Epigenetic control of macrophage shape transition towards an atypical elongated phenotype by histone deacetylase activity

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Cabanel, Mariana ^a   Brand, Camila ^a   Oliveira Nunes, Maria Cecilia ^a   Cabral Piccin, Mariela Pires ^a   Lopes, Marcela Freitas ^a   Brito, Jose Marques ^a   De Oliveira, Felipe Leite ^a   El Cheikh, Marcia Cury ^a   Carneiro, Katia ^a  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CCL1 CHEMOKINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HISTONE DEACETYLASE; INTERLEUKIN 12; INTERLEUKIN 1BETA; NITRIC OXIDE; THYMUS AND ACTIVATION REGULATED CHEMOKINE; TRICHOSTATIN A; TUMOR NECROSIS FACTOR ALPHA; ANTIINFLAMMATORY AGENT; CHEMOKINE; HDAC1 PROTEIN, MOUSE; HISTONE DEACETYLASE 1; HYDROXAMIC ACID;

ANIMAL CELL; ARTICLE; BONE MARROW DERIVED MACROPHAGE; CELL DIFFERENTIATION; CELL ELONGATION; CELL SHAPE; CONTROLLED STUDY; CYTOKINE RELEASE; MACROPHAGE; MALE; MONOCYTE; MOUSE; MYELOID PROGENITOR CELL; NONHUMAN; PHENOTYPIC PLASTICITY; ANIMAL; BONE MARROW CELL; C57BL MOUSE; CHEMISTRY; CYTOLOGY; ENZYMOLOGY; FLOW CYTOMETRY; GENETIC EPIGENESIS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; METABOLISM; PHENOTYPE; STEM CELL;

ANIMALS; ANTI-INFLAMMATORY AGENTS; BONE MARROW CELLS; CELL DIFFERENTIATION; CHEMOKINES; EPIGENESIS, GENETIC; FLOW CYTOMETRY; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HISTONE DEACETYLASE 1; HYDROXAMIC ACIDS; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MONOCYTES; NITRIC OXIDE; PHENOTYPE; STEM CELLS;

EID: 84941287142     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132984     Document Type: Article

References (26)

1. Mosser DM, Edwards JP (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969. doi:10.1038/nri2448 PMID: 19029990.
2. Shivdasani RA (1997) Stem cell transcription factors. Hematol Oncol Clin North Am 11: 1199-1206. PMID: 9443052.
3. Shivdasani RA, Fielder P, Keller GA, Orkin SH, de Sauvage FJ (1997) Regulation of the serum concentration of thrombopoietin in thrombocytopenic NF-E2 knockout mice. Blood 90: 1821-1827. PMID: 9292514.
4. Shivdasani RA, Fujiwara Y, McDevitt MA, Orkin SH (1997) A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development. EMBO J 16: 3965-3973. PMID: 9233806.
5. DeKoter RP, Walsh JC, Singh H (1998) PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors. EMBO J 17: 4456-4468. PMID: 9687512.
6. Kawamoto H, Ikawa T, Masuda K, Wada H, Katsura Y (2010) A map for lineage restriction of progenitors during hematopoiesis: The essence of the myeloid-based model. Immunol Rev 238: 23-36. doi:10.1111/j.1600-065X.2010.00959.x PMID: 20969582.
7. Gregoretti IV, Lee YM, Goodson HV (2004) Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 338: 17-31. PMID: 15050820.
8. Jenuwein T, Allis CD (2001) Translating the histone code. Science 293: 1074-1080. PMID: 11498575.
9. Haberland M, Montgomery RL, Olson EN (2009) The many roles of histone deacetylases in development and physiology: implications for disease and therapy. Nat Rev Genet 10: 32-42. doi:10.1038/nrg2485 PMID: 19065135.
10. Carneiro K, Donnet C, Rejtar T, Karger BL, Barisone GA, Díaz E, et al. (2011) Histone Deacetylase activity is necessary for left-right patterning during vertebrate development. BMC Dev Biol 11: 29. doi:10.1186/1471-213X-11-29 PMID: 21599922.
11. Tseng AS, Carneiro K, Lemire JM, Levin M (2011) HDAC Activity Is Required during Xenopus Tail Regeneration. PLoS One 6: E26382. doi:10.1371/journal.pone.0026382 PMID: 22022609.
12. Han SB, Lee JK (2009) Anti-inflammatory effect of Trichostatin-A on murine bone marrow-derived macrophages. Arch Pharm Res 32: 613-624. doi:10.1007/s12272-009-1418-4 PMID: 19407980.
13. Chen X, Barozzi I, Termanini A, Prosperini E, Recchiuti A, Dalli J, et al. (2012) Requirement for the histone deacetylase Hdac3 for the inflammatory gene expression program in macrophages. Proc Natl Acad Sci U S A 109: E2865-E2874. doi:10.1073/pnas.1121131109 PMID: 22802645.
14. Drummond DC, Noble CO, Kirpotin DB, Guo Z, Scott GK, Benz CC (2005) Clinical development of histone deacetylase inhibitors as anticancer agents. Annu Rev Pharmacol Toxicol 45: 495-528. PMID: 15822187.
15. McWhorter FY, Wang T, Nguyen P, Chung T, Liu WF (2013) Modulation of macrophage phenotype by cell shape. Proc Natl Acad Sci U S A 110: 17253-17258. doi:10.1073/pnas.1308887110 PMID: 24101477.
16. Yoshida M, Kijima M, Akita M, Beppu T (1990) Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J Biol Chem 265: 17174-17179. PMID: 2211619.
17. el-Cheikh MC, Borojevic R (1990) Extramedullar proliferation of eosinophil granulocytes in chronic schistosomiasis mansoni is mediated by a factor secreted by inflammatory macrophages. Infect Immun 58: 816-821. PMID: 2106496.
18. Kraal G, Rep M, Janse M (1987) Macrophages in T and B cell compartments and other tissue macrophages recognized by monoclonal antibody MOMA-2. An immunohistochemical study. Scand J Immunol 26: 653-661. PMID: 3321409.
19. Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaun SR (1982) Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 126: 131-138. PMID: 7181105.
20. Rahman MM, Kukita A, Kukita T, Shobuike T, Nakamura T, Kohashi O (2003) Two histone deacetylase inhibitors, trichostatin A and sodium butyrate, suppress differentiation into osteoclasts but not into macrophages. Blood 101: 3451-3459. PMID: 12511413.
21. Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, et al. (2013) Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes. PLoS One 8: E78045. doi:10.1371/journal.pone.0078045 PMID: 24205083.
22. Laribee RN, Klemsz MJ (2001) Loss of PU.1 expression following inhibition of histone deacetylases. J Immunol 167: 5160-5166. PMID: 11673528.
23. Karpurapu M, Wang X, Deng J, Park H, Xiao L, Sadikot RT, et al. (2011) Functional PU.1 in macrophages has a pivotal role in NF-kappaB activation and neutrophilic lung inflammation during endotoxemia. Blood 118: 5255-5266. doi:10.1182/blood-2011-03-341123 PMID: 21937699.
24. Mullican SE, Gaddis CA, Alenghat T, Nair MG, Giacomin PR, Everett LJ, et al. (2011) Histone deacetylase 3 is an epigenomic brake in macrophage alternative activation. Genes Dev 25: 2480-2488. doi:10.1101/gad.175950.111 PMID: 22156208.
25. Tabas I (2010) Macrophage death and defective inflammation resolution in atherosclerosis. Nat Rev Immunol 10: 36-46. doi:10.1038/nri2675 PMID: 19960040.
26. Odegaard JI, Chawla A (2011) Alternative macrophage activation and metabolism. Annu Rev Pathol 6: 275-297. doi:10.1146/annurev-pathol-011110-130138 PMID: 2103422.