-
1
-
-
5044226336
-
Systems biology in drug discovery
-
Butcher, E. C., Berg, E. L., Kunkel, E. J. Systems biology in drug discovery. Nat. Biotechnol. 22, 1253-1259 (2004).
-
(2004)
Nat. Biotechnol
, vol.22
, pp. 1253-1259
-
-
Butcher, E.C.1
Berg, E.L.2
Kunkel, E.J.3
-
2
-
-
14144249767
-
Vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines
-
Gonzalez-Nicolini, V., Fussenegger, M. In vitro assays for anticancer drug discovery--a novel approach based on engineered mammalian cell lines. Anticancer Drugs. 16, 223-228 (2005).
-
(2005)
Anticancer Drugs
, vol.16
, pp. 223-228
-
-
Gonzalez-Nicolini, V.1
Fussenegger, M.2
-
3
-
-
33745223454
-
Cell microarrays in drug discovery
-
Castel, D., Pitaval, A., Debily, M. A., Gidrol, X. Cell microarrays in drug discovery. Drug Discov. Today. 11, 616-622 (2006).
-
(2006)
Drug Discov. Today
, vol.11
, pp. 616-622
-
-
Castel, D.1
Pitaval, A.2
Debily, M.A.3
Gidrol, X.4
-
4
-
-
70349429760
-
2D and 3D cell microarrays in pharmacology
-
Gidrol, X., et al. 2D and 3D cell microarrays in pharmacology. Current Opin. Pharmacol. 9, 664-668 (2009).
-
(2009)
Current Opin. Pharmacol
, vol.9
, pp. 664-668
-
-
Gidrol, X.1
-
5
-
-
84865453325
-
The multicellular tumor spheroid model for high-throughput cancer drug discovery
-
LaBarbera, D. V., Reid, B. G., Yoo, B. H. The multicellular tumor spheroid model for high-throughput cancer drug discovery. Expert Opin. Drug Discov. 7, 819-830 (2012).
-
(2012)
Expert Opin. Drug Discov
, vol.7
, pp. 819-830
-
-
Labarbera, D.V.1
Reid, B.G.2
Yoo, B.H.3
-
6
-
-
84875038481
-
Decline in new drug launches: Myth or reality? Retrospective observational study using 30 years of data from the UK
-
Ward, D. J., Martino, O. I., Simpson, S., Stevens, A. J. Decline in new drug launches: myth or reality? Retrospective observational study using 30 years of data from the UK. BMJ Open. 3, (2013).
-
(2013)
BMJ Open
, pp. 3
-
-
Ward, D.J.1
Martino, O.I.2
Simpson, S.3
Stevens, A.J.4
-
7
-
-
34547931078
-
Modeling tissue morphogenesis and cancer in 3D
-
Yamada, K. M., Cukierman, E. Modeling tissue morphogenesis and cancer in 3D. Cell. 130, 601-610 (2007).
-
(2007)
Cell
, vol.130
, pp. 601-610
-
-
Yamada, K.M.1
Cukierman, E.2
-
8
-
-
77953916745
-
Multicellular tumor spheroids: An underestimated tool is catching up again
-
Hirschhaeuser, F., et al. Multicellular tumor spheroids: An underestimated tool is catching up again. J. Biotechnol. 148, 3-15 (2010).
-
(2010)
J. Biotechnol
, vol.148
, pp. 3-15
-
-
Hirschhaeuser, F.1
-
9
-
-
77954518306
-
Tumor engineering: The other face of tissue engineering. Tissue Eng
-
Ghajar, C. M., Bissell, M. J. Tumor engineering: the other face of tissue engineering. Tissue Eng. A. 16, 2153-2156 (2010).
-
(2010)
Tissue Eng. A
, vol.16
, pp. 2153-2156
-
-
Ghajar, C.M.1
Bissell, M.J.2
-
10
-
-
34248650697
-
The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression
-
Kenny, P. A., et al. The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol. Oncol. 1, 84-96 (2007).
-
(2007)
Mol. Oncol
, vol.1
, pp. 84-96
-
-
Kenny, P.A.1
-
11
-
-
0021693130
-
Liquid-overlay culture of cellular spheroids
-
Carlsson, J., Yuhas, J. M. Liquid-overlay culture of cellular spheroids. Rec. Results Cancer Res. 95, 1-23 (1984).
-
(1984)
Rec. Results Cancer Res
, vol.95
, pp. 1-23
-
-
Carlsson, J.1
Yuhas, J.M.2
-
12
-
-
0035073872
-
Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells
-
Wartenberg, M., et al. Tumor-induced angiogenesis studied in confrontation cultures of multicellular tumor spheroids and embryoid bodies grown from pluripotent embryonic stem cells. FASEB J. 15, 995-1005 (2001).
-
(2001)
FASEB J
, vol.15
, pp. 995-1005
-
-
Wartenberg, M.1
-
13
-
-
77956104185
-
Stimuli-responsive microwells for formation and retrieval of cell aggregates
-
Tekin, H., et al. Stimuli-responsive microwells for formation and retrieval of cell aggregates. Lab chip. 10, 2411-2418 (2010).
-
(2010)
Lab Chip
, vol.10
, pp. 2411-2418
-
-
Tekin, H.1
-
14
-
-
84889672208
-
A microfluidic device for uniform-sized cell spheroids formation, culture, harvesting and flow cytometry analysis
-
Patra, B., et al. A microfluidic device for uniform-sized cell spheroids formation, culture, harvesting and flow cytometry analysis. Biomicrofluidics. 7, 54114 (2013).
-
(2013)
Biomicrofluidics
, vol.7
, pp. 54114
-
-
Patra, B.1
-
15
-
-
84903650325
-
Hierlemann, A. Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis. Nat
-
Frey, O., Misun, P. M., Fluri, D. A., Hengstler, J. G., Hierlemann, A. Reconfigurable microfluidic hanging drop network for multi-tissue interaction and analysis. Nat. Commun. 5, 4250 (2014).
-
(2014)
Commun
, vol.5
, pp. 4250
-
-
Frey, O.1
Misun, P.M.2
Fluri, D.A.3
Hengstler, J.G.4
-
16
-
-
84861460487
-
Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates
-
Hsiao, A. Y., et al. Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates. Biomed. Microdev. 14, 313-323 (2012).
-
(2012)
Biomed. Microdev
, vol.14
, pp. 313-323
-
-
Hsiao, A.Y.1
-
17
-
-
84869495994
-
Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy
-
Mehta, G., Hsiao, A. Y., Ingram, M., Luker, G. D., Takayama, S. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy. J. Control. Release. 164, 192-204 (2012).
-
(2012)
J. Control. Release
, vol.164
, pp. 192-204
-
-
Mehta, G.1
Hsiao, A.Y.2
Ingram, M.3
Luker, G.D.4
Takayama, S.5
-
18
-
-
0030697292
-
Three-dimensional cell cultures: From molecular mechanisms to clinical applications
-
Mueller-Klieser, W. Three-dimensional cell cultures: from molecular mechanisms to clinical applications. Am. J. Physiol. 273, C1109-C1123 (1997).
-
(1997)
Am. J. Physiol
, vol.273
, pp. C1109-C1123
-
-
Mueller-Klieser, W.1
-
20
-
-
84879607828
-
Surface tension-mediated, concave-microwell arrays for large-scale, simultaneous production of homogeneously sized embryoid bodies
-
Jeong, G. S., et al. Surface tension-mediated, concave-microwell arrays for large-scale, simultaneous production of homogeneously sized embryoid bodies. Adv. Healthc. Mater. 2, 119-125 (2013).
-
(2013)
Adv. Healthc. Mater
, vol.2
, pp. 119-125
-
-
Jeong, G.S.1
-
21
-
-
84896305360
-
Transfer imaging, and analysis plate for facile handling of 384 hanging drop 3D tissue spheroids
-
Cavnar, S. P., Salomonsson, E., Luker, K. E., Luker, G. D., Takayama, S. Transfer imaging, and analysis plate for facile handling of 384 hanging drop 3D tissue spheroids. JALA. 19, 208-214 (2014).
-
(2014)
JALA
, vol.19
, pp. 208-214
-
-
Cavnar, S.P.1
Salomonsson, E.2
Luker, K.E.3
Luker, G.D.4
Takayama, S.5
-
22
-
-
84925017729
-
High throughput, polymeric aqueous two-phase printing of tumor spheroids
-
Atefi, E., Lemmo, S., Fyffe, D., Luker, G. D., Tavana, H. High throughput, polymeric aqueous two-phase printing of tumor spheroids. Adv. Func. Mater. 24, 6509-6515 (2014).
-
(2014)
Adv. Func. Mater
, vol.24
, pp. 6509-6515
-
-
Atefi, E.1
Lemmo, S.2
Fyffe, D.3
Luker, G.D.4
Tavana, H.5
-
23
-
-
84906939113
-
Optimization of aqueous biphasic tumor spheroid microtechnology for anti-cancer drug testing in 3D culture
-
Lemmo, S., Atefi, E., Luker, G. D., Tavana, H. Optimization of aqueous biphasic tumor spheroid microtechnology for anti-cancer drug testing in 3D culture. Cell. Mol. Bioeng. 7, 344-354 (2014).
-
(2014)
Cell. Mol. Bioeng
, vol.7
, pp. 344-354
-
-
Lemmo, S.1
Atefi, E.2
Luker, G.D.3
Tavana, H.4
-
25
-
-
84887303908
-
Cell co-culture patterning using aqueous two-phase systems
-
Frampton, J. P., White, J. B., Abraham, A. T., Takayama, S. Cell co-culture patterning using aqueous two-phase systems. J. Vis. Exp. (73), (2013).
-
(2013)
J. Vis. Exp
, Issue.73
-
-
Frampton, J.P.1
White, J.B.2
Abraham, A.T.3
Takayama, S.4
-
26
-
-
84899851972
-
Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA
-
Frampton, J. P., et al. Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Sci. Rep. 4, 4878 (2014).
-
(2014)
Sci. Rep
, vol.4
, pp. 4878
-
-
Frampton, J.P.1
-
27
-
-
84898896311
-
Label-free direct visual analysis of hydrolytic enzyme activity using aqueous twophase system droplet phase transitions
-
Lai, D., Frampton, J. P., Tsuei, M., Kao, A., Takayama, S. Label-free direct visual analysis of hydrolytic enzyme activity using aqueous twophase system droplet phase transitions. Anal. Chem. 86, 4052-4057 (2014).
-
(2014)
Anal. Chem
, vol.86
, pp. 4052-4057
-
-
Lai, D.1
Frampton, J.P.2
Tsuei, M.3
Kao, A.4
Takayama, S.5
-
28
-
-
84890789226
-
Automated spatio-temporally controlled cell microprinting with polymeric aqueous biphasic system
-
Petrak, D., Atefi, E., Yin, L., Chilian, W., Tavana, H. Automated spatio-temporally controlled cell microprinting with polymeric aqueous biphasic system. Biotech. Bioeng. 11, 404-412 (2014).
-
(2014)
Biotech. Bioeng
, vol.11
, pp. 404-412
-
-
Petrak, D.1
Atefi, E.2
Yin, L.3
Chilian, W.4
Tavana, H.5
-
29
-
-
69249083781
-
Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells
-
Tavana, H., et al. Nanolitre liquid patterning in aqueous environments for spatially defined reagent delivery to mammalian cells. Nat. Mater. 8, 736-741 (2009).
-
(2009)
Nat. Mater
, vol.8
, pp. 736-741
-
-
Tavana, H.1
-
30
-
-
80051705566
-
Polymeric aqueous biphasic system rehydration facilitates high throughput cell exclusion patterning for cell migration studies
-
Tavana, H., et al. Polymeric aqueous biphasic system rehydration facilitates high throughput cell exclusion patterning for cell migration studies. Adv. Func. Mater. 21, 2920-2926 (2011).
-
(2011)
Adv. Func. Mater
, vol.21
, pp. 2920-2926
-
-
Tavana, H.1
-
31
-
-
77954847405
-
Polymeric aqueous biphasic systems for non-contact cell printing on cells: Engineering heterocellular embryonic stem cell niches
-
Tavana, H., Mosadegh, B., Takayama, S. Polymeric aqueous biphasic systems for non-contact cell printing on cells: engineering heterocellular embryonic stem cell niches. Adv. Mater. 22, 2628-2631 (2010).
-
(2010)
Adv. Mater
, vol.22
, pp. 2628-2631
-
-
Tavana, H.1
Mosadegh, B.2
Takayama, S.3
-
32
-
-
80051781545
-
Microprinted feeder cells guide embryonic stem cell fate
-
Tavana, H., Mosadegh, B., Zamankhan, P., Grotberg, J. B., Takayama, S. Microprinted feeder cells guide embryonic stem cell fate. Biotechnol. Bioeng. 108, 2509-2516 (2011).
-
(2011)
Biotechnol. Bioeng
, vol.108
, pp. 2509-2516
-
-
Tavana, H.1
Mosadegh, B.2
Zamankhan, P.3
Grotberg, J.B.4
Takayama, S.5
-
34
-
-
77955692939
-
Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts
-
Olsen, C. J., Moreira, J., Lukanidin, E. M., Ambartsumian, N. S. Human mammary fibroblasts stimulate invasion of breast cancer cells in a three-dimensional culture and increase stroma development in mouse xenografts. BMC Cancer. 10, 444 (2010).
-
(2010)
BMC Cancer
, vol.10
, pp. 444
-
-
Olsen, C.J.1
Moreira, J.2
Lukanidin, E.M.3
Ambartsumian, N.S.4
-
35
-
-
84902469661
-
Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival
-
Ozdemir, B. C., et al. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 25, 719-734 (2014).
-
(2014)
Cancer Cell
, vol.25
, pp. 719-734
-
-
Ozdemir, B.C.1
-
36
-
-
63649097667
-
Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids
-
Hsiao, A. Y., et al. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids. Biomaterials. 30, 3020-3027 (2009).
-
(2009)
Biomaterials
, vol.30
, pp. 3020-3027
-
-
Hsiao, A.Y.1
-
37
-
-
60549103259
-
Spheroid-based drug screen: Considerations and practical approach
-
Friedrich, J., Seidel, C., Ebner, R., Kunz-Schughart, L. A. Spheroid-based drug screen: considerations and practical approach. Nat. Protoc. 4, 309-324 (2009).
-
(2009)
Nat. Protoc
, vol.4
, pp. 309-324
-
-
Friedrich, J.1
Seidel, C.2
Ebner, R.3
Kunz-Schughart, L.A.4
-
38
-
-
48349094384
-
Unraveling the microenvironmental influences on the normal mammary gland and breast cancer
-
Weigelt, B., Bissell, M. J. Unraveling the microenvironmental influences on the normal mammary gland and breast cancer. Semin. Cancer Biol. 18, 311-321 (2008).
-
(2008)
Semin. Cancer Biol.
, vol.18
, pp. 311-321
-
-
Weigelt, B.1
Bissell, M.J.2
-
39
-
-
8144228952
-
Friends or foes- Bipolar effects of the tumour stroma in cancer
-
Mueller, M. M., Fusenig, N. E. Friends or foes - bipolar effects of the tumour stroma in cancer. Nature Reviews Cance. 4, 839-849 (2004).
-
(2004)
Nature Reviews Cance
, vol.4
, pp. 839-849
-
-
Mueller, M.M.1
Fusenig, N.E.2
|