ELQ-300 prodrugs for enhanced delivery and single-dose cure of malaria

Antimicrobial Agents and Chemotherapy

Volumn 59, Issue 9, 2015, Pages 5555-5560

  Miley, Galen P ^a   Pou, Sovitj ^a   Winter, Rolf ^a   Nilsen, Aaron ^a   Li, Yuexin ^a   Kelly, Jane X ^a   Stickles, Allison M ^b   Mather, Michael W ^c   Forquer, Isaac P ^a   Pershing, April M ^c   White, Karen ^d   Shackleford, David ^d   Saunders, Jessica ^d   Chen, Gong ^d   Ting, Li Min ^e   Kim, Kami ^e   Zakharov, Lev N ^f   Donini, Cristina ^g   Burrows, Jeremy N ^g   Vaidya, Akhil B ^c   Charman, Susan A ^d   Riscoe, Michael K ^a,b   more..

^a PORTLAND VA MEDICAL CENTER   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^d MONASH UNIVERSITY   (Australia)

^e ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^f UNIVERSITY OF OREGON   (United States)

^g Medicines for Malaria Venture   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ELQ 300; ELQ 337; MACROGOL 400; PRODRUG; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; VERAPAMIL; WARFARIN; 6-CHLORO-7-METHOXY-2-METHYL-3-(4-(4-(TRIFLUOROMETHOXY)PHENOXY)PHENYL)QUINOLIN-4(1H)-ONE; QUINOLONE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; AREA UNDER THE CURVE; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG HALF LIFE; DRUG SYNTHESIS; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MALARIA; MAXIMUM PLASMA CONCENTRATION; METABOLIC STABILITY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; RODENT MALARIA; SINGLE DRUG DOSE; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECT; PATHOGENICITY;

ANIMALS; ANTIMALARIALS; CRYSTALLOGRAPHY, X-RAY; ELECTRON TRANSPORT COMPLEX III; FEMALE; MALARIA; MICE; PLASMODIUM FALCIPARUM; PRODRUGS; QUINOLONES;

EID: 84940937886     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.01183-15     Document Type: Article

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