FLIMX: A software package to determine and analyze the fluorescence lifetime in time-resolved fluorescence data from the human eye

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Klemm, Matthias ^a   Schweitzer, Dietrich ^b   Peters, Sven ^b   Sauer, Lydia ^b   Hammer, Martin ^b   Haueisen, Jens ^a  

^a ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ALGORITHM; ANIMAL TISSUE; ARTICLE; ARTIFACT; CLINICAL ARTICLE; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; EYE; EYE FUNDUS; FEMALE; FLUORESCENCE LIFETIME IMAGING OPHTHALMOSCOPY; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; LENS; MALE; MATHEMATICAL COMPUTING; NONHUMAN; OPHTHALMOSCOPY; RETINA GANGLION CELL; RETINA MACULA HOLE; RETINA MACULA LUTEA; ANIMAL; CYTOLOGY; DIABETES MELLITUS; FLUORESCENCE; FLUORESCENCE IMAGING; IMAGE PROCESSING; MIDDLE AGED; PATHOLOGY; PIG; PROCEDURES; RETINA TEAR; SOFTWARE; TIME FACTOR;

ADULT; AGED; ANIMALS; ARTIFACTS; DIABETES MELLITUS; EYE; FEMALE; FLUORESCENCE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; OPHTHALMOSCOPY; OPTICAL IMAGING; RETINAL GANGLION CELLS; RETINAL PERFORATIONS; SOFTWARE; SWINE; TIME FACTORS;

EID: 84941254689     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0131640     Document Type: Article

References (44)

1. Hammer M, Konigsdorffer E, Liebermann C, Framme C, Schuch G, Schweitzer D, et al. Ocular fundus auto-fluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graef Arch Clin Exp. 2008; 246(1):105-14. doi: 10.1007/s00417-007- 0639-9 PMID: ISI:000251092800014.
2. Spaide RF, Schmitz-Valckenberg S, Holz FG, Bird AC. Fundus autofluorescence imaging-Review and perspectives. Retina-J Ret Vit Dis. 2008; 28(3):385-409. PMID: ISI:000253951500002.
3. Schweitzer D, Schenke S, Hammer M, Schweitzer F, Jentsch S, Birckner E, et al. Towards metabolic mapping of the human retina. Microsc Res Techniq. 2007; 70(5):410-9. doi: 10.1002/Jemt.20427 PMID: ISI:000246408100004.
4. Schweitzer D, Hammer M, Schweitzer F, Anders R, Doebbecke T, Schenke S, et al. In vivo measurement of time-resolved autofluorescence at the human fundus. J Biomed Opt. 2004; 9(6):1214-22. doi: 10.1117/1.1806833 PMID: ISI:000225697400014.
5. Schweitzer D, Gaillard ER, Dillon J, Mullins RF, Russell S, Hoffmann B, et al. Time-Resolved Autofluorescence Imaging of Human Donor Retina Tissue from Donors with Significant Extramacular Drusen. Invest Ophth Vis Sci. 2012; 53(7):3376-86. doi: 10.1167/Iovs.11-8970 PMID: ISI:000306181200014.
6. Schweitzer D, Deutsch L, Klemm M, Jentsch S, Hammer M, Peters S, et al. Fluorescence lifetime imaging ophthalmoscopy in type 2 diabetic patients who have no signs of diabetic retinopathy. J Biomed Opt. 2015; 20(6):061106. doi: 10.1117/1.JBO.20.6.061106
7. Ramm L, Jentsch S, Augsten R, Hammer M. Fluorescence lifetime imaging ophthalmoscopy in glaucoma. Graef Arch Clin Exp. 2014; 252(12):2025-6. PMID: WOS:000345589300022.
8. Jentsch S, Schweitzer D, Schmidtke KU, Peters S, Dawczynski J, Bar KJ, et al. Retinal fluorescence lifetime imaging ophthalmoscopy measures depend on the severity of Alzheimer's disease. Acta ophthalmologica. 2014.Epub 2014/12/09. doi: 10.1111/aos.12609 PMID: 25482990.
9. Lakowicz JR. Principles of Fluorescence Spectroscopy. 3rd ed. New York: Springer; 2006. 954 p.
10. Becker W. Fluorescence lifetime imaging-techniques and applications. Journal of Microscopy. 2012; 247(2):119-36. doi: 10.1111/j.1365-2818.2012.03618.x PMID: ISI:000306311800001.
11. Marcu L. Fluorescence Lifetime Techniques in Medical Applications. Ann Biomed Eng. 2012; 40 (2):304-31. Epub 2012/01/26. doi: 10.1007/s10439-011-0495-y PMID: 22273730.
12. Ware WR, Doemeny LJ, Nemzek TL. Deconvolution of Fluorescence and Phosphorescence Decay Curves-Least-Squares Method. J Phys Chem-Us. 1973; 77(17):2038-48. PMID: ISI: A1973Q464000003.
13. Enderlein J, Erdmann R. Fast fitting of multi-exponential decay curves. Opt Commun. 1997; 134(1- 6):371-8. PMID: ISI:A1997WB60100059.
14. Laptenok S, Mullen KM, Borst JW, van Stokkum IHM, Apanasovich VV, Visser AJWG. Fluorescence Lifetime Imaging Microscopy (FLIM) data analysis with TIMP. J Stat Softw. 2007; 18(8). PMID: ISI:000244068000001.
15. Warren SC, Margineanu A, Alibhai D, Kelly DJ, Talbot C, Alexandrov Y, et al. Rapid Global Fitting of Large Fluorescence Lifetime Imaging Microscopy Datasets. Plos One. 2013; 8(8). doi: 10.1371/journal. pone.0070687 PMID: WOS:000324465000120.
16. Lee KCB, Siegel J, Webb SED, Leveque-Fort S, Cole MJ, Jones R, et al. Application of the stretched exponential function to fluorescence lifetime imaging. Biophys J. 2001; 81(3):1265-74. PMID: ISI:000170600800006.
17. Schweitzer D. Metabolic mapping. In: Holz FG, Spaide RF, editors. Medical Retina: Focus on Retinal Imaging (Essentials in Ophthalmology). Essentials in Ophthalmology. Heidelberg: Springer; 2010.p. 107-23.
18. Klemm M, Dietzel A, Haueisen J, Nagel E, Hammer M, Schweitzer D. Repeatability of Autofluorescence Lifetime Imaging at the Human Fundus in Healthy Volunteers. Curr Eye Res. 2013; 38(7):793- 801. doi: 10.3109/02713683.2013.779723 PMID: WOS:000319754700011.
19. Institute ANS, America LIo. American National Standard for Safe Use of Lasers (ANSI Z136.1): Laser Institute of America; 2007.
20. Becker W. Advanced time-correlated single photon counting techniques. Berlin: Springer; 2005. 401 p.
21. Becker W. The bh TCPSC Handbook. 5th ed. Berlin: Becker & Hickl GmbH; 2012. 690 p.
22. Luchowski R, Szabelski M, Sarkar P, Apicella E, Midde K, Raut S, et al. Fluorescence Instrument Response Standards in Two-Photon Time-Resolved Spectroscopy. Appl Spectrosc. 2010; 64(8):918-22 PMID: WOS:000280894300011. doi: 10.1366/000370210792081000
23. Pau H, Degen J, Schmidtke HH. Different Regional Changes of Fluorescence-Spectra of Clear Human Lenses and Nuclear Cataracts. Graef Arch Clin Exp. 1993; 231(11):656-61. doi: 10.1007/Bf00921961 PMID: WOS:A1993MC88500008.
24. Berendschot TTJM, DeLint PJ, van Norren D. Fundus reflectance-historical and present ideas. Prog Retin Eye Res. 2003; 22(2):171-200. PMID: WOS:000181646900003.
25. Goss DA, West RW. Introduction to the optics of the eye. Boston: Butterworth-Heinemann; 2001. 234 p.
26. O'Connor DV, Ware WR, Andre JC. Deconvolution of Fluorescence Decay Curves-Critical Comparison of Techniques. J Phys Chem-Us. 1979; 83(10):1333-43. PMID: ISI:A1979GV58600019.
27. Schweitzer D, Quick S, Schenke S, Klemm M, Gehlert S, Hammer M, et al. Comparison of parameters of time-resolved autofluorescence between healthy subjects and patients suffering from early AMD. Ophthalmologe. 2009; 106(8):714-22. doi: 10.1007/s00347-009-1975-4 PMID: ISI:000269189800007.
28. Koellner M, Wolfrum J. How Many Photons Are Necessary for Fluorescence-Lifetime Measurements. Chem Phys Lett. 1992; 200(1-2):199-204. PMID: ISI:A1992JZ55400033.
29. Schweitzer D, Klemm M, Hammer M, Jentsch S, Schweitzer F. Method for simultaneous detection of functionality and tomography. Clinical and Biomedical Spectroscopy. 2009; 7368:736804. doi: 10.1364/ECBO.2009.7368-04
30. Dillon J, Atherton SJ. Time Resolved Spectroscopic Studies on the Intact Human Lens. Photochem Photobiol. 1990; 51(4):465-8. doi: 10.1111/j.1751-1097.1990.tb01738.x PMID: WOS: A1990CY40100010.
31. Leung RWK, Yeh SCA, Fang QY. Effects of incomplete decay in fluorescence lifetime estimation. Biomedical Optics Express. 2011; 2(9):2517-31. PMID: ISI:000299883200007. doi: 10.1364/BOE.2. 002517
32. Neyman J, Pearson ES. On the Use and Interpretation of Certain Test Criteria for Purposes of Statistical Inference. Biometrika. 1928; 20A(3-4):263-94. doi: 10.1093/biomet/20A.3-4.263
33. Turton DA, Reid GD, Beddard GS. Accurate analysis of fluorescence decays from single molecules in photon counting experiments. Anal Chem. 2003; 75(16):4182-7. doi: 10.1021/Ac034325k PMID: ISI:000184798100030.
34. Rechenberg I, Eigen M. Evolutionsstrategie: Optimierung technischer Systeme nach Prinzipien der biologischen Evolution. Stuttgart-Bad Cannstadt: Frommann-Holzboog; 1973. 170 p.
35. Kennedy JF, Eberhart RC, Shi Y. Swarm intelligence. San Francisco: Morgan Kaufmann Publishers; 2001. xxvii, 512 p. p.
36. Marquardt DW. An Algorithm for Least-Squares Estimation of Nonlinear Parameters. J Soc Ind Appl Math. 1963; 11(2):431-41. PMID: ISI:A1963WW43200015.
37. Nelder JA, Mead R. A Simplex-Method for Function Minimization. Comput J. 1965; 7(4):308-13. PMID: ISI:A1965CLA3200015.
38. Storn R, Price K. Differential evolution-A simple and efficient heuristic for global optimization over continuous spaces. J Global Optim. 1997; 11(4):341-59. PMID: ISI:A1997YF22800001.
39. Clerc M, Kennedy J. The particle swarm-Explosion, stability, and convergence in a multidimensional complex space. Ieee T Evolut Comput. 2002; 6(1):58-73. PMID: ISI:000173995900006.
40. Dysli C, Quellec G, Abegg M, Menke MN, Wolf-Schnurrbusch U, Kowal J, et al. Quantitative analysis of fluorescence lifetime measurements of the macula using the fluorescence lifetime imaging ophthalmoscope in healthy subjects. Invest Ophth Vis Sci. 2014; 55(4):2106-13. Medline:PMID: 24569585.
41. Grading Diabetic-Retinopathy from Stereoscopic Color Fundus Photographs-An Extension of the Modified Airlie House Classification-ETDRS Report Number 10.Ophthalmology. 1991; 98(5):786-806. PMID: WOS:A1991FL41900005.
42. Holm S. A Simple Sequentially Rejective Multiple Test Procedure. Scand J Stat. 1979; 6(2):65-70. PMID: WOS:A1979JY78700003.
43. Hollander M, Wolfe DA. Nonparametric statistical methods. 2nd ed. New York: Wiley; 1999. xiv, 787 p. p.
44. Peters S, Hammer M, Schweitzer D. Two-photon excited fluorescence microscopy application for ex vivo investigation of ocular fundus samples. Proceedings of the SPIE-The International Society for Optical Engineering. 2011; 8086(Advanced Microscopy Techniques II):808605. doi: 10.1117/12. 889807 PMID: INSPEC:12097760.