Down-regulation of IL-8 by high-dose Vitamin D is specific to hyperinflammatory macrophages and involves mechanisms beyond up-regulation of DUSP1

British Journal of Pharmacology

Volumn 172, Issue 19, 2015, Pages 4757-4771

  Dauletbaev, N ^a   Herscovitch, K ^a   Das, M ^a   Chen, H ^a   Bernier, J ^b   Matouk, E ^b   Berube J ^c   Rousseau, S ^c   Lands, L C ^a,d  

^a RESEARCH INSTITUTE OF THE MCGILL UNIVERSITY HEALTH CENTRE   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d MONTREAL CHILDREN S HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIFEDIOL; CALCITRIOL; DEXAMETHASONE; INTERLEUKIN 8; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE 1; PARICALCITOL; VIRULENCE FACTOR; VITAMIN D; CALCIDIOL 1 MONOOXYGENASE; CALCITRIOL RECEPTOR; COLECALCIFEROL 24 HYDROXYLASE; CYP24A1 PROTEIN, HUMAN; CYP27B1 PROTEIN, HUMAN; DIHYDROXY-VITAMIN D3; DUSP1 PROTEIN, HUMAN; ERGOCALCIFEROL; VDR PROTEIN, HUMAN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; BACTERIAL VIRULENCE; CAUCASIAN; CONTROLLED STUDY; CYSTIC FIBROSIS; DOWN REGULATION; DRUG MEGADOSE; DUSP1 GENE; GENE; HUMAN; LOW DRUG DOSE; MACROPHAGE; METABOLITE; MONOCYTE; PHENOTYPE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TRANSCRIPTION REGULATION; UPREGULATION; ADULT; ANALOGS AND DERIVATIVES; BLOOD; CELL CULTURE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; YOUNG ADULT;

25-HYDROXYVITAMIN D3 1-ALPHA-HYDROXYLASE; ADULT; CALCIFEDIOL; CELLS, CULTURED; CYSTIC FIBROSIS; DOWN-REGULATION; DUAL SPECIFICITY PHOSPHATASE 1; ERGOCALCIFEROLS; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-8; MACROPHAGES; RECEPTORS, CALCITRIOL; UP-REGULATION; VITAMIN D; VITAMIN D3 24-HYDROXYLASE; YOUNG ADULT;

EID: 84940942531     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13249     Document Type: Article

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