Skeletal Effects of Smoking

Current Osteoporosis Reports

Volumn 13, Issue 5, 2015, Pages 302-309

  Cusano, Natalie E ^a  

^a NewYork Presbyterian Hospital   (United States)

Author keywords

Bone; Fractures; Osteoporosis; Skeleton; Smoking

Indexed keywords

NICOTINIC RECEPTOR; POLYCHLORINATED DIBENZODIOXIN;

BALANCE IMPAIRMENT; BONE CHARACTERISTICS AND FUNCTIONS; BONE DENSITY; BONE QUALITY; DISEASE ASSOCIATION; FALLING; FRACTURE; FRACTURE NONUNION; FRAGILITY FRACTURE; GAIT; HUMAN; MOTOR COORDINATION; MUSCLE STRENGTH; NEUROMUSCULAR DISEASE; NONHUMAN; OSTEOBLAST; OSTEOCLAST; PATHOPHYSIOLOGY; RECEPTOR BINDING; REVIEW; RISK FACTOR; SARCOPENIA; SMOKING; SMOKING CESSATION; SMOKING HABIT; TRABECULAR BONE; ADVERSE EFFECTS; FRACTURES, BONE; OSTEOPOROSIS;

BONE DENSITY; FRACTURES, BONE; HUMANS; OSTEOPOROSIS; SMOKING;

EID: 84941025246     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-015-0278-8     Document Type: Review

References (64)

1. Jamal A, Agaku IT, O’Connor E, King BA, Kenemer JB, Neff L. Current cigarette smoking among adults—United States, 2005–2013. MMWR. 2014;63(47):1108–12.
2. Ng M, Freeman MK, Fleming TD, Robinson M, Dwyer-Lindgren L, Thomson B, et al. Smoking prevalence and cigarette consumption in 187 countries, 1980–2012. JAMA. 2014;311(2):183–92.
3. Daniell HW. Osteoporosis and smoking. JAMA. 1972;221(5):509.
4. Daniell HW. Osteoporosis of the slender smoker. Vertebral compression fractures and loss of metacarpal cortex in relation to postmenopausal cigarette smoking and lack of obesity. Arch Intern Med. 1976;136(3):298–304.
5. Burge R, Dawson-Hughes B, Solomon DH, Wong JB, King A, Tosteson A. Incidence and economic burden of osteoporosis-related fractures in the United States, 2005–2025. J Bone Miner Res Off J Am Soc Bone Miner Res. 2007;22(3):465–75.
6. Kanis JA, Johnell O, Oden A, Johansson H, De Laet C, Eisman JA, et al. Smoking and fracture risk: a meta-analysis. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2005;16(2):155–62.
7. Kanis JA. Diagnosis of osteoporosis and assessment of fracture risk. Lancet. 2002;359(9321):1929–36.
8. Law MR, Hackshaw AK. A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect. BMJ. 1997;315(7112):841–6.
9. Ward KD, Klesges RC. A meta-analysis of the effects of cigarette smoking on bone mineral density. Calcif Tissue Int. 2001;68(5):259–70.
10. Kiel DP, Zhang Y, Hannan MT, Anderson JJ, Baron JA, Felson DT. The effect of smoking at different life stages on bone mineral density in elderly men and women. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 1996;6(3):240–8.
11. Vestergaard P, Mosekilde L. Fracture risk associated with smoking: a meta-analysis. J Intern Med. 2003;254(6):572–83.
12. Osteoporosis prevention, diagnosis, and therapy. NIH consensus statement. 2000;29;17(1):1-36.
13. Leslie WD, Rubin MR, Schwartz AV, Kanis JA. Type 2 diabetes and bone. J Bone Miner Res Off J Am Soc Bone Miner Res. 2012;27(11):2231–7.
14. Stein EM, Silva BC, Boutroy S, Zhou B, Wang J, Udesky J, et al. Primary hyperparathyroidism is associated with abnormal cortical and trabecular microstructure and reduced bone stiffness in postmenopausal women. J Bone Miner Res Off J Am Soc Bone Miner Res. 2013;28(5):1029–40.
15. Szulc P, Debiesse E, Boutroy S, Vilauphiou N, Chapurlat R. Poor trabecular microarchitecture in male current smokers: the cross-sectional STRAMBO study. Calcif Tissue Int. 2011;89(4):303–11. This paper provides important data on skeletal microarchitectural changes in adult male smokers.
16. Lorentzon M, Mellstrom D, Haug E, Ohlsson C. Smoking is associated with lower bone mineral density and reduced cortical thickness in young men. J Clin Endocrinol Metab. 2007;92(2):497–503.
17. Rudang R, Darelid A, Nilsson M, Nilsson S, Mellstrom D, Ohlsson C, et al. Smoking is associated with impaired bone mass development in young adult men: a 5-year longitudinal study. J Bone Miner Res Off J Am Soc Bone Miner Res. 2012;27(10):2189–97. Paper presents evidence that smoking impairs bone quality in young men.
18. Taes Y, Lapauw B, Vanbillemont G, Bogaert V, De Bacquer D, Goemaere S, et al. Early smoking is associated with peak bone mass and prevalent fractures in young, healthy men. J Bone Miner Res Off J Am Soc Bone Miner Res. 2010;25(2):379–87.
19. Nelson HD, Nevitt MC, Scott JC, Stone KL, Cummings SR. Smoking, alcohol, and neuromuscular and physical function of older women. Study of Osteoporotic Fractures Research Group. JAMA. 1994;272(23):1825–31.
20. Szulc P, Duboeuf F, Marchand F, Delmas PD. Hormonal and lifestyle determinants of appendicular skeletal muscle mass in men: the MINOS study. Am J Clin Nutr. 2004;80(2):496–503.
21. Fletcher PC, Hirdes JP. Risk factor for accidental injuries within senior citizens’ homes: analysis of the Canadian survey on ageing and independence. J Gerontol Nurs. 2005;31(2):49–57.
22. Faulkner KA, Cauley JA, Studenski SA, Landsittel DP, Cummings SR, Ensrud KE, et al. Lifestyle predicts falls independent of physical risk factors. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2009;20(12):2025–34.
23. Lord SR, Ward JA, Williams P, Anstey KJ. An epidemiological study of falls in older community-dwelling women: the Randwick falls and fractures study. Aust J Public Health. 1993;17(3):240–5.
24. Grundstrom AC, Guse CE, Layde PM. Risk factors for falls and fall-related injuries in adults 85 years of age and older. Arch Gerontol Geriatr. 2012;54(3):421–8.
25. Cairoli E, Eller-Vainicher C, Ulivieri FM, Zhukouskaya VV, Palmieri S, Morelli V, et al. Factors associated with bisphosphonate treatment failure in postmenopausal women with primary osteoporosis. Osteoporosis Int J Established Result Cooperation Between Eur Found Osteoporosis Natl Osteoporosis Found USA. 2014;25(4):1401–10. Paper provides data that smoking may cause bisphosphonate treatment failure.
26. Scolaro JA, Schenker ML, Yannascoli S, Baldwin K, Mehta S, Ahn J. Cigarette smoking increases complications following fracture: a systematic review. J Bone Joint Surg Am. 2014;96(8):674–81. Excellent review of the post-fracture complications of smoking.
27. Antonova E, Le TK, Burge R, Mershon J. Tibia shaft fractures: costly burden of nonunions. BMC Musculoskelet Disord. 2013;14:42.
28. Mineur YS, Abizaid A, Rao Y, Salas R, DiLeone RJ, Gundisch D, et al. Nicotine decreases food intake through activation of POMC neurons. Science. 2011;332(6035):1330–2.
29. Krall EA, Dawson-Hughes B. Smoking and bone loss among postmenopausal women. J Bone Miner Res Off J Am Soc Bone Miner Res. 1991;6(4):331–8.
30. Krall EA, Dawson-Hughes B. Smoking increases bone loss and decreases intestinal calcium absorption. J Bone Miner Res Off J Am Soc Bone Miner Res. 1999;14(2):215–20.
31. Landin-Wilhelmsen K, Wilhelmsen L, Lappas G, Rosen T, Lindstedt G, Lundberg PA, et al. Serum intact parathyroid hormone in a random population sample of men and women: relationship to anthropometry, life-style factors, blood pressure, and vitamin D. Calcif Tissue Int. 1995;56(2):104–8.
32. Brot C, Jorgensen NR, Sorensen OH. The influence of smoking on vitamin D status and calcium metabolism. Eur J Clin Nutr. 1999;53(12):920–6.
33. Szulc P, Garnero P, Claustrat B, Marchand F, Duboeuf F, Delmas PD. Increased bone resorption in moderate smokers with low body weight: the Minos study. J Clin Endocrinol Metab. 2002;87(2):666–74.
34. Wong PK, Christie JJ, Wark JD. The effects of smoking on bone health. Clin Sci (Lond). 2007;113(5):233–41.
35. Winternitz WW, Quillen D. Acute hormonal response to cigarette smoking. J Clin Pharmacol. 1977;17(7):389–97.
36. Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME. Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology (Berlin). 1982;78(4):305–8.
37. Seyler Jr LE, Fertig J, Pomerleau O, Hunt D, Parker K. The effects of smoking on ACTH and cortisol secretion. Life Sci. 1984;34(1):57–65.
38. Baron JA, Comi RJ, Cryns V, Brinck-Johnsen T, Mercer NG. The effect of cigarette smoking on adrenal cortical hormones. J Pharmacol Exp Ther. 1995;272(1):151–5.
39. Field AE, Colditz GA, Willett WC, Longcope C, McKinlay JB. The relation of smoking, age, relative weight, and dietary intake to serum adrenal steroids, sex hormones, and sex hormone-binding globulin in middle-aged men. J Clin Endocrinol Metab. 1994;79(5):1310–6.
40. Yeh J, Barbieri RL. Twenty-four-hour urinary-free cortisol in premenopausal cigarette smokers and nonsmokers. Fertil Steril. 1989;52(6):1067–9.
41. McKinlay SM, Bifano NL, McKinlay JB. Smoking and age at menopause in women. Ann Intern Med. 1985;103(3):350–6.
42. Midgette AS, Baron JA. Cigarette smoking and the risk of natural menopause. Epidemiology. 1990;1(6):474–80.
43. Bjarnason NH, Christiansen C. The influence of thinness and smoking on bone loss and response to hormone replacement therapy in early postmenopausal women. J Clin Endocrinol Metab. 2000;85(2):590–6.
44. Michnovicz JJ, Hershcopf RJ, Naganuma H, Bradlow HL, Fishman J. Increased 2-hydroxylation of estradiol as a possible mechanism for the anti-estrogenic effect of cigarette smoking. N Engl J Med. 1986;315(21):1305–9.
45. Briggs MH. Cigarette smoking and infertility in men. Med J Aust. 1973;1(12):616–7.
46. Shaarawy M, Mahmoud KZ. Endocrine profile and semen characteristics in male smokers. Fertil Steril. 1982;38(2):255–7.
47. English KM, Pugh PJ, Parry H, Scutt NE, Channer KS, Jones TH. Effect of cigarette smoking on levels of bioavailable testosterone in healthy men. Clin Sci (Lond). 2001;100(6):661–5.
48. Wang W, Yang X, Liang J, Liao M, Zhang H, Qin X, et al. Cigarette smoking has a positive and independent effect on testosterone levels. Hormones (Athens). 2013;12(4):567–77.
49. Duthie GG, Arthur JR, James WP. Effects of smoking and vitamin E on blood antioxidant status. Am J Clin Nutr. 1991;53(4 Suppl):1061S–3.
50. Valavanidis A, Vlachogianni T, Fiotakis K. Tobacco smoke: involvement of reactive oxygen species and stable free radicals in mechanisms of oxidative damage, carcinogenesis and synergistic effects with other respirable particles. Int J Environ Res Public Health. 2009;6(2):445–62.
51. Callaway DA, Jiang JX. Reactive oxygen species and oxidative stress in osteoclastogenesis, skeletal aging and bone diseases. J Bone Miner Metab. 2015.
52. Melhus H, Michaelsson K, Holmberg L, Wolk A, Ljunghall S. Smoking, antioxidant vitamins, and the risk of hip fracture. J Bone Miner Res Off J Am Soc Bone Miner Res. 1999;14(1):129–35.
53. Yan C, Avadhani NG, Iqbal J. The effects of smoke carcinogens on bone. Curr Osteoporos Rep. 2011;9(4):202–9. Excellent review on the effects of nicotine and other cigarette toxins on bone tissue.
54. Walker LM, Preston MR, Magnay JL, Thomas PB, El Haj AJ. Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture. Bone. 2001;28(6):603–8.
55. Wejheden C, Brunnberg S, Larsson S, Lind PM, Andersson G, Hanberg A. Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype. Toxicol Sci. 2010;114(1):48–58.
56. Singh SU, Casper RF, Fritz PC, Sukhu B, Ganss B, Girard Jr B, et al. Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol. J Endocrinol. 2000;167(1):183–95.
57. Ko CH, Chan RL, Siu WS, Shum WT, Leung PC, Zhang L, et al. Deteriorating effect on bone metabolism and microstructure by passive cigarette smoking through dual actions on osteoblast and osteoclast. Calcif Tissue Int. 2015;96(5):389–400. This paper provides evidence that passive smoking exposure may have direct effects on osteoblasts and osteoclasts.
58. Nguyen TV, Kelly PJ, Sambrook PN, Gilbert C, Pocock NA, Eisman JA. Lifestyle factors and bone density in the elderly: implications for osteoporosis prevention. J Bone Miner Res Off J Am Soc Bone Miner Res. 1994;9(9):1339–46.
59. Hollenbach KA, Barrett-Connor E, Edelstein SL, Holbrook T. Cigarette smoking and bone mineral density in older men and women. Am J Public Health. 1993;83(9):1265–70.
60. Cornuz J, Feskanich D, Willett WC, Colditz GA. Smoking, smoking cessation, and risk of hip fracture in women. Am J Med. 1999;106(3):311–4.
61. Olofsson H, Byberg L, Mohsen R, Melhus H, Lithell H, Michaelsson K. Smoking and the risk of fracture in older men. J Bone Miner Res Off J Am Soc Bone Miner Res. 2005;20(7):1208–15.
62. Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE, et al. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142(4):233–9.
63. Kenfield SA, Stampfer MJ, Rosner BA, Colditz GA. Smoking and smoking cessation in relation to mortality in women. JAMA. 2008;299(17):2037–47.
64. Cao Y, Kenfield S, Song Y, Rosner B, Qiu W, Sesso HD, et al. Cigarette smoking cessation and total and cause-specific mortality: a 22-year follow-up study among US male physicians. Arch Intern Med. 2011;171(21):1956–9.