Comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of hepatic steatosis

European Radiology

Volumn 25, Issue 10, 2015, Pages 2869-2879

  Kukuk, Guido M ^a   Hittatiya, Kanishka ^a   Sprinkart, Alois M ^a,b   Eggers, Holger ^c   Gieseke, Jürgen ^a,d   Block, Wolfgang ^a   Moeller, Philipp ^a   Willinek, Winfried A ^a   Spengler, Ulrich ^a   Trebicka, Jonel ^a   Fischer, Hans Peter ^a   Schild, Hans H ^a   Träber, Frank ^a  

^a UNIVERSITY OF BONN   (Germany)

^b RUHR UNIVERSITY BOCHUM   (Germany)

^c PHILIPS RESEARCH LABORATORIES   (Germany)

^d PHILIPS HEALTHCARE   (United States)

Author keywords

Histology; Liver fat quantification; Magnetic resonance imaging; Magnetic resonance spectroscopy; Steatosis

Indexed keywords

ADOLESCENT; ADULT; AGED; ARTICLE; CONTROLLED STUDY; FAT CONTENT; FATTY LIVER; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; LIPID ANALYSIS; LIVER BIOPSY; LIVER CELL; LIVER HISTOLOGY; MAJOR CLINICAL STUDY; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY RELAXOMETRY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; COMPARATIVE STUDY; COMPUTER PROGRAM; HISTOLOGY; MIDDLE AGED; PATHOLOGY; PROCEDURES; PROSPECTIVE STUDY; YOUNG ADULT;

ADOLESCENT; ADULT; AGED; FATTY LIVER; FEMALE; HEPATOCYTES; HISTOLOGICAL TECHNIQUES; HUMANS; MAGNETIC RESONANCE IMAGING; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; SOFTWARE; YOUNG ADULT;

EID: 84941413289     PISSN: 09387994     EISSN: 14321084     Source Type: Journal    
DOI: 10.1007/s00330-015-3703-6     Document Type: Article

References (47)

1. Blachier M, Leleu H, Peck-Radosavljevic M, Valla DC, Roudot-Thoraval F (2013) The burden of liver disease in Europe: a review of available epidemiological data. J Hepatol 58:593–608
2. Cairns SR, Peters TJ (1983) Biochemical analysis of hepatic lipid in alcoholic and diabetic and control subjects. Clin Sci (Lond) 65:645–652
3. Brunt EM, Neuschwander-Tetri BA, Burt AD (2012) Fatty liver disease: alcoholic and non-alcoholic. In: Burt AD, Portmann BC, Ferell LD (eds) MacSween's Pathology of the Liver. Churchill Livingstone Elsevier, Toronto, pp 293–359
4. Lee RG (1994) Fatty change and steatohepatitis. In: Lee RG (ed) Diagnostic liver pathology. Mosby, St. Louis, pp 167–194
5. Neuschwander-Tetri BA, Caldwell SH (2003) Nonalcoholic steatohepatitis: summary of an AASLD Single Topic Conference. Hepatology 37:1202–1219
6. Chalasani N, Younossi Z, Lavine JE et al (2012) The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology 55:2005–2023
7. Reid AE (2010) Nonalcoholic fatty liver disease. In: Feldman M, Friedman LS, Brandt LJ (eds) Sleisenger and Fordtran's gastrointestinal and liver disease. Saunders Elsevier, Philadelphia, pp 1401–1412
8. Strassburg CP, Manns MP (2006) Approaches to liver biopsy techniques–revisited. Semin Liver Dis 26:318–327
9. Hatfield MK, Beres RA, Sane SS, Zaleski GX (2008) Percutaneous imaging-guided solid organ core needle biopsy: coaxial versus noncoaxial method. AJR Am J Roentgenol 190:413–417
10. Bravo AA, Sheth SG, Chopra S (2001) Liver biopsy. N Engl J Med 344:495–500
11. Ratziu V, Charlotte F, Heurtier A et al (2005) Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease. Gastroenterology 128:1898–1906
12. Bohte AE, van Werven JR, Bipat S, Stoker J (2011) The diagnostic accuracy of US, CT, MRI and 1H-MRS for the evaluation of hepatic steatosis compared with liver biopsy: a meta-analysis. Eur Radiol 21:87–97
13. Reeder SB, Cruite I, Hamilton G, Sirlin CB (2011) Quantitative assessment of liver fat with magnetic resonance imaging and spectroscopy. J Magn Reson Imaging 34:729–749
14. Banerjee R, Pavlides M, Tunnicliffe EM et al (2014) Multiparametric magnetic resonance for the non-invasive diagnosis of liver disease. J Hepatol 60:69–77
15. McPherson S, Jonsson JR, Cowin GJ et al (2009) Magnetic resonance imaging and spectroscopy accurately estimate the severity of steatosis provided the stage of fibrosis is considered. J Hepatol 51:389–397
16. Valls C, Iannacconne R, Alba E et al (2006) Fat in the liver: diagnosis and characterization. Eur Radiol 16:2292–2308
17. Berglund J, Ahlstrom H, Johansson L, Kullberg J (2011) Two-point dixon method with flexible echo times. Magn Reson Med 65:994–1004
18. Eggers H, Brendel B, Duijndam A, Herigault G (2011) Dual-echo Dixon imaging with flexible choice of echo times. Magn Reson Med 65:96–107
19. Idilman IS, Aniktar H, Idilman R et al (2013) Hepatic steatosis: quantification by proton density fat fraction with MR imaging versus liver biopsy. Radiology 267:767–775
20. Reeder SB (2013) Emerging quantitative magnetic resonance imaging biomarkers of hepatic steatosis. Hepatology 58:1877–1880
21. Reeder SB, Sirlin CB (2010) Quantification of liver fat with magnetic resonance imaging. Magn Reson Imaging Clin N Am 18:337-–357, ix
22. Dixon WT (1984) Simple proton spectroscopic imaging. Radiology 153:189–194
23. Eggers H, Perkins TG, Hussain SM (2011) Influence of Spectral Model and Signal Decay on Hepatic Fat Fraction Measurements at 3 T with Dual-Echo Dixon Imaging. Proc Int Soc Magn Reson Med 19:573
24. Yu H, Shimakawa A, McKenzie CA, Brodsky E, Brittain JH, Reeder SB (2008) Multiecho water-fat separation and simultaneous R2* estimation with multifrequency fat spectrum modeling. Magn Reson Med 60:1122–1134
25. Tang A, Tan J, Sun M et al (2013) Nonalcoholic fatty liver disease: MR imaging of liver proton density fat fraction to assess hepatic steatosis. Radiology 267:422–431
26. Noureddin M, Lam J, Peterson MR et al (2013) Utility of magnetic resonance imaging versus histology for quantifying changes in liver fat in nonalcoholic fatty liver disease trials. Hepatology 58:1930–1940
27. Kleiner DE, Brunt EM, Van Natta M et al (2005) Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41:1313–1321
28. Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA, Bacon BR (1999) Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions. Am J Gastroenterol 94:2467–2474
29. d'Assignies G, Kauffmann C, Boulanger Y et al (2011) Simultaneous assessment of liver volume and whole liver fat content: a step towards one-stop shop preoperative MRI protocol. Eur Radiol 21:301–309
30. Lin ZH, Xin YN, Dong QJ et al (2011) Performance of the aspartate aminotransferase-to-platelet ratio index for the staging of hepatitis C-related fibrosis: an updated meta-analysis. Hepatology 53:726–736
31. Frahm J, Merboldt K, Hänicke W (1987) Localized proton spectroscopy using stimulated echoes. J Magn Reson 72:502–508
32. Vanhamme L, van den Boogaart A, Van Huffel S (1997) Improved method for accurate and efficient quantification of MRS data with use of prior knowledge. J Magn Reson 129:35–43
33. Naressi A, Couturier C, Castang I, de Beer R, Graveron-Demilly D (2001) Java-based graphical user interface for MRUI, a software package for quantitation of in vivo/medical magnetic resonance spectroscopy signals. Comput Biol Med 31:269–286
34. Ren J, Dimitrov I, Sherry AD, Malloy CR (2008) Composition of adipose tissue and marrow fat in humans by 1H NMR at 7 Tesla. J Lipid Res 49:2055–2062
35. Hamilton G, Yokoo T, Bydder M et al (2011) In vivo characterization of the liver fat (1)H MR spectrum. NMR Biomed 24:784–790
36. Johnson NA, Walton DW, Sachinwalla T et al (2008) Noninvasive assessment of hepatic lipid composition: Advancing understanding and management of fatty liver disorders. Hepatology 47:1513–1523
37. Vuppalanchi R, Cummings OW, Saxena R et al (2007) Relationship among histologic, radiologic, and biochemical assessments of hepatic steatosis: a study of human liver samples. J Clin Gastroenterol 41:206–210
38. Henninger B, Kremser C, Rauch S et al (2013) Evaluation of liver fat in the presence of iron with MRI using T2* correction: a clinical approach. Eur Radiol 23:1643–1649
39. Lee SS, Lee Y, Kim N et al (2011) Hepatic fat quantification using chemical shift MR imaging and MR spectroscopy in the presence of hepatic iron deposition: validation in phantoms and in patients with chronic liver disease. J Magn Reson Imaging 33:1390–1398
40. Kang BK, Yu ES, Lee SS et al (2012) Hepatic fat quantification: a prospective comparison of magnetic resonance spectroscopy and analysis methods for chemical-shift gradient echo magnetic resonance imaging with histologic assessment as the reference standard. Invest Radiol 47:368–375
41. Hines CD, Frydrychowicz A, Hamilton G et al (2011) T(1) independent, T(2) (*) corrected chemical shift based fat-water separation with multi-peak fat spectral modeling is an accurate and precise measure of hepatic steatosis. J Magn Reson Imaging 33:873–881
42. Koelblinger C, Krssak M, Maresch J et al (2012) Hepatic steatosis assessment with 1H-spectroscopy and chemical shift imaging at 3.0 T before hepatic surgery: reliable enough for making clinical decisions? Eur J Radiol 81:2990–2995
43. Hu HH, Kim HW, Nayak KS, Goran MI (2010) Comparison of fat-water MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity (Silver Spring) 18:841–847
44. El-Badry AM, Breitenstein S, Jochum W et al (2009) Assessment of hepatic steatosis by expert pathologists: the end of a gold standard. Ann Surg 250:691–697
45. Marsman H, Matsushita T, Dierkhising R et al (2004) Assessment of donor liver steatosis: pathologist or automated software? Hum Pathol 35:430–435
46. Kremer GJ, Kößling FK, Lange HJ, N. V (1969) Fat content of the liver: a chemical and histological study. Dtsch Med Wochenschr 94:163-169
47. Szczepaniak LS, Babcock EE, Schick F et al (1999) Measurement of intracellular triglyceride stores by H spectroscopy: validation in vivo. Am J Physiol 276:977–989