Mitochondrial ATP-sensitive K+ channels mediate the antioxidative influence of diosgenin on myocardial reperfusion injury in rat hearts

General Physiology and Biophysics

Volumn 34, Issue 3, 2015, Pages 323-329

  Badalzadeh, Reza ^a,b,c   Yavari, Raana ^c   Chalabiani, Dorna ^c  

^a TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Diosgenin; I R injury; Mito KATP channels; Oxidative stress

Indexed keywords

5 HYDROXYDECANOIC ACID; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CREATINE KINASE MB; DIOSGENIN; GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SUPEROXIDE DISMUTASE; ANTIOXIDANT; CARDIOTONIC AGENT; REACTIVE OXYGEN METABOLITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; HEART PROTECTION; MALE; NONHUMAN; OXIDATIVE STRESS; RAT; REPERFUSION INJURY; ANIMAL; CHANNEL GATING; DRUG EFFECTS; METABOLISM; MITOCHONDRION; MYOCARDIAL REPERFUSION INJURY; TREATMENT OUTCOME; WISTAR RAT;

ANIMALS; ANTIOXIDANTS; CARDIOTONIC AGENTS; DIOSGENIN; ION CHANNEL GATING; KATP CHANNELS; MALE; MITOCHONDRIA; MYOCARDIAL REPERFUSION INJURY; OXIDATIVE STRESS; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; TREATMENT OUTCOME;

EID: 84941051723     PISSN: 02315882     EISSN: 13384325     Source Type: Journal    
DOI: 10.4149/gpb_2015009     Document Type: Article

References (31)

1. Belisle E., Kowaltowski A. J. (2002): Opening of mitochondrial K-channels increases ischemic ATP levels by preventing hydrolysis. J. Bioenerg. Biomembr. 34, 285-298 http://dx.doi.org/10.1023/A:1020256502583
2. Bradford M.M. (1976): Rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem.72, 248-254 http://dx.doi.org/10.1016/0003-2697(76)90527-3
3. Braunwald E., Kloner R. A. (1985): Myocardial reperfusion: a double edged sword? J. Clin Invest. 76, 1713-1719 http://dx.doi.org/10.1172/JCI112160
4. Corbiere C., Liagre B., Bianchi A. (2003): Different contribution of apoptosis to the antiproliferative effects of diosgenin and other plant steroids, hecogenin and togogenin, on human 1547 osteosarcoma cells. Int. J. Oncol. 22, 899-905
5. Delmas-Beauvieux M. C., Peuchant E., Dumon M. F., Receveur M. C., Le Bras M., Clerc M. (1995): Relationship between red blood cell antioxidant enzymatic system status and lipoperoxidation during the acute phase of malaria. Clin. Biochem. 28, 163-169 http://dx.doi.org/10.1016/0009-9120(94)00071-3
6. Derek J., Hausen L., Derek M. Y. (2013): Myocardial ischemiareperfusion injury: a neglected therapeutic target. J. Clin. Invest. 123, 92-100 http://dx.doi.org/10.1172/JCI62874
7. Draper H. H., Hadley M. (1990): Malondialdehyde determination as index of lipid peroxidation. Methods. Enzymol. 186, 421-431 http://dx.doi.org/10.1016/0076-6879(90)86135-i
8. Ebrahimi H., Badalzadeh R., Mohammadi M., Yousefi B. (2014): Diosgenin attenuates inflammatory response induced by myocardial reperfusion injury: role of mitochondrial ATP-sensitive potassium channels. J. Physiol. Biochem. 70, 425-432 http://dx.doi.org/10.1007/s13105-014-0320-9
9. Facundo H. T., De paula J. G., Santos C. C. X., Ferranti R., Laurindo F. R. M., Kowaltowski A. J. (2006a): Ischemic preconditioning requires increase in reactive oxygen release independent of mitochondrial K channel activity. Free Radic. Biol. Med. 40, 469-479 http://dx.doi.org/10.1016/j.freeradbiomed.2005.08.041
10. Facundo H. T., Fornazari M., Kowaltowski A. J. (2006b): Tissue protection mediated by mitochondrial K channels. Biochim. Biophys. Acta 1762, 202-212 http://dx.doi.org/10.1016/j.bbadis.2005.06.003
11. Ferranti R., Da silva M. M., Kowaltowski A. J. (2003): Mitochondrial ATP-sensitive K channel opening decreases reactive oxygen species generation. FEBS lett. 536, 51-55 http://dx.doi.org/10.1016/S0014-5793(03)00007-3
12. Ghyasi R., Mohammadi M., Badalzadeh R., Rashidi B., Sepehri G. (2011): The effect of mebudipine on cardiac function and activity of the myocardial nitric oxide system in ischaemia-reperfusion injury in rats. Cardiovasc. J. Afr. 22, 319-323 http://dx.doi.org/10.5830/CVJA-2010-078
13. Gong G., Qin Y., Huang W., Zhou S., Wu X., Yang X., Zhao Y., Li D. (2010): Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen-peroxide induced apoptosis. Chem. Biol. Interact. 184, 366-375 http://dx.doi.org/10.1016/j.cbi.2010.02.005
14. Gong G., Qin Y., Huang W. (2011): Anti-thrombosis effect of diosgenin extract from dioscorea zingiberensis C.H Wright in vitro and in vivo. Phytomedicine 18, 458-463 http://dx.doi.org/10.1016/j.phymed.2010.08.015
15. Hearse D. J., Humphrey S. M., Chain E. B. (1973): Abrupt reoxygenation of the anoxic potassium-arrested perfused rat heart: a study of myocardial enzyme release. J. Mol. Cell. Cardiol. 5, 395-407 http://dx.doi.org/10.1016/0022-2828(73)90030-8
16. Heberty T. F. F., Juliana G. D. P., Alicia J. (2007): Mitochondrial ATP-sensitive K+ channels are redox-sensitive pathways that control reactive oxygen species production. Free Radic. Biol. Med. 42, 1039-1048 http://dx.doi.org/10.1016/j.freeradbiomed.2007.01.001
17. Jayachandran K. S., Hannah R., Vasanthi G. V. (2009): Antilipoperoxidative and membrane stabilizing effect of diosgenin in experimentally induced myocardial infarction. Mol. Cell. Biochem. 327, 203-210 http://dx.doi.org/10.1007/s11010-009-0058-9
18. Jnarez-Oropeza M. A., Diaz-Zagoya J. C., Rabinowitz J. L. (1987): In vivo and in vitro studies of hypocholesterolemic effects of diosgenin in rats. Int. J. Biochem. 19, 679-683 http://dx.doi.org/10.1016/0020-711X(87)90080-2
19. Kowaltowski A. J., Seetharaman S., Paucek P., Garlid K. D. (2001): Bioenergetic consequences of opening the ATP-sensitive K channel of heart mitochondria. Am. J. Physiol. 280, H649-657
20. Loubani M., Gali-anes M. (2002): Pharmacological and ischemic preconditioning of the human myocardium: mitoKATP channels are upstream and p38MAPK is downstream of PKC. BMC Physiol. 18, 2-10
21. Manivannan J., Arunagiri P., Sivasubramanian J., Balamurugan E. (2013): Diosgenin prevents hepatic oxidative stress, lipid peroxidation and molecular alterations in chronic renal failure rats. IJNPND 3, 289-293
22. McAnuff M. A., Harding W. W., Omoruyi F.O., Jacobs H., Morrison E. Y. (2005): Hypoglycemic effects of steroidal sapogenin isolated from Jamaican bitter yam, Dioscorea polygonoids. Food Chem. Toxical. 43, 1667-1672 http://dx.doi.org/10.1016/j.fct.2005.05.008
23. Paglia D. E., Valentine W. N. (1967): Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J. Lab. Clin. Med. 70, 158-169
24. Qin J., Kang Y., Xu Z., Zang C., Fang B., Liu X. (2014): Dioscin prevents the mitochondrial apoptosis and attenuates oxidative stress in cardiac H9C2 cells. Drug Res. (Stuttg) 664, 47-52
25. Raju J., Mehta R. (2009): Cancer chemopreventive and therapeutic effects of diosgenin, a food saponin. Nutr. Cancer 61, 27-35 http://dx.doi.org/10.1080/01635580802357352
26. Rothermel B., Vega R. B., Yang J., Wu H., Bassel-Duby R., Williams R. S. (2000): A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275, 8719-8725 http://dx.doi.org/10.1074/jbc.275.12.8719
27. Sasaaki N., Sato T., Ohler A. (2000): Activation of mitochondrial ATP-dependent potassium channels by nitric oxide. Circulation 101, 439-445 http://dx.doi.org/10.1161/01.CIR.101.4.439
28. Son I. S., Kim J. H., Sohn H. Y., Kim J. S. (2007): Antioxidative and hypolipidemic effects of diosgenin, a steroidal saponin of Yam (Dioscorea Spp) on high-cholestrol fed rats. Biothechnol. Biochem. 71, 3063-3071 http://dx.doi.org/10.1271/bbb.70472
29. Vanden Hoek T. L., Becker L. B., Shao Z. H., Li C. Q., Schumacker P. T. (2000): Preconditioning in cardiomyocytes protects by attenuating oxidant stress at reperfusion. Circ. Res. 86, 541-548 http://dx.doi.org/10.1161/01.RES.86.5.541
30. Verma S., Fedak P. W. M., Weisel R. D., Butany J., Rao V., Mailtand A., Li R. K., Dhillon B., Yau T. M. (2002): Fundamentals of reperfusion injury for the clinical cardiologist. Circulation 105, 2332-2336 http://dx.doi.org/10.1161/01.CIR.0000016602.96363.36
31. Zweier J. L., Flaherty J. T., Weisfeldt M. L. (1987): Direct measurement of free radical generation following reperfusion of ischemic myocardium. Proc. Natl. Acad. Sci. USA 84, 1404-1407 http://dx.doi.org/10.1073/pnas.84.5.1404