Comparison of parameters of time-resolved autofluorescence between healthy subjects and patients suffering from early AMD;Vergleich von Parametern der zeitaufgelösten Autofluoreszenz bei Gesunden und Patienten mit früher AMD

Ophthalmologe

Volumn 106, Issue 8, 2009, Pages 714-722

  Schweitzer, Dr ^a   Quick, S ^a   Schenke, S ^a   Klemm, M ^b   Gehlert, S ^a   Hammer, M ^a   Jentsch, S ^a   Fischer, S J ^c  

^a JENA UNIVERSITY HOSPITAL   (Germany)

^b ILMENAU UNIVERSITY OF TECHNOLOGY   (Germany)

^c Heidelberg Engineering   (Germany)

Author keywords

Age related macular degeneration; Laser scanning ophthalmoscopy; Metabolism; NADH; Time resolved fluorescence

Indexed keywords

BIOLOGICAL MARKER;

ADULT; ARTICLE; COMPARATIVE STUDY; CONFOCAL MICROSCOPY; EVALUATION; FEMALE; HUMAN; MALE; METABOLISM; METHODOLOGY; OPHTHALMOSCOPY; REPRODUCIBILITY; RETINA MACULA DEGENERATION; SENSITIVITY AND SPECIFICITY; SPECTROFLUOROMETRY;

ADULT; BIOLOGICAL MARKERS; FEMALE; HUMANS; MACULAR DEGENERATION; MALE; MICROSCOPY, CONFOCAL; OPHTHALMOSCOPY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, FLUORESCENCE;

EID: 70349854700     PISSN: 0941293X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00347-009-1975-4     Document Type: Article

References (24)

1. AREDS reportVIII (2001) Arch Ophthalmology 119(10):1417-1436
2. American National Standard for the safe use of la- ser ANSI Z 136.1-2000 (2000) Laser Institute of America, Suite 128, 13501 Ingenuite Drive, Orlando, Fl 32826
3. Ben-Shabat S, Parish CA,Vollmer H et al (2002) Biosynthetic studies of A2E, a major Fluorophore of retinal pigment epithelial lipofuscin. J Biol Chem 277(9):7183-7190
4. Bindewald A, Bird AC, Dandekar SS et al (2005) Classification of fundus autofluorescence patterns in early age-related macular diseases. Invest Ophthalmol Vis Sci 46:3309-3314
5. Boettner EA,Wolter JR (1962) Transmission of the ocular media. Invest Ophthalmol Vis Sci 1:776-783
6. BuiTV, HanY, Radu RA et al (2006) Characterization of native retinal fluorophores involved in biosynthesis of A2E and Lipofuscin-associated retinopathies. J Biol Chem 281(26):18112-18119
7. Chance B (1976) Pyridine nucleotides as an indica- tor of the oxygen requirements for energy-linked functions of mitochondria. Circ Res 38(5, Suppl 1): I31-I38
8. Cubeddu R,Taroni P, Hu DN et al (1999) Photophysical studies of A2E, putative precursor of lipofuscin, in human retinal pigment epithel cells. Photochem Photobiol 70(2):172-175
9. Eldred GE, Katz ML (1988) Fluorophores of the hu- man pigment epithelium: Separation and spectral characterization. Exp Eye Res 47:71-86
10. Eldred GE, Lasky MR (1993) Retinal age-pigments generated by self-assembling lysosomotropic detergents. Nature 361:724-726
11. Fishkin NE, Sparrow JR, Allikmets R, Nakanishi K (2005) Isolation and characterization of a retinal pigment epithel cell fluorophore: an all-trans-retinal dimer conjugate. PNAS 102(20):7091-7096
12. Hammer M, Richter S, Kobuch K, Schweitzer D (2005) Lipofuscin accumulation in an organotypic perfusion culture of porcine fundi under oxidative stress and blue light Irradiation. Invest Ophthalmol Vis Sci 46:E-Abstract 251
13. Hammer M, Richter S, Kobuch K et al (2008) Intrinsic tissue fluorescence in an organotypic perfusion culture of the porcine ocular fundus exposed to lue light and free radicals. Graefes Arch Clin Exp ophthalmol 4246:979-988
14. JangYP, Matsuda H, ItagakiY et al (2005) Characterization of peroxy-A2E and furan-A2E photooxidation products and detection in human and mouse etinal pigment epithel cell lipofuscin. J Biol Chem 280(48):39732-39739
15. Kayatz P,Thumann G, Luther T et al (2001) Oxidation causes melanin fluorescence. Invest Ophthalmol Vis Sci 42(1):241-246
16. Kim SR, He J,Yanase E et al (2007) Characterization f dihydro-A2PE: an intermediate in the A2E biosynthetic pathway. Biochemistry 46(35):10122-10129
17. Lakowicz JR (2006) Principles of fluorescence spectroscopy.Third Edition. Springer Science Business Media, New York
18. Lamb LE, Ye T, Haralampus-Grynaviski NM et al (2001) Primary photophysical properties of A2E in solution. J Phys Chem B 105(46):11507-11512
19. Parish CA, Hashimoto M, Nakanishi K et al (1998) Isolation and one step preparation of A2E and isoA2E, fluorophores from human retinal pigment epithelium. Prov Natl Acad Sci USA 95:14609-14613
20. Schweitzer D, Jentsch S, Schenke S et a (2007) Spectral and time-resolved studies on ocular structures. In: Schweitzer D, Fitzmaurice M (eds) Diagnostic Optical Spectroscopy in Biomedicine IV. Progress in biomedical optics and imaging. 8, 41 SPIE/OSAVol. 6628:662807-662811-662807-662812
21. Schweitzer D, Schenke S, Hammer M et al (2007) Towards metabolic Mapping of the Human Retina. Microsc Res Tech 70:410-419
22. Schweitzer D, Hammer M, Jentsch S, Schenke S (2007) Interpretation of measurements of dynamic fluorescence of the eye. Advanced Photon Counting Techniques II. In: BeckerW (ed) SPIEVol. 6771: 677108-677111-677108-677112
23. Sparrow JR, Nakanishi K, Parish CA (2000)The lipofuscin fluorophore A2E mediates blue light-induced damage to retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 41(7):1981-1989
24. Wang Z, Keller LMM, Dillon J, Gaillard ER (2006) Oxidation of A2E results in the formation of highly reactive aldehydes and ketones. Photochem Photobiol 82:1251-1257