Cardiovascular Complications of Calcium Supplements

Journal of Cellular Biochemistry

Volumn 116, Issue 4, 2015, Pages 494-501

  Reid, Ian R ^a,b   Bristow, Sarah M ^a   Bolland, Mark J ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b AUCKLAND DISTRICT HEALTH BOARD   (New Zealand)

Author keywords

CALCIUM; MYOCARDIAL INFARCTION; OSTEOPOROSIS; STROKE

Indexed keywords

CALCIUM; CALCIUM INTAKE; VITAMIN D;

ARTICLE; CALCIUM BLOOD LEVEL; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; HUMAN; META ANALYSIS (TOPIC); OBSERVATIONAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); SUPPLEMENTATION; ADVERSE EFFECTS; BLOOD; CALCIUM INTAKE; CARDIOVASCULAR DISEASES; CLINICAL TRIAL (TOPIC); META ANALYSIS; RISK FACTOR;

CALCIUM, DIETARY; CARDIOVASCULAR DISEASES; CLINICAL TRIALS AS TOPIC; HUMANS; RISK FACTORS; VITAMIN D;

EID: 84941082970     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.25028     Document Type: Article

References (55)

1. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR,. 2010a. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: Meta-analysis. BMJ 341: C3691.
2. Bolland MJ, Barber PA, Doughty RN, Mason B, Horne A, Ames R, Gamble GD, Grey A, Reid IR,. 2008. Vascular events in healthy older women receiving calcium supplementation: Randomised controlled trial. BMJ 336: 262-266.
3. Bolland MJ, Grey A,. 2014. A comparison of adverse event and fracture efficacy data for strontium ranelate in regulatory documents and the publication record. BMJ Open 4: e05787.
4. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR,. 2011a. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 342:d2040. doi: 10.1136/bmj.d2040
5. Bolland MJ, Grey A, Gamble GD, Reid IR,. 2011b. Calcium and vitamin D supplements and health outcomes: A reanalysis of the Women's Health Initiative (WHI) limited-access data set. Am J Clin Nutr 94: 1144-1149.
6. Bolland MJ, Grey A, Gamble GD, Reid IR,. 2014. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: A trial sequential meta-analysis. The Lancet Diabetes and Endocrinology 2: 307-320.
7. Bolland MJ, Grey A, Reid IR,. 2013. Calcium supplements and cardiovascular risk: 5 years on. Ther Adv Drug Saf 4: 199-210.
8. Bolland MJ, Wang TKM, van Pelt NC, Horne AM, Mason BH, Ames RW, Grey AB, Ruygrok PN, Gamble GD, Reid IR,. 2010b. Abdominal aortic calcification on vertebral morphometry images predicts incident myocardial infarction. J Bone Miner Res 25: 505-512.
9. Bristow SM, Gamble GD, Stewart A, Horne L, House ME, Aati O, Mihov B, Horne AM, Reid IR,. 2014. Acute and 3-month effects of microcrystalline hydroxyapatite, calcium citrate and calcium carbonate on serum calcium and markers of bone turnover: A randomised controlled trial in postmenopausal women. Br J Nutr doi: 10.1017/S0007114514002785
10. Chapuy MC, Arlot ME, Duboeuf F, Brun J, Crouzet B, Arnaud S, Delmas PD, Meunier PJ,. 1992. Vitamin-D3 and calcium to prevent hip fractures in elderly women. New England Journal of Medicine 327: 1637-1642.
11. Curtis JR, Delzell E, Chen L, Black D, Ensrud K, Judd S, Safford MM, Schwartz AV, Bauer DC,. 2011. The relationship between bisphosphonate adherence and fracture: Is it the behavior or the medication? Results from the placebo arm of the fracture intervention trial. J Bone Miner Res 26: 683-688.
12. Daly R, Ebeling P, Khan B, Nowson C,. 2009. Effects of calcium-vitamin D3 fortified milk on abdominal aortic calcification in older men: retrospective analysis of a 2-year randomised controlled trial. J Bone Miner Res 24 supp 1: s65-s66.
13. Di Iorio B, Bellasi A, Russo D,. 2012. Mortality in Kidney Disease Patients Treated with Phosphate Binders: A Randomized Study. Clin J Am Soc Nephro 7: 487-493.
14. Ford JA, MacLennan GS, Avenell A, Bolland M, Grey A, Witham M,. 2014. Cardiovascular disease and vitamin D supplementation: Trial analysis, systematic review, and meta-analysis. Am Journal Clin Nutr 100: 746-755.
15. Fryer RM, Segreti JA, Widomski DL, Franklin PH, Banfor PN, Koch KA, Nakane M, Wu-Wong JR, Cox BF, Reinhart GA,. 2007. Systemic activation of the calcium sensing receptor produces acute effects on vascular tone and circulatory function in uremic and normal rats: Focus on central versus peripheral control of vascular tone and blood pressure by cinacalcet. J Pharm Exp Ther 323: 217-226.
16. Gallagher JC, Smith LM, Yalamanchili V,. 2014. Incidence of hypercalciuria and hypercalcemia during vitamin D and calcium supplementation in older women. Menopause 21: 1173-1180.
17. Grant AM, Avenell A, Campbell MK, McDonald AM, MacLennan GS, McPherson GC, Anderson FH, Cooper C, Francis RM, Donaldson C, Gillespie WJ, Robinson CM, Torgerson DJ, Wallace WA,. 2005. Oral vitamin D3 and calcium for secondary prevention of low-trauma fractures in elderly people (Randomised Evaluation of Calcium Or vitamin D, RECORD): A randomised placebo-controlled trial. Lancet 365: 1621-1628.
18. Guillemant J, Guillemant S, 1993. Comparison of the Suppressive Effect of Two Doses (500 mg vs 1500mg) of Oral Calcium on Parathyroid Hormone Secretion, on Urinary Cyclic AMP. Calcif Tissue Int 53: 304-306.
19. Hilgard P, 1973. Experimental hypercalcaemia and whole blood clotting. J Clin Path 28: 616-619.
20. Hsia J, Heiss G, Ren H, Allison M, Dolan NC, Greenland P, Heckbert SR, Johnson KC, Manson JE, Sidney S, Trevisan M, 2007. Calcium/vitamin D supplementation and cardiovascular events. Circulation 115: 846-854.
21. Jackson RD, LaCroix AZ, Gass M, Wallace RB, Robbins J, Lewis CE, Bassford T, Beresford SAA, Black HR, Blanchette P, Bonds DE, Brunner RL, Brzyski RG, Caan B, Cauley JA, Chlebowski RT, Cummings SR, Granek I, Hays J, Heiss G, Hendrix SL, Howard BV, Hsia J, Hubbell FA, Johnson KC, Judd H, Kotchen JM, Kuller LH, Langer RD, Lasser NL, Limacher MC, Ludlam S, Manson JE, Margolis KL, McGowan J, Ockene JK, O'Sullivan MJ, Phillips L, Prentice RL, Sarto GE, Stefanick ML, Van Horn L, Wactawski-Wende J, Whitlock E, Anderson GL, Assaf AR, Barad D, 2006. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med 354: 669-683.
22. James MFM, Roche AM, 2004. Dose-response relationship between plasma ionized calcium concentration and thrombelastography. J Cardiothorac Vasc Anesth 18: 581-586.
23. Kamycheva E, Jorde R, Haug E, Sager G, Sundsfjord J, 2005. Effects of acute hypercalcaemia on blood pressure in subjects with and without parathyroid hormone secretion. Acta Physiol Scandinavica 184: 113-119.
24. Kruger MC, Hurst PRv, Booth CL, Kuhn-Sherlock B, Todd JM, Schollum LM, 2014. Postprandial metabolic responses of serum calcium, parathyroid hormone and C-telopeptide of type I collagen to three doses of calcium delivered in milk. J Nutr Sci 3: e6 doi: 10.1017/jns.2014.2
25. Kwak SM, Kim JS, Choi Y, Chang Y, Kwon MJ, Jung JG, Jeong C, Ahn J, Kim HS, Shin H, Ryu S, 2014. Dietary intake of calcium and phosphorus and serum concentration in relation to the risk of coronary artery calcification in asymptomatic adults. Arterioscler Thromb Vasc Biol 34: 1763-1769.
26. Lamas GA, Goertz C, Boineau R, Mark DB, Rozema T, Nahin RL, Lindblad L, Lewis EF, Drisko J, Lee KL, Tact Investigators 2013. Effect of disodium EDTA chelation regimen on cardiovascular events in patients with previous myocardial infarction. The TACT randomized trial. JAMA 309: 1241-1250.
27. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP, 2007. Vitamin D and calcium supplementation reduces cancer risk: Results of a randomized trial. Am J Clin Nutr 85: 1586-91.
28. Larsen ER, Mosekilde L, Foldspang A, 2004. Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: A pragmatic population-based 3-year intervention study. J Bone Min Res 19: 370-378.
29. Leifsson BG, Ahren B, 1996. Serum calcium and survival in a large health screening program. J Clin Endocrinol Metab 81: 2149-2153.
30. Lewis JR, Calver J, Zhu K, Flicker L, Prince RL, 2011. Calcium supplementation and the risks of atherosclerotic vascular disease in older women: Results of a 5-year RCT and a 4.5-year follow-up. J Bone Min Res 26: 35-41.
31. Lewis JR, Radavelli-Bagatini S, Rejnmark L, Chen JS, Simpson JM, Lappe JM, Mosekilde L, Prentice RL, Prince RL, 2014. The effects of calcium supplementation on verified coronary heart disease hospitalization and death in postmenopausal women: A collaborative meta-analysis of randomized controlled trials. J Bone Miner Res doi: [ 10.1002/jbmr.2311
32. Lewis JR, Zhu K, Prince RL, 2012. Adverse events from calcium supplementation: relationship to errors in myocardial infarction self-reporting in randomized controlled trials of calcium supplementation. J Bone Min Res 27: 719-722.
33. Li S, Na L, Li Y, Gong L, Yuan F, Niu Y, Zhao Y, Sun C, 2013. Long-term calcium supplementation may have adverse effects on serum cholesterol and carotid intima-media thickness in postmenopausal women: A double-blind, randomized, placebo-controlled trial. Am J Clin Nutr 98: 1353-1359.
34. Lind L, Skarfors E, Berglund L, Lithell H, Ljunghall S, 1997. Serum calcium: A new, independent, prospective risk factor for myocardial infarction in middle-aged men followed for 18 years. J Clin Epidemiol 50: 967-73.
35. Locatelli F, Cavalli A, Tucci B, 2010. The growing problem of intradialytic hypertension. Nat Rev Nephrol 6: 41-48.
36. Lubwama R, Nguyen A, Modi A, Diana C, Miller PD, 2014. Prevalence of renal impairment among osteoporotic women in the USA, NHANES 2005-2008: Is treatment with bisphosphonates an option ? Osteoporos Int 25: 1607-1615.
37. Lutsey PL, Alonso A, Michos ED, Loehr LR, Astor BC, Coresh J, Folsom AR,. 2014. Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: The Atherosclerosis Risk in Communities (ARIC) Study. Am J Clin Nutr 100: 756-64.
38. Mao P-J, Zhang C, Tang L, Xian Y-Q, Li Y-S, Wang W-D, Zhu X-H, Qiu H-L, He J, Zhou Y-H, 2013. Effect of calcium or vitamin D supplementation on vascular outcomes: A meta-analysis of randomized controlled trials. Int J Cardiol 169: 106-111.
39. Marz W, Seelhorst U, Wellnitz B, Tiran B, Obermayer-Pietsch B, Renner W, Boehm BO, Ritz E, Hoffmann MM, 2007. Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality. J Clin Endocrinol Metab 92: 2363-2369.
40. Nilsson IL, Rastad J, Johansson K, Lind L, 2001. Endothelial vasodilatory function and blood pressure response to local and systemic hypercalcemia. Surgery 130: 986-990.
41. Paik JM, Curhan GC, Sun Q, Rexrode KM, Manson JE, Rimm EB, Taylor EN, 2014. Calcium supplement intake and risk of cardiovascular disease in women. Osteoporos Int 25: 2047-2056.
42. Radford LT, Bolland MJ, Gamble GD, Grey A, Reid IR, 2013. Subgroup analysis for the risk of cardiovascular disease with calcium supplements. BoneKEy Reports 2:doi: 10.1038/bonekey.2013.27
43. Reid IR, Bolland MJ, 2014. Calcium risk-benefit updated-New WHI analyses. Maturitas 77: 1-3.
44. Reid IR, Bolland MJ, Avenell A, Grey A, 2011a Cardiovascular effects of calcium supplementation. Osteoporos Int doi: 10.1007/s00198-011-1599- 9.
45. Reid IR, Bolland MJ, Sambrook PN, Grey A, 2011b Calcium supplementation: Balancing the cardiovascular risks. Maturitas 69: 289-295.
46. Reid IR, Horne A, Mason B, Ames R, Bava U, Gamble GD, 2005. Effects of calcium supplementation on body weight and blood pressure in normal older women: A randomized controlled trial. J Clin Endocrinol Metab 90: 3824-3829.
47. Reid IR, Mason B, Horne A, Ames R, Reid HE, Bava U, Bolland MJ, Gamble GD, 2006. Randomized controlled trial of calcium in healthy older women. Am J Med 119: 777-785.
48. Reynolds JL, Joannides AJ, Skepper JN, Mcnair R, Schurgers LJ, Proudfoot D, Jahnen-Dechent W, Weissberg PL, Shanahan CM, 2004. Human Vascular Smooth Muscle Cells Undergo Vesicle-Mediated Calcification in Response to Changes in Extracellular Calcium and Phosphate Concentrations: A Potential Mechanism for Accelerated Vascular Calcification in ESRD.J. Am. Soc Nephrol 15: 2857-2867.
49. Rubin MR, Rundek T, McMahon DJ, Lee H-S, Sacco RL, Silverberg SJ, 2007. Carotid artery plaque thickness is associated with increased serum calcium levels: the Northern Manhattan study. Atherosclerosis 194: 426-32.
50. Russo D, Miranda I, Ruocco C, Battaglia Y, Buonanno E, Manzi S, Russo L, Scafarto A, Andreucci VE, 2007. The progression of coronary artery calcification in predialysis patients on calcium carbonate or sevelamer. Kidney Int 72: 1255-1261.
51. Sambrook PN, Cameron ID, Chen JS, Cumming RG, Durvasula S, Herrmann M, Kok C, Lord SR, Macara M, March LM, Mason RS, Seibel MJ, Wilson N, Simpson JM, 2012. Does increased sunlight exposure work as a strategy to improve vitamin D status in the elderly: A cluster randomised controlled trial. Osteoporos Int 23: 615-624.
52. Shin S, Kim KJ, Chang HJ, Cho I, Kim YJ, Choi BW, Rhee Y, Lim SK, Yang WI, Shim CY, Ha JW, Jang Y, Chung N, 2012. Impact of serum calcium and phosphate on coronary atherosclerosis detected by cardiac computed tomography. Eur Heart J 33: 2873-2881.
53. Slinin Y, Blackwell T, Ishani A, Cummings SR, Ensrud KE, 2011. Serum calcium, phosphorus and cardiovascular events in post-menopausal women. Int J Cardiol 149: 3350.
54. Wang L, Manson JE, Song YQ, Sesso HD, 2010. Systematic Review: Vitamin D and Calcium Supplementation in Prevention of Cardiovascular Events. Ann Intern Med 152: 315-323.
55. Yang H, Curinga G, Giachelli CM, 2004. Elevated extracellular calcium levels induce smooth muscle cell matrix mineralization in vitro. Kidney Int 66: 2293-2299.