Viral fusion protein transmembrane domain adopts β-strand structure to facilitate membrane topological changes for virus-cell fusion

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 35, 2015, Pages 10926-10931

  Yao, Hongwei ^a   Lee, Michelle W ^b   Waring, Alan J ^c,d   Wong, Gerard C L ^b   Hong, Mei ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Engineering IV   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Conformational polymorphism; Membrane curvature; Peptide membrane interactions; Small angle X ray scattering; Solid state NMR spectroscopy

Indexed keywords

PHOSPHATIDYLCHOLINE; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLGLYCEROL; VIRUS FUSION PROTEIN; GLYCOPROTEIN GP 41; GP41 PROTEIN, HUMAN IMMUNODEFICIENCY VIRUS 1; MEMBRANE LIPID; VIRUS HEMAGGLUTININ; WATER;

ALPHA HELIX; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL FUSION; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFUSION COEFFICIENT; HYDROPHOBICITY; LIPID MEMBRANE; MEMBRANE STRUCTURE; NITROGEN NUCLEAR MAGNETIC RESONANCE; NONHUMAN; PARAINFLUENZA VIRUS 5; PHASE TRANSITION; PHOSPHORUS NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN LIPID INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; SURFACE CHARGE; VIRUS CELL FUSION; VIRUS CELL INTERACTION; VIRUS ENVELOPE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; SMALL ANGLE SCATTERING; X RAY DIFFRACTION;

CELL FUSION; HEMAGGLUTININS, VIRAL; HIV ENVELOPE PROTEIN GP41; MEMBRANE LIPIDS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; SCATTERING, SMALL ANGLE; VIRAL FUSION PROTEINS; WATER; X-RAY DIFFRACTION;

EID: 84941010285     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1501430112     Document Type: Article

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