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Volumn 59, Issue 9, 2015, Pages 5654-5663

Protective effect of ginsenosides Rg1 and Re on lipopolysaccharide-induced sepsis by competitive binding to toll-like receptor 4

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOOXYGENASE 2; GINSENOSIDE RE; GINSENOSIDE RG 1; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; PROTECTIVE AGENT; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; GINSENOSIDE;

EID: 84940944912     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01381-15     Document Type: Article
Times cited : (41)

References (43)
  • 1
    • 84862814776 scopus 로고    scopus 로고
    • Kinetics of IL-6 and TNF-alpha changes in a canine model of sepsis induced by endotoxin
    • Song R, Kim J, Yu D, Park C, Park J. 2012. Kinetics of IL-6 and TNF-alpha changes in a canine model of sepsis induced by endotoxin. Vet Immunol Immunopathol 146:143-149. http://dx.doi.org/10.1016/j.vetimm.2012.02.008.
    • (2012) Vet Immunol Immunopathol , vol.146 , pp. 143-149
    • Song, R.1    Kim, J.2    Yu, D.3    Park, C.4    Park, J.5
  • 2
    • 0034958947 scopus 로고    scopus 로고
    • Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
    • Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit Care Med 29:1303-1310. http://dx.doi.org/10.1097/00003246-200107000-00002.
    • (2001) Crit Care Med , vol.29 , pp. 1303-1310
    • Angus, D.C.1    Linde-Zwirble, W.T.2    Lidicker, J.3    Clermont, G.4    Carcillo, J.5    Pinsky, M.R.6
  • 4
    • 84866350562 scopus 로고    scopus 로고
    • α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis
    • Lee SK, Kim SD, Lee HY, Baek SH, Ko MJ, Son BG, Park S, Choi YW, Bae YS 2012. α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis. Biochem Biophys Res Commun 426:226-231. http://dx.doi.org/10.1016/j.bbrc.2012.08.070.
    • (2012) Biochem Biophys Res Commun , vol.426 , pp. 226-231
    • Lee, S.K.1    Kim, S.D.2    Lee, H.Y.3    Baek, S.H.4    Ko, M.J.5    Son, B.G.6    Park, S.7    Choi, Y.W.8    Bae, Y.S.9
  • 5
    • 84860832650 scopus 로고    scopus 로고
    • Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
    • Ohto U, Fukase K, Miyake K, Shimizu T. 2012. Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc Natl Acad Sci U S A 109:7421-7426. http://dx.doi.org/10.1073/pnas.1201193109.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 7421-7426
    • Ohto, U.1    Fukase, K.2    Miyake, K.3    Shimizu, T.4
  • 9
    • 0036093865 scopus 로고    scopus 로고
    • Inflammation and the development of pancreatic cancer
    • Farrow B, Evers BM 2002. Inflammation and the development of pancreatic cancer. Surg Oncol 10:153-169. http://dx.doi.org/10.1016/S0960-7404(02)00015-4.
    • (2002) Surg Oncol , vol.10 , pp. 153-169
    • Farrow, B.1    Evers, B.M.2
  • 10
    • 0035451363 scopus 로고    scopus 로고
    • Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: Down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation
    • Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK, Lee SS 2001. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation. Mutat Res 480-481:243-268.
    • (2001) Mutat Res , vol.480-481 , pp. 243-268
    • Surh, Y.J.1    Chun, K.S.2    Cha, H.H.3    Han, S.S.4    Keum, Y.S.5    Park, K.K.6    Lee, S.S.7
  • 11
    • 0033952703 scopus 로고    scopus 로고
    • Tlr4: Central component of the sole mammalian LPS sensor
    • Beutler B. 2000. Tlr4: central component of the sole mammalian LPS sensor. Curr Opin Immunol 12:20-26. http://dx.doi.org/10.1016/S0952-7915(99)00046-1.
    • (2000) Curr Opin Immunol , vol.12 , pp. 20-26
    • Beutler, B.1
  • 12
    • 3142713223 scopus 로고    scopus 로고
    • Inhibition of endotoxin response by synthetic TLR4 antagonists
    • Hawkins LD, Christ WJ, Rossignol DP 2004. Inhibition of endotoxin response by synthetic TLR4 antagonists. Curr Top Med Chem 4:1147-1171. http://dx.doi.org/10.2174/1568026043388123.
    • (2004) Curr Top Med Chem , vol.4 , pp. 1147-1171
    • Hawkins, L.D.1    Christ, W.J.2    Rossignol, D.P.3
  • 13
    • 70350304545 scopus 로고    scopus 로고
    • Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model
    • Takashima K, Matsunaga N, Yoshimatsu M, Hazeki K, Kaisho T, Uekata M, Hazeki O, Akira S, Iizawa Y, Ii M. 2009. Analysis of binding site for the novel small-molecule TLR4 signal transduction inhibitor TAK-242 and its therapeutic effect on mouse sepsis model. Br J Pharmacol 157:1250-1262. http://dx.doi.org/10.1111/j.1476-5381.2009.00297.x.
    • (2009) Br J Pharmacol , vol.157 , pp. 1250-1262
    • Takashima, K.1    Matsunaga, N.2    Yoshimatsu, M.3    Hazeki, K.4    Kaisho, T.5    Uekata, M.6    Hazeki, O.7    Akira, S.8    Iizawa, Y.9    Ii, M.10
  • 14
    • 84874898980 scopus 로고    scopus 로고
    • Ginsenoside rh2 downregulates LPS-induced NF-kappa B activation through inhibition of TAK1 phosphorylation in RAW 264.7 murine macrophage
    • Lian LH, Jin Q, Song SZ, Wu YL, Bai T, Jiang S, Li Q, Yang N, Nan JX 2013. Ginsenoside Rh2 downregulates LPS-induced NF-kappa B activation through inhibition of TAK1 phosphorylation in RAW 264.7 murine macrophage. Evid Based Complement Alternat Med 2013:646728.
    • (2013) Evid Based Complement Alternat Med , vol.2013
    • Lian, L.H.1    Jin, Q.2    Song, S.Z.3    Wu, Y.L.4    Bai, T.5    Jiang, S.6    Li, Q.7    Yang, N.8    Nan, J.X.9
  • 15
    • 0037428002 scopus 로고    scopus 로고
    • Adjuvant effect of ginseng extracts on the immune responses to immunisation against staphylococcus aureus in dairy cattle
    • Hu S, Concha C, Lin F, Persson WK 2003. Adjuvant effect of ginseng extracts on the immune responses to immunisation against Staphylococcus aureus in dairy cattle. Vet Immunol Immunopathol 91:29-37. http://dx.doi.org/10.1016/S0165-2427(02)00264-7.
    • (2003) Vet Immunol Immunopathol , vol.91 , pp. 29-37
    • Hu, S.1    Concha, C.2    Lin, F.3    Persson, W.K.4
  • 16
    • 0037427999 scopus 로고    scopus 로고
    • Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and erysipelothrix rhusiopathiae
    • Rivera E, Daggfeldt A, Hu S. 2003. Ginseng extract in aluminium hydroxide adjuvanted vaccines improves the antibody response of pigs to porcine parvovirus and Erysipelothrix rhusiopathiae. Vet Immunol Immunopathol 91:19-27. http://dx.doi.org/10.1016/S0165-2427(02)00269-6.
    • (2003) Vet Immunol Immunopathol , vol.91 , pp. 19-27
    • Rivera, E.1    Daggfeldt, A.2    Hu, S.3
  • 17
    • 76849115746 scopus 로고    scopus 로고
    • Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside re
    • Song X, Chen J, Sakwiwatkul K, Li R, Hu S. 2010. Enhancement of immune responses to influenza vaccine (H3N2) by ginsenoside Re. Int Immunopharmacol 10:351-356. http://dx.doi.org/10.1016/j.intimp.2009.12.009.
    • (2010) Int Immunopharmacol , vol.10 , pp. 351-356
    • Song, X.1    Chen, J.2    Sakwiwatkul, K.3    Li, R.4    Hu, S.5
  • 18
    • 40449126802 scopus 로고    scopus 로고
    • Ginsenoside rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice
    • Sun J, Song X, Hu S. 2008. Ginsenoside Rg1 and aluminum hydroxide synergistically promote immune responses to ovalbumin in BALB/c mice. Clin Vaccine Immunol 15:303-307. http://dx.doi.org/10.1128/CVI.00448-07.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 303-307
    • Sun, J.1    Song, X.2    Hu, S.3
  • 19
    • 48749094892 scopus 로고    scopus 로고
    • A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials
    • Xiang YZ, Shang HC, Gao XM, Zhang BL 2008. A comparison of the ancient use of ginseng in traditional Chinese medicine with modern pharmacological experiments and clinical trials. Phytother Res 22:851-858. http://dx.doi.org/10.1002/ptr.2384.
    • (2008) Phytother Res , vol.22 , pp. 851-858
    • Xiang, Y.Z.1    Shang, H.C.2    Gao, X.M.3    Zhang, B.L.4
  • 20
    • 84861479561 scopus 로고    scopus 로고
    • Ginsenosides rg1 and re act as adjuvant via TLR4 signaling pathway
    • Su F, Yuan L, Zhang L, Hu S. 2012. Ginsenosides Rg1 and Re act as adjuvant via TLR4 signaling pathway. Vaccine 30:4106-4112. http://dx.doi.org/10.1016/j.vaccine.2012.03.052.
    • (2012) Vaccine , vol.30 , pp. 4106-4112
    • Su, F.1    Yuan, L.2    Zhang, L.3    Hu, S.4
  • 22
    • 0034458811 scopus 로고    scopus 로고
    • Formation of monoclonal antibody against a major ginseng component, ginsenoside rg1 and its characterization. Monoclonal antibody for a ginseng saponin
    • Fukuda N, Tanaka H, Shoyama Y. 2000. Formation of monoclonal antibody against a major ginseng component, ginsenoside Rg1 and its characterization. Monoclonal antibody for a ginseng saponin. Cytotechnology 34:197-204.
    • (2000) Cytotechnology , vol.34 , pp. 197-204
    • Fukuda, N.1    Tanaka, H.2    Shoyama, Y.3
  • 23
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method
    • Livak KJ, Schmittgen TD 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 25:402-408. http://dx.doi.org/10.1006/meth.2001.1262.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 24
    • 77958029276 scopus 로고    scopus 로고
    • Quantitative correlation of physical and chemical properties with chemical structure: Utility for prediction
    • Katritzky AR, Kuanar M, Slavov S, Hall CD, Karelson M, Kahn I, Dobchev DA 2010. Quantitative correlation of physical and chemical properties with chemical structure: utility for prediction. Chem Rev 110: 5714-5789. http://dx.doi.org/10.1021/cr900238d.
    • (2010) Chem Rev , vol.110 , pp. 5714-5789
    • Katritzky, A.R.1    Kuanar, M.2    Slavov, S.3    Hall, C.D.4    Karelson, M.5    Kahn, I.6    Dobchev, D.A.7
  • 25
    • 62849112750 scopus 로고    scopus 로고
    • Calculation of molecular lipophilicity: State-of-The-art and comparison of log P methods on more than 96,000 compounds
    • Mannhold R, Poda GI, Ostermann C, Tetko IV 2009. Calculation of molecular lipophilicity: state-of-the-art and comparison of log P methods on more than 96,000 compounds. J Pharm Sci 98:861-893. http://dx.doi.org/10.1002/jps.21494.
    • (2009) J Pharm Sci , vol.98 , pp. 861-893
    • Mannhold, R.1    Poda, G.I.2    Ostermann, C.3    Tetko, I.V.4
  • 26
    • 0001509942 scopus 로고    scopus 로고
    • Prediction of physicochemical parameters by atomic contributions
    • Wildman SA, Crippen GM 1999. Prediction of physicochemical parameters by atomic contributions. J Chem Inf Comput Sci 39:868-873. http://dx.doi.org/10.1021/ci990307l.
    • (1999) J Chem Inf Comput Sci , vol.39 , pp. 868-873
    • Wildman, S.A.1    Crippen, G.M.2
  • 27
    • 84872727236 scopus 로고    scopus 로고
    • TAK-242, a small-molecule inhibitor of toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells
    • Hussey SE, Liang H, Costford SR, Klip A, DeFronzo RA, Sanchez-Avila A, Ely B, Musi N. 2013. TAK-242, a small-molecule inhibitor of Toll-like receptor 4 signalling, unveils similarities and differences in lipopolysaccharide- and lipid-induced inflammation and insulin resistance in muscle cells. Biosci Rep 33:37-47.
    • (2013) Biosci Rep , vol.33 , pp. 37-47
    • Hussey, S.E.1    Liang, H.2    Costford, S.R.3    Klip, A.4    DeFronzo, R.A.5    Sanchez-Avila, A.6    Ely, B.7    Musi, N.8
  • 28
    • 0022476714 scopus 로고
    • Permeability of small nonelectrolytes through lipid bilayer membranes
    • Walter A, Gutknecht J. 1986. Permeability of small nonelectrolytes through lipid bilayer membranes. JMembr Biol 90:207-217. http://dx.doi.org/10.1007/BF01870127.
    • (1986) JMembr Biol , vol.90 , pp. 207-217
    • Walter, A.1    Gutknecht, J.2
  • 29
    • 0037451929 scopus 로고    scopus 로고
    • The epidemiology of sepsis in the United States from 1979 through 2000
    • Martin GS, Mannino DM, Eaton S, Moss M. 2003. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 348: 1546-1554. http://dx.doi.org/10.1056/NEJMoa022139.
    • (2003) N Engl J Med , vol.348 , pp. 1546-1554
    • Martin, G.S.1    Mannino, D.M.2    Eaton, S.3    Moss, M.4
  • 30
    • 0029944101 scopus 로고    scopus 로고
    • Sepsis and cytokines: Current status
    • Blackwell TS, Christman JW 1996. Sepsis and cytokines: current status. Br J Anaesth 77:110-117. http://dx.doi.org/10.1093/bja/77.1.110.
    • (1996) Br J Anaesth , vol.77 , pp. 110-117
    • Blackwell, T.S.1    Christman, J.W.2
  • 31
    • 0028239555 scopus 로고
    • Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra sepsis syndrome study group
    • Fisher CJ, Jr, Dhainaut JF, Opal SM, Pribble JP, Balk RA, Slotman GJ, Iberti TJ, Rackow EC, Shapiro MJ, Greenman RL, et al. 1994. Recombinant human interleukin 1 receptor antagonist in the treatment of patients with sepsis syndrome. Results from a randomized, double-blind, placebo-controlled trial. Phase III rhIL-1ra Sepsis Syndrome Study Group. JAMA 271:1836-1843.
    • (1994) JAMA , vol.271 , pp. 1836-1843
    • Fisher, C.J.1    Dhainaut, J.F.2    Opal, S.M.3    Pribble, J.P.4    Balk, R.A.5    Slotman, G.J.6    Iberti, T.J.7    Rackow, E.C.8    Shapiro, M.J.9    Greenman, R.L.10
  • 32
    • 0032497152 scopus 로고    scopus 로고
    • Secrecy and transparency of medicines licensing in the EU
    • Abraham J, Lewis G. 1998. Secrecy and transparency of medicines licensing in the EU. Lancet 352:480-482. http://dx.doi.org/10.1016/S0140-6736(97)11282-X.
    • (1998) Lancet , vol.352 , pp. 480-482
    • Abraham, J.1    Lewis, G.2
  • 33
    • 34547510802 scopus 로고    scopus 로고
    • Structural biology of the LPS recognition
    • Jerala R. 2007. Structural biology of the LPS recognition. Int J Med Microbiol 297:353-363. http://dx.doi.org/10.1016/j.ijmm.2007.04.001.
    • (2007) Int J Med Microbiol , vol.297 , pp. 353-363
    • Jerala, R.1
  • 34
    • 0025166114 scopus 로고
    • CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC 1990. CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science 249:1431-1433. http://dx.doi.org/10.1126/science.1698311.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 36
    • 0028899305 scopus 로고
    • Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14
    • Gegner JA, Ulevitch RJ, Tobias PS 1995. Lipopolysaccharide (LPS) signal transduction and clearance. Dual roles for LPS binding protein and membrane CD14. J Biol Chem 270:5320-5325.
    • (1995) J Biol Chem , vol.270 , pp. 5320-5325
    • Gegner, J.A.1    Ulevitch, R.J.2    Tobias, P.S.3
  • 37
    • 0033532629 scopus 로고    scopus 로고
    • MD-2, a molecule that confers lipopolysaccharide responsiveness on toll-like receptor 4
    • Shimazu R, Akashi S, Ogata H, Nagai Y, Fukudome K, Miyake K, Kimoto M. 1999. MD-2, a molecule that confers lipopolysaccharide responsiveness on Toll-like receptor 4. J Exp Med 189:1777-1782. http://dx.doi.org/10.1084/jem.189.11.1777.
    • (1999) J Exp Med , vol.189 , pp. 1777-1782
    • Shimazu, R.1    Akashi, S.2    Ogata, H.3    Nagai, Y.4    Fukudome, K.5    Miyake, K.6    Kimoto, M.7
  • 38
    • 0036217821 scopus 로고    scopus 로고
    • Natural products as targeted modulators of the nuclear factor-kappaB pathway
    • Bremner P, Heinrich M. 2002. Natural products as targeted modulators of the nuclear factor-kappaB pathway. J Pharm Pharmacol 54:453-472. http://dx.doi.org/10.1211/0022357021778637.
    • (2002) J Pharm Pharmacol , vol.54 , pp. 453-472
    • Bremner, P.1    Heinrich, M.2
  • 39
    • 0034008116 scopus 로고    scopus 로고
    • Microcirculatory dysfunction in sepsis: A pathogenetic basis for therapy?
    • Lehr HA, Bittinger F, Kirkpatrick CJ 2000. Microcirculatory dysfunction in sepsis: a pathogenetic basis for therapy? J Pathol 190:373-386. http://dx.doi.org/10.1002/(SICI)1096-9896(200002)190:3<373::AID-PATH593>3.0.CO;2-3.
    • (2000) J Pathol , vol.190 , pp. 373-386
    • Lehr, H.A.1    Bittinger, F.2    Kirkpatrick, C.J.3
  • 40
    • 0037180768 scopus 로고    scopus 로고
    • The immunopathogenesis of sepsis
    • Cohen J. 2002. The immunopathogenesis of sepsis. Nature 420:885-891. http://dx.doi.org/10.1038/nature01326.
    • (2002) Nature , vol.420 , pp. 885-891
    • Cohen, J.1
  • 41
    • 0038062839 scopus 로고    scopus 로고
    • Proinflammatory cytokines and sepsis syndrome: Not enough, or too much of a good thing?
    • Netea MG, van der Meer JW, van Deuren M, Kullberg BJ. 2003. Proinflammatory cytokines and sepsis syndrome: not enough, or too much of a good thing? Trends Immunol 24:254-258. http://dx.doi.org/10.1016/S1471-4906(03)00079-6.
    • (2003) Trends Immunol , vol.24 , pp. 254-258
    • Netea, M.G.1    Van Der Meer, J.W.2    Van Deuren, M.3    Kullberg, B.J.4
  • 42
    • 0038578608 scopus 로고    scopus 로고
    • Novel strategies for the treatment of sepsis
    • Riedemann NC, Guo RF, Ward PA 2003. Novel strategies for the treatment of sepsis. Nat Med 9:517-524. http://dx.doi.org/10.1038/nm0503-517.
    • (2003) Nat Med , vol.9 , pp. 517-524
    • Riedemann, N.C.1    Guo, R.F.2    Ward, P.A.3
  • 43
    • 77954096689 scopus 로고    scopus 로고
    • IL-6: Regulator of treg/Th17 balance
    • Kimura A, Kishimoto T. 2010. IL-6: regulator of Treg/Th17 balance. Eur J Immunol 40:1830-1835. http://dx.doi.org/10.1002/eji.201040391.
    • (2010) Eur J Immunol , vol.40 , pp. 1830-1835
    • Kimura, A.1    Kishimoto, T.2


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