Pathological von Willebrand factor fibers resist tissue plasminogen activator and ADAMTS13 while promoting the contact pathway and shear-induced platelet activation

Journal of Thrombosis and Haemostasis

Volumn 13, Issue 9, 2015, Pages 1699-1708

  Herbig, B A ^a   Diamond, S L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Blood platelets; Coronary stenosis; Thrombolytic therapy; Tissue plasminogen activator; Von Willebrand factor

Indexed keywords

4 [4 [4 (AMINOIMINOMETHYL)PHENYL] 1 PIPERAZINYL] 1 PIPERIDINEACETIC ACID; APIXABAN; BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 12A; DEXTRO PHENYLALANYLPROLYLARGINYL CHLOROMETHYL KETONE; FIBRIN; PADGEM PROTEIN; THROMBIN; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR; VON WILLEBRAND FACTOR CLEAVING PROTEINASE; ADAM PROTEIN; ADAMTS13 PROTEIN, HUMAN; BIOPOLYMER; FIBRINOGEN RECEPTOR; PIPERAZINE DERIVATIVE; PIPERIDINE DERIVATIVE; PLASMIN; PROTEIN SUBUNIT;

ARTICLE; ENZYME ACTIVITY; FIBRIN FORMATION; FIBRIN POLYMERIZATION; HUMAN; MICROFLUIDICS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SHEAR FLOW; SHEAR RATE; SHEAR STRESS; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; ANTAGONISTS AND INHIBITORS; BLOOD; BLOOD CLOTTING; BLOOD RHEOLOGY; CHEMISTRY; DRUG EFFECTS; IN VITRO STUDY; LAB ON A CHIP; PHYSIOLOGY; PROTEIN SUBUNIT; SOLUBILITY; ULTRASTRUCTURE; YOUNG MODULUS;

ADAM PROTEINS; ADAMTS13 PROTEIN; BIOPOLYMERS; BLOOD COAGULATION; ELASTIC MODULUS; FIBRINOLYSIN; HEMORHEOLOGY; HUMANS; IN VITRO TECHNIQUES; LAB-ON-A-CHIP DEVICES; P-SELECTIN; PIPERAZINES; PIPERIDINES; PLATELET ACTIVATION; PLATELET ADHESIVENESS; PLATELET GLYCOPROTEIN GPIIB-IIIA COMPLEX; PROTEIN SUBUNITS; SOLUBILITY; TISSUE PLASMINOGEN ACTIVATOR; VON WILLEBRAND FACTOR;

EID: 84940895784     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.13044     Document Type: Article

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