Transfer of Alopecia Areata to C3H/HeJ Mice Using Cultured Lymph Node-Derived Cells

Journal of Investigative Dermatology

Volumn 135, Issue 10, 2015, Pages 2530-2532

  Wang, Eddy H C ^a   Khosravi Maharlooei, Mohsen ^a   Jalili, Reza Baradar ^a   Yu, Richard ^a   Ghahary, Aziz ^a   Shapiro, Jerry ^b   McElwee, Kevin J ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALOPECIA AREATA; ANIMAL EXPERIMENT; ANIMAL MODEL; CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; FEMALE; HAIR LOSS; IMMUNOHISTOLOGY; LETTER; LYMPH NODE CELL; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SKIN TRANSPLANTATION; ANIMAL; C3H MOUSE; CELL TRANSPLANTATION; CYTOLOGY; DISEASE MODEL; HUMAN; IMMUNOLOGY; INTRALESIONAL DRUG ADMINISTRATION; LYMPH NODE; METABOLISM; PATHOLOGY; PROCEDURES; RANDOMIZATION; SENSITIVITY AND SPECIFICITY; XENOGRAFT;

CD3 ANTIGEN; CD4 ANTIGEN;

ALOPECIA AREATA; ANIMALS; ANTIGENS, CD3; ANTIGENS, CD4; CELL TRANSPLANTATION; CELLS, CULTURED; DISEASE MODELS, ANIMAL; FEMALE; HETEROGRAFTS; HUMANS; INJECTIONS, INTRALESIONAL; LYMPH NODES; MICE; MICE, INBRED C3H; RANDOM ALLOCATION; SENSITIVITY AND SPECIFICITY;

EID: 84941425208     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.176     Document Type: Letter

References (10)

1. Gilhar A, Keren A, Shemer A et al. (2013) Autoimmune disease induction in a healthy human organ: a humanized mouse model of alopecia areata. J Invest Dermatol 133: 844-7
2. McElwee KJ, Boggess D, King LE Jr et al. (1998) Experimental induction of alopecia areata-like hair loss in C3H/HeJ mice using full-thickness skin grafts. J Invest Dermatol 111: 797-803
3. McElwee KJ, Freyschmidt-Paul P, Hoffmann R et al. (2005a) Transfer of CD8(+) cells induces localized hair loss whereas CD4(+)/CD25 cells promote systemic alopecia areata and CD4(+)/CD25(+) cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 124: 947-57
4. McElwee KJ, Yu M, Park SW et al. (2005b) What can we learn from animal models of Alopecia areata? Dermatology 211: 47-53
5. Oliver RF, Jahoda CA, Horne KA et al. (1991) The DEBR rat model for alopecia areata. J Invest Dermatol 96: 97S
6. Sun J, Silva KA, McElwee KJ et al. (2008) The C3H/ HeJ mouse and DEBR rat models for alopecia areata: review of preclinical drug screening approaches and results. Exp Dermatol 17: 793-805
7. Sundberg JP, Cordy WR, King LE Jr (1994) Alopecia areata in aging C3H/HeJ mice. J Invest Dermatol 102: 847-56
8. Wang E, McElwee K (2014) Induction of alopecia areata in C3H/HeJ mice via cultured cell transfer. Protoc Exchange; doi: 10. 1038/protex. 2014. 050
9. Wang E, McElwee KJ (2011) Etiopathogenesis of alopecia areata: why do our patients get it? Dermatol Ther 24: 337-47
10. Xing L, Dai Z, Jabbari A et al. (2014) Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat Med 20: 1043-9