Erythrocyte fatty acid profiles and plasma homocysteine, folate and vitamin B6 and B12 in recurrent depression: Implications for co-morbidity with cardiovascular disease

Psychiatry Research

Volumn 229, Issue 3, 2015, Pages 992-998

  Assies, Johanna ^a   Mocking, Roel J T ^a   Lok, Anja ^a,b   Koeter, Maarten W J ^a   Bockting, Claudi L H ^c,d   Visser, Ieke ^a   Pouwer, François ^e   Ruhé, Henricus G ^a,c   Schene, Aart H ^a,f,g  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b Arq Psychotrauma Expert Group   (Netherlands)

^c UNIVERSITY OF GRONINGEN   (Netherlands)

^d UTRECHT UNIVERSITY   (Netherlands)

^e TILBURG UNIVERSITY   (Netherlands)

^f RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^g RADBOUD UNIVERSITY   (Netherlands)

Author keywords

Cardiovascular disease; Chain length; One carbon cycle; Oxidative stress; Peroxidation index; Polyunsaturated fatty acids; Unsaturation index

Indexed keywords

ARACHIDONIC ACID; CYANOCOBALAMIN; DOCOSAHEXAENOIC ACID; FATTY ACID; FOLIC ACID; HOMOCYSTEINE; ICOSAPENTAENOIC ACID; POLYUNSATURATED FATTY ACID; PYRIDOXINE; VITAMIN B COMPLEX;

ADULT; AGED; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CARBON METABOLISM; CARDIOVASCULAR DISEASE; CELL MEMBRANE; COMORBIDITY; CONTROLLED STUDY; ERYTHROCYTE; FATTY ACID METABOLISM; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; OXIDATIVE STRESS; PEROXIDATION; PRIORITY JOURNAL; RECURRENT DISEASE; BLOOD; FEMALE; MALE; METABOLISM; MIDDLE AGED;

ADULT; CARDIOVASCULAR DISEASES; COMORBIDITY; DEPRESSIVE DISORDER, MAJOR; ERYTHROCYTES; FATTY ACIDS; FEMALE; FOLIC ACID; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; RECURRENCE; VITAMIN B 12; VITAMIN B 6; VITAMIN B COMPLEX;

EID: 84941258801     PISSN: 01651781     EISSN: 18727123     Source Type: Journal    
DOI: 10.1016/j.psychres.2015.06.025     Document Type: Article

References (69)

1. Assies J., Lok A., Bockting C.L., Weverling G.J., Lieverse R., Visser I., Abeling N.G.G.M., Duran M., Schene A.H. Fatty acids and homocysteine in patients with recurrent depression: an explorative pilot study. Prostaglandins Leukot. Essent. Fatty Acids 2004, 70:349-356.
2. Assies J., Mocking R.J.T., Lok A., Ruhe H.G., Pouwer F., Schene A.H. Effects of oxidative stress on fatty acid- and one-carbon-metabolism in psychiatric and cardiovascular disease comorbidity. Acta Psychiatr. Scand. 2014, 130:163-180.
3. Assies J., Pouwer F., Lok A., Mocking R.J., Bockting C.L., Visser I., Abeling N.G., Duran M., Schene A.H. Plasma and erythrocyte fatty acid patterns in patients with recurrent depression: a matched case-control study. PLOS ONE 2010, 5(e10635):1-9.
4. Baek D., Park Y. Association between erythrocyte n-3 polyunsaturated fatty acids and biomarkers of inflammation and oxidative stress in patients with and without depression. Prostaglandins, Leukotrienes Essent. Fatty Acids 2013, 89:291-296.
5. Bjelland I., Tell G.S., Vollset S.E., Refsum H., Ueland P.M. Folate, vitamin B12, homocysteine and the MTHFR 677C>T polymorphism in anxiety and depression: the Hordaland Homocysteine Study. Arch. Gen. Psychiatr. 2003, 60:618-626.
6. Bockting C.L.H., Schene A.H., Spinhoven P., Koeter M.W.J., Huyser J., Kamphuis J.H. Preventing relapse/recurrence in recurrent depression with cognitive therapy: a randomized controlled trial. J. Consult. Clin. Psychol. 2005, 73:647-657.
7. Bottiglieri T. Homocysteine and folate metabolism in depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 2005, 29:1103-1112.
8. Berstad P., Konstatinova V., Refsum H., Nurk E., Vollset E., Tell G.S., Ueland P.M., Drevon G.A. Dietary fat and plasma total homocysteine concentrations in 2 adult age groups: the Hordaland Homocysteine Study. Am. J. Clin. Nutr. 2007, 85:1598-1605.
9. Carver J.D., Benford V.J., Han B., Cantor A.B. The relationship between age and the fatty acid composition of cerebral cortex and erythrocytes in human subjects. Brain Res. Bull. 2001, 56:79-85.
10. Crowe F.L., Skeaff C.M., McMahon J.A., Williams S.M., Green T.J. Lowering plasma homocysteine concentrations of older men and women with folate, vitamin B-12, and vitamin B-6 does not affect the proportion of (n-3) long chain polyunsaturated fatty acids in plasma phosphatidylcholine. J. Nutr. 2008, 138:551-555.
11. Davidson M.H. Omega-3 fatty acids: new insights into the pharmacology and biology of docosahexaenoic acid, docosapentaenoic acid and eicosapentaeoic acid. Curr. Opin. Lipidol. 2013, 24:467-474.
12. Delmastro-Greenwood M., Freeman B.A., Gelhaus Wendell S. Redox-dependent anti-inflammatory signalling actions of unsaturated fatty acids. Annu. Rev. Physiol. 2014, 76:79-105.
13. Devlin A.M., Green T.J. Mechanisms of altered fatty acid and phospholipid levels in hyperhomocysteinemia. Clin. Lipidol. 2009, 4:159-166.
14. Donders A.R., van der Heyden G.J., Stijnen T., Moons K.G. Review: a gentle introduction to imputation of missing values. J. Clin. Epidemiol. 2006, 59:1087-1091.
15. First M.B., Gibbon M., Spitzer R.L., Williams J.B. User Guide for the Structured Clinical Interview for DSM-IV Axis-I Disorders 1996, American Psychiatric Association, Washington, DC.
16. Forman H.J., Zhang H., Rinna A. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol. Aspects Med. 2009, 30:1-12.
17. Fuchs D., Jaeger M., Widner B., Wirleiter B., Artner-Dworzak E., Lehlhuber F. Is hyperhomocysteinemia due to the oxidative depletion of folate rather than to insufficient dietary intake?. Clin. Chem. Lab. Med. 2001, 39:691-704.
18. Giustarini D., Dalle -Donne I., Tsikas D., Rossi R. Oxidative stress and human diseases: origin, link, measurement, mechanisms, and biomarkers. Crit. Rev. Clin. Lab. Sci. 2009, 46:241-281.
19. Goldbacher E.M., Bromberger J., Matthews K.A. Lifetime history of major depression in development of the metabolic syndrome in middle-aged women. Psychosom. Med. 2009, 71:266-271.
20. Graham J.W. Missing data analysis: making it work in the real world. Annu. Rev. Psychol. 2009, 60:549-576.
21. Guest J., Garg M., Bilgin A., Grant R. Relationship between central and peripheral fatty acids in humans. Lipids Health Dis. 2013, 12:79.
22. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 1960, 23:56-62.
23. Harris W.S., Miller M., Tighe A.P., Davidson M.H., Schaefer E.J. Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives. Atherosclerosis 2008, 197:12-24.
24. Hoffman M. Hypothesis: hyperhomocysteinemia is an indicator of oxidant stress. Med. Hypotheses 2011, 77:1088-1193.
25. Howard D., Mathias R.A., Seeds M.C., Herrington D.M., Hixson J.E., Shimmin L.C., Hawkins G.A., Sellers M., Ainsworth H.C., Sergeant S., Miller L.R., Chilton F.H. DNA methylation in an enhancer region of the FADS cluster is associated with FADS activity in the human liver. PLOS ONE 2014, 9(e97510):1-7.
26. Huang T., Asimi S., Lou D., Li D. Plasma phospholipid polyunsaturated fatty acids and homocysteine in Chinese type 2 diabetes patients. Asia Pacific J. Clin. Nutr. 2012, 21:394-399.
27. Huang T.Y.X., Shou T., Wahlqvist M.L., Li D. Associations of plasma phospholipids fatty acids with plasma homocysteine in Chinese vegetarians. Br. J. Nutr. 2013, 109:1688-1694.
28. Huang T., Wahlqvist M.L., Li D. Effect of n-3 polyunsaturated fatty acid gene expression of the critical enzymes involved in homocysteine metabolism. Nutr. J. 2012, 11:1-6.
29. Huang T., Zheng J., Chen Y., Yang B., Wahlqvist.M.L., Li D. High consumption of omega-3 polyunsaturated fatty acids decrease plasma homocysteine: a meta-analysis of randomized, placebo-controlled trials. Nutrition 2011, 27:863-867.
30. Hulbert A.J., Pamplona R., Bullenstein R., Buttmer W.A. Life and death: metabolic rate, membrane composition and life span of animals. Physiol. Rev. 2007, 87:1175-1231.
31. Humphrey L.L., Fu R., Rogers K., Freeman M., Helfand M. Homocysteine and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clinic Proc. 2008, 83:1203-1212.
32. Kahl G., Greggersen W., Schweiger U., Cordes J., Balijepalli C., Losch C., Moebus S. Prevalence of the metabolic syndrome in unipolar major depression. Eur. Arch. Psychiatry Clin. Neurosci. 2012, 262:313-320.
33. Kale A., Naphade N., Sapkale S., Karaju M., Pillai A., Joshi S., Mahadik S. Reduced folic acid, vitamin B12 and docosahexaenoic acid and increased homocysteine and cortisol in never-medicated schizophrenia patients: implications for altered one-carbon metabolism. Psychiatry Res. 2010, 175:47-53.
34. Kim J.M., Stewart R., Kim S.W., Yang S.J., Shin I.S., Yoon J.S. Predictive value of folate, vitamin B12 and homocysteine in late-life depression. Br. J. Psychiatry 2008, 192:268-274.
35. Kume A., Kurotani K., Sato M., Ejima Y., Pham N.M., Nanri A., Kuwahara K., Mizoue T. Polyunsaturated fatty acids in serum and homocysteine concentrations in Japanese men and women. Nutr. Metab. (Lond.) 2013, 10(41):1-8.
36. Lin P.Y., Huang S.Y., Su K.P. A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression. Biol. Psychiatry 2010, 68:140-147.
37. Li D., Mann N.J., Sinclair A. A significant inverse relationship between concentrations of plasma homocysteine and phospholipid docosahexaenoic acid in healthy male subjects. Lipids 2006, 41:85-89.
38. Li D., Yu X.M., Xie H.B., Zhang Y.H., Wang Q., Zhou X.Q., Yu P., Wang L.J. Platelet phospholipid n-3 PUFA negatively associated with plasma homocysteine in middle-aged and geriatric hyperlipaemia patients. Prostaglandins Leukotrienes Essent. Fatty Acids 2007, 76:293-297.
39. Lok A., Mocking R.J.T., Assies J., Koeter M.W.J., Bockting C.L.H., de Vries G.J., Visser I., Derks E.M., Kayser M., Schene A.H. The one-carbon-cycle and methylenetetrahydrofolate reductase (MTHFR)C677T polymorphisms in recurrent Major Depressive Disorder; influence of antidepressant use and depressive state?. J. Affect. Disorders 2014, 166:115-123.
40. Lok A., Mocking R.J., Ruhe H.G., Visser I., Koeter M.W., Assies J., Bockting C.L., Olff M., Schene A.H. Longitudinal hypothalamic-pituitary-adrenal axis trait and state effects in recurrent depression. Psychoneuroendocrinol. 2011, 37:892-902.
41. Lu Y., Vaarhorst A., Merry A.H.H., Dolle M.E.T., Hovenier R., Imholz S., Heijmans B.T., Muller M., Slagboom P.E., van den Brandt P.A., Gorgels A.P.M., Boer J.M.A., Feskens E.J.M. Markers of endogenous desaturase activity and risk of coronary heart disease in the CAREMA Cohort study. PLOS ONE 2012, 7(e41681):1-7.
42. McGowan P.O., Meany M.J., Szyf M. Diet and the epigenetic (re)programming of phenotypic differences in behavior. Brain Res. 2008, 1237:12-24.
43. McIntyre R.S., Rasgon N.L., Kemp D.E., Nguen H.T., Law C.W.Y., Taylor V.H., Woldeyohannes H.O. Metabolic syndrome and major depressive disorder: co-occurrence and pathophysiologic overlap. Curr. Diabetes Rep. 2009, 9:51-59.
44. McNamara R.K. Evaluation of docosahexaenoic deficiency as preventable risk factor for recurrent affective disorders: current status, future directions, and dietary recommendations. Prostaglandins Leukotrienes Essent. Fatty Acids 2009, 81:223-231.
45. McNamara R.K. Deciphering the role of docosahexaenoic acid in brain maturation and pathology with magnetic resonance imaging. Prostaglandins Leukotrienes Essent. Fatty Acids 2013, 88:33-42.
46. Mocking R.J., Assies J., Lok A., Ruhe H.G., Koeter M.W., Visser I., Bockting C.L., Schene A.H. Statistical methodological issues in handling of fatty acid data: percentage or concentration, imputation and indices. Lipids 2012, 47:541-547.
47. Mocking R.J.T., Assies J., Bot M., Jansen E.H.J.L.M., Schene A.H., Pouwer F. Biological effects off add-on eicosapentaenoic acid supplementation in diabetes mellitus and co-morbid depression: a randomized controlled trial. PLOS ONE 2012, 7(e 49431):1-11.
48. Mocking R.J., Ruhé H.G., Assies J., Lok A., Koeter M.W., Visser I., Bockting C.L., Schene A.H. Relationship between the hypothalamic-pituitary-adrenal-axis and fatty acid metabolism in recurrent depression. Psychoneuroendocrinology 2013, 38:1607-1617.
49. Morris M.S., Fava M., Jacques P.F., Selhub J., Rosenberg I.H. Depression and folate status in the US population. Psychother. Psychosom. 2003, 69:80-87.
50. Mozzafarian D., Wu J.H. Omega-3 fatty acids and cardiovascular disease: effects on risk factors, molecular pathways, and clinical events. J. Am. Coll. Cardiol. 2011, 58:2047-2067.
51. Murakami K., Mizoue T., Sasaki S., Ohta M., Sato.M., Matsushita Y., Mishima N. Dietary intake of folate, other B vitamins, and ω/3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults. Nutrition 2008, 24:140-147.
52. Nabi H., Bochud M., Glaus J., Lasserre A.M., Waeber G., Vollenweider P., Preisig M. Association of serum homocysteine with major depressive disorder: results from a large population-based study. Psychoneuroendocrinology 2013, 38:2309-2318.
53. Naviaux R.K. Oxidative shielding or oxidative stress?. J. Pharmacol. Exp. Ther. 2012, 342:608-618.
54. Naviaux R.K. Metabolic features of the cell danger response. Mitochondrion 2014, 16:7-17.
55. Ng F., Berk M., Dean O., Bush A.I. Oxidative stress in psychiatric disorders: evidence base and therapeutic implications. Int. J. Pharmacol. 2008, 110:126-134.
56. Obeid R., Herrmann W. Homocysteine and lipids: S-adenosyl methionine as a key intermediate. FEBS Lett. 2009, 583:1215-1225.
57. Piolot A., Blache D., Boulet L., Fortin L.J., Dubreuil D., Marcoux C., Davignon J., Lussier-Cacan S. Effect of fish oil on LDL oxidation and plasma homocysteine concentrations in health. J. Lab. Clin. Med. 2003, 141:41-49.
58. Piomelli D., Astarita G., Rapaka R. A neuroscientist's guide to lipidomics. Nat. Rev. Neurosci. 2007, 8:743-754.
59. Pita M.L., Delgado M.J. Folate administration increases n-3 polyunsaturated fatty acids in rat plasma and tissue lipids. Thromb Haemost. 2000, 84(3):420-423.
60. Pooya Sh, Djalali Jalali M., Djazayery Jazayery A., Saedisomeolia A., Reza Esharaghian M., Toorang F. The efficacy of omega-3 fatty acid supplementation on plasma homocysteine and malondialdehyde levels of type 2 diabetic patients. Nutr. Metab. Cardiovasc. Dis. 2010, 20:326-331.
61. Roberts C.K., Sindh K.K. Oxidative stress and metabolic syndrome. Life Sci. 2009, 84:705-712.
62. Schiavone S., Jacquet V., Trabace L., Krause K.H. Severe life stress and oxidative stress in the brain from animal models to human pathology. Antioxid. Redox Signal. 2012, 18:1475-1490.
63. Selley M.L. A metabolic link between S-adenosylhomocysteine and polyunsaturated fatty acid metabolism in Alzheimer's disease. Neurobiol. Aging 2007, 28:1834-1839.
64. Severus W.E., Litmann A.B., Stoll A.L. Omega 3 fatty acids, homocysteine, and the increased cardiovascular mortality in major depressive disorder. Harv. Rev. Psychiatry 2001, 9:280-293.
65. Stanger O., Fowler B., Piertzik K., Huemer M., Haschke-Becher E., Semmler A., Lorenzl S., Linnebank M. Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Review of. Neurotherapeutics 2009, 9:1393-1412.
66. Terlecky S.R., Terlecky L.J., Giordano C.R. Peroxisomes, oxidative stress, and inflammation. World J. Biol. Chem. 2012, 3:93-97.
67. Wang Z.-M., Zhou B., Lie Z.L., Nie Z.L., Gao W., Wang Y.S., Zhao H., Zhu J., Yan J.J., Wang L.S. Folate and risk of coronary heart disease: a meta-analysis of prospective studies. Nutr. Metab. Cardiovasc. Dis. 2012, 22:890-899.
68. Zeman M., Zak A., Vecka M., Tyrzicka E., Pisarikova A., Stankova B. N-3 fatty acid supplementation decreases plasma homocysteine in diabetic dyslipidemia treated with statin-fibrate combination. J. Nutr. Biochem. 2006, 17:379-384.
69. Zhao M., Lamers Y., Ralat M.A., Coats B., Chi Y.Y., Muller K.E., Bain J.R., Shankar M.N., Newgard C.B., Stacpoole P.W., Gregory J.F. Marginal vitamin B-6 deficiency decrease plasma (n-3) and (n-6) PUFA concentrations in healthy men and women. J. Nutr. 2012, 142:1791-1797.