No association of the Ser/Cys311 DRD2 molecular variant with schizophrenia using a classical case control study and the haplotype relative risk

Schizophrenia Research

Volumn 25, Issue 2, 1997, Pages 117-121

  Verga, Massimiliano ^a   Macciardi, Fabio ^a,b   Pedrini, Silvia ^a   Cohen, Susanna ^a   Smeraldi, Enrico ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Association study; Dopamine D2 receptor gene; Haplotype relative risk; Schizophrenia

Indexed keywords

DOPAMINE; DOPAMINE 2 RECEPTOR; HLA DR ANTIGEN;

ADULT; ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; FEMALE; GENE FREQUENCY; GENETIC MARKER; GENETIC RISK; HAPLOTYPE; HUMAN; HUMAN CELL; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SCHIZOPHRENIA; SEQUENCE ANALYSIS;

AGE OF ONSET; ALLELES; DNA; FEMALE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; RECEPTORS, DOPAMINE D2; SCHIZOPHRENIA;

EID: 0030946130     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0920-9964(97)00013-3     Document Type: Article

References (20)

1. American Psychiatric Association (1987) Diagnostic and Statistical Manual of Mental Disorders, 3rd Edn. revised. American Psychiatric Association, Washington.
2. Arinami, T., Itokawa, M., Enguchi, H., Tagaya, H., Yano, S., Shimizu, H., Hamaguchi and Toru, M. (1994) Association of dopamine D2 receptor molecular variant with schizophrenia. Lancet 343, 703-704.
3. Asherson, P., Williams, N., Roberts, E., McGuffin, M. and Owen, M. (1994) DRD2 Ser311 Cys311 polymorphism in schizophrenia. Lancet 343(8904), 1045.
4. Battaglia, M., Bernardeschi, L., Franchini, L., Bellodi, L. and Smeraldi, E. (1995) A family study of schizotypal disorder. Schizophr. Bull. 21(1), 33-45.
5. Castiglione, C.M., Deinard, A.S., Speed, W.C., Sirugo, G., Rosenbaum, H.C., Zhang, Y., Grandy, D.K., Grigorenko, E.L., Bonne-Tamir, B., Pakstis, A.J., Kidd, J.R. and Kidd, K.K. (1995) Evolution of haplotypes at the DRD2 locus. Am. J. Hum. Genet. 57, 1445-1456.
6. Chen, C.H., Chien, S.H. and Hwu, H.G. (1996) No association of dopamine D2 receptor molecular variant Cys311 and schizophrenia in chinese patients. Am. J. Med. Genet. (Neuropsychiat. Genet.) 67, 418-420.
7. Gejman, P.V., Ram, A., Gelernter, J., Friedman, E., Cao, Q., Pickar, D., Blum, K., Noble, E.P., Kranzler, H.R., O'Malley, S., Hamer, D.H., Whitsitt, F., Rao, P., DeLisi, L.E., Virkkunen, M., Linnoil, M., Goldman, D. and Gershon, E.S. (1994) No structural mutation in the dopamine D2 receptor gene in alcoholism or schizophrenia. Analysis using denaturing gradient gel electrophoresis. J. Am. Med. Assoc. 271, 204-208.
8. Grandy, D.K., Litt, M., Allen, M., Bunzow, J.R., Marchionni, M., Makam, H., Reed, L., Magenis, R.E. and Civelli, O. (1989) The human dopamine D2 receptor gene is located on chromosome 11 at q-22 q-23 and identifies a TaqI RFLP. Am. J. Hum. Genet. 45, 778-785.
9. Hattori, M., Nanko, S., Dai, X.Y., Fukuda, R. and Kazamatsuri, H. (1994) Mismatch PCR RFLP detection of DRD2 Ser311Cys polymorphism and schizophrenia. Biochem. Biophys. Res. Commun. 29(202), 757-763.
10. Higuchi, S., Muramatsu, T., Murayama, M. and Hayashida, M. (1994) Association of structural polymorphism of the dopamine D2 receptor gene and alcoholism. Biochem. Biophys. Res. Commun. 204(3), 1199-1205.
11. Itokawa, M., Arinami, T., Futamura, N., Hamaguchi, H. and Toru, M. (1993) A structural polymorphism of human dopamine D2 receptor, D2 (Ser311-Cys). Biochem. Biophys. Res. Commun. 196(3), 1369-1375.
12. Lahiri, D.K. and Nurnberg, J.I. Jr. (1991) A rapid non-enzymatic method for the preparation of HMW DNA from blood for RFLP studies. Nucleic Acids Res. 19, 5444.
13. Laurent C., Bodeau-Pean, S., Campion, D., D'Amato, T., Jay, M., Dollfus, S., Thibault, F., Petit, M., Samolyk, D., Martinez, M. and Mallet, J. (1994) No major role for the dopamine D2 receptor Ser Cys311 mutation in schizophrenia. Psychiat. Genet. (4), 229-230.
14. Nanko, S., Hattori, M., Dai, X.Y., Fukuda, R. and Kazamatsuri, H. (1994) DRD2 Ser311 Cys311 polymorphism in schizophrenia. Lancet 343(8904), 1044.
15. Nothen, M.M., Wildenauer, D., Cichon, S., Albus, M., Maier, W., Minges, J., Lichtermann, D., Bondy, B., Rietschel, M., Korner, J., Fimmers, R. and Propping, P. (1994) Dopamine D2 receptor molecular variant and schizophrenia. Lancet 343(8908), 1301-1302.
16. Robins, L., Helzer, J.E., Cottler, R. and Goldring, E. (1989) NIMH Diagnostic Interview Schedule: version III-R (DIS-R). Washington University School of Medicine, St. Louis, MO.
17. Sasaki, T., Macciardi, F.M., Badri, F., Verga, M., Meltzer, H.Y., Lieberman, J., Howard, A., Bean, G., Joffe, R.T., Hudson, C.J. and Kennedy, J.L. (1996) No evidence for association of dopamine D2 receptor variant (Ser311 Cys311) with major psychosis. Am. J. Med. Genet. (Neuropsychiat. Genet.) 67, 415-417.
18. Seeman, P. (1987) Dopamine receptors and the dopamine hypothesis of schizophrenia. Synapse 1, 133-152.
19. Shaikh, S., Collier, D., Arranz, M., Ball, D., Gill, M. and Kerwin, R. (1994) DRD2 Ser311 Cys311 polymorphism in schizophrenia. Lancet 343(8904), 1045-1046.
20. Terwilliger, J.D. and Ott, J. (1992) A haplotype-based 'Haplotype Relative Risk' approach to detecting allelic associations. Hum. Hered. 42, 337-346.