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Volumn 41, Issue 8, 2015, Pages 680-689

Action and resistance of monoclonal CD20 antibodies therapy in B-cell Non-Hodgkin Lymphomas

Author keywords

Apoptosis; CD20; Monoclonal antibodies; Non Hodgkin Lymphomas; Rituximab

Indexed keywords

CHLORAMBUCIL; CYCLOPHOSPHAMIDE; DOXORUBICIN; FAS ANTIGEN; FLUDARABINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OBINUTUZUMAB; OCRELIZUMAB; OFATUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PREDNISONE; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; RITUXIMAB; TOSITUMOMAB; VELTUZUMAB; VINCRISTINE; ANTINEOPLASTIC AGENT; CD20 ANTIGEN; MONOCLONAL ANTIBODY;

EID: 84941022593     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2015.05.007     Document Type: Review
Times cited : (52)

References (123)
  • 2
    • 84895287749 scopus 로고    scopus 로고
    • Rituximab: pharmacology, clinical indications and health benefits
    • Nova Science Publishers, New York, NY, USA, G.V. Lake-Bakaar (Ed.)
    • Méndez M., Provencio M. Rituximab: pharmacology, clinical indications and health benefits. Rituximab: pharmacology, clinical indications and health effects 2013, 1-30. Nova Science Publishers, New York, NY, USA. G.V. Lake-Bakaar (Ed.).
    • (2013) Rituximab: pharmacology, clinical indications and health effects , pp. 1-30
    • Méndez, M.1    Provencio, M.2
  • 3
    • 84925558249 scopus 로고    scopus 로고
    • Maintenance with rituximab is safe and not associated with severe or uncommon infections in patients with follicular lymphoma: results from the phase IIIb MAXIMA study
    • Witzens-Harig M., Foá R., Di Rocco A., van Hazel G., Chamone D.F.A., Rowe J.M., et al. Maintenance with rituximab is safe and not associated with severe or uncommon infections in patients with follicular lymphoma: results from the phase IIIb MAXIMA study. Ann Hematol 2014.
    • (2014) Ann Hematol
    • Witzens-Harig, M.1    Foá, R.2    Di Rocco, A.3    van Hazel, G.4    Chamone, D.F.A.5    Rowe, J.M.6
  • 4
    • 0036408912 scopus 로고    scopus 로고
    • CD20-mediated apoptosis: signalling through lipid rafts
    • Deans J.P., Li H., Polyak M.J. CD20-mediated apoptosis: signalling through lipid rafts. Immunology 2002, 107(2):176-182.
    • (2002) Immunology , vol.107 , Issue.2 , pp. 176-182
    • Deans, J.P.1    Li, H.2    Polyak, M.J.3
  • 5
    • 0345337254 scopus 로고    scopus 로고
    • Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program
    • McLaughlin P., Grillo-López A.J., Link B.K., Levy R., Czuczman M.S., Williams M.E., et al. Rituximab chimeric anti-CD20 monoclonal antibody therapy for relapsed indolent lymphoma: half of patients respond to a four-dose treatment program. J Clin Oncol 1998, 16(8):2825-2833.
    • (1998) J Clin Oncol , vol.16 , Issue.8 , pp. 2825-2833
    • McLaughlin, P.1    Grillo-López, A.J.2    Link, B.K.3    Levy, R.4    Czuczman, M.S.5    Williams, M.E.6
  • 6
    • 7844225540 scopus 로고    scopus 로고
    • Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma
    • Berinstein N.L., Grillo-López A.J., White C.A., Bence-Bruckler I., Maloney D., Czuczman M., et al. Association of serum Rituximab (IDEC-C2B8) concentration and anti-tumor response in the treatment of recurrent low-grade or follicular non-Hodgkin's lymphoma. Ann Oncol 1998, 9(9):995-1001.
    • (1998) Ann Oncol , vol.9 , Issue.9 , pp. 995-1001
    • Berinstein, N.L.1    Grillo-López, A.J.2    White, C.A.3    Bence-Bruckler, I.4    Maloney, D.5    Czuczman, M.6
  • 7
    • 84939170825 scopus 로고    scopus 로고
    • Increased rituximab (R) doses and effect on risk of elderly male patients with aggressive CD20+ B-cell lymphomas: results from the SEXIE-R-CHOP-14 trial of the DSHNHL
    • Pfreundschuh M., Held G., Zeynalova S., Zwick C., Haenel M., LorenzTruemper L., et al. Increased rituximab (R) doses and effect on risk of elderly male patients with aggressive CD20+ B-cell lymphomas: results from the SEXIE-R-CHOP-14 trial of the DSHNHL. J Clin Oncol 2014, 32:5s. [suppl; abstr 8501].
    • (2014) J Clin Oncol , vol.32 , pp. 5s
    • Pfreundschuh, M.1    Held, G.2    Zeynalova, S.3    Zwick, C.4    Haenel, M.5    LorenzTruemper, L.6
  • 8
    • 84878925989 scopus 로고    scopus 로고
    • Diagnosis and treatment of primary CNS lymphoma
    • Korfel A., Schlegel U. Diagnosis and treatment of primary CNS lymphoma. Nat Rev Neurol 2013, 9(6):317-327.
    • (2013) Nat Rev Neurol , vol.9 , Issue.6 , pp. 317-327
    • Korfel, A.1    Schlegel, U.2
  • 9
    • 0036713218 scopus 로고    scopus 로고
    • Intraventricular and intravenous treatment of a patient with refractory primary CNS lymphoma using rituximab
    • Pels H., Schulz H., Manzke O., Hom E., Thall A., Engert A. Intraventricular and intravenous treatment of a patient with refractory primary CNS lymphoma using rituximab. J Neurooncol 2002, 59(3):213-216.
    • (2002) J Neurooncol , vol.59 , Issue.3 , pp. 213-216
    • Pels, H.1    Schulz, H.2    Manzke, O.3    Hom, E.4    Thall, A.5    Engert, A.6
  • 11
    • 53749085410 scopus 로고    scopus 로고
    • Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma
    • Marcus R., Imrie K., Solal-Celigny P., Catalano J.V., Dmoszynska A., Raposo J.C., et al. Phase III study of R-CVP compared with cyclophosphamide, vincristine, and prednisone alone in patients with previously untreated advanced follicular lymphoma. J Clin Oncol 2008, 26(28):4579-4586.
    • (2008) J Clin Oncol , vol.26 , Issue.28 , pp. 4579-4586
    • Marcus, R.1    Imrie, K.2    Solal-Celigny, P.3    Catalano, J.V.4    Dmoszynska, A.5    Raposo, J.C.6
  • 12
    • 78650823247 scopus 로고    scopus 로고
    • Rituximab maintenance for 2years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomized controlled trial
    • Salles G., Seymour J.F., Offner F., López-Guillermo A., Belada D., Xerri L., et al. Rituximab maintenance for 2years in patients with high tumour burden follicular lymphoma responding to rituximab plus chemotherapy (PRIMA): a phase 3, randomized controlled trial. Lancet 2011, 377(9759):42-51.
    • (2011) Lancet , vol.377 , Issue.9759 , pp. 42-51
    • Salles, G.1    Seymour, J.F.2    Offner, F.3    López-Guillermo, A.4    Belada, D.5    Xerri, L.6
  • 13
    • 0037165261 scopus 로고    scopus 로고
    • CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma
    • Coiffier B., Lepage E., Briere J., Herbrecht R., Tilly H., Bouabdallah R., et al. CHOP chemotherapy plus rituximab compared with CHOP alone in elderly patients with diffuse large-B-cell lymphoma. N Engl J Med 2002, 346(4):235-242.
    • (2002) N Engl J Med , vol.346 , Issue.4 , pp. 235-242
    • Coiffier, B.1    Lepage, E.2    Briere, J.3    Herbrecht, R.4    Tilly, H.5    Bouabdallah, R.6
  • 14
    • 77957664665 scopus 로고    scopus 로고
    • Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial
    • Hallek M., Fischer K., Fingerle-Rowson G., Fink A.M., Busch R., Mayer J., et al. Addition of rituximab to fludarabine and cyclophosphamide in patients with chronic lymphocytic leukaemia: a randomised, open-label, phase 3 trial. Lancet 2010, 376(9747):1164-1174.
    • (2010) Lancet , vol.376 , Issue.9747 , pp. 1164-1174
    • Hallek, M.1    Fischer, K.2    Fingerle-Rowson, G.3    Fink, A.M.4    Busch, R.5    Mayer, J.6
  • 15
    • 33746961890 scopus 로고    scopus 로고
    • Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks
    • Cohen S.B., Emery P., Greenwald M.W., Dougados M., Furie R.A., Genovese M.C., et al. Rituximab for rheumatoid arthritis refractory to anti-tumor necrosis factor therapy: results of a multicenter, randomized, double-blind, placebo-controlled, phase III trial evaluating primary efficacy and safety at twenty-four weeks. Arthritis Rheum 2006, 54(9):2793-2806.
    • (2006) Arthritis Rheum , vol.54 , Issue.9 , pp. 2793-2806
    • Cohen, S.B.1    Emery, P.2    Greenwald, M.W.3    Dougados, M.4    Furie, R.A.5    Genovese, M.C.6
  • 16
    • 2442522360 scopus 로고    scopus 로고
    • The CD20 Calcium Channel Is Localized to Microvilli and Constitutively Associated with Membrane Rafts antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism
    • Li H., Ayer L.M., Polyak M.J., Mutch C.M., Petrie R.J., Gauthier L., et al. The CD20 Calcium Channel Is Localized to Microvilli and Constitutively Associated with Membrane Rafts antibody binding increases the affinity of the association through an epitope-dependent cross-linking-independent mechanism. J Biol Chem 2004, 279(19):19893-19901.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19893-19901
    • Li, H.1    Ayer, L.M.2    Polyak, M.J.3    Mutch, C.M.4    Petrie, R.J.5    Gauthier, L.6
  • 17
    • 0037105388 scopus 로고    scopus 로고
    • Colocalization of the B-cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts
    • Petrie R.J., Deans J.P. Colocalization of the B-cell receptor and CD20 followed by activation-dependent dissociation in distinct lipid rafts. J Immunol 2002, 169(6):2886-2891.
    • (2002) J Immunol , vol.169 , Issue.6 , pp. 2886-2891
    • Petrie, R.J.1    Deans, J.P.2
  • 18
    • 34249692537 scopus 로고    scopus 로고
    • Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions
    • Bonavida B. Rituximab-induced inhibition of antiapoptotic cell survival pathways: implications in chemo/immunoresistance, rituximab unresponsiveness, prognostic and novel therapeutic interventions. Oncogene 2007, 26(25):3629-3636.
    • (2007) Oncogene , vol.26 , Issue.25 , pp. 3629-3636
    • Bonavida, B.1
  • 19
    • 0142180086 scopus 로고    scopus 로고
    • Store-operated cation entry mediated by CD20 in membrane rafts
    • Li H., Ayer L.M., Lytton J., Deans J.P. Store-operated cation entry mediated by CD20 in membrane rafts. J Biol Chem 2003, 278(43):42427-42434.
    • (2003) J Biol Chem , vol.278 , Issue.43 , pp. 42427-42434
    • Li, H.1    Ayer, L.M.2    Lytton, J.3    Deans, J.P.4
  • 20
    • 33746047673 scopus 로고    scopus 로고
    • Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity
    • van Meerten T., van Rijn R.S., Hol S., Hagenbeek A., Ebeling S.B. Complement-induced cell death by rituximab depends on CD20 expression level and acts complementary to antibody-dependent cellular cytotoxicity. Clin Cancer Res 2006, 12(13):4027-4035.
    • (2006) Clin Cancer Res , vol.12 , Issue.13 , pp. 4027-4035
    • van Meerten, T.1    van Rijn, R.S.2    Hol, S.3    Hagenbeek, A.4    Ebeling, S.B.5
  • 21
    • 0033055251 scopus 로고    scopus 로고
    • Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression
    • Davis T.A., Czerwinski D.K., Levy R. Therapy of B-cell lymphoma with anti-CD20 antibodies can result in the loss of CD20 antigen expression. Clin Cancer Res 1999, 5(3):611-615.
    • (1999) Clin Cancer Res , vol.5 , Issue.3 , pp. 611-615
    • Davis, T.A.1    Czerwinski, D.K.2    Levy, R.3
  • 22
    • 35748962939 scopus 로고    scopus 로고
    • Rituximab-CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models
    • Li Y., Williams M.E., Cousar J.B., Pawluczkowycz A.W., Lindorfer M.A., Taylor R.P. Rituximab-CD20 complexes are shaved from Z138 mantle cell lymphoma cells in intravenous and subcutaneous SCID mouse models. J Immunol 2007, 179(6):4263-4271.
    • (2007) J Immunol , vol.179 , Issue.6 , pp. 4263-4271
    • Li, Y.1    Williams, M.E.2    Cousar, J.B.3    Pawluczkowycz, A.W.4    Lindorfer, M.A.5    Taylor, R.P.6
  • 23
    • 84875754643 scopus 로고    scopus 로고
    • LBCD19 is a useful B-cell marker after treatment with rituximab: comment on the article by Jones et al.
    • Kamburova E.G., Koenen H.J.M.P., Joosten I., Hilbrands L.B LBCD19 is a useful B-cell marker after treatment with rituximab: comment on the article by Jones et al. Arthritis Rheum 2013, 65(4):1130-1131.
    • (2013) Arthritis Rheum , vol.65 , Issue.4 , pp. 1130-1131
    • Kamburova, E.G.1    Koenen, H.J.M.P.2    Joosten, I.3    Hilbrands, L.B.4
  • 24
    • 65249189320 scopus 로고    scopus 로고
    • Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in Non-Hodgkin's Lymphoma
    • Terui Y., Mishima Y., Sugimura N., Kojima K., Sakurai T., Mishima Y., et al. Identification of CD20 C-terminal deletion mutations associated with loss of CD20 expression in Non-Hodgkin's Lymphoma. Clin Cancer Res 2009, 15(7):2523-2530.
    • (2009) Clin Cancer Res , vol.15 , Issue.7 , pp. 2523-2530
    • Terui, Y.1    Mishima, Y.2    Sugimura, N.3    Kojima, K.4    Sakurai, T.5    Mishima, Y.6
  • 26
    • 62949152339 scopus 로고    scopus 로고
    • CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure
    • Johnson N.A., Leach S., Woolcock B., deLeeuw R.J., Bashashati A., Sehn L.H., et al. CD20 mutations involving the rituximab epitope are rare in diffuse large B-cell lymphomas and are not a significant cause of R-CHOP failure. Haematologica 2009, 94(3):423-427.
    • (2009) Haematologica , vol.94 , Issue.3 , pp. 423-427
    • Johnson, N.A.1    Leach, S.2    Woolcock, B.3    deLeeuw, R.J.4    Bashashati, A.5    Sehn, L.H.6
  • 27
    • 66549111370 scopus 로고    scopus 로고
    • Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance
    • Hiraga J., Tomita A., Sugimoto T., Shimada K., Ito M., Nakamura S., et al. Down-regulation of CD20 expression in B-cell lymphoma cells after treatment with rituximab-containing combination chemotherapies: its prevalence and clinical significance. Blood 2009, 113(20):4885-4893.
    • (2009) Blood , vol.113 , Issue.20 , pp. 4885-4893
    • Hiraga, J.1    Tomita, A.2    Sugimoto, T.3    Shimada, K.4    Ito, M.5    Nakamura, S.6
  • 28
    • 77954679392 scopus 로고    scopus 로고
    • Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection
    • Beers S.A., French R.R., Chan H.T.C., Lim S.H., Jarrett T.C., Vidal R.M., et al. Antigenic modulation limits the efficacy of anti-CD20 antibodies: implications for antibody selection. Blood 2010, 115(25):5191-5201.
    • (2010) Blood , vol.115 , Issue.25 , pp. 5191-5201
    • Beers, S.A.1    French, R.R.2    Chan, H.T.C.3    Lim, S.H.4    Jarrett, T.C.5    Vidal, R.M.6
  • 29
    • 40949136882 scopus 로고    scopus 로고
    • Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels
    • Czuczman M.S., Olejniczak S., Gowda A., Kotowski A., Binder A., Kaur H., et al. Acquirement of rituximab resistance in lymphoma cell lines is associated with both global CD20 gene and protein down-regulation regulated at the pretranscriptional and posttranscriptional levels. Clin Cancer Res 2008, 14(5):1561-1570.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1561-1570
    • Czuczman, M.S.1    Olejniczak, S.2    Gowda, A.3    Kotowski, A.4    Binder, A.5    Kaur, H.6
  • 30
    • 84909634201 scopus 로고    scopus 로고
    • Postulated mechanisms of resistance of B-cell non-Hodgkin lymphoma to rituximab treatment regimens: strategies to overcome resistance
    • Bonavida B. Postulated mechanisms of resistance of B-cell non-Hodgkin lymphoma to rituximab treatment regimens: strategies to overcome resistance. Semin Oncol 2014, 41(5):667-677.
    • (2014) Semin Oncol , vol.41 , Issue.5 , pp. 667-677
    • Bonavida, B.1
  • 31
    • 30444461383 scopus 로고    scopus 로고
    • Fcγ receptors: old friends and new family members
    • Nimmerjhan F., Ravetch J.V. Fcγ receptors: old friends and new family members. Immunity 2006, 24:19-28.
    • (2006) Immunity , vol.24 , pp. 19-28
    • Nimmerjhan, F.1    Ravetch, J.V.2
  • 32
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes R.A., Towers T.L., Presta L.G., Ravetch J.V. Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nat Med 2000, 6(4):443-446.
    • (2000) Nat Med , vol.6 , Issue.4 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 33
    • 3042592452 scopus 로고    scopus 로고
    • The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy
    • Uchida J., Hamaguchi Y., Oliver J.A., Ravetch J.V., Poe J.C., Haas K.M., et al. The innate mononuclear phagocyte network depletes B lymphocytes through Fc receptor-dependent mechanisms during anti-CD20 antibody immunotherapy. J Exp Med 2004, 199(12):1659-1669.
    • (2004) J Exp Med , vol.199 , Issue.12 , pp. 1659-1669
    • Uchida, J.1    Hamaguchi, Y.2    Oliver, J.A.3    Ravetch, J.V.4    Poe, J.C.5    Haas, K.M.6
  • 34
    • 51649123832 scopus 로고    scopus 로고
    • Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV
    • Minard-Colin V., Xiu Y., Poe J.C., Horikawa M., Magro C.M., Hamaguchi Y., et al. Lymphoma depletion during CD20 immunotherapy in mice is mediated by macrophage FcgammaRI, FcgammaRIII, and FcgammaRIV. Blood 2008, 112(4):1205-1213.
    • (2008) Blood , vol.112 , Issue.4 , pp. 1205-1213
    • Minard-Colin, V.1    Xiu, Y.2    Poe, J.C.3    Horikawa, M.4    Magro, C.M.5    Hamaguchi, Y.6
  • 35
    • 33845795327 scopus 로고    scopus 로고
    • A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent Non-Hodgkin's Lymphoma
    • Khan K.D., Emmanouilides C., Benson D.M., Hurst D., Garcia P., Michelson G., et al. A phase 2 study of rituximab in combination with recombinant interleukin-2 for rituximab-refractory indolent Non-Hodgkin's Lymphoma. Clin Cancer Res 2006, 12(23):7046-7053.
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 7046-7053
    • Khan, K.D.1    Emmanouilides, C.2    Benson, D.M.3    Hurst, D.4    Garcia, P.5    Michelson, G.6
  • 36
    • 34948881806 scopus 로고    scopus 로고
    • Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism
    • Hatjiharissi E., Xu L., Santos D.D., Hunter Z.R., Ciccarelli B.T., Verselis S., et al. Increased natural killer cell expression of CD16, augmented binding and ADCC activity to rituximab among individuals expressing the FcγRIIIa-158 V/V and V/F polymorphism. Blood 2007 Oct 1, 110(7):2561-2564.
    • (2007) Blood , vol.110 , Issue.7 , pp. 2561-2564
    • Hatjiharissi, E.1    Xu, L.2    Santos, D.D.3    Hunter, Z.R.4    Ciccarelli, B.T.5    Verselis, S.6
  • 37
    • 84862123411 scopus 로고    scopus 로고
    • Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone
    • Persky D.O., Dornan D., Goldman B.H., Braziel R.M., Fisher R.I., LeBlanc M., et al. Fc gamma receptor 3a genotype predicts overall survival in follicular lymphoma patients treated on SWOG trials with combined monoclonal antibody plus chemotherapy but not chemotherapy alone. Haematologica 2012, 97(6):937-942.
    • (2012) Haematologica , vol.97 , Issue.6 , pp. 937-942
    • Persky, D.O.1    Dornan, D.2    Goldman, B.H.3    Braziel, R.M.4    Fisher, R.I.5    LeBlanc, M.6
  • 38
    • 35748951343 scopus 로고    scopus 로고
    • FcγRIIIA and FcγRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab
    • Carlotti E., Palumbo G.A., Oldani E., Tibullo D., Salmoiraghi S., Rossi A., et al. FcγRIIIA and FcγRIIA polymorphisms do not predict clinical outcome of follicular non-Hodgkin's lymphoma patients treated with sequential CHOP and rituximab. Haematologica 2007, 92(8):1127-1130.
    • (2007) Haematologica , vol.92 , Issue.8 , pp. 1127-1130
    • Carlotti, E.1    Palumbo, G.A.2    Oldani, E.3    Tibullo, D.4    Salmoiraghi, S.5    Rossi, A.6
  • 39
    • 84866863976 scopus 로고    scopus 로고
    • Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms
    • Ghesquières H., Cartron G., Seymour J.F., Delfau-Larue M.-H., Offner F., Soubeyran P., et al. Clinical outcome of patients with follicular lymphoma receiving chemoimmunotherapy in the PRIMA study is not affected by FCGR3A and FCGR2A polymorphisms. Blood 2012, 120(13):2650-2657.
    • (2012) Blood , vol.120 , Issue.13 , pp. 2650-2657
    • Ghesquières, H.1    Cartron, G.2    Seymour, J.F.3    Delfau-Larue, M.-H.4    Offner, F.5    Soubeyran, P.6
  • 40
    • 80055101171 scopus 로고    scopus 로고
    • The impact of Fc-γ receptor polymorphisms in elderly patients with diffuse large B-cell lymphoma treated with CHOP with or without rituximab
    • Ahlgrimm M., Pfreundschuh M., Kreuz M., Regitz E., Preuss K.-D., Bittenbring J. The impact of Fc-γ receptor polymorphisms in elderly patients with diffuse large B-cell lymphoma treated with CHOP with or without rituximab. Blood 2011, 118(17):4657-4662.
    • (2011) Blood , vol.118 , Issue.17 , pp. 4657-4662
    • Ahlgrimm, M.1    Pfreundschuh, M.2    Kreuz, M.3    Regitz, E.4    Preuss, K.-D.5    Bittenbring, J.6
  • 41
    • 79960421233 scopus 로고    scopus 로고
    • FcγRIIA and FcγRIIIA polymorphisms do not influence survival and response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy in patients with diffuse large B-cell lymphoma
    • Fabisiewicz A., Paszkiewicz-Kozik E., Osowiecki M., Walewski J., Siedlecki J.A. FcγRIIA and FcγRIIIA polymorphisms do not influence survival and response to rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone immunochemotherapy in patients with diffuse large B-cell lymphoma. Leuk Lymphoma 2011, 52(8):1604-1606.
    • (2011) Leuk Lymphoma , vol.52 , Issue.8 , pp. 1604-1606
    • Fabisiewicz, A.1    Paszkiewicz-Kozik, E.2    Osowiecki, M.3    Walewski, J.4    Siedlecki, J.A.5
  • 42
    • 84876822432 scopus 로고    scopus 로고
    • At diagnosis, diffuse large B-cell lymphoma patients show impaired rituximab-mediated NK-cell cytotoxicity
    • Danielou-Lazareth A., Henry G., Geromin D., Khaznadar Z., Briere J., Tamouza R., et al. At diagnosis, diffuse large B-cell lymphoma patients show impaired rituximab-mediated NK-cell cytotoxicity. Eur J Immunol 2013, 43(5):1383-1388.
    • (2013) Eur J Immunol , vol.43 , Issue.5 , pp. 1383-1388
    • Danielou-Lazareth, A.1    Henry, G.2    Geromin, D.3    Khaznadar, Z.4    Briere, J.5    Tamouza, R.6
  • 43
    • 34447548552 scopus 로고    scopus 로고
    • The efficacy of rituximab plus Hyper-CVAD regimen in mantle cell lymphoma is independent of FCgammaRIIIa and FCgammaRIIa polymorphisms
    • Galimberti S., Palumbo G.A., Caracciolo F., Benedetti E., Pelosini M., Brizzi S., et al. The efficacy of rituximab plus Hyper-CVAD regimen in mantle cell lymphoma is independent of FCgammaRIIIa and FCgammaRIIa polymorphisms. J Chemother 2007, 19(3):315-321.
    • (2007) J Chemother , vol.19 , Issue.3 , pp. 315-321
    • Galimberti, S.1    Palumbo, G.A.2    Caracciolo, F.3    Benedetti, E.4    Pelosini, M.5    Brizzi, S.6
  • 44
    • 19944425937 scopus 로고    scopus 로고
    • FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia
    • Lin T.S., Flinn I.W., Modali R., Lehman T.A., Webb J., Waymer S., et al. FCGR3A and FCGR2A polymorphisms may not correlate with response to alemtuzumab in chronic lymphocytic leukemia. Blood 2005, 105(1):289-291.
    • (2005) Blood , vol.105 , Issue.1 , pp. 289-291
    • Lin, T.S.1    Flinn, I.W.2    Modali, R.3    Lehman, T.A.4    Webb, J.5    Waymer, S.6
  • 45
    • 20044363597 scopus 로고    scopus 로고
    • Polymorphisms in FcgammaRIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenström's macroglobulinemia
    • Treon S.P., Hansen M., Branagan A.R., Verselis S., Emmanouilides C., Kimby E., et al. Polymorphisms in FcgammaRIIIA (CD16) receptor expression are associated with clinical response to rituximab in Waldenström's macroglobulinemia. J Clin Oncol 2005, 23(3):474-481.
    • (2005) J Clin Oncol , vol.23 , Issue.3 , pp. 474-481
    • Treon, S.P.1    Hansen, M.2    Branagan, A.R.3    Verselis, S.4    Emmanouilides, C.5    Kimby, E.6
  • 46
    • 74949083067 scopus 로고    scopus 로고
    • Immunoglobulin G Fc receptor FcγRIIIA 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with Non-Hodgkin's Lymphoma
    • Weng W.-K., Negrin R.S., Lavori P., Horning S.J. Immunoglobulin G Fc receptor FcγRIIIA 158 V/F polymorphism correlates with rituximab-induced neutropenia after autologous transplantation in patients with Non-Hodgkin's Lymphoma. J Clin Oncol 2010, 28(2):279-284.
    • (2010) J Clin Oncol , vol.28 , Issue.2 , pp. 279-284
    • Weng, W.-K.1    Negrin, R.S.2    Lavori, P.3    Horning, S.J.4
  • 47
    • 84867473636 scopus 로고    scopus 로고
    • Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma
    • Keane C., Nourse J.P., Crooks P., Nguyen-Van D., Mutsando H., Mollee P., et al. Homozygous FCGR3A-158V alleles predispose to late onset neutropenia after CHOP-R for diffuse large B-cell lymphoma. Intern Med J 2012, 42(10):1113-1119.
    • (2012) Intern Med J , vol.42 , Issue.10 , pp. 1113-1119
    • Keane, C.1    Nourse, J.P.2    Crooks, P.3    Nguyen-Van, D.4    Mutsando, H.5    Mollee, P.6
  • 48
    • 0642373290 scopus 로고    scopus 로고
    • Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma
    • Weng W.K., Levy R. Two immunoglobulin G fragment C receptor polymorphisms independently predict response to rituximab in patients with follicular lymphoma. J Clin Oncol 2003, 21(21):3940-3947.
    • (2003) J Clin Oncol , vol.21 , Issue.21 , pp. 3940-3947
    • Weng, W.K.1    Levy, R.2
  • 49
    • 19944415842 scopus 로고    scopus 로고
    • FcgammaRIIB expression in diffuse large B-cell lymphomas does not alter the response to CHOP+rituximab (R-CHOP)
    • Camilleri-Broët S., Mounier N., Delmer A., Brière J., Casasnovas O., Cassard L., et al. FcgammaRIIB expression in diffuse large B-cell lymphomas does not alter the response to CHOP+rituximab (R-CHOP). Leukemia 2004, 18(12):2038-2040.
    • (2004) Leukemia , vol.18 , Issue.12 , pp. 2038-2040
    • Camilleri-Broët, S.1    Mounier, N.2    Delmer, A.3    Brière, J.4    Casasnovas, O.5    Cassard, L.6
  • 50
    • 68449103580 scopus 로고    scopus 로고
    • Genetic polymorphism of the inhibitory IgG Fc receptor FcγRIIb is not associated with clinical outcome in patients with follicular lymphoma treated with rituximab
    • Weng W.-K., Levy R. Genetic polymorphism of the inhibitory IgG Fc receptor FcγRIIb is not associated with clinical outcome in patients with follicular lymphoma treated with rituximab. Leuk Lymphoma 2009, 50(5):723-727.
    • (2009) Leuk Lymphoma , vol.50 , Issue.5 , pp. 723-727
    • Weng, W.-K.1    Levy, R.2
  • 52
    • 84927604777 scopus 로고    scopus 로고
    • Combination of lenalidomide and rituximab overcomes rituximab-resistance in patients with indolent B-cell and mantle cell lymphomas
    • Chong E.A., Ahmadi T., Aqui N., Svoboda J., Nasta S.D., Mato A.R., et al. Combination of lenalidomide and rituximab overcomes rituximab-resistance in patients with indolent B-cell and mantle cell lymphomas. Clin Cancer Res 2015.
    • (2015) Clin Cancer Res
    • Chong, E.A.1    Ahmadi, T.2    Aqui, N.3    Svoboda, J.4    Nasta, S.D.5    Mato, A.R.6
  • 53
    • 52949138251 scopus 로고    scopus 로고
    • The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy
    • Zhou X., Hu W., Qin X. The role of complement in the mechanism of action of rituximab for B-cell lymphoma: implications for therapy. Oncologist 2008, 13(9):954-966.
    • (2008) Oncologist , vol.13 , Issue.9 , pp. 954-966
    • Zhou, X.1    Hu, W.2    Qin, X.3
  • 54
    • 0028074679 scopus 로고
    • Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps
    • Ollert M.W., Kadlec J.V., David K., Petrella E.C., Bredehorst R., Vogel C.W. Antibody-mediated complement activation on nucleated cells. A quantitative analysis of the individual reaction steps. J Immunol 1994, 153(5):2213-2221.
    • (1994) J Immunol , vol.153 , Issue.5 , pp. 2213-2221
    • Ollert, M.W.1    Kadlec, J.V.2    David, K.3    Petrella, E.C.4    Bredehorst, R.5    Vogel, C.W.6
  • 55
    • 0042346042 scopus 로고    scopus 로고
    • Complement activation determines the therapeutic activity of rituximab in vivo
    • Gaetano N.D., Cittera E., Nota R., Vecchi A., Grieco V., Scanziani E., et al. Complement activation determines the therapeutic activity of rituximab in vivo. J Immunol 2003, 171(3):1581-1587.
    • (2003) J Immunol , vol.171 , Issue.3 , pp. 1581-1587
    • Gaetano, N.D.1    Cittera, E.2    Nota, R.3    Vecchi, A.4    Grieco, V.5    Scanziani, E.6
  • 57
    • 1342282157 scopus 로고    scopus 로고
    • Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia
    • Kennedy A.D., Beum P.V., Solga M.D., DiLillo D.J., Lindorfer M.A., Hess C.E., et al. Rituximab infusion promotes rapid complement depletion and acute CD20 loss in chronic lymphocytic leukemia. J Immunol 2004, 172(5):3280-3288.
    • (2004) J Immunol , vol.172 , Issue.5 , pp. 3280-3288
    • Kennedy, A.D.1    Beum, P.V.2    Solga, M.D.3    DiLillo, D.J.4    Lindorfer, M.A.5    Hess, C.E.6
  • 58
    • 58149176733 scopus 로고    scopus 로고
    • A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma
    • Racila E., Link B.K., Weng W.-K., Witzig T.E., Ansell S., Maurer M.J., et al. A polymorphism in the complement component C1qA correlates with prolonged response following rituximab therapy of follicular lymphoma. Clin Cancer Res 2008, 14(20):6697-6703.
    • (2008) Clin Cancer Res , vol.14 , Issue.20 , pp. 6697-6703
    • Racila, E.1    Link, B.K.2    Weng, W.-K.3    Witzig, T.E.4    Ansell, S.5    Maurer, M.J.6
  • 59
    • 84864911803 scopus 로고    scopus 로고
    • Homozygous A polymorphism of the complement C1qA276 correlates with prolonged overall survival in patients with diffuse large B-cell lymphoma treated with R-CHOP
    • Jin X., Ding H., Ding N., Fu Z., Song Y., Zhu J. Homozygous A polymorphism of the complement C1qA276 correlates with prolonged overall survival in patients with diffuse large B-cell lymphoma treated with R-CHOP. J Hematol Oncol 2012, 16(5):51.
    • (2012) J Hematol Oncol , vol.16 , Issue.5 , pp. 51
    • Jin, X.1    Ding, H.2    Ding, N.3    Fu, Z.4    Song, Y.5    Zhu, J.6
  • 60
    • 0037306893 scopus 로고    scopus 로고
    • In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas
    • Manches O., Lui G., Chaperot L., Gressin R., Molens J.-P., Jacob M.-C., et al. In vitro mechanisms of action of rituximab on primary non-Hodgkin lymphomas. Blood 2003, 101(3):949-954.
    • (2003) Blood , vol.101 , Issue.3 , pp. 949-954
    • Manches, O.1    Lui, G.2    Chaperot, L.3    Gressin, R.4    Molens, J.-P.5    Jacob, M.-C.6
  • 61
    • 0038518572 scopus 로고    scopus 로고
    • Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance
    • Bannerji R., Kitada S., Flinn I.W., Pearson M., Young D., Reed J.C., et al. Apoptotic-regulatory and complement-protecting protein expression in chronic lymphocytic leukemia: relationship to in vivo rituximab resistance. J Clin Oncol 2003, 21(8):1466-1471.
    • (2003) J Clin Oncol , vol.21 , Issue.8 , pp. 1466-1471
    • Bannerji, R.1    Kitada, S.2    Flinn, I.W.3    Pearson, M.4    Young, D.5    Reed, J.C.6
  • 62
    • 0035469885 scopus 로고    scopus 로고
    • Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma
    • Weng W.-K., Levy R. Expression of complement inhibitors CD46, CD55, and CD59 on tumor cells does not predict clinical outcome after rituximab treatment in follicular non-Hodgkin lymphoma. Blood 2001, 98(5):1352-1357.
    • (2001) Blood , vol.98 , Issue.5 , pp. 1352-1357
    • Weng, W.-K.1    Levy, R.2
  • 63
    • 0035760902 scopus 로고    scopus 로고
    • CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59
    • Golay J., Lazzari M., Facchinetti V., Bernasconi S., Borleri G., Barbui T., et al. CD20 levels determine the in vitro susceptibility to rituximab and complement of B-cell chronic lymphocytic leukemia: further regulation by CD55 and CD59. Blood 2001, 98(12):3383-3389.
    • (2001) Blood , vol.98 , Issue.12 , pp. 3383-3389
    • Golay, J.1    Lazzari, M.2    Facchinetti, V.3    Bernasconi, S.4    Borleri, G.5    Barbui, T.6
  • 64
    • 35948989248 scopus 로고    scopus 로고
    • In vivo targeting of human neutralizing antibodies against CD55 and CD59 to lymphoma cells increases the antitumor activity of rituximab
    • Macor P., Tripodo C., Zorzet S., Piovan E., Bossi F., Marzari R., et al. In vivo targeting of human neutralizing antibodies against CD55 and CD59 to lymphoma cells increases the antitumor activity of rituximab. Cancer Res 2007, 67(21):10556-10563.
    • (2007) Cancer Res , vol.67 , Issue.21 , pp. 10556-10563
    • Macor, P.1    Tripodo, C.2    Zorzet, S.3    Piovan, E.4    Bossi, F.5    Marzari, R.6
  • 65
    • 0034796371 scopus 로고    scopus 로고
    • Synergism between fludarabine and rituximab revealed in a follicular lymphoma cell line resistant to the cytotoxic activity of either drug alone
    • Di Gaetano N., Xiao Y., Erba E., Bassan R., Rambaldi A., Golay J., et al. Synergism between fludarabine and rituximab revealed in a follicular lymphoma cell line resistant to the cytotoxic activity of either drug alone. Br J Haematol 2001, 114(4):800-809.
    • (2001) Br J Haematol , vol.114 , Issue.4 , pp. 800-809
    • Di Gaetano, N.1    Xiao, Y.2    Erba, E.3    Bassan, R.4    Rambaldi, A.5    Golay, J.6
  • 66
    • 38049049866 scopus 로고    scopus 로고
    • Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin
    • Hu W., Ferris S.P., Tweten R.K., Wu G., Radaeva S., Gao B., et al. Rapid conditional targeted ablation of cells expressing human CD59 in transgenic mice by intermedilysin. Nat Med 2008, 14(1):98-103.
    • (2008) Nat Med , vol.14 , Issue.1 , pp. 98-103
    • Hu, W.1    Ferris, S.P.2    Tweten, R.K.3    Wu, G.4    Radaeva, S.5    Gao, B.6
  • 67
    • 0035525769 scopus 로고    scopus 로고
    • Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species
    • Bellosillo B., Villamor N., López-Guillermo A., Marcé S., Esteve J., Campo E., et al. Complement-mediated cell death induced by rituximab in B-cell lymphoproliferative disorders is mediated in vitro by a caspase-independent mechanism involving the generation of reactive oxygen species. Blood 2001, 98(9):2771-2777.
    • (2001) Blood , vol.98 , Issue.9 , pp. 2771-2777
    • Bellosillo, B.1    Villamor, N.2    López-Guillermo, A.3    Marcé, S.4    Esteve, J.5    Campo, E.6
  • 68
    • 20444395865 scopus 로고    scopus 로고
    • Enhanced expression of CD20 in human tumor B cells is controlled through ERK-dependent mechanisms
    • Wojciechowski W., Li H., Marshall S., Dell'Agnola C., Espinoza-Delgado I. Enhanced expression of CD20 in human tumor B cells is controlled through ERK-dependent mechanisms. J Immunol 2005, 174(12):7859-7868.
    • (2005) J Immunol , vol.174 , Issue.12 , pp. 7859-7868
    • Wojciechowski, W.1    Li, H.2    Marshall, S.3    Dell'Agnola, C.4    Espinoza-Delgado, I.5
  • 69
    • 84865071316 scopus 로고    scopus 로고
    • High reproducible ADCC analysis revealed a competitive relation between ADCC and CDC and differences between FcγRIIIa polymorphism
    • Mishima Y., Terui Y., Mishima Y., Kuniyoshi R., Matsusaka S., Mikuniya M., et al. High reproducible ADCC analysis revealed a competitive relation between ADCC and CDC and differences between FcγRIIIa polymorphism. Int Immunol 2012, 24(8):477-483.
    • (2012) Int Immunol , vol.24 , Issue.8 , pp. 477-483
    • Mishima, Y.1    Terui, Y.2    Mishima, Y.3    Kuniyoshi, R.4    Matsusaka, S.5    Mikuniya, M.6
  • 71
    • 0141704595 scopus 로고    scopus 로고
    • CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts
    • Chan H.T.C., Hughes D., French R.R., Tutt A.L., Walshe C.A., Teeling J.L., et al. CD20-induced lymphoma cell death is independent of both caspases and its redistribution into Triton X-100 insoluble membrane rafts. Cancer Res 2003, 63(17):5480-5489.
    • (2003) Cancer Res , vol.63 , Issue.17 , pp. 5480-5489
    • Chan, H.T.C.1    Hughes, D.2    French, R.R.3    Tutt, A.L.4    Walshe, C.A.5    Teeling, J.L.6
  • 72
    • 46949084417 scopus 로고    scopus 로고
    • A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab
    • Daniels I., Turzanski J., Haynes A.P. A requirement for calcium in the caspase-independent killing of Burkitt lymphoma cell lines by Rituximab. Br J Haematol 2008, 142(3):394-403.
    • (2008) Br J Haematol , vol.142 , Issue.3 , pp. 394-403
    • Daniels, I.1    Turzanski, J.2    Haynes, A.P.3
  • 73
    • 84887097534 scopus 로고    scopus 로고
    • Hydroxyurea potentiates the caspase-independent killing of B-cell lines by rituximab and GA101
    • Daniels I., Abulayha A., Haynes A.P. Hydroxyurea potentiates the caspase-independent killing of B-cell lines by rituximab and GA101. Oncol Res 2012, 20(12):545-555.
    • (2012) Oncol Res , vol.20 , Issue.12 , pp. 545-555
    • Daniels, I.1    Abulayha, A.2    Haynes, A.P.3
  • 74
    • 25444436462 scopus 로고    scopus 로고
    • Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking
    • Unruh T.L., Li H., Mutch C.M., Shariat N., Grigoriou L., Sanyal R., et al. Cholesterol depletion inhibits src family kinase-dependent calcium mobilization and apoptosis induced by rituximab crosslinking. Immunology 2005, 116(2):223-232.
    • (2005) Immunology , vol.116 , Issue.2 , pp. 223-232
    • Unruh, T.L.1    Li, H.2    Mutch, C.M.3    Shariat, N.4    Grigoriou, L.5    Sanyal, R.6
  • 75
    • 41549118473 scopus 로고    scopus 로고
    • Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20
    • Winiarska M., Bil J., Wilczek E., Wilczynski G.M., Lekka M., Engelberts P.J., et al. Statins Impair Antitumor Effects of Rituximab by Inducing Conformational Changes of CD20. PLoS Med 2008, 5(3):e64.
    • (2008) PLoS Med , vol.5 , Issue.3 , pp. e64
    • Winiarska, M.1    Bil, J.2    Wilczek, E.3    Wilczynski, G.M.4    Lekka, M.5    Engelberts, P.J.6
  • 76
    • 28744442248 scopus 로고    scopus 로고
    • Rituximab (chimeric anti-CD20) sensitizes B-NHL cell lines to Fas-induced apoptosis
    • Vega M.I., Huerta-Yepez S., Jazirehi A.R., Garban H., Bonavida B. Rituximab (chimeric anti-CD20) sensitizes B-NHL cell lines to Fas-induced apoptosis. Oncogene 2005, 24(55):8114-8127.
    • (2005) Oncogene , vol.24 , Issue.55 , pp. 8114-8127
    • Vega, M.I.1    Huerta-Yepez, S.2    Jazirehi, A.R.3    Garban, H.4    Bonavida, B.5
  • 77
    • 23444459884 scopus 로고    scopus 로고
    • Rituximab-induced inhibition of YY1 and Bcl-xL expression in ramos Non-Hodgkin's lymphoma cell line via inhibition of NF-κB activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively
    • Vega M.I., Jazirehi A.R., Huerta-Yepez S., Bonavida B. Rituximab-induced inhibition of YY1 and Bcl-xL expression in ramos Non-Hodgkin's lymphoma cell line via inhibition of NF-κB activity: role of YY1 and Bcl-xL in Fas resistance and chemoresistance, respectively. J Immunol 2005, 175(4):2174-2183.
    • (2005) J Immunol , vol.175 , Issue.4 , pp. 2174-2183
    • Vega, M.I.1    Jazirehi, A.R.2    Huerta-Yepez, S.3    Bonavida, B.4
  • 78
    • 0035283079 scopus 로고    scopus 로고
    • Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3
    • Wieder T., Essmann F., Prokop A., Schmelz K., Schulze-Osthoff K., Beyaert R., et al. Activation of caspase-8 in drug-induced apoptosis of B-lymphoid cells is independent of CD95/Fas receptor-ligand interaction and occurs downstream of caspase-3. Blood 2001, 97(5):1378-1387.
    • (2001) Blood , vol.97 , Issue.5 , pp. 1378-1387
    • Wieder, T.1    Essmann, F.2    Prokop, A.3    Schmelz, K.4    Schulze-Osthoff, K.5    Beyaert, R.6
  • 79
    • 33846920348 scopus 로고    scopus 로고
    • Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B-cells to Fas-induced apoptosis
    • Stel A.J., ten Cate B., Jacobs S., Kok J.W., Spierings D.C.J., Dondorff M., et al. Fas receptor clustering and involvement of the death receptor pathway in rituximab-mediated apoptosis with concomitant sensitization of lymphoma B-cells to Fas-induced apoptosis. J Immunol 2007, 178(4):2287-2295.
    • (2007) J Immunol , vol.178 , Issue.4 , pp. 2287-2295
    • Stel, A.J.1    ten Cate, B.2    Jacobs, S.3    Kok, J.W.4    Spierings, D.C.J.5    Dondorff, M.6
  • 80
    • 67349200795 scopus 로고    scopus 로고
    • The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells
    • Eeva J., Nuutinen U., Ropponen A., Mättö M., Eray M., Pellinen R., et al. The involvement of mitochondria and the caspase-9 activation pathway in rituximab-induced apoptosis in FL cells. Apoptosis 2009, 14(5):687-698.
    • (2009) Apoptosis , vol.14 , Issue.5 , pp. 687-698
    • Eeva, J.1    Nuutinen, U.2    Ropponen, A.3    Mättö, M.4    Eray, M.5    Pellinen, R.6
  • 81
    • 39049144862 scopus 로고    scopus 로고
    • Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists
    • Bremer E., ten Cate B., Samplonius D.F., Mueller N., Wajant H., Stel A.J., et al. Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists. Cancer Res 2008, 68(2):597-604.
    • (2008) Cancer Res , vol.68 , Issue.2 , pp. 597-604
    • Bremer, E.1    ten Cate, B.2    Samplonius, D.F.3    Mueller, N.4    Wajant, H.5    Stel, A.J.6
  • 82
    • 40949083386 scopus 로고    scopus 로고
    • Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression
    • Olejniczak S.H., Hernandez-Ilizaliturri F.J., Clements J.L., Czuczman M.S. Acquired resistance to rituximab is associated with chemotherapy resistance resulting from decreased Bax and Bak expression. Clin Cancer Res 2008, 14(5):1550-1560.
    • (2008) Clin Cancer Res , vol.14 , Issue.5 , pp. 1550-1560
    • Olejniczak, S.H.1    Hernandez-Ilizaliturri, F.J.2    Clements, J.L.3    Czuczman, M.S.4
  • 83
    • 54049145194 scopus 로고    scopus 로고
    • Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma
    • Pro B., Leber B., Smith M., Fayad L., Romaguera J., Hagemeister F., et al. Phase II multicenter study of oblimersen sodium, a Bcl-2 antisense oligonucleotide, in combination with rituximab in patients with recurrent B-cell non-Hodgkin lymphoma. Br J Haematol 2008, 143(3):355-360.
    • (2008) Br J Haematol , vol.143 , Issue.3 , pp. 355-360
    • Pro, B.1    Leber, B.2    Smith, M.3    Fayad, L.4    Romaguera, J.5    Hagemeister, F.6
  • 84
    • 77956396829 scopus 로고    scopus 로고
    • Oncogenic activation of NF-κB
    • Staudt L.M. Oncogenic activation of NF-κB. Cold Spring Harb Perspect Biol 2010, 2(6):a000109.
    • (2010) Cold Spring Harb Perspect Biol , vol.2 , Issue.6 , pp. a000109
    • Staudt, L.M.1
  • 85
    • 11244254238 scopus 로고    scopus 로고
    • Rituximab (Chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-κB signaling pathway in Non-Hodgkin's Lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis
    • Jazirehi A.R., Huerta-Yepez S., Cheng G., Bonavida B. Rituximab (Chimeric anti-CD20 monoclonal antibody) inhibits the constitutive nuclear factor-κB signaling pathway in Non-Hodgkin's Lymphoma B-cell lines: role in sensitization to chemotherapeutic drug-induced apoptosis. Cancer Res 2005, 65(1):264-276.
    • (2005) Cancer Res , vol.65 , Issue.1 , pp. 264-276
    • Jazirehi, A.R.1    Huerta-Yepez, S.2    Cheng, G.3    Bonavida, B.4
  • 86
    • 73949123882 scopus 로고    scopus 로고
    • Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 MAb: implication in chemosensitization
    • Vega M.I., Martínez-Paniagua M., Huerta-Yepez S., González-Bonilla C., Uematsu N., Bonavida B. Dysregulation of the cell survival/anti-apoptotic NF-kappaB pathway by the novel humanized BM-ca anti-CD20 MAb: implication in chemosensitization. Int J Oncol 2009, 35(6):1289-1296.
    • (2009) Int J Oncol , vol.35 , Issue.6 , pp. 1289-1296
    • Vega, M.I.1    Martínez-Paniagua, M.2    Huerta-Yepez, S.3    González-Bonilla, C.4    Uematsu, N.5    Bonavida, B.6
  • 87
    • 55049126696 scopus 로고    scopus 로고
    • The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs
    • Vega M.I., Martinez-Paniagua M., Jazirehi A.R., Huerta-Yepez S., Umezawa K., Martinez-Maza O., et al. The NF-kappaB inhibitors (bortezomib and DHMEQ) sensitise rituximab-resistant AIDS-B-non-Hodgkin lymphoma to apoptosis by various chemotherapeutic drugs. Leuk Lymphoma 2008, 49(10):1982-1994.
    • (2008) Leuk Lymphoma , vol.49 , Issue.10 , pp. 1982-1994
    • Vega, M.I.1    Martinez-Paniagua, M.2    Jazirehi, A.R.3    Huerta-Yepez, S.4    Umezawa, K.5    Martinez-Maza, O.6
  • 88
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon A.S., Hagan S., Rath O., Kolch W. MAP kinase signalling pathways in cancer. Oncogene 2007, 26(22):3279-3290.
    • (2007) Oncogene , vol.26 , Issue.22 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 89
    • 0034894958 scopus 로고    scopus 로고
    • Inhibition of interleukin 10 by rituximab results in down-regulation of Bcl-2 and sensitization of B-cell Non-Hodgkin's Lymphoma to apoptosis
    • Alas S., Emmanouilides C., Bonavida B. Inhibition of interleukin 10 by rituximab results in down-regulation of Bcl-2 and sensitization of B-cell Non-Hodgkin's Lymphoma to apoptosis. Clin Cancer Res 2001, 7(3):709-723.
    • (2001) Clin Cancer Res , vol.7 , Issue.3 , pp. 709-723
    • Alas, S.1    Emmanouilides, C.2    Bonavida, B.3
  • 90
    • 2442681173 scopus 로고    scopus 로고
    • Rituximab (anti-CD20) selectively modifies Bcl-xL and apoptosis protease activating factor-1 (Apaf-1) expression and sensitizes human non-Hodgkin's lymphoma B-cell lines to paclitaxel-induced apoptosis
    • Jazirehi A.R., Gan X.-H., Vos S.D., Emmanouilides C., Bonavida B. Rituximab (anti-CD20) selectively modifies Bcl-xL and apoptosis protease activating factor-1 (Apaf-1) expression and sensitizes human non-Hodgkin's lymphoma B-cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 2003, 2(11):1183-1193.
    • (2003) Mol Cancer Ther , vol.2 , Issue.11 , pp. 1183-1193
    • Jazirehi, A.R.1    Gan, X.-H.2    Vos, S.D.3    Emmanouilides, C.4    Bonavida, B.5
  • 91
    • 2442684327 scopus 로고    scopus 로고
    • Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance
    • Vega M.I., Huerta-Yepaz S., Garban H., Jazirehi A., Emmanouilides C., Bonavida B. Rituximab inhibits p38 MAPK activity in 2F7 B NHL and decreases IL-10 transcription: pivotal role of p38 MAPK in drug resistance. Oncogene 2004, 23(20):3530-3540.
    • (2004) Oncogene , vol.23 , Issue.20 , pp. 3530-3540
    • Vega, M.I.1    Huerta-Yepaz, S.2    Garban, H.3    Jazirehi, A.4    Emmanouilides, C.5    Bonavida, B.6
  • 92
    • 0037082469 scopus 로고    scopus 로고
    • The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism
    • Pedersen I.M., Buhl A.M., Klausen P., Geisler C.H., Jurlander J. The chimeric anti-CD20 antibody rituximab induces apoptosis in B-cell chronic lymphocytic leukemia cells through a p38 mitogen activated protein-kinase-dependent mechanism. Blood 2002, 99(4):1314-1319.
    • (2002) Blood , vol.99 , Issue.4 , pp. 1314-1319
    • Pedersen, I.M.1    Buhl, A.M.2    Klausen, P.3    Geisler, C.H.4    Jurlander, J.5
  • 93
    • 0037236924 scopus 로고    scopus 로고
    • Inhibition of constitutive STAT3 activity sensitizes resistant Non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis
    • Alas S., Bonavida B. Inhibition of constitutive STAT3 activity sensitizes resistant Non-Hodgkin's lymphoma and multiple myeloma to chemotherapeutic drug-mediated apoptosis. Clin Cancer Res 2003, 9(1):316-326.
    • (2003) Clin Cancer Res , vol.9 , Issue.1 , pp. 316-326
    • Alas, S.1    Bonavida, B.2
  • 94
    • 4944264724 scopus 로고    scopus 로고
    • Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of Non-Hodgkin's Lymphoma B-cells by rituximab
    • Jazirehi A.R., Vega M.I., Chatterjee D., Goodglick L., Bonavida B. Inhibition of the Raf-MEK1/2-ERK1/2 signaling pathway, Bcl-xL down-regulation, and chemosensitization of Non-Hodgkin's Lymphoma B-cells by rituximab. Cancer Res 2004, 64(19):7117-7126.
    • (2004) Cancer Res , vol.64 , Issue.19 , pp. 7117-7126
    • Jazirehi, A.R.1    Vega, M.I.2    Chatterjee, D.3    Goodglick, L.4    Bonavida, B.5
  • 95
    • 4444274529 scopus 로고    scopus 로고
    • Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis
    • Jazirehi A.R., Bonavida B. Resveratrol modifies the expression of apoptotic regulatory proteins and sensitizes non-Hodgkin's lymphoma and multiple myeloma cell lines to paclitaxel-induced apoptosis. Mol Cancer Ther 2004, 3(1):71-84.
    • (2004) Mol Cancer Ther , vol.3 , Issue.1 , pp. 71-84
    • Jazirehi, A.R.1    Bonavida, B.2
  • 97
    • 33845501828 scopus 로고    scopus 로고
    • Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
    • Uddin S., Hussain A.R., Siraj A.K., Manogaran P.S., Al-Jomah N.A., Moorji A., et al. Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival. Blood 2006, 108(13):4178-4186.
    • (2006) Blood , vol.108 , Issue.13 , pp. 4178-4186
    • Uddin, S.1    Hussain, A.R.2    Siraj, A.K.3    Manogaran, P.S.4    Al-Jomah, N.A.5    Moorji, A.6
  • 98
    • 77951693077 scopus 로고    scopus 로고
    • High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy
    • Hasselblom S., Hansson U., Olsson M., Torén L., Bergström A., Nilsson-Ehle H., et al. High immunohistochemical expression of p-AKT predicts inferior survival in patients with diffuse large B-cell lymphoma treated with immunochemotherapy. Br J Haematol 2010, 149(4):560-568.
    • (2010) Br J Haematol , vol.149 , Issue.4 , pp. 560-568
    • Hasselblom, S.1    Hansson, U.2    Olsson, M.3    Torén, L.4    Bergström, A.5    Nilsson-Ehle, H.6
  • 99
    • 34249734458 scopus 로고    scopus 로고
    • Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis
    • Suzuki E., Umezawa K., Bonavida B. Rituximab inhibits the constitutively activated PI3K-Akt pathway in B-NHL cell lines: involvement in chemosensitization to drug-induced apoptosis. Oncogene 2007, 26(42):6184-6193.
    • (2007) Oncogene , vol.26 , Issue.42 , pp. 6184-6193
    • Suzuki, E.1    Umezawa, K.2    Bonavida, B.3
  • 102
    • 84901724050 scopus 로고    scopus 로고
    • A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL)
    • Kahl B.S., Spurgeon S.E., Furman R.R., Flinn I.W., Coutre S.E., Brown J.R., et al. A phase 1 study of the PI3Kδ inhibitor idelalisib in patients with relapsed/refractory mantle cell lymphoma (MCL). Blood 2014, 123(22):3398-3405.
    • (2014) Blood , vol.123 , Issue.22 , pp. 3398-3405
    • Kahl, B.S.1    Spurgeon, S.E.2    Furman, R.R.3    Flinn, I.W.4    Coutre, S.E.5    Brown, J.R.6
  • 103
    • 84875651324 scopus 로고    scopus 로고
    • Everolimus in combination with rituximab induces complete responses in heavily pretreated diffuse large B-cell lymphoma
    • Barnes J.A., Jacobsen E., Feng Y., Freedman A., Hochberg E.P., LaCasce A.S., et al. Everolimus in combination with rituximab induces complete responses in heavily pretreated diffuse large B-cell lymphoma. Haematologica 2013, 98(4):615-619.
    • (2013) Haematologica , vol.98 , Issue.4 , pp. 615-619
    • Barnes, J.A.1    Jacobsen, E.2    Feng, Y.3    Freedman, A.4    Hochberg, E.P.5    LaCasce, A.S.6
  • 104
    • 68949102180 scopus 로고    scopus 로고
    • Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma
    • Hess G., Herbrecht R., Romaguera J., Verhoef G., Crump M., Gisselbrecht C., et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. J Clin Oncol 2009, 27(23):3822-3829.
    • (2009) J Clin Oncol , vol.27 , Issue.23 , pp. 3822-3829
    • Hess, G.1    Herbrecht, R.2    Romaguera, J.3    Verhoef, G.4    Crump, M.5    Gisselbrecht, C.6
  • 105
    • 79953182631 scopus 로고    scopus 로고
    • Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a multi-center Phase 2 study
    • Ansell S.M., Tang H., Kurtin P.J., Koenig P.A., Inwards D.J., Shah K., et al. Temsirolimus and rituximab in patients with relapsed or refractory mantle cell lymphoma: a multi-center Phase 2 study. Lancet Oncol 2011, 12(4):361-368.
    • (2011) Lancet Oncol , vol.12 , Issue.4 , pp. 361-368
    • Ansell, S.M.1    Tang, H.2    Kurtin, P.J.3    Koenig, P.A.4    Inwards, D.J.5    Shah, K.6
  • 106
    • 78651232150 scopus 로고    scopus 로고
    • BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties
    • Nishida M., Uematsu N., Kobayashi H., Matsunaga Y., Ishida S., Takata M., et al. BM-ca is a newly defined type I/II anti-CD20 monoclonal antibody with unique biological properties. Int J Oncol 2011, 38(2):335-344.
    • (2011) Int J Oncol , vol.38 , Issue.2 , pp. 335-344
    • Nishida, M.1    Uematsu, N.2    Kobayashi, H.3    Matsunaga, Y.4    Ishida, S.5    Takata, M.6
  • 107
    • 77955300283 scopus 로고    scopus 로고
    • Ofatumumab, a novel anti-CD20 monoclonal antibody for the treatment of B-cell malignancies
    • Cheson B.D. Ofatumumab, a novel anti-CD20 monoclonal antibody for the treatment of B-cell malignancies. J Clin Oncol 2010, 28(21):3525-3530.
    • (2010) J Clin Oncol , vol.28 , Issue.21 , pp. 3525-3530
    • Cheson, B.D.1
  • 108
    • 84874835426 scopus 로고    scopus 로고
    • Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties
    • Rafiq S., Butchar J.P., Cheney C., Mo X., Trotta R., Caligiuri M., et al. Comparative assessment of clinically utilized CD20-directed antibodies in chronic lymphocytic leukemia cells reveals divergent NK cell, monocyte, and macrophage properties. J Immunol 2013, 190(6):2702-2711.
    • (2013) J Immunol , vol.190 , Issue.6 , pp. 2702-2711
    • Rafiq, S.1    Butchar, J.P.2    Cheney, C.3    Mo, X.4    Trotta, R.5    Caligiuri, M.6
  • 109
    • 84896716648 scopus 로고    scopus 로고
    • Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia
    • Baig N.A., Taylor R.P., Lindorfer M.A., Church A.K., LaPlant B.R., Pettinger A.M., et al. Induced resistance to ofatumumab-mediated cell clearance mechanisms, including complement-dependent cytotoxicity, in chronic lymphocytic leukemia. J Immunol 2014, 192(4):1620-1629.
    • (2014) J Immunol , vol.192 , Issue.4 , pp. 1620-1629
    • Baig, N.A.1    Taylor, R.P.2    Lindorfer, M.A.3    Church, A.K.4    LaPlant, B.R.5    Pettinger, A.M.6
  • 110
    • 47049124865 scopus 로고    scopus 로고
    • First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial
    • Hagenbeek A., Gadeberg O., Johnson P., Pedersen L.M., Walewski J., Hellmann A., et al. First clinical use of ofatumumab, a novel fully human anti-CD20 monoclonal antibody in relapsed or refractory follicular lymphoma: results of a phase 1/2 trial. Blood 2008, 111(12):5486-5495.
    • (2008) Blood , vol.111 , Issue.12 , pp. 5486-5495
    • Hagenbeek, A.1    Gadeberg, O.2    Johnson, P.3    Pedersen, L.M.4    Walewski, J.5    Hellmann, A.6
  • 111
    • 38949185742 scopus 로고    scopus 로고
    • Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study
    • Coiffier B., Lepretre S., Pedersen L.M., Gadeberg O., Fredriksen H., van Oers M.H.J., et al. Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study. Blood 2008, 111(3):1094-1100.
    • (2008) Blood , vol.111 , Issue.3 , pp. 1094-1100
    • Coiffier, B.1    Lepretre, S.2    Pedersen, L.M.3    Gadeberg, O.4    Fredriksen, H.5    van Oers, M.H.J.6
  • 112
    • 84899473410 scopus 로고    scopus 로고
    • Ofatumumab monotherapy in relapsed/refractory mantle cell lymphoma - a phase II trial
    • Furtado M., Dyer M.J.S., Johnson R., Berrow M., Rule S. Ofatumumab monotherapy in relapsed/refractory mantle cell lymphoma - a phase II trial. Br J Haematol 2014, 165(4):575-578.
    • (2014) Br J Haematol , vol.165 , Issue.4 , pp. 575-578
    • Furtado, M.1    Dyer, M.J.S.2    Johnson, R.3    Berrow, M.4    Rule, S.5
  • 113
    • 84885428115 scopus 로고    scopus 로고
    • A multicentre, phase II trial of ofatumumab monotherapy in relapsed/progressive diffuse large B-cell lymphoma
    • Coiffier B., Radford J., Bosly A., Martinelli G., Verhoef G., Barca G., et al. A multicentre, phase II trial of ofatumumab monotherapy in relapsed/progressive diffuse large B-cell lymphoma. Br J Haematol 2013, 163(3):334-342.
    • (2013) Br J Haematol , vol.163 , Issue.3 , pp. 334-342
    • Coiffier, B.1    Radford, J.2    Bosly, A.3    Martinelli, G.4    Verhoef, G.5    Barca, G.6
  • 114
    • 84925496626 scopus 로고    scopus 로고
    • Results of a phase II study of bendamustine and ofatumumab in untreated indolent B-cell non-Hodgkin's lymphoma
    • Czuczman M.S., Kahanic S., Forero A., Davis G., Munteanu M., VanDenNeste E., et al. Results of a phase II study of bendamustine and ofatumumab in untreated indolent B-cell non-Hodgkin's lymphoma. Ann Hematol 2015.
    • (2015) Ann Hematol
    • Czuczman, M.S.1    Kahanic, S.2    Forero, A.3    Davis, G.4    Munteanu, M.5    VanDenNeste, E.6
  • 115
    • 70249106098 scopus 로고    scopus 로고
    • Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results
    • Morschhauser F., Leonard J.P., Fayad L., Coiffier B., Petillon M.-O., Coleman M., et al. Humanized anti-CD20 antibody, veltuzumab, in refractory/recurrent non-Hodgkin's lymphoma: phase I/II results. J Clin Oncol 2009, 27(20):3346-3353.
    • (2009) J Clin Oncol , vol.27 , Issue.20 , pp. 3346-3353
    • Morschhauser, F.1    Leonard, J.P.2    Fayad, L.3    Coiffier, B.4    Petillon, M.-O.5    Coleman, M.6
  • 116
    • 79953883456 scopus 로고    scopus 로고
    • Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma
    • Negrea G.O., Elstrom R., Allen S.L., Rai K.R., Abbasi R.M., Farber C.M., et al. Subcutaneous injections of low-dose veltuzumab (humanized anti-CD20 antibody) are safe and active in patients with indolent non-Hodgkin's lymphoma. Haematologica 2011, 96(4):567-573.
    • (2011) Haematologica , vol.96 , Issue.4 , pp. 567-573
    • Negrea, G.O.1    Elstrom, R.2    Allen, S.L.3    Rai, K.R.4    Abbasi, R.M.5    Farber, C.M.6
  • 117
    • 77955175014 scopus 로고    scopus 로고
    • Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
    • Morschhauser F., Marlton P., Vitolo U., Lindén O., Seymour J.F., Crump M., et al. Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma. Ann Oncol 2010, 21(9):1870-1876.
    • (2010) Ann Oncol , vol.21 , Issue.9 , pp. 1870-1876
    • Morschhauser, F.1    Marlton, P.2    Vitolo, U.3    Lindén, O.4    Seymour, J.F.5    Crump, M.6
  • 118
    • 84905972726 scopus 로고    scopus 로고
    • Translational medicine in action: anti-CD20 therapy in lymphoma
    • Lim S.H., Levy R. Translational medicine in action: anti-CD20 therapy in lymphoma. J Immunol 2014, 193(4):1519-1524.
    • (2014) J Immunol , vol.193 , Issue.4 , pp. 1519-1524
    • Lim, S.H.1    Levy, R.2
  • 119
    • 84928005736 scopus 로고    scopus 로고
    • Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo
    • Roghanian A., Teige I., Mårtensson L., Cox K.L., Kovacek M., Ljungars A., et al. Antagonistic human FcγRIIB (CD32B) antibodies have anti-tumor activity and overcome resistance to antibody therapy in vivo. Cancer Cell 2015, 27(4):473-488.
    • (2015) Cancer Cell , vol.27 , Issue.4 , pp. 473-488
    • Roghanian, A.1    Teige, I.2    Mårtensson, L.3    Cox, K.L.4    Kovacek, M.5    Ljungars, A.6
  • 120
    • 84891398531 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) in patients with relapsed/refractory indolent non-Hodgkin lymphoma: results from the phase II GAUGUIN study
    • Salles G.A., Morschhauser F., Solal-Céligny P., Thieblemont C., Lamy T., Tilly H., et al. Obinutuzumab (GA101) in patients with relapsed/refractory indolent non-Hodgkin lymphoma: results from the phase II GAUGUIN study. J Clin Oncol 2013, 31(23):2920-2926.
    • (2013) J Clin Oncol , vol.31 , Issue.23 , pp. 2920-2926
    • Salles, G.A.1    Morschhauser, F.2    Solal-Céligny, P.3    Thieblemont, C.4    Lamy, T.5    Tilly, H.6
  • 121
    • 84891442057 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) monotherapy in relapsed/refractory diffuse large B-cell lymphoma or mantle-cell lymphoma: results from the phase II GAUGUIN study
    • Morschhauser F.A., Cartron G., Thieblemont C., Solal-Céligny P., Haioun C., Bouabdallah R., et al. Obinutuzumab (GA101) monotherapy in relapsed/refractory diffuse large B-cell lymphoma or mantle-cell lymphoma: results from the phase II GAUGUIN study. J Clin Oncol 2013, 31(23):2912-2919.
    • (2013) J Clin Oncol , vol.31 , Issue.23 , pp. 2912-2919
    • Morschhauser, F.A.1    Cartron, G.2    Thieblemont, C.3    Solal-Céligny, P.4    Haioun, C.5    Bouabdallah, R.6
  • 122
    • 84887146061 scopus 로고    scopus 로고
    • Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: results of the GAUDI study (BO21000)
    • Radford J., Davies A., Cartron G., Morschhauser F., Salles G., Marcus R., et al. Obinutuzumab (GA101) plus CHOP or FC in relapsed/refractory follicular lymphoma: results of the GAUDI study (BO21000). Blood 2013, 122(7):1137-1143.
    • (2013) Blood , vol.122 , Issue.7 , pp. 1137-1143
    • Radford, J.1    Davies, A.2    Cartron, G.3    Morschhauser, F.4    Salles, G.5    Marcus, R.6
  • 123
    • 84894552888 scopus 로고    scopus 로고
    • Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions
    • Goede V., Fischer K., Busch R., Engelke A., Eichhorst B., Wendtner C.M., et al. Obinutuzumab plus chlorambucil in patients with CLL and coexisting conditions. N Engl J Med 2014, 370(12):1101-1110.
    • (2014) N Engl J Med , vol.370 , Issue.12 , pp. 1101-1110
    • Goede, V.1    Fischer, K.2    Busch, R.3    Engelke, A.4    Eichhorst, B.5    Wendtner, C.M.6


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