Serum magnesium, phosphorus, and calcium are associated with risk of incident heart failure: The Atherosclerosis Risk in Communities (ARIC) Study

American Journal of Clinical Nutrition

Volumn 100, Issue 3, 2014, Pages 756-764

  Lutsey, Pamela L ^a   Alonso, Alvaro ^a   Michos, Erin D ^b   Loehr, Laura R ^c   Astor, Brad C ^d   Coresh, Josef ^e   Folsom, Aaron R ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c IL   (United States)

^d UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^e JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CREATININE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MAGNESIUM; PHOSPHORUS; SERUM ALBUMIN; TRIACYLGLYCEROL; BIOLOGICAL MARKER;

ADULT; AFRICAN AMERICAN; ALBUMIN BLOOD LEVEL; ALCOHOL CONSUMPTION; ARTICLE; ATHEROSCLEROSIS; BEHAVIOR; BLOOD SAMPLING; BODY MASS; CALCIUM BLOOD LEVEL; CARDIOVASCULAR RISK; CAUCASIAN; CHOLESTEROL BLOOD LEVEL; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DIETARY INTAKE; DISEASE ASSOCIATION; EDUCATION; FEMALE; GLOMERULUS FILTRATION RATE; HEART FAILURE; HUMAN; HYPERTENSION; INCIDENCE; ISCHEMIC HEART DISEASE; KIDNEY FUNCTION; MAGNESIUM BLOOD LEVEL; MAJOR CLINICAL STUDY; MALE; PHOSPHATE BLOOD LEVEL; SMOKING; SYSTOLIC BLOOD PRESSURE; BLOOD; CLINICAL TRIAL; COHORT ANALYSIS; FOLLOW UP; HYPERCALCEMIA; HYPERPHOSPHATEMIA; MAGNESIUM DEFICIENCY; MIDDLE AGED; MULTICENTER STUDY; PATHOPHYSIOLOGY; PROPORTIONAL HAZARDS MODEL; RISK FACTOR; UNITED STATES;

ATHEROSCLEROSIS; BIOLOGICAL MARKERS; CALCIUM; COHORT STUDIES; FEMALE; FOLLOW-UP STUDIES; HEART FAILURE; HUMANS; HYPERCALCEMIA; HYPERPHOSPHATEMIA; INCIDENCE; MAGNESIUM; MAGNESIUM DEFICIENCY; MALE; MIDDLE AGED; PHOSPHORUS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS; UNITED STATES;

EID: 84907355772     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.085167     Document Type: Article

References (50)

1. Lloyd-Jones DM, Larson MG, Leip EP, Beiser A, D'Agostino RB, Kannel WB, Murabito JM, Vasan RS, Benjamin EJ, Levy D. Lifetime risk for developing congestive heart failure. Circulation 2002;106:3068-72.
2. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al. Heart disease and stroke statistics - 2013 update: a report from the American Heart Association. Circulation 2013;127:e6-245.
3. Rude RK. Magnesium. In: Coates PM, Betz JM, Blackman MR, Cragg GM, eds. Encyclopedia of dietary supplements. New York, NY: Informa Healthcare, 2010:527-37.
4. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA. Serum phosphorus levels associate with coronary atherosclerosis in young adults. J Am Soc Nephrol 2009;20:397-404.
5. Amann K, Tornig J, Kugel B, Gross M-L, Tyralla K, El-Shakmak A, Szabo A, Ritz E. Hyperphosphatemia aggravates cardiac fibrosis and microvascular disease in experimental uremia. Kidney Int 2003;63:1296-301. (Pubitemid 36349995)
6. Foley RN, Collins AJ, Herzog CA, Ishani A, Kalra PA. Serum phosphate and left ventricular hypertrophy in young adults: the Coronary Artery Risk Development in Young Adults Study. Kidney Blood Press Res 2009;32:37-44.
7. Reid IR, Bolland M, Avenell A, Grey A. Cardiovascular effects of calcium supplementation. Osteoporos Int 2011;22:1649-58.
8. Reid IR, Bolland MJ. Calcium supplements: bad for the heart? Heart 2012;98:895-6.
9. Jee SH, Miller ER, Guallar E, Singh VK, Appel LJ, Klag MJ. The effect of magnesium supplementation on blood pressure: a meta-analysis of randomized clinical trials. Am J Hypertens 2002;15:691-6. (Pubitemid 34804274)
10. He K, Liu K, Daviglus ML, Morris SJ, Loria CM, Van Horn L, Jacobs DR, Savage PJ. Magnesium intake and incidence of metabolic syndrome among young adults. Circulation 2006;113:1675-82.
11. Song Y, He K, Levitan EB, Manson JE, Liu S. Effects of oral magnesium supplementation on glycaemic control in type 2 diabetes: a meta-analysis of randomized double-blind controlled trials. Diabetes Med 2006;23:1050-6. (Pubitemid 44401132)
12. Onufrak SJ, Bellasi A, Shaw LJ, Herzog CA, Cardarelli F, Wilson PW, Vaccarino V, Raggi P. Phosphorus levels are associated with subclinical atherosclerosis in the general population. Atherosclerosis 2008;199:424-31.
13. Dhingra R, Gona P, Benjamin EJ, Wang TJ, Aragam J, D'Agostino RB, Kannel WB, Vasan RS. Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community. Eur J Heart Fail 2010;12:812-8.
14. Ohira T, Peacock JM, Iso H, Chambless LE, Rosamond WD, Folsom AR. Serum and dietary magnesium and risk of ischemic stroke. Am J Epidemiol 2009;169:1437-44.
15. Liao F, Folsom AR, Brancati FL. Is low magnesium concentration a risk factor for coronary heart disease? The Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 1998;136:480-90. (Pubitemid 28413547)
16. Peacock JM, Ohira T, Post W, Sotoodehnia N, Rosamond W, Folsom AR. Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2010;160:464-70.
17. Chakraborti S, Chakraborti T, Mandal M, Mandal A, Das S, Ghosh S. Protective role of magnesium in cardiovascular diseases: a review. Mol Cell Biochem 2002;238:163-79. (Pubitemid 35023539)
18. Eisenberg MJ. Magnesium deficiency and sudden death. Am Heart J 1992;124:544-9.
19. Misialek JR, Lopez FL, Lutsey PL, Huxley RR, Peacock JM, Chen LY, Soliman EZ, Agarwal SK, Alonso A. Serum and dietary magnesium and incidence of atrial fibrillation in whites and in African Americans; Atherosclerosis Risk in Communities (ARIC) Study. Circ J 2013;77:323-9.
20. Dhingra R, Sullivan LM, Fox CS, Wang TJ, D'Agostino RB Sr, Gaziano JM, Vasan RS. Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 2007;167:879-85. (Pubitemid 46762749)
21. Foley RN, Collins AJ, Ishani A, Kalra PA. Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study. Am Heart J 2008;156:556-63.
22. Lind L, Skarfors E, Berglund L, Lithell H, Ljunghall S. Serum calcium: a new, independent, prospective risk factor for myocardial infarction in middle-aged men followed for 18 years. J Clin Epidemiol 1997;50:967-73. (Pubitemid 27423528)
23. Jorde R, Sundsfjord J, Fitzgerald P, Bønaa KH. Serum calcium and cardiovascular risk factors and diseases: the Tromsø Study. Hypertension 1999;34:484-90. (Pubitemid 29426768)
24. Tonelli M, Sacks F, Pfeffer M, Gao Z, Curhan G. Relation between serum phosphate level and cardiovascular event rate in people with coronary disease. Circulation 2005;112:2627-33. (Pubitemid 41532599)
25. The ARIC Investigators. The Atherosclerosis Risk in Communities (ARIC) Study: design and objectives. Am J Epidemiol 1989;129:687-702.
26. The ARIC Investigators. ARIC: Atherosclerosis Risk in Communities Study: operations manual 10. Clinical chemistry determinations. Bethesda, MD: National Heart, Lung, and Blood Institute, 1987.
27. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, Kusek JW, Eggers P, Van Lente F, Greene T, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med 2009;150:604-12.
28. Eriksson H, Caidaul K, Larsson B, Ohlson L-O, Welin L, Wilhelmsen L, Svardsudd K. Cardiac and pulmonary causes of dyspnoea - validation of a scoring test for clinical-epidemiological use: the Study of Men Born in 1913. Eur Heart J 1987;8:1007-14. (Pubitemid 17133021)
29. Loehr LR, Rosamond WD, Chang PP, Folsom AR, Chambless LE. Heart failure incidence and survival (from the Atherosclerosis Risk in Communities Study). Am J Cardiol 2008;101:1016-22.
30. Rosamond WD, Chang PP, Baggett C, Johnson A, Bertoni AG, Shahar E, Deswal A, Heiss G, Chambless LE. Classification of heart failure in the Atherosclerosis Risk in Communities (ARIC) Study: a comparison of diagnostic criteria. Circ Heart Fail 2012;5:152-9.
31. Folsom AR, Yatsuya H, Nettleton JA, Lutsey PL, Cushman M, Rosamond WD. Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J Am Coll Cardiol 2011;57:1690-6.
32. Fox KF, Cowie MR, Wood DA, Coats AJS, Gibbs JSR, Underwood SR, Turner RM, Poole-Wilson PA, Davies SW, Sutton GC. Coronary artery disease as the cause of incident heart failure in the population. Eur Heart J 2001;22:228-36. (Pubitemid 32622473)
33. Arinzon Z, Peisakh A, Schrire S, Berner YN. Prevalence of hypomagnesemia (HM) in a geriatric long-term care (LTC) setting. Arch Gerontol Geriatr 2010;51:36-40.
34. Adamopoulos C, Pitt B, Sui X, Love TE, Zannad F, Ahmed A. Low serum magnesium and cardiovascular mortality in chronic heart failure: a propensity-matched study. Int J Cardiol 2009;136:270-7.
35. Witte KKA, Nikitin NP, Parker AC, von Haehling S, Volk H-D, Anker SD, Clark AL, Cleland JGF. The effect of micronutrient supplementation on quality-of-life and left ventricular function in elderly patients with chronic heart failure. Eur Heart J 2005;26:2238-44. (Pubitemid 41541386)
36. Almoznino-Sarafian D, Sarafian G, Berman S, Shteinshnaider M, Tzur I, Cohen N, Gorelik O. Magnesium administration may improve heart rate variability in patients with heart failure. Nutr Metab Cardiovasc Dis 2009;19:641-5.
37. Miller S, Crystal E, Garfinkle M, Lau C, Lashevsky I, Connolly SJ. Effects of magnesium on atrial fibrillation after cardiac surgery: a meta-analysis. Heart 2005;91:618-23. (Pubitemid 40559351)
38. Ho KM, Lewis JP. Prevention of atrial fibrillation in cardiac surgery: time to consider a multimodality pharmacological approach. Cardiovasc Ther 2010;28:59-65.
39. Lopez FL, Agarwal SK, Grams ME, Loehr LR, Soliman EZ, Lutsey PL, Chen LY, Huxley RR, Alonso A. Relation of serum phosphorus levels to the incidence of atrial fibrillation (from the Atherosclerosis Risk in Communities [ARIC] Study). Am J Cardiol 2013;111:857-62.
40. Khan AM, Lubitz SA, Sullivan LM, Sun JX, Levy D, Vasan RS, Magnani JW, Ellinor PT, Benjamin EJ, Wang TJ. Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Circulation 2013;127:33-8.
41. Wang TJ, Larson MG, Levy D, Vasan RS, Leip EP, Wolf PA, D'Agostino RB, Murabito JM, Kannel WB, Benjamin EJ. Temporal relations of atrial fibrillation and congestive heart failure and their joint influence on mortality: the Framingham Heart Study. Circulation 2003;107:2920-5. (Pubitemid 36736633)
42. Chamberlain AM, Redfield MM, Alonso A, Weston SA, Roger VL. Atrial fibrillation and mortality in heart failure: a community study. Circ Heart Fail 2011;4:740-6.
43. Palmer SC, Hayen A, Macaskill P, Pellegrini F, Craig JC, Elder GJ, Strippoli GFM. Serum levels of phosphorus, parathyroid hormone, and calcium and risks of death and cardiovascular disease in individuals with chronic kidney disease. JAMA 2011;305:1119-27.
44. Faul C, Amaral AP, Oskouei B, Hu M-C, Sloan A, Isakova T, Gutiérrez OM, Aguillon-Prada R, Lincoln J, Hare JM, et al. FGF23 induces left ventricular hypertrophy. J Clin Invest 2011;121:4393-408.
45. Ix JH, Katz R, Kestenbaum BR, de Boer IH, Chonchol M, Mukamal KJ, Rifkin D, Siscovick DS, Sarnak MJ, Shlipak MG. Fibroblast growth factor-23 and death, heart failure, and cardiovascular events in community-living individuals: CHS (Cardiovascular Health Study). J Am Coll Cardiol 2012;60:200-7.
46. Parker BD, Schurgers LJ, Brandenburg VM, Christenson RH, Vermeer C, Ketteler M, Shlipak MG, Whooley MA, Ix JH. The associations of fibroblast growth factor 23 and uncarboxylated matrix Gla protein with mortality in coronary artery disease: the Heart and Soul Study. Ann Intern Med 2010;152:640-8.
47. Wang L, Manson JE, Song Y, Sesso HD. Systematic review: vitamin D and calcium supplementation in prevention of cardiovascular events. Ann Intern Med 2010;152:315-23.
48. Bolland MJ, Grey A, Avenell A, Gamble GD, Reid IR. Calcium supplements with or without vitamin D and risk of cardiovascular events: reanalysis of the Women's Health Initiative limited access dataset and meta-analysis. BMJ 2011;342:d2040.
49. Bolland MJ, Avenell A, Baron JA, Grey A, MacLennan GS, Gamble GD, Reid IR. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010; 341:c3691.
50. Byrd-Bredbenner C, Moe G, Beshgetoor D, Berning J. Wardlaw's perspectives in nutrition. 9th ed. New York, NY: McGraw-Hill, 2013.