Pharmacological TLR4 inhibition protects against acute and chronic fat-induced insulin resistance in rats

PLoS ONE

Volumn 10, Issue 7, 2015, Pages

  Zhang, Ning ^a   Liang, Hanyu ^a,b,c   Farese, Robert V ^d,e   Li, Ji ^a,b   Musi, Nicolas ^a,b,c   Hussey, Sophie E ^d,e  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b University of Texas Health Science Center   (United States)

^c SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^d UNIVERSITY OF SOUTH FLORIDA   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERITORAN; GLUCOSE; INSULIN; INTRALIPID; PLACEBO; RESATORVID; TOLL LIKE RECEPTOR 4; ETHYL 6-(N-(2-CHLORO-4-FLUOROPHENYL)SULFAMOYL)CYCLOHEX-1-ENE-1-CARBOXYLATE; LIPID; LIPID A; SULFONAMIDE; TLR4 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIC INTAKE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; DRUG PELLET; GLUCONEOGENESIS; IN VIVO STUDY; INSULIN RESISTANCE; LIPID DIET; LIVER; LOW DRUG DOSE; LOW FAT DIET; MALE; NONHUMAN; OBESITY; PROPHYLAXIS; RAT; RECEPTOR BLOCKING; SLOW DRUG RELEASE; STEADY STATE; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; LONG EVANS RAT; METABOLISM; PATHOLOGY; WISTAR RAT;

ANIMALS; BODY WEIGHT; DIET, HIGH-FAT; GLUCOSE; INSULIN RESISTANCE; LIPID A; LIPIDS; LIVER; MALE; OBESITY; RATS, LONG-EVANS; RATS, WISTAR; SULFONAMIDES; TOLL-LIKE RECEPTOR 4;

EID: 84941205508     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0132575     Document Type: Article

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