMOR CELL LINE; VIRIDIPLANTAE;

BREAST NEOPLASMS; CELL LINE, TUMOR; CORE BINDING FACTOR ALPHA 1 SUBUNIT; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LACTONES; PLANT EXTRACTS; SESQUITERPENES; TRANSCRIPTIONAL ACTIVATION; VIRIDIPLANTAE;

EID: 84907199739     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.2014.2643     Document Type: Article

References (33)

1. Siegel R, Naishadham D and Jemal A: Cancer Statistics, 2013. CA Cancer J Clin 63: 11-30, 2013.
2. Leong SP, Cady B, Jablons DM, et al: Clinical patterns of metastasis. Cancer Metastasis Rev 25: 221-232, 2006.
3. Stevanovic A, Lee P and Wilcken N: Metastatic breast cancer. Aust Fam Physician 35: 309-312, 2006.
4. Liu S, Goldstein RH, Scepansky EM, et al: Inhibition of rhoassociated kinase signaling prevents breast cancer metastasis to human bone. Cancer Res 69: 8742-8751, 2009.
5. Newman DJ: Natural products as leads to potential drugs: An old process or the new hope for drug discovery? J Med Chem 51: 2589-2599, 2008.
6. Hristova K, Lam M, Feild T, et al: Transmitting tissue ECM distribution and composition, and pollen germinability in Sarcandra glabra and Chloranthus japonicus (Chloranthaceae). Ann Bot 96: 779-791, 2005.
7. Editorial Committee of the Administration Bureau of Traditional Chinese Medicine: Genus Chloranthaceae. In: Chinese Materia Medica (zhonghua Bencao). Shanghai Science & Technology Press, Shanghai, pp2051-2061, 1998.
8. Pan C, Xu H, Peng H, et al: Resource investigation and exploitable foreground of Sarcandra glabra. Zhong Yao Cai 27: 556-557, 2004.
9. National Committee of Pharmacopoeia: Pharmacopoeia of People's Republic of China. 2010 ed. China Medical Science Press, Beijing, pp842, 2010.
10. Wang QH, Kuang HX, Yang BY, et al: Sesquiterpenes from Chloranthus japonicus. J Nat Prod 74: 16-20, 2011.
11. Zhang M, Wang JS, Wang PR, et al: Sesquiterpenes from the aerial part of Chloranthus japonicus and their cytotoxicities. Fitoterapia 83: 1604-1609, 2012.
12. Kwon OE, Lee HS, Lee SW, et al: Dimeric sesquiterpenoids isolated from Chloranthus japonicus inhibited the expression of cell adhesion molecules. J Ethnoparmacol 104: 270-277, 2006.
13. Fu J, Ding Y, Huang D, et al: The retinoid X receptor-selective ligand, LGD1069, inhibits tumor-induced angiogenesis via suppression of VEGF in human non-small cell lung cancer. Cancer Lett 248: 153-163, 2007.
14. Chambers AF and Matrisian LM: Changing views of the role of matrix metalloproteinases in metastasis. J Natl Cancer Inst 89: 1260-1270, 1997.
15. Inman CK and Shore P: The osteoblast transcription factor Runx2 is expressed in mammary epithelial cells and mediates osteopontin expression. J Biol Chem 278: 48684-48689, 2003.
16. Roy R, Yang J and Moses MA: Matrix metalloproteinases as novel biomarkers and potential therapeutic targets in human cancer. J Clin Oncol 27: 5287-5297, 2009.
17. Duffy MJ, Maguire TM, Hill A, et al: Metalloproteinases: Role in breast carcinogenesis, invasion and metastasis. Breast Cancer Res 2: 252-257, 2000.
18. Radisky ES and Radisky DC: Matrix metalloproteinase-induced epithelial-mesenchymal transition in breast cancer. J Mammary Gland Biol Neoplasia 15: 201-212, 2010.
19. Lian JB, Stein JL, Stein GS, et al: Runx2/Cbfa1 functions: Diverse regulation of gene transcription by chromatin remodeling and co-regulatory protein interactions. Connect Tissue Res 44: 141-148, 2003.
20. Karsenty G: Role of Cbfa1 in osteoblast differentiation and function. Semin Cell Dev Biol 11: 343-346, 2000.
21. Komori T: Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem 87: 1-8, 2002.
22. Stein GS, Lian JB, A. van Wijnen J, et al: Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression. Oncogene 23: 4315-4329, 2004.
23. Inman CK, Li N and Shore P: Oct-1 counteracts autoinhibition of Runx2 DNA binding to form a novel Runx2/Oct-1 complex on the promoter of the mammary gland-specific gene beta-casein. Mol Cell Biol 25: 3182-3193, 2005.
24. Barnes GL, Javed A, Waller SM, et al: Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells. Cancer Res 63: 2631-2637, 2003.
25. Shore P: A role for Runx2 in normal mammary gland and breast cancer bone metastasis. J Cell Biochem 96: 484-489, 2005.
26. Ganss B, Kim RH and Sodek J: Bone sialoprotein. Crit Rev Oral Biol Med 10: 79-98, 1999.
27. Bellahcène A and Castronovo V: Expression of bone matrix proteins in human breast cancer: Potential roles in microcalcification formation and in the genesis of bone metastases. Bull Cancer 84: 17-24, 1997.
28. Sun L, Vitolo M and Passaniti A: Runt-related gene 2 in endothelial cells: Inducible expression and specific regulation of cell migration and invasion. Cancer Res 61: 4994-5001, 2001.
29. Chimge NO, Baniwal SK, Little GH, et al: Regulation of breast cancer metastasis by Runx2 and estrogen signaling: The role of SNAI2. Breast Cancer Res 13: R127, 2011.
30. Jiménez MJ, Balbín M, López JM, et al: Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol 19: 4431-4442, 1999.
31. Selvamurugan N and Partridge NC: Constitutive expression and regulation of collagenase-3 in human breast cancer cells. Mol Cell Biol Res Commun 3: 218-223, 2000.
32. Selvamurugan N, Kwok S and Partridge NC: Smad3 interacts with JunB and Cbfa1/Runx2 for transforming growth factor-beta1-stimulated collagenase-3 expression in human breast cancer cells. J Biol Chem 279: 27764-27773, 2004.
33. Pratap J, Javed A, Languino LR, et al: The Runx2 osteogenic transcription factor regulates matrix metalloproteinase 9 in bone metastatic cancer cells and controls cell invasion. Mol Cell Biol 25: 8581-8591, 2005.