-
1
-
-
0141890200
-
Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14
-
Akashi S., Saitoh S., Wakabayashi Y., Kikuchi T., Takamura N., Nagai Y., Kusumoto Y., Fukase K., Kusumoto S., Adachi Y., Kosugi A., and Miyake K. Lipopolysaccharide interaction with cell surface Toll-like receptor 4-MD-2: higher affinity than that with MD-2 or CD14. J. Exp. Med. 198 (2003) 1035-1042
-
(2003)
J. Exp. Med.
, vol.198
, pp. 1035-1042
-
-
Akashi, S.1
Saitoh, S.2
Wakabayashi, Y.3
Kikuchi, T.4
Takamura, N.5
Nagai, Y.6
Kusumoto, Y.7
Fukase, K.8
Kusumoto, S.9
Adachi, Y.10
Kosugi, A.11
Miyake, K.12
-
2
-
-
3142724031
-
Toll-like receptor signalling
-
Akira S., and Takeda K. Toll-like receptor signalling. Nat. Rev. Immunol. 4 (2004) 499-511
-
(2004)
Nat. Rev. Immunol.
, vol.4
, pp. 499-511
-
-
Akira, S.1
Takeda, K.2
-
3
-
-
32944464648
-
Pathogen recognition and innate immunity
-
Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
-
(2006)
Cell
, vol.124
, pp. 783-801
-
-
Akira, S.1
Uematsu, S.2
Takeuchi, O.3
-
4
-
-
2442643942
-
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
-
Chuang T., and Ulevitch R. Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. Nat. Immunol. 5 (2004) 495-502
-
(2004)
Nat. Immunol.
, vol.5
, pp. 495-502
-
-
Chuang, T.1
Ulevitch, R.2
-
5
-
-
0037180768
-
The immunopathogenesis of sepsis
-
Cohen J. The immunopathogenesis of sepsis. Nature 420 (2002) 885-891
-
(2002)
Nature
, vol.420
, pp. 885-891
-
-
Cohen, J.1
-
6
-
-
0037127309
-
MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor
-
da Silva Correia J., and Ulevitch R. MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J. Biol. Chem. 277 (2002) 1845-1854
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1845-1854
-
-
da Silva Correia, J.1
Ulevitch, R.2
-
8
-
-
0021798736
-
Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities
-
Galanos C., Luderitz O., Rietschel E., Westphal O., Brade H., Brade L., Freudenberg M., Schade U., Imoto M., Yoshimura H., Kusumoto S., and Shiba T. Synthetic and natural Escherichia coli free lipid A express identical endotoxic activities. Eur. J. Biochem. 148 (1985) 1-5
-
(1985)
Eur. J. Biochem.
, vol.148
, pp. 1-5
-
-
Galanos, C.1
Luderitz, O.2
Rietschel, E.3
Westphal, O.4
Brade, H.5
Brade, L.6
Freudenberg, M.7
Schade, U.8
Imoto, M.9
Yoshimura, H.10
Kusumoto, S.11
Shiba, T.12
-
9
-
-
0036222620
-
Human Toll-like receptor 4 recognizes host-specific LPS modifications
-
Hajjar A., Ernst R., Tsai J., Wilson C., and Miller S. Human Toll-like receptor 4 recognizes host-specific LPS modifications. Nat. Immunol. 3 (2002) 354-359
-
(2002)
Nat. Immunol.
, vol.3
, pp. 354-359
-
-
Hajjar, A.1
Ernst, R.2
Tsai, J.3
Wilson, C.4
Miller, S.5
-
10
-
-
0033120081
-
Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product
-
Hoshino K., Takeuchi O., Kawai T., Sanjo H., Ogawa T., Takeda Y., Takeda K., and Akira S. Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J. Immunol. 162 (1999) 3749-3752
-
(1999)
J. Immunol.
, vol.162
, pp. 3749-3752
-
-
Hoshino, K.1
Takeuchi, O.2
Kawai, T.3
Sanjo, H.4
Ogawa, T.5
Takeda, Y.6
Takeda, K.7
Akira, S.8
-
11
-
-
33644508366
-
Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
-
Husebye H., Halaas Ø., Stenmark H., Tunheim G., Sandanger Ø., Bogen B., Brech A., Latz E., and Espevik T. Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity. EMBO J. 25 (2006) 683-692
-
(2006)
EMBO J.
, vol.25
, pp. 683-692
-
-
Husebye, H.1
Halaas, Ø.2
Stenmark, H.3
Tunheim, G.4
Sandanger, Ø.5
Bogen, B.6
Brech, A.7
Latz, E.8
Espevik, T.9
-
13
-
-
33646494167
-
Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering
-
Kobayashi M., Saitoh S., Tanimura N., Takahashi K., Kawasaki K., Nishijima M., Fujimoto Y., Fukase K., Akashi-Takamura S., and Miyake K. Regulatory roles for MD-2 and TLR4 in ligand-induced receptor clustering. J. Immunol. 176 (2006) 6211-6218
-
(2006)
J. Immunol.
, vol.176
, pp. 6211-6218
-
-
Kobayashi, M.1
Saitoh, S.2
Tanimura, N.3
Takahashi, K.4
Kawasaki, K.5
Nishijima, M.6
Fujimoto, Y.7
Fukase, K.8
Akashi-Takamura, S.9
Miyake, K.10
-
14
-
-
0347659154
-
Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs
-
Kusumoto S., Fukase K., Fukase Y., Kataoka M., Yoshizaki H., Sato K., Oikawa M., and Suda Y. Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs. J. Endotoxin Res. 9 (2003) 361-366
-
(2003)
J. Endotoxin Res.
, vol.9
, pp. 361-366
-
-
Kusumoto, S.1
Fukase, K.2
Fukase, Y.3
Kataoka, M.4
Yoshizaki, H.5
Sato, K.6
Oikawa, M.7
Suda, Y.8
-
15
-
-
34250854079
-
The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4
-
Mata-Haro V., Cekic C., Martin M., Chilton P., Casella C., and Mitchell T. The vaccine adjuvant monophosphoryl lipid A as a TRIF-biased agonist of TLR4. Science 316 (2007) 1628-1632
-
(2007)
Science
, vol.316
, pp. 1628-1632
-
-
Mata-Haro, V.1
Cekic, C.2
Martin, M.3
Chilton, P.4
Casella, C.5
Mitchell, T.6
-
16
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Nagai Y., Akashi S., Nagafuku M., Ogata M., Iwakura Y., Akira S., Kitamura T., Kosugi A., Kimoto M., and Miyake K. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol. 3 (2002) 667-672
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667-672
-
-
Nagai, Y.1
Akashi, S.2
Nagafuku, M.3
Ogata, M.4
Iwakura, Y.5
Akira, S.6
Kitamura, T.7
Kosugi, A.8
Kimoto, M.9
Miyake, K.10
-
17
-
-
20244384395
-
Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression
-
Nomura F., Akashi S., Sakao Y., Sato S., Kawai T., Matsumoto M., Nakanishi K., Kimoto M., Miyake K., Takeda K., and Akira S. Endotoxin tolerance in mouse peritoneal macrophages correlates with down-regulation of surface toll-like receptor 4 expression. J. Immunol. 164 (2000) 3476-3479
-
(2000)
J. Immunol.
, vol.164
, pp. 3476-3479
-
-
Nomura, F.1
Akashi, S.2
Sakao, Y.3
Sato, S.4
Kawai, T.5
Matsumoto, M.6
Nakanishi, K.7
Kimoto, M.8
Miyake, K.9
Takeda, K.10
Akira, S.11
-
18
-
-
0032509295
-
Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene
-
Poltorak A., He X., Smirnova I., Liu M., Van Huffel C., Du X., Birdwell D., Alejos E., Silva M., Galanos C., Freudenberg M., Ricciardi-Castagnoli P., Layton B., and Beutler B. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282 (1998) 2085-2088
-
(1998)
Science
, vol.282
, pp. 2085-2088
-
-
Poltorak, A.1
He, X.2
Smirnova, I.3
Liu, M.4
Van Huffel, C.5
Du, X.6
Birdwell, D.7
Alejos, E.8
Silva, M.9
Galanos, C.10
Freudenberg, M.11
Ricciardi-Castagnoli, P.12
Layton, B.13
Beutler, B.14
-
19
-
-
0345561540
-
Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4)
-
Qureshi S., Lariviere L., Leveque G., Clermont S., Moore K., Gros P., and Malo D. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med. 189 (1999) 615-625
-
(1999)
J. Exp. Med.
, vol.189
, pp. 615-625
-
-
Qureshi, S.1
Lariviere, L.2
Leveque, G.3
Clermont, S.4
Moore, K.5
Gros, P.6
Malo, D.7
-
21
-
-
0034795208
-
Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability
-
Randow F., and Seed B. Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability. Nat. Cell Biol. 3 (2001) 891-896
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 891-896
-
-
Randow, F.1
Seed, B.2
-
22
-
-
3242690772
-
Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization
-
Saitoh S., Akashi S., Yamada T., Tanimura N., Kobayashi M., Konno K., Matsumoto F., Fukase K., Kusumoto S., Nagai Y., et al. Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization. Int. Immunol. 16 (2004) 961-969
-
(2004)
Int. Immunol.
, vol.16
, pp. 961-969
-
-
Saitoh, S.1
Akashi, S.2
Yamada, T.3
Tanimura, N.4
Kobayashi, M.5
Konno, K.6
Matsumoto, F.7
Fukase, K.8
Kusumoto, S.9
Nagai, Y.10
-
23
-
-
0032533819
-
The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity
-
Schromm A., Brandenburg K., Loppnow H., Zahringer U., Rietschel E., Carroll S., Koch M., Kusumoto S., and Seydel U. The charge of endotoxin molecules influences their conformation and IL-6-inducing capacity. J. Immunol. 161 (1998) 5464-5471
-
(1998)
J. Immunol.
, vol.161
, pp. 5464-5471
-
-
Schromm, A.1
Brandenburg, K.2
Loppnow, H.3
Zahringer, U.4
Rietschel, E.5
Carroll, S.6
Koch, M.7
Kusumoto, S.8
Seydel, U.9
-
24
-
-
0001654207
-
Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion
-
Schromm A., Brandenburg K., Loppnow H., Moran A., Koch M., Rietschel E., and Seydel U. Biological activities of lipopolysaccharides are determined by the shape of their lipid A portion. Eur. J. Biochem. 267 (2000) 2008-2013
-
(2000)
Eur. J. Biochem.
, vol.267
, pp. 2008-2013
-
-
Schromm, A.1
Brandenburg, K.2
Loppnow, H.3
Moran, A.4
Koch, M.5
Rietschel, E.6
Seydel, U.7
-
25
-
-
0033532629
-
MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4
-
Shimazu R., Akashi S., Ogata H., Nagai Y., Fukudome K., Miyake K., and Kimoto M. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J. Exp. Med. 189 (1999) 1777-1782
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1777-1782
-
-
Shimazu, R.1
Akashi, S.2
Ogata, H.3
Nagai, Y.4
Fukudome, K.5
Miyake, K.6
Kimoto, M.7
-
26
-
-
36549072863
-
A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses
-
Takahashi K., Shibata T., Akashi-Takamura S., Kiyokawa T., Wakabayashi Y., Tanimura N., Kobayashi T., Matsumoto F., Fukui R., Kouro T., Nagai Y., Takatsu K., Saitoh S.-I., and Miyake K. A protein associated with Toll-like receptor (TLR) 4 (PRAT4A) is required for TLR-dependent immune responses. J. Exp. Med. 204 (2007) 2963-2976
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2963-2976
-
-
Takahashi, K.1
Shibata, T.2
Akashi-Takamura, S.3
Kiyokawa, T.4
Wakabayashi, Y.5
Tanimura, N.6
Kobayashi, T.7
Matsumoto, F.8
Fukui, R.9
Kouro, T.10
Nagai, Y.11
Takatsu, K.12
Saitoh, S.-I.13
Miyake, K.14
-
27
-
-
0024529891
-
The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome
-
Waage A., Brandtzaeg P., Halstensen A., Kierulf P., and Espevik T. The complex pattern of cytokines in serum from patients with meningococcal septic shock. Association between interleukin 6, interleukin 1, and fatal outcome. J. Exp. Med. 169 (1989) 333-338
-
(1989)
J. Exp. Med.
, vol.169
, pp. 333-338
-
-
Waage, A.1
Brandtzaeg, P.2
Halstensen, A.3
Kierulf, P.4
Espevik, T.5
-
28
-
-
33746214788
-
A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4
-
Wakabayashi Y., Kobayashi M., Akashi-Takamura S., Tanimura N., Konno K., Takahashi K., Ishii T., Mizutani T., Iba H., Kouro T., Takaki S., Takatsu K., Oda Y., Ishihama Y., Saitoh S.-I., and Miyake K. A protein associated with toll-like receptor 4 (PRAT4A) regulates cell surface expression of TLR4. J. Immunol. 177 (2006) 1772-1779
-
(2006)
J. Immunol.
, vol.177
, pp. 1772-1779
-
-
Wakabayashi, Y.1
Kobayashi, M.2
Akashi-Takamura, S.3
Tanimura, N.4
Konno, K.5
Takahashi, K.6
Ishii, T.7
Mizutani, T.8
Iba, H.9
Kouro, T.10
Takaki, S.11
Takatsu, K.12
Oda, Y.13
Ishihama, Y.14
Saitoh, S.-I.15
Miyake, K.16
-
29
-
-
34547953017
-
Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4
-
Wang Y., Chen T., Han C., He D., Liu H., An H., Cai Z., and Cao X. Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Blood 110 (2007) 962-971
-
(2007)
Blood
, vol.110
, pp. 962-971
-
-
Wang, Y.1
Chen, T.2
Han, C.3
He, D.4
Liu, H.5
An, H.6
Cai, Z.7
Cao, X.8
-
30
-
-
33847260278
-
Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages
-
Yang Y., Liu B., Dai J., Srivastava P., Zammit D., Lefrançois L., and Li Z. Heat shock protein gp96 is a master chaperone for toll-like receptors and is important in the innate function of macrophages. Immunity 26 (2007) 215-226
-
(2007)
Immunity
, vol.26
, pp. 215-226
-
-
Yang, Y.1
Liu, B.2
Dai, J.3
Srivastava, P.4
Zammit, D.5
Lefrançois, L.6
Li, Z.7
|