The effects of smoke carcinogens on bone

Current Osteoporosis Reports

Volumn 9, Issue 4, 2011, Pages 202-209

  Yan, Carol ^a   Avadhani, Narayan G ^a   Iqbal, Jameel ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Bone; Bone remodeling; Carcinogens; Osteoporosis; Tobacco smoking

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 25 HYDROXYVITAMIN D; AROMATIC HYDROCARBON RECEPTOR; CALCIUM; CARCINOGEN; ESTROGEN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; POLYCYCLIC AROMATIC HYDROCARBON; TESTOSTERONE;

ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE REMODELING; BONE STRENGTH; CARCINOGENIC ACTIVITY; CIGARETTE SMOKING; FRACTURE NONUNION; FRAGILITY FRACTURE; GROWTH INHIBITION; HIP FRACTURE; HUMAN; LONG TERM EXPOSURE; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; OSTEOLYSIS; OSTEOPOROSIS; PARATHYROID HORMONE RELEASE; POSTMENOPAUSE; PROTEINASE INHIBITION; SMOKING CESSATION;

BONE AND BONES; BONE DENSITY; BONE REMODELING; CARCINOGENS; HUMANS; OSTEOPOROSIS; RISK FACTORS; SMOKING;

EID: 81255157687     PISSN: 15441873     EISSN: 15442241     Source Type: Journal    
DOI: 10.1007/s11914-011-0068-x     Document Type: Article

References (36)

1. H Wipfli JM Samet 2009 Global economic and health benefits of tobacco control: part 1 Clin Pharmacol Ther 86 3 263 271 19536067 1:STN:280: DC%2BD1MrnslGluw%3D%3D 10.1038/clpt.2009.93
2. KD Ward RC Klesges 2001 A meta-analysis of the effects of cigarette smoking on bone mineral density Calcif Tissue Int 68 5 259 270 11683532 1:CAS:528:DC%2BD3MXlsVyrurY%3D 10.1007/BF02390832 (Pubitemid 32565727)
3. JA Kanis O Johnell A Oden H Johansson C De Laet JA Eisman, et al. 2005 Smoking and fracture risk: a meta-analysis Osteoporos Int 16 2 155 162 15175845 1:STN:280:DC%2BD2M%2FksVentA%3D%3D 10.1007/s00198-004-1640-3 (Pubitemid 40193202)
4. J Cornuz D Feskanich WC Willett GA Colditz 1999 Smoking, smoking cessation, and risk of hip fracture in women Am J Med 106 3 311 314 10190380 1:STN:280:DyaK1M3gsVKmtw%3D%3D 10.1016/S0002-9343(99)00022-4 (Pubitemid 29153409)
5. JL Hopper E Seeman 1994 The bone density of female twins discordant for tobacco use N Engl J Med 330 6 387 392 8284003 1:STN:280:DyaK2c7htFOnsA%3D%3D 10.1056/NEJM199402103300603 (Pubitemid 24045655)
6. RJ MacInnis C Cassar CA Nowson LM Paton L Flicker JL Hopper, et al. 2003 Determinants of bone density in 30- to 65-year-old women: a co-twin study J Bone Miner Res 18 9 1650 1656 12968674 1:STN:280:DC%2BD3svisl2nsw%3D%3D 10.1359/jbmr.2003.18.9.1650 (Pubitemid 37022923)
7. EA Krall B Dawson-Hughes 1991 Smoking and bone loss among postmenopausal women J Bone Miner Res 6 4 331 338 1858519 1:STN:280:DyaK3MzhsVahsA%3D%3D 10.1002/jbmr.5650060404
8. MR Law AK Hackshaw 1997 A meta-analysis of cigarette smoking, bone mineral density and risk of hip fracture: recognition of a major effect BMJ 315 7112 841 846 9353503 1:STN:280:DyaK1c%2FhsVygsg%3D%3D 10.1136/bmj.315.7112.841 (Pubitemid 27420442)
9. P Szulc P Garnero B Claustrat F Marchand F Duboeuf PD Delmas 2002 Increased bone resorption in moderate smokers with low body weight: the Minos study J Clin Endocrinol Metab 87 2 666 674 11836302 1:CAS:528: DC%2BD38XhsVSisr8%3D 10.1210/jc.87.2.666 (Pubitemid 34158235)
10. TV Nguyen PJ Kelly PN Sambrook C Gilbert NA Pocock JA Eisman 1994 Lifestyle factors and bone density in the elderly: implications for osteoporosis prevention J Bone Miner Res 9 9 1339 1346 7817817 1:STN:280: DyaK2M7hslGktg%3D%3D 10.1002/jbmr.5650090904 (Pubitemid 24268844)
11. LM Walker MR Preston JL Magnay PB Thomas AJ El Haj 2001 Nicotinic regulation of c-fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture Bone 28 6 603 608 11425648 1:CAS:528:DC%2BD3MXks1Olsbc%3D 10.1016/S8756-3282(01)00427-6 (Pubitemid 32586069)
12. BD Haverstock VJ Mandracchia 1998 Cigarette smoking and bone healing: implications in foot and ankle surgery J Foot Ankle Surg 37 1 69 74 9470121 1:STN:280:DyaK1c7jtVyqtQ%3D%3D 10.1016/S1067-2516(98)80015-X discussion 78 (Pubitemid 28051684)
13. H Olofsson L Byberg R Mohsen H Melhus H Lithell K Michaelsson 2005 Smoking and the risk of fracture in older men J Bone Miner Res 20 7 1208 1215 15940374 10.1359/JBMR.050208 (Pubitemid 40863809)
14. T Jamsa M Viluksela JT Tuomisto J Tuomisto J Tuukkanen 2001 Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on bone in two rat strains with different aryl hydrocarbon receptor structures J Bone Miner Res 16 10 1812 1820 11585345 1:CAS:528:DC%2BD3MXnsVKqt7Y%3D 10.1359/jbmr.2001.16.10.1812 (Pubitemid 32911487)
15. HM Miettinen P Pulkkinen T Jamsa J Koistinen U Simanainen J Tuomisto, et al. 2005 Effects of in utero and lactational TCDD exposure on bone development in differentially sensitive rat lines Toxicol Sci 85 2 1003 1012 15746008 1:CAS:528:DC%2BD2MXksVSjtro%3D 10.1093/toxsci/kfi136 (Pubitemid 40851977)
16. GA Blanco EL Cooper 2004 Immune systems, geographic information systems (GIS), environment and health impacts J Toxicol Environ Health B Crit Rev 7 6 465 480 15586880 1:CAS:528:DC%2BD2cXot1Ojt7o%3D 10.1080/10937400490512375 (Pubitemid 39487652)
17. J Ilvesaro R Pohjanvirta J Tuomisto M Viluksela J Tuukkanen 2005 Bone resorption by aryl hydrocarbon receptor-expressing osteoclasts is not disturbed by TCDD in short-term cultures Life Sci 77 12 1351 1366 15913656 1:CAS:528:DC%2BD2MXlvFehsLY%3D 10.1016/j.lfs.2005.01.027 (Pubitemid 40943676)
18. WK Ramp LG Lenz RJ Galvin 1991 Nicotine inhibits collagen synthesis and alkaline phosphatase activity, but stimulates DNA synthesis in osteoblast-like cells Proc Soc Exp Biol Med 197 1 36 43 1850524 1:CAS:528:DyaK3MXisValtrg%3D
19. N Ortego-Centeno M Munoz-Torres E Jodar J Hernandez-Quero A Jurado-Duce J de la Higuera Torres-Puchol 1997 Effect of tobacco consumption on bone mineral density in healthy young males Calcif Tissue Int 60 6 496 500 9164822 1:CAS:528:DyaK2sXjsFartL4%3D 10.1007/s002239900270 (Pubitemid 27230007)
20. MC Gracia 2010 Possible influence of nicotine on osteoporosis Med Hypotheses 75 1 133 134 20219290 1:CAS:528:DC%2BC3cXmslWnt7g%3D 10.1016/j.mehy.2010.02.007
21. DE Rothem L Rothem M Soudry A Dahan R Eliakim 2009 Nicotine modulates bone metabolism-associated gene expression in osteoblast cells J Bone Miner Metab 27 5 555 561 19436947 1:CAS:528:DC%2BD1MXpvF2rsrk%3D 10.1007/s00774-009- 0075-5
22. M Naruse Y Ishihara S Miyagawa-Tomita A Koyama H Hagiwara 2002 3-Methylcholanthrene, which binds to the arylhydrocarbon receptor, inhibits proliferation and differentiation of osteoblasts in vitro and ossification in vivo Endocrinology 143 9 3575 3581 12193573 1:CAS:528:DC%2BD38XmsVSgu70%3D 10.1210/en.2002-220003 (Pubitemid 34925734)
23. M Korkalainen E Kallio A Olkku K Nelo J Ilvesaro J Tuukkanen, et al. 2009 Dioxins interfere with differentiation of osteoblasts and osteoclasts Bone 44 6 1134 1142 19264158 1:CAS:528:DC%2BD1MXlslWis78%3D 10.1016/j.bone.2009.02.019 This paper shows that OCN and ALP are lower in arylhydrocarbon knockout mice, thus suggesting a role in the normal development of bone cells.
24. JB Lian GS Stein 1993 The developmental stages of osteoblast growth and differentiation exhibit selective responses of genes to growth factors (TGF beta 1) and hormones (vitamin D and glucocorticoids) J Oral Implantol 19 2 95 105 8246305 1:STN:280:DyaK2c%2Fms1WqtA%3D%3D discussion 136-107
25. GS Stein JB Lian 1993 Molecular mechanisms mediating proliferation/ differentiation interrelationships during progressive development of the osteoblast phenotype Endocr Rev 14 4 424 442 8223340 1:CAS:528: DyaK3sXmtVSis78%3D (Pubitemid 23238925)
26. C Wejheden S Brunnberg S Larsson PM Lind G Andersson A Hanberg 2010 Transgenic mice with a constitutively active aryl hydrocarbon receptor display a gender-specific bone phenotype Toxicol Sci 114 1 48 58 19934163 1:CAS:528:DC%2BC3cXhvF2qtLY%3D 10.1093/toxsci/kfp284 This paper shows that in vivo measures reflecting osteoclast activity are increased in female mice with a CA-AhR.
27. SU Singh RF Casper PC Fritz B Sukhu B Ganss B Girard Jr JF Savouret HC Tenenbaum 2000 Inhibition of dioxin effects on bone formation in vitro by a newly described aryl hydrocarbon receptor antagonist, resveratrol J Endocrinol 167 1 183 195 11018766 1:CAS:528:DC%2BD3MXptVehtg%3D%3D 10.1677/joe.0.1670183
28. I Voronov K Li HC Tenenbaum MF Manolson 2008 Benzo[a]pyrene inhibits osteoclastogenesis by affecting RANKL-induced activation of NF-kappaB Biochem Pharmacol 75 10 2034 2044 18396263 1:CAS:528:DC%2BD1cXlsFOmsbw%3D 10.1016/j.bcp.2008.02.025 This paper explores the mechanism of action of carcinogens on osteoclasts, demonstrating that they suppress osteoclastogenesis.
29. M Naruse E Otsuka Y Ishihara S Miyagawa-Tomita H Hagiwara 2004 Inhibition of osteoclast formation by 3-methylcholanthrene, a ligand for arylhydrocarbon receptor: suppression of osteoclast differentiation factor in osteogenic cells Biochem Pharmacol 67 1 119 127 14667934 1:CAS:528:DC%2BD3sXps1Oktrw%3D 10.1016/j.bcp.2003.08.038 (Pubitemid 37518539)
30. RL Lees VK Sabharwal JN Heersche 2001 Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films Bone 28 2 187 194 11182377 1:CAS:528: DC%2BD3MXhtFehu7k%3D 10.1016/S8756-3282(00)00433-6 (Pubitemid 32143685)
31. PK Wong JJ Christie JD Wark 2007 The effects of smoking on bone health Clin Sci (Lond) 113 5 233 241 1:CAS:528:DC%2BD2sXotlegsbY%3D 10.1042/CS20060173 This is an excellent review detailing many clinical studies on smoking and bone loss (Pubitemid 47372681)
32. RD Bruno VC Njar 2007 Targeting cytochrome P450 enzymes: a new approach in anti-cancer drug development Bioorg Med Chem 15 15 5047 5060 17544277 1:CAS:528:DC%2BD2sXmtlahsbg%3D 10.1016/j.bmc.2007.05.046 (Pubitemid 46880385)
33. Y Tsuchiya M Nakajima T Yokoi 2005 Cytochrome P450-mediated metabolism of estrogens and its regulation in human Cancer Lett 227 2 115 124 16112414 1:CAS:528:DC%2BD2MXosVaju7s%3D 10.1016/j.canlet.2004.10.007 (Pubitemid 41174580)
34. S Safe F Wang W Porter R Duan A McDougal 1998 Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms Toxicol Lett 102-103 343 347 10022276 10.1016/S0378-4274(98)00331-2 (Pubitemid 29021243)
35. DR Boverhof JC Kwekel DG Humes LD Burgoon TR Zacharewski 2006 Dioxin induces an estrogen-like, estrogen receptor-dependent gene expression response in the murine uterus Mol Pharmacol 69 5 1599 1606 16467188 1:CAS:528: DC%2BD28XksVWrt7k%3D 10.1124/mol.105.019638
36. PB Rapuri JC Gallagher KE Balhorn KL Ryschon 2000 Smoking and bone metabolism in elderly women Bone 27 3 429 436 10962356 1:CAS:528: DC%2BD3cXmtVGjtr8%3D 10.1016/S8756-3282(00)00341-0 (Pubitemid 30658128)