Selective overexpression of toll-like receptor-4 in skeletal muscle impairs metabolic adaptation to high-fat feeding

American Journal of Physiology - Regulatory Integrative and Comparative Physiology

Volumn 309, Issue 3, 2015, Pages R304-R313

  McMillan, Ryan P ^a   Wu, Yaru ^a   Voelker, Kevin ^a   Fundaro, Gabrielle ^a   Kavanaugh, John ^a   Stevens, Joseph R ^a   Shabrokh, Elika ^b   Ali, Mostafa ^a   Harvey, Mordecai ^a   Anderson, Angela S ^a   Boutagy, Nabil E ^a   Mynatt, Randall L ^c   Frisard, Madlyn I ^a   Hulver, Matthew W ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Fatty acid oxidation; High fat diet; Reactive oxygen species; Skeletal muscle; Toll like receptor 4

Indexed keywords

REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 4; TLR4 PROTEIN, MOUSE;

ADAPTATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY FAT; BODY WEIGHT; CONTROLLED STUDY; FATTY ACID OXIDATION; GASTROCNEMIUS MUSCLE; GLUCOSE TOLERANCE; LIPID DIET; MITOCHONDRIAL RESPIRATION; MOUSE; MUSCLE METABOLISM; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUADRICEPS FEMORIS MUSCLE; SKELETAL MUSCLE; ANIMAL; ANIMAL FOOD; BODY COMPOSITION; C57BL MOUSE; ENERGY METABOLISM; INSULIN RESISTANCE; MALE; METABOLISM; MITOCHONDRION; OBESITY; PHYSIOLOGY;

ADAPTATION, PHYSIOLOGICAL; ANIMAL FEED; ANIMALS; BODY COMPOSITION; BODY WEIGHT; DIET, HIGH-FAT; ENERGY METABOLISM; INSULIN RESISTANCE; MALE; MICE, INBRED C57BL; MITOCHONDRIA; MUSCLE, SKELETAL; OBESITY; TOLL-LIKE RECEPTOR 4;

EID: 84941243220     PISSN: 03636119     EISSN: 15221490     Source Type: Journal    
DOI: 10.1152/ajpregu.00139.2015     Document Type: Article

References (21)

1. Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, Bastelica D, Neyrinck AM, Fava F, Tuohy KM, Chabo C, Waget A, Delmee E, Cousin B, Sulpice T, Chamontin B, Ferrieres J, Tanti JF, Gibson GR, Casteilla L, Delzenne NM, Alessi MC, Burcelin R. Metabolic endotoxemia initiates obesity and insulin resistance. Diabetes 56: 1761-1772, 2007.
2. Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, Delzenne NM, Burcelin R. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57: 1470-1481, 2008.
3. Chait A, Kim F. Saturated fatty acids and inflammation: who pays the toll? Arterioscler Thromb Vasc Biol 30: 692-693, 2010.
4. Davis JE, Gabler NK, Walker-Daniels J, Spurlock ME. Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat. Obesity (Silver Spring) 16: 1248-1255, 2008.
5. Frisard MI, McMillan RP, Marchand J, Wahlberg KA, Wu Y, Voelker KA, Heilbronn L, Haynie K, Muoio B, Li L, Hulver MW. Toll-like receptor 4 modulates skeletal muscle substrate metabolism. Am J Physiol Endocrinol Metab 298: E988-E998, 2010.
6. Frisard MI, Wu Y, McMillan RP, Voelker KA, Wahlberg KA, Anderson AS, Boutagy N, Resendes K, Ravussin E, Hulver MW. Low levels of lipopolysaccharide modulate mitochondrial oxygen consumption in skeletal muscle. Metabolism 64: 416-427, 2015.
7. Furukawa S, Fujita T, Shimabukuro M, Iwaki M, Yamada Y, Nakajima Y, Nakayama O, Makishima M, Matsuda M, Shimomura I. Increased oxidative stress in obesity and its impact on metabolic syndrome. J Clin Invest 114: 1752-1761, 2004.
8. Gerencser AA, Neilson A, Choi SW, Edman U, Yadava N, Oh RJ, Ferrick DA, Nicholls DG, Brand MD. Quantitative microplate-based respirometry with correction for oxygen diffusion. Anal Chem 81: 6868-6878, 2009.
9. Huang S, Rutkowsky JM, Snodgrass RG, Ono-Moore KD, Schneider DA, Newman JW, Adams SH, Hwang DH. Saturated fatty acids activate TLR-mediated proinflammatory signaling pathways. J Lipid Res 53: 2002-2013, 2012.
10. Kim F, Pham M, Luttrell I, Bannerman DD, Tupper J, Thaler J, Hawn TR, Raines EW, Schwartz MW. Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity. Circ Res 100: 1589-1596, 2007.
11. Kirkinezos IG, Moraes CT. Reactive oxygen species and mitochondrial diseases. Sem Cell Dev Biol 12: 449-457, 2001.
12. Kolek MJ, Carlquist JF, Muhlestein JB, Whiting BM, Horne BD, Bair TL, Anderson JL. Toll-like receptor 4 gene Asp299Gly polymorphism is associated with reductions in vascular inflammation, angiographic coronary artery disease, and clinical diabetes. Am Heart J 148: 1034-1040, 2004.
13. Reyna SM, Ghosh S, Tantiwong P, Meka CS, Eagan P, Jenkinson CP, Cersosimo E, Defronzo RA, Coletta DK, Sriwijitkamol A, Musi N. Elevated toll-like receptor 4 expression and signaling in muscle from insulin-resistant subjects. Diabetes 57: 2595-2602, 2008.
14. Saitoh S. Chaperones and transport proteins regulate TLR4 trafficking and activation. Immunobiology 214: 594-600, 2009.
15. Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, Flier JS. TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest 116: 3015-3025, 2006.
16. Stump CS, Henriksen EJ, Wei Y, Sowers JR. The metabolic syndrome: role of skeletal muscle metabolism. Ann Med 38: 389-402, 2006.
17. Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B, Mirmira RG. Islet β-cell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 61: 818-827, 2012.
18. Tsukumo DM, Carvalho-Filho MA, Carvalheira JB, Prada PO, Hirabara SM, Schenka AA, Araujo EP, Vassallo J, Curi R, Velloso LA, Saad MJ. Loss-of-function mutation in Toll-like receptor 4 prevents dietinduced obesity and insulin resistance. Diabetes 56: 1986-1998, 2007.
19. Uchida K. 4-Hydroxy-2-nonenal: a product and mediator of oxidative stress. Prog Lipid Res 42: 318-343, 2003.
20. Wellen KE, Hotamisligil GS. Inflammation, stress, and diabetes. J Clin Invest 115: 1111-1119, 2005.
21. Wellen KE, Hotamisligil GS. Obesity-induced inflammatory changes in adipose tissue. J Clin Invest 112: 1785-1788, 2003.