Functional relevance of a six mesenchymal gene signature in epithelial-mesenchymal transition (EMT) reversal by the triple angiokinase inhibitor, nintedanib (BIBF1120)

Oncotarget

Volumn 6, Issue 26, 2015, Pages 22098-22113

  Huang, Ruby Yun Ju ^a,b   Kuay, Kuee Theng ^b   Tan, Tuan Zea ^b   Asad, Mohammad ^a   Tang, Hei Mui ^b   Chun Ng, Aloysius Hsien ^c   Ye, Jieru ^b,c   Chung, Vin Yee ^b   Thiery, Jean Paul ^b,d,e  

^a NATIONAL UNIVERSITY HEALTH SYSTEM   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^d INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^e NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

EMT reversal; Epithelial mesenchymal transition (EMT); Nintedanib; SiRNA screen; Triple angiokinase inhibitor

Indexed keywords

NINTEDANIB; SARACATINIB; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR ZEB1; UVOMORULIN; ANTINEOPLASTIC AGENT; ENZYME INHIBITOR; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CD99L2 GENE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; EMP3 GENE; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE; GENE EXPRESSION; GENE IDENTIFICATION; GENE SILENCING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ITGA5 GENE; MOUSE; NONHUMAN; OVARIAN CANCER CELL LINE; PROTEIN EXPRESSION; SYDE1 GENE; UPREGULATION; VIM GENE; ZEB1 GENE; ANIMAL; BAGG ALBINO MOUSE; DRUG EFFECTS; GENETICS; METABOLISM; NUDE MOUSE; OVARIAN NEOPLASMS; PATHOLOGY; TREATMENT OUTCOME; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME INHIBITORS; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; HUMANS; INDOLES; MICE; MICE, INBRED BALB C; MICE, NUDE; OVARIAN NEOPLASMS; TREATMENT OUTCOME;

EID: 84941236553     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.4300     Document Type: Article

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