Long-Term Amorphous Drug Stability Predictions Using Easily Calculated, Predicted, and Measured Parameters

Molecular Pharmaceutics

Volumn 12, Issue 9, 2015, Pages 3389-3398

  Nurzyńska, Katarzyna ^a   Booth, Jonathan ^b   Roberts, Clive J ^a   McCabe, James ^b   Dryden, Ian ^a   Fischer, Peter M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

amorphous; crystallization; poorly soluble drug; prediction; stability

Indexed keywords

AMORPHOUS DRUG; DRUG; UNCLASSIFIED DRUG;

AMORPHOUS DRUG STABILITY; ARTICLE; CHEMICAL STRUCTURE; COOLING; CRYSTALLIZATION; DRUG STABILITY; ENTHALPY; EXPLANATORY VARIABLE; MELTING POINT; MICROSCOPY; MOLECULAR WEIGHT; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; QUENCH COOLING; RESPONSE VARIABLE; STATISTICAL MODEL; THERMODYNAMICS; CHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; HYDROGEN BOND; KINETICS; MEDICINAL CHEMISTRY; SOLUBILITY; TEMPERATURE; TRANSITION TEMPERATURE; X RAY DIFFRACTION;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; HYDROGEN BONDING; KINETICS; MODELS, STATISTICAL; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; TEMPERATURE; THERMODYNAMICS; TRANSITION TEMPERATURE; X-RAY DIFFRACTION;

EID: 84941114243     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/acs.molpharmaceut.5b00409     Document Type: Article

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