Repeatability of autofluorescence lifetime imaging at the human fundus in healthy volunteers

Current Eye Research

Volumn 38, Issue 7, 2013, Pages 793-801

  Klemm, Matthias ^a   Dietzel, Alexander ^a   Haueisen, Jens ^a   Nagel, Edgar ^a,b   Hammer, Martin ^c   Schweitzer, Dietrich ^c  

^a ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^b Ophthalmic Practice Ankermedicum   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Eye; in vivo FLIM; Metabolic mapping; Retina

Indexed keywords

ADULT; ARTICLE; AUTOFLUORESCENCE; EYE FUNDUS; EYE MOVEMENT; EYE TRACKING; FLUORESCENCE LIFETIME IMAGING; HUMAN; MEASUREMENT REPEATABILITY; METABOLISM; NORMAL HUMAN; OPHTHALMOSCOPE; OPTIC DISK; PHOTON; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETINA FOVEA; RETINA IMAGE; RETINA MACULA LUTEA;

ADULT; FLUORESCEIN ANGIOGRAPHY; FLUORESCENCE; FLUORESCENT DYES; HEALTHY VOLUNTEERS; HUMANS; OPTICAL IMAGING; REPRODUCIBILITY OF RESULTS; RETINA; RHODAMINES; ROSE BENGAL;

EID: 84878503752     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2013.779723     Document Type: Article

References (24)

1. Hammer M, Konigsdorffer E, Liebermann C, Framme C, Schuch G, Schweitzer D, et al. Ocular fundus autofluorescence observations at different wavelengths in patients with age-related macular degeneration and diabetic retinopathy. Graef Arch Clin Exp 2008;246:105-114
2. Spaide RF, Schmitz-Valckenberg S, Holz FG, Bird AC. Fundus autofluorescence imaging-review and perspectives. Retina-J Ret Vit Dis 2008;28:385-409
3. Lakowicz Jr. Principles of fluorescence spectroscopy. New York: Springer; 2006
4. Marcu L. Fluorescence lifetime techniques in medical applications. Ann Biomed Eng 2012;40:304-331
5. Schweitzer D, Hammer M, Schweitzer F, Anders R, Doebbecke T, Schenke S, et al. In vivo measurement of time-resolved autofluorescence at the human fundus. J Biomed Opt 2004;9:1214-1222
6. Schweitzer D, Schenke S, Hammer M, Schweitzer F, Jentsch S, Birckner E, et al. Towards metabolic mapping of the human retina. Microsc Res Techniq 2007;70:410-419
7. Peters S, Hammer M, Schweitzer D. Two-photon excited fluorescence microscopy application for ex vivo investigation of ocular fundus samples. Eur Conf Biomed Opt 2011; 8086:808605 (10 pp.).
8. Schweitzer D, Gaillard ER, Dillon J, Mullins RF, Russell S, Hoffmann B, et al. Time-resolved autofluorescence imaging of human donor retina tissue from donors with significant extramacular drusen. Invest Ophth Vis Sci 2012; 53:3376-3386
9. Lois N, Halfyard AS, Bunce C, Bird AC, Fitzke FW. Reproducibility of fundus autofluorescence measurements obtained using a confocal scanning laser ophthalmoscope. Brit J Ophthalmol 1999;83:276-279
10. Bellmann C, Rubin GS, Kabanarou SA, Bird AC, Fitzke FW. Fundus autofluorescence imaging compared with different confocal scanning laser ophthalmoscopes. Brit J Ophthalmol 2003;87:1381-1386
11. Schweitzer D. Metabolic mapping. In: Holz FG, Spaide RF, editors. Medical retina: Focus on retinal imaging (essentials in ophthalmology). Heidelberg: Springer; 2010. pp 107-123
12. ANSI. American national standard for safe use of lasers (ANSI Z136.1). Orlando (FL): Laser Institute of America; 2007
13. Becker W. The bh TCPSC handbook. Berlin: Springer; 2010
14. Becker W. Advanced time-correlated single photon counting techniques. Berlin: Springer; 2005
15. Mikhailov VP, Demchuk MI, Yumashev KV. Possibility of the investigation of conformational changes in protein molecules with fluorescent probes in the picosecond time range. J Appl Spectrosc (USA) 1982;37:60-64
16. Vickers GH, Miller RM, Hieftje GM. Time-resolved fluorescence with an optical-fiber probe. Anal Chim Acta 1987; 192:145-153
17. Boens N, Qin WW, Basaric N, Hofkens J, Ameloot M, Pouget J, et al. Fluorescence lifetime standards for time and frequency domain fluorescence spectroscopy. Anal Chem 2007;79:2137-2149
18. van de Kraats J, Norren D. Optical density of the aging human ocular media in the visible and the UV. J Opt Soc Am A 2007;24:1842-1857
19. Bland JM, Altman DG. Statistical-methods for assessing agreement between 2 methods of clinical measurement. Lancet 1986;1:307-310
20. Delori F, Greenberg JP, Woods RL, Fischer J, Duncker T, Sparrow J, et al. Quantitative measurements of autofluorescence with the scanning laser ophthalmoscope. Invest Ophth Vis Sci 2011;52:9379-9390
21. Krishna MMG, Periasamy N. Spectrally constrained global analysis of fluorescence decays in biomembrane systems. Anal Biochem 1997;253:1-7.
22. Digman MA, Caiolfa VR, Zamai M, Gratton E. The phasor approach to fluorescence lifetime imaging analysis. Biophys J 2008;94:L14-L16
23. Schweitzer D, Quick S, Schenke S, Klemm M, Gehlert S, Hammer M, et al. Comparison of parameters of timeresolved autofluorescence between healthy subjects and patients suffering from early AMD. Ophthalmologe 2009; 106:714-722
24. Schweitzer D, Quick S, Klemm M, Hammer M, Jentsch S, Dawczynski J. Time-resolved autofluorescence in retinal vascular occlusions. Ophthalmologe 2010;107:1145-1152