Insulin sensitivity and β-cell function improve after gastric bypass in severely obese adolescents

Journal of Pediatrics

Volumn 167, Issue 5, 2015, Pages 1042-1048.e1

  Inge, Thomas H ^a   Prigeon, Ronald L ^b   Elder, Deborah A ^a   Jenkins, Todd M ^a   Cohen, Robert M ^c   Xanthakos, Stavra A ^a   Benoit, Stephen C ^c   Dolan, Lawrence M ^a   Daniels, Stephen R ^d   D'Alessio, David A ^e,f  

^a CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^d UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f DURHAM VA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE BLOOD LEVEL; INSULIN;

ADOLESCENT; ANALYSIS; BODY MASS; DIET RESTRICTION; FEMALE; GASTRIC BYPASS SURGERY; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE TEST; HUMAN; INSULIN RESISTANCE; LONGITUDINAL STUDY; MALE; METABOLISM; PANCREAS ISLET BETA CELL; PEDIATRIC OBESITY; PHYSIOLOGY; PROSPECTIVE STUDY; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; BLOOD GLUCOSE; BODY MASS INDEX; FASTING; FEMALE; GASTRIC BYPASS; GLUCOSE TOLERANCE TEST; HUMANS; INSULIN; INSULIN RESISTANCE; INSULIN-SECRETING CELLS; LONGITUDINAL STUDIES; MALE; PEDIATRIC OBESITY; PROSPECTIVE STUDIES; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84941249313     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2015.08.020     Document Type: Article

References (42)

1. Y. Claire Wang, S.L. Gortmaker, and E.M. Taveras Trends and racial/ethnic disparities in severe obesity among US children and adolescents, 1976-2006 Int J Pediatr Obes 6 2011 12 20
2. A.S. Kelly, S.E. Barlow, G. Rao, T.H. Inge, L.L. Hayman, J. Steinberger, and et al. Severe obesity in children and adolescents: identification, associated health risks, and treatment approaches: a scientific statement from the American Heart Association Circulation 128 2013 1689 1712
3. M.L. Cruz, G.Q. Shaibi, M.J. Weigensberg, D. Spruijt-Metz, G.D. Ball, and M.I. Goran Pediatric obesity and insulin resistance: chronic disease risk and implications for treatment and prevention beyond body weight modification Annu Rev Nutr 25 2005 435 468
4. R.A. DeFronzo, R.C. Bonadonna, and E. Ferrannini Pathogenesis of NIDDM. A balanced overview Diabetes Care 15 1992 318 368
5. S.E. Kahn, R.L. Prigeon, D.K. McCulloch, E.J. Boyko, R.N. Bergman, M.W. Schwartz, and et al. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function Diabetes 42 1993 1663 1672
6. C. Giannini, and S. Caprio Islet function in obese adolescents Diabetes Obes Metab 14 Suppl 3 2012 40 45
7. O. Pinhas-Hamiel, L.M. Dolan, S.R. Daniels, D. Standiford, P.R. Khoury, and P. Zeitler Increased incidence of non-insulin-dependent diabetes mellitus among adolescents J Pediatr 128 1996 608 615
8. E. D'Adamo, and S. Caprio Type 2 diabetes in youth: epidemiology and pathophysiology Diabetes Care 34 Suppl 2 2011 S161 S165
9. P. Danielsson, J. Kowalski, O. Ekblom, and C. Marcus Response of severely obese children and adolescents to behavioral treatment Arch Pediatr Adolesc Med 166 2012 1103 1108
10. M. Savoye, P. Nowicka, M. Shaw, S. Yu, J. Dziura, G. Chavent, and et al. Long-term results of an obesity program in an ethnically diverse pediatric population Pediatrics 127 2011 402 410
11. L. McGovern, J.N. Johnson, R. Paulo, A. Hettinger, V. Singhal, C. Kamath, and et al. Clinical review: treatment of pediatric obesity: a systematic review and meta-analysis of randomized trials J Clin Endocrinol Metab 93 2008 4600 4605
12. H. Buchwald, Y. Avidor, E. Braunwald, M.D. Jensen, W. Pories, K. Fahrbach, and et al. Bariatric surgery: a systematic review and meta-analysis JAMA 292 2004 1724 1737
13. D. Bradley, C. Conte, B. Mittendorfer, J.C. Eagon, J.E. Varela, E. Fabbrini, and et al. Gastric bypass and banding equally improve insulin sensitivity and beta cell function J Clin Invest 122 2012 4667 4674
14. E. Lin, S.S. Davis, J. Srinivasan, J.F. Sweeney, T.R. Ziegler, L. Phillips, and et al. Dual mechanism for type-2 diabetes resolution after Roux-en-Y gastric bypass Am Surg 75 2009 498 502 discussion 502-3
15. E. Garcia-Fuentes, J.M. Garcia-Almeida, J. Garcia-Arnes, J. Rivas-Marin, J.L. Gallego-Perales, B. Gonzalez-Jimenez, and et al. Morbidly obese individuals with impaired fasting glucose have a specific pattern of insulin secretion and sensitivity: effect of weight loss after bariatric surgery Obes Surg 16 2006 1179 1188
16. P.R. Schauer, D.L. Bhatt, J.P. Kirwan, K. Wolski, S.A. Brethauer, S.D. Navaneethan, and et al. Bariatric surgery versus intensive medical therapy for diabetes-3-year outcomes N Engl J Med 370 2014 2002 2013
17. J. Vidal, J. Nicolau, F. Romero, R. Casamitjana, D. Momblan, I. Conget, and et al. Long-term effects of Roux-en-Y gastric bypass surgery on plasma glucagon-like peptide-1 and islet function in morbidly obese subjects J Clin Endocrinol Metab 94 2009 884 891
18. E. Lin, Z. Liang, J. Frediani, S.S. Davis Jr., J.F. Sweeney, T.R. Ziegler, and et al. Improvement in beta-cell function in patients with normal and hyperglycemia following Roux-en-Y gastric bypass surgery Am J Physiol Endocrinol Metab 299 2010 E706 E712
19. S. Salinari, A. Bertuzzi, C. Guidone, E. Previti, F. Rubino, and G. Mingrone Insulin sensitivity and secretion changes after gastric bypass in normotolerant and diabetic obese subjects Ann Surg 257 2013 462 468
20. T.H. Inge, T.M. Jenkins, M. Zeller, L. Dolan, S.R. Daniels, V.F. Garcia, and et al. Baseline BMI is a strong predictor of nadir BMI after adolescent gastric bypass J Pediatr 156 2010 103 108.e1
21. T.H. Inge, G. Miyano, J. Bean, M. Helmrath, A. Courcoulas, C.M. Harmon, and et al. Reversal of type 2 diabetes mellitus and improvements in cardiovascular risk factors after surgical weight loss in adolescents Pediatrics 123 2009 214 222
22. G. Miyano, T.M. Jenkins, S.A. Xanthakos, V.F. Garcia, and T.H. Inge Perioperative outcome of laparoscopic Roux-en-Y gastric bypass: a children's hospital experience J Pediatr Surg 48 2013 2092 2098
23. T.H. Inge, M.H. Zeller, T.M. Jenkins, M. Helmrath, M.L. Brandt, M.P. Michalsky, and et al. Perioperative outcomes of adolescents undergoing bariatric surgery: the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study JAMA Pediatr 168 2014 47 53
24. D.T. Finegood, I.M. Hramiak, and J. Dupre A modified protocol for estimation of insulin sensitivity with the minimal model of glucose kinetics in patients with insulin-dependent diabetes J Clin Endocrinol Metab 70 1990 1538 1549
25. D.A. Elder, R.L. Prigeon, R.P. Wadwa, L.M. Dolan, and D.A. D'Alessio Beta-cell function, insulin sensitivity, and glucose tolerance in obese diabetic and nondiabetic adolescents and young adults J Clin Endocrinol Metab 91 2006 185 191
26. L.M. Dolan, J. Bean, D. D'Alessio, R.M. Cohen, J.A. Morrison, E. Goodman, and et al. Frequency of abnormal carbohydrate metabolism and diabetes in a population-based screening of adolescents J Pediatr 146 2005 751 758
27. R.N. Bergman, Y.Z. Ider, C.R. Bowden, and C. Cobelli Quantitative estimation of insulin sensitivity Am J Physiol 236 1979 E667 E677
28. R.N. Bergman, M. Ader, K. Huecking, and G. Van Citters Accurate assessment of beta-cell function: the hyperbolic correction Diabetes 51 Suppl 1 2002 S212 S220
29. F. Rodieux, V. Giusti, D.A. D'Alessio, M. Suter, and L. Tappy Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release Obesity (Silver Spring) 16 2008 298 305
30. S. Camastra, E. Muscelli, A. Gastaldelli, J.J. Holst, B. Astiarraga, S. Baldi, and et al. Long-term effects of bariatric surgery on meal disposal and beta-cell function in diabetic and nondiabetic patients Diabetes 62 2013 3709 3717
31. J.P. Chanoine, S. Hampl, C. Jensen, M. Boldrin, and J. Hauptman Effect of orlistat on weight and body composition in obese adolescents: a randomized controlled trial JAMA 293 2005 2873 2883
32. L. Plum, L. Ahmed, G. Febres, M. Bessler, W. Inabnet, E. Kunreuther, and et al. Comparison of glucostatic parameters after hypocaloric diet or bariatric surgery and equivalent weight loss Obesity (Silver Spring) 19 2011 2149 2157
33. M. Savoye, S. Caprio, J. Dziura, A. Camp, G. Germain, C. Summers, and et al. Reversal of early abnormalities in glucose metabolism in obese youth: results of an intensive lifestyle randomized controlled trial Diabetes Care 37 2014 317 324
34. M. Rosenbaum, C. Nonas, R. Weil, M. Horlick, I. Fennoy, I. Vargas, and et al. School-based intervention acutely improves insulin sensitivity and decreases inflammatory markers and body fatness in junior high school students J Clin Endocrinol Metab 92 2007 504 508
35. M.E. Roder, D. Porte Jr., R.S. Schwartz, and S.E. Kahn Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus J Clin Endocrinol Metab 83 1998 604 608
36. R.C. Loopstra-Masters, S.M. Haffner, C. Lorenzo, L.E. Wagenknecht, and A.J. Hanley Proinsulin-to-C-peptide ratio versus proinsulin-to-insulin ratio in the prediction of incident diabetes: the Insulin Resistance Atherosclerosis Study (IRAS) Diabetologia 54 2011 3047 3054
37. S.E. Kahn, D.L. Leonetti, R.L. Prigeon, E.J. Boyko, R.W. Bergstrom, and W.Y. Fujimoto Relationship of proinsulin and insulin with noninsulin-dependent diabetes mellitus and coronary heart disease in Japanese-American men: impact of obesity-clinical research center study J Clin Endocrinol Metab 80 1995 1399 1406
38. M.A. Reed, W.J. Pories, W. Chapman, J. Pender, R. Bowden, H. Barakat, and et al. Roux-en-Y gastric bypass corrects hyperinsulinemia implications for the remission of type 2 diabetes J Clin Endocrinol Metab 96 2011 2525 2531
39. R. Morinigo, A.M. Lacy, R. Casamitjana, S. Delgado, R. Gomis, and J. Vidal GLP-1 and changes in glucose tolerance following gastric bypass surgery in morbidly obese subjects Obesity Surgery 16 2006 1594 1601
40. N.B. Jorgensen, S.H. Jacobsen, C. Dirksen, K.N. Bojsen-Moller, L. Naver, L. Hvolris, and et al. Acute and long-term effects of Roux-en-Y gastric bypass on glucose metabolism in subjects with Type 2 diabetes and normal glucose tolerance Am J Physiol Endocrinol Metab 303 2012 E122 E131
41. P.R. Schauer, B. Burguera, S. Ikramuddin, D. Cottam, W. Gourash, G. Hamad, and et al. Effect of laparoscopic Roux-en Y gastric bypass on type 2 diabetes mellitus Annals of Surgery 238 2003 467 484 discussion 84-5
42. W.J. Pories, K.G. MacDonald Jr., E.J. Morgan, M.K. Sinha, G.L. Dohm, M.S. Swanson, and et al. Surgical treatment of obesity and its effect on diabetes: 10-y follow-up Am J Clin Nutr 55 1992 582S 585S